{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:54:36Z","timestamp":1793332476049,"version":"4.5.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Purpose<\/jats:title>\n \n To determine the role of Lactobacillus strains and their combinations in inhibiting the colonization of\n H. pylori<\/jats:italic>\n and gastric mucosa inflammation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Human gastric adenocarcinoma AGS cells were incubated with H. pylori and six probiotic strains (\n Lactobacillus acidophilus<\/jats:italic>\n NCFM,\n L. acidophilus<\/jats:italic>\n La-14,\n Lactiplantibacillus plantarum<\/jats:italic>\n Lp-115,\n Lacticaseibacillus paracasei<\/jats:italic>\n Lpc-37,\n Lacticaseibacillus rhamnosus<\/jats:italic>\n Lr-32, and\n L. rhamnosus<\/jats:italic>\n GG) and the adhesion ability of\n H. pylori<\/jats:italic>\n in different combinations was evaluated by fluorescence microscopy and urease activity assay. Male C57BL\/6 mice were randomly divided into five groups (uninfected,\n H. pylori<\/jats:italic>\n ,\n H. pylori<\/jats:italic>\n +NCFM,\n H. pylori<\/jats:italic>\n +Lp-115, and\n H. pylori<\/jats:italic>\n +NCFM+Lp-115) and treated with two lactobacilli strains (NCFM and Lp-115) for six weeks.\n H. pylori<\/jats:italic>\n colonization and tissue inflammation statuses were determined by rapid urease test, Hematoxylin-Eosin (HE) staining, immunohistochemistry, and qRT-PCR and ELISA.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n L. acidophilus<\/jats:italic>\n NCFM,\n L. acidophilus<\/jats:italic>\n La-14,\n L. plantarum<\/jats:italic>\n Lp-115,\n L. paracasei<\/jats:italic>\n Lpc-37,\n L. rhamnosus<\/jats:italic>\n Lr-32, and\n L. rhamnosus<\/jats:italic>\n GG reduced\n H. pylori<\/jats:italic>\n adhesion and inflammation caused by\n H. pylori<\/jats:italic>\n infection in AGS cells and mice. Among all probiotics\n L. acidophilus<\/jats:italic>\n NCFM and\n L. plantarum<\/jats:italic>\n , Lp-115 showed significant effects on the\n H. pylori<\/jats:italic>\n eradication and reduction of inflammation\n in-vitro<\/jats:italic>\n and\n in-vivo<\/jats:italic>\n . Compared with the\n H. pylori<\/jats:italic>\n infection group, the mRNA and protein expression levels of IL-8 and TNF-\u03b1 in the six\n Lactobacillus<\/jats:italic>\n intervention groups were significantly reduced. The changes in the urease activity (\n ureA<\/jats:italic>\n and\n ureB<\/jats:italic>\n ) for 1-7h in each group showed that\n L. acidophilus<\/jats:italic>\n NCFM,\n L. acidophilus<\/jats:italic>\n La-14,\n L. plantarum<\/jats:italic>\n Lp-115, and\n L. rhamnosus<\/jats:italic>\n GG effectively reduced the colonization of\n H. pylori<\/jats:italic>\n . We observed a higher ratio of lymphocyte and plasma cell infiltration into the lamina propria of the gastric mucosa and neutrophil infiltration in\n H. pylori<\/jats:italic>\n +NCFM+Lp-115 mice. The infiltration of inflammatory cells in lamina propria of the gastric mucosa was reduced in the\n H. pylori<\/jats:italic>\n +NCFM+Lp-115 group. Additionally, the expression of IFN-\u03b3 was decreased significantly in the NCFM and Lp-115 treated C57BL\/6 mice.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n L. acidophilus<\/jats:italic>\n NCFM and\n L. plantarum<\/jats:italic>\n Lp-115 can reduce the adhesion of\n H. pylori<\/jats:italic>\n and inhibit the gastric inflammatory response caused by\n H. pylori<\/jats:italic>\n infection.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2023.1196084","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T09:43:34Z","timestamp":1691574214000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Lactobacillus acidophilus NCFM and Lactiplantibacillus plantarum Lp-115 inhibit Helicobacter pylori colonization and gastric inflammation in a murine model"],"prefix":"10.3389","volume":"13","author":[{"given":"Siqi","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FeiFei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihtisham","family":"Bukhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C.","family":"Ouwehand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1590\/S0004-2803.201800000-70","article-title":"Honey-derived lactobacillus rhamnosus alleviates helicobacter pylori-induced gastro-intestinal infection and gastric inflammation in C57bl\/6 mice: an immuno-histologic study","volume":"55","author":"Asgari","year":"2018","journal-title":"Arq. 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