{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:40:25Z","timestamp":1792885225159,"version":"4.5.0"},"reference-count":116,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, endochondral ossification and epidermis tissue homeostasis. Additionally, it has been reported that JunB has great regulatory functions in innate and adaptive immune responses by regulating the differentiation and cytokine secretion of immune cells including T cells, dendritic cells and macrophages, while also facilitating the effector of neutrophils and natural killer cells. Furthermore, a growing body of studies have shown that JunB is involved in tumorigenesis through regulating cell proliferation, differentiation, senescence and metastasis, particularly affecting the tumor microenvironment through transcriptional promotion or suppression of oncogenes in tumor cells or immune cells. This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory mechanisms within tumor-associated immune processes.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1222265","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T02:35:11Z","timestamp":1693794911000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":100,"title":["JunB: a paradigm for Jun family in immune response and cancer"],"prefix":"10.3389","volume":"13","author":[{"given":"Fu-jia","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-ying","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.2217\/imt-2021-0187","article-title":"Gene signatures with therapeutic value: emerging perspective for personalized immunotherapy in renal cancer","volume":"13","author":"Ahluwalia","year":"2021","journal-title":"Immunotherapy"},{"key":"B2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/imr.12301","article-title":"The E3 ligase Itch in immune regulation and beyond","volume":"266","author":"Aki","year":"2015","journal-title":"Immunol. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2920","DOI":"10.1002\/cam4.886","article-title":"CCL2 as a potential therapeutic target for clear cell renal cell carcinoma","volume":"5","author":"Arakaki","year":"2016","journal-title":"Cancer Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1093\/emboj\/19.9.2056","article-title":"Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression","volume":"19","author":"Bakiri","year":"2000","journal-title":"EMBO J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"6789","DOI":"10.1158\/1078-0432.CCR-04-0306","article-title":"Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature","volume":"10","author":"Bieche","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41467-017-00380-3","article-title":"JunB promotes Th17 cell identity and restrains alternative CD4(+) T-cell programs during inflammation","volume":"8","author":"Carr","year":"2017","journal-title":"Nat. Commun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nrd.2018.169","article-title":"Targeting macrophages: therapeutic approaches in cancer","volume":"17","author":"Cassetta","year":"2018","journal-title":"Nat. Rev. Drug Discovery"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1084\/jem.20172026","article-title":"USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein","volume":"215","author":"Chen","year":"2018","journal-title":"J. Exp. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1006\/niox.2001.0415","article-title":"JunB\/AP-1 and NF-kappa B-mediated induction of nitric oxide synthase by bovine type I collagen in serum-stimulated murine macrophages","volume":"6","author":"Cho","year":"2002","journal-title":"Nitric. Oxide"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120231","article-title":"Skp2 promotes APL progression through the stabilization of oncoprotein PML-RAR alpha and the inhibition of JunB expression","volume":"289","author":"Dan","year":"2022","journal-title":"Life Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/nrc1209","article-title":"AP-1: a double-edged sword in tumorigenesis","volume":"3","author":"Eferl","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1038\/leu.2016.358","article-title":"The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment","volume":"31","author":"Fan","year":"2017","journal-title":"Leukemia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.leukres.2015.11.016","article-title":"miRNA-149 promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia","volume":"41","author":"Fan","year":"2016","journal-title":"Leukemia Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1038\/s41375-021-01271-9","article-title":"JunB is a key regulator of multiple myeloma bone marrow angiogenesis","volume":"35","author":"Fan","year":"2021","journal-title":"Leukemia"},{"key":"B15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/ni763","article-title":"Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation","volume":"3","author":"Fang","year":"2002","journal-title":"Nat. Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1128\/MCB.01620-07","article-title":"JunB breakdown in mid\/late G2 is required for down regulation of cyclin A2 levels and proper mitosis","volume":"95","author":"Farras","year":"2008","journal-title":"Bull. Du Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41590-019-0343-z","article-title":"Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils","volume":"20","author":"Fischer","year":"2019","journal-title":"Nat. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"939","DOI":"10.4161\/cbt.8.10.8213","article-title":"Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells","volume":"8","author":"Fiskus","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"B19","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/sj.jid.5700123","article-title":"Delayed wound healing and epidermal hyperproliferation in mice lacking JunB in the skin","volume":"126","author":"Florin","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/pim.12215","article-title":"Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections","volume":"37","author":"Fontana","year":"2015","journal-title":"Parasite Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4049\/jimmunol.1401595","article-title":"JUNB is a key transcriptional modulator of macrophage activation","volume":"194","author":"Fontana","year":"2015","journal-title":"J. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/s0014-5793(02)02295-0","article-title":"NF-kappaB elements contribute to junB inducibility by lipopolysaccharide in the murine macrophage cell line RAW264.7","volume":"513","author":"Frazier-Jessen","year":"2002","journal-title":"FEBS Lett."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.4049\/jimmunol.1900128","article-title":"BATF-interacting proteins dictate specificity in th subset activity","volume":"203","author":"Fu","year":"2019","journal-title":"J. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.4049\/jimmunol.180.9.5983","article-title":"SUMOylation regulates the transcriptional activity of JunB in T lymphocytes","volume":"180","author":"Garaude","year":"2008","journal-title":"J. Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3324\/haematol.2019.241307","article-title":"miR-939 acts as tumor suppressor by modulating JUNB transcriptional activity in pediatric anaplastic large cell lymphoma","volume":"106","author":"Garbin","year":"2021","journal-title":"Haematologica"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00924","article-title":"Dendritic cells and their role in immunotherapy","volume":"11","author":"Gardner","year":"2020","journal-title":"Front. Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1083\/jcb.201109045","article-title":"JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-beta","volume":"196","author":"Gervasi","year":"2012","journal-title":"J. Cell Biol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009585","article-title":"An NF-kappaB-dependent role for JunB in the induction of proinflammatory cytokines in LPS-activated bone marrow-derived dendritic cells","volume":"5","author":"Gomard","year":"2010","journal-title":"PloS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"9729","DOI":"10.1002\/jcp.29784","article-title":"Tumor-associated macrophages promote prostate cancer progression via exosome-mediated miR-95 transfer","volume":"235","author":"Guan","year":"2020","journal-title":"J. Cell Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.ccr.2009.03.008","article-title":"Lessons learned from the study of JunB: new insights for normal and leukemia stem cell biology","volume":"15","author":"Guzman","year":"2009","journal-title":"Cancer Cell."},{"key":"B31","doi-asserted-by":"publisher","first-page":"6321","DOI":"10.1093\/emboj\/cdf648","article-title":"Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB","volume":"21","author":"Hartenstein","year":"2002","journal-title":"EMBO J."},{"key":"B32","doi-asserted-by":"publisher","first-page":"15628","DOI":"10.1038\/ncomms15628","article-title":"JunB is essential for IL-23-dependent pathogenicity of Th17 cells","volume":"8","author":"Hasan","year":"2017","journal-title":"Nat. Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"4587","DOI":"10.1242\/jcs.00772","article-title":"Defective endochondral ossification in mice with strongly compromised expression of JunB","volume":"116","author":"Hess","year":"2003","journal-title":"J. Cell Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.leukres.2009.03.044","article-title":"Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia","volume":"33","author":"Hoshino","year":"2009","journal-title":"Leuk Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.901030","article-title":"JunB is critical for survival of T helper cells","volume":"13","author":"Hsieh","year":"2022","journal-title":"Front. Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0284-4","article-title":"JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma","volume":"35","author":"Hyakusoku","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4859","DOI":"10.1074\/jbc.M107243200","article-title":"Role of JunB in erythroid differentiation","volume":"277","author":"Jacobs-Helber","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.mvr.2016.02.004","article-title":"AP-1 transcription factor mediates VEGF-induced endothelial cell migration and proliferation","volume":"105","author":"Jia","year":"2016","journal-title":"Microvasc Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/jid.2011.1","article-title":"c-Jun promotes whereas JunB inhibits epidermal neoplasia","volume":"131","author":"Jin","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000447076","article-title":"Leukemia","volume":"43","author":"Juliusson","year":"2016","journal-title":"Prog. Tumor Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1038\/onc.2011.475","article-title":"JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma","volume":"31","author":"Kanno","year":"2012","journal-title":"Oncogene"},{"key":"B42","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1080\/25785826.2021.1872838","article-title":"Regulation of T cell differentiation by the AP-1 transcription factor JunB","volume":"44","author":"Katagiri","year":"2021","journal-title":"Immunol. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/s41385-019-0182-0","article-title":"JunB plays a crucial role in development of regulatory T cells by promoting IL-2 signaling","volume":"12","author":"Katagiri","year":"2019","journal-title":"Mucosal Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1083\/jcb.2003081551956c","article-title":"Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects","volume":"195","author":"Kenner","year":"2011","journal-title":"J. Cell Biol."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-441","article-title":"Expression of activator protein-1 (AP-1) family members in breast cancer","volume":"13","author":"Kharman-Biz","year":"2013","journal-title":"BMC Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/s41590-021-00968-4","article-title":"Distinct transcription factor networks control neutrophil-driven inflammation","volume":"22","author":"Khoyratty","year":"2021","journal-title":"Nat. Immunol."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102547","article-title":"Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis","volume":"116","author":"Kobayashi","year":"2021","journal-title":"J. Autoimmun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1038\/s41467-018-07735-4","article-title":"JunB regulates homeostasis and suppressive functions of effector regulatory T cells","volume":"9","author":"Koizumi","year":"2018","journal-title":"Nat. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"4408","DOI":"10.1158\/1078-0432.CCR-07-4120","article-title":"Function of JunB in transient amplifying cell senescence and progression of human prostate cancer","volume":"14","author":"Konishi","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41419-020-2522-0","article-title":"PKCtheta-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization","volume":"11","author":"Kumar","year":"2020","journal-title":"Cell Death Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/nm.2966","article-title":"PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas","volume":"18","author":"Laimer","year":"2012","journal-title":"Nat. Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1053\/j.semdp.2019.12.002","article-title":"Pathology and genetics of anaplastic large cell lymphoma","volume":"37","author":"Leventaki","year":"2020","journal-title":"Semin. Diagn. Pathol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/emboj\/18.2.420","article-title":"Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.cellsig.2016.05.016","article-title":"Itch promotes the neddylation of JunB and regulates JunB-dependent transcription","volume":"28","author":"Li","year":"2016","journal-title":"Cell Signal"},{"key":"B55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.semcancer.2019.08.012","article-title":"Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets","volume":"60","author":"Liang","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1172\/JCI41749","article-title":"Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice","volume":"120","author":"Licht","year":"2010","journal-title":"J. Clin. Invest."},{"key":"B57","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1083\/jcb.200605149","article-title":"JunB is required for endothelial cell morphogenesis by regulating core-binding factor beta","volume":"175","author":"Licht","year":"2006","journal-title":"J. Cell Biol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","article-title":"The neutrophil's role during health and disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol. Rev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1532\/IJH97.A10514","article-title":"Usefulness of quantitative assessment of JunB gene expression as a marker for monitoring chronic myeloid leukemia patients undergoing imatinib therapy","volume":"84","author":"Liu","year":"2006","journal-title":"Int. J. Hematol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/j.cmet.2021.04.001","article-title":"Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance","volume":"33","author":"Liu","year":"2021","journal-title":"Cell Metab."},{"key":"B61","doi-asserted-by":"publisher","first-page":"109634","DOI":"10.1016\/j.celrep.2021.109634","article-title":"Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging","volume":"36","author":"Maity","year":"2021","journal-title":"Cell Rep."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2021.101481","article-title":"The role of dendritic cells in cancer and anti-tumor immunity","volume":"52","author":"Marciscano","year":"2021","journal-title":"Semin. Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.1093\/emboj\/cdf389","article-title":"Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B","volume":"21","author":"Mathas","year":"2002","journal-title":"EMBO J."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-9597-4_1","article-title":"Introduction to the immune system","volume":"2024","author":"McComb","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nm1579","article-title":"Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia","volume":"13","author":"Mullican","year":"2007","journal-title":"Nat. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4049\/jimmunol.176.1.7","article-title":"Cutting edge: the AP-1 subunit JunB determines NK cell-mediated target cell killing by regulation of the NKG2D-ligand RAE-1epsilon","volume":"176","author":"Nausch","year":"2006","journal-title":"J. Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1038\/s41418-021-00765-4","article-title":"The AP-1 transcription factors c-Jun and JunB are essential for CD8alpha conventional dendritic cell identity","volume":"28","author":"Novoszel","year":"2021","journal-title":"Cell Death Differ."},{"key":"B68","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1182\/blood.V80.9.2298.2298","article-title":"Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6","volume":"80","author":"Oritani","year":"1992","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1091\/mbc.E17-06-0342","article-title":"STAT3 controls COL1A2 enhancer activation cooperatively with JunB, regulates type I collagen synthesis posttranscriptionally, and is essential for lung myofibroblast differentiation","volume":"29","author":"Papaioannou","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s0092-8674(01)00188-x","article-title":"Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage","volume":"104","author":"Passegue","year":"2001","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s13059-022-02800-0","article-title":"New roles for AP-1\/JUNB in cell cycle control and tumorigenic cell invasion via regulation of cyclin E1 and TGF-beta2","volume":"23","author":"Perez-Benavente","year":"2022","journal-title":"Genome Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"20423","DOI":"10.1073\/pnas.0910371106","article-title":"Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling","volume":"106","author":"Pflegerl","year":"2009","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B73","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.cyto.2014.09.011","article-title":"T cell subsets and their signature cytokines in autoimmune and inflammatory diseases","volume":"74","author":"Raphael","year":"2015","journal-title":"Cytokine"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1182\/blood-2005-02-0717","article-title":"Effect of transcription-factor concentrations on leukemic stem cells","volume":"106","author":"Rosenbauer","year":"2005","journal-title":"Blood"},{"key":"B75","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng1361","article-title":"Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1","volume":"36","author":"Rosenbauer","year":"2004","journal-title":"Nat. Genet."},{"key":"B76","doi-asserted-by":"publisher","first-page":"8908","DOI":"10.1093\/nar\/gkt669","article-title":"Chromatin loop organization of the junb locus in mouse dendritic cells","volume":"41","author":"Salem","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ccr.2009.02.016","article-title":"JunB Protects against Myeloid Malignancies by Limiting Hematopoietic Stem Cell Proliferation and Differentiation without Affecting Self-Renewal","volume":"15","author":"Santaguida","year":"2009","journal-title":"Cancer Cell"},{"key":"B78","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/s0090-4295(03)00758-1","article-title":"Cellular and molecular biology of the prostate: stem cell biology","volume":"62","author":"Schalken","year":"2003","journal-title":"Urology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1093\/emboj\/18.4.934","article-title":"JunB is essential for mamMalian placentation","volume":"18","author":"Schorpp-Kistner","year":"1999","journal-title":"EMBO J."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01713","article-title":"Microenvironmental regulation of tumor progression and therapeutic response in brain metastasis","volume":"10","author":"Schulz","year":"2019","journal-title":"Front. Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3322\/caac.21438","article-title":"Hodgkin lymphoma: A review and update on recent progress","volume":"68","author":"Shanbhag","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1038\/s41467-018-05726-z","article-title":"JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin","volume":"9","author":"Singh","year":"2018","journal-title":"Nat. Commun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.ccr.2006.11.009","article-title":"PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells","volume":"10","author":"Somervaille","year":"2006","journal-title":"Cancer Cell"},{"key":"B84","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.bbrc.2011.02.126","article-title":"JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation","volume":"407","author":"Son","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/ng1898","article-title":"Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells","volume":"38","author":"Steidl","year":"2006","journal-title":"Nat. Genet."},{"key":"B86","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.leukres.2009.11.016","article-title":"DNA methylation does not regulate JUNB expression in CML: comment on \"Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia\" by Hoshino et\u00a0al","volume":"34","author":"Strathdee","year":"2010","journal-title":"Leuk Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"B88","doi-asserted-by":"publisher","first-page":"102554","DOI":"10.1016\/j.jbc.2022.102554","article-title":"m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-beta-induced epithelial-mesenchymal transition of lung cancer cells","volume":"298","author":"Suphakhong","year":"2022","journal-title":"J. Biol. Chem."},{"key":"B89","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.3892\/ol.2017.6714","article-title":"Low expression of microRNA-1908 predicts a poor prognosis for patients with ovarian cancer","volume":"14","author":"Teng","year":"2017","journal-title":"Oncol. Lett."},{"key":"B90","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1172\/JCI70405","article-title":"JUNB\/AP-1 controls IFN-gamma during inflammatory liver disease","volume":"123","author":"Thomsen","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B91","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/cdd.2014.213","article-title":"Loss of JUNB\/AP-1 promotes invasive prostate cancer","volume":"22","author":"Thomsen","year":"2015","journal-title":"Cell Death Differ."},{"key":"B92","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.amjms.2017.01.019","article-title":"AP-1 expression and its clinical relevance in immune disorders and cancer","volume":"353","author":"Trop-Steinberg","year":"2017","journal-title":"Am. J. Med. Sci."},{"key":"B93","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/jcp.29843","article-title":"JunB can enhance the transcription of IL-8 in oral squamous cell carcinoma","volume":"236","author":"Tsunoda","year":"2021","journal-title":"J. Cell Physiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.celrep.2019.09.042","article-title":"Cutaneous immune cell-microbiota interactions are controlled by epidermal JunB\/AP-1","volume":"29","author":"Uluckan","year":"2019","journal-title":"Cell Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"5123","DOI":"10.1172\/JCI121227","article-title":"SMAD4 promotes TGF-beta-independent NK cell homeostasis and maturation and antitumor immunity","volume":"128","author":"Wang","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B96","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bbrc.2020.01.042","article-title":"The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB","volume":"524","author":"Wanna-udom","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B97","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.ajpath.2011.10.007","article-title":"Ets-1 activates overexpression of JunB and CD30 in Hodgkin's lymphoma and anaplastic large-cell lymphoma","volume":"180","author":"Watanabe","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/labinvest.3700696","article-title":"Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma","volume":"88","author":"Watanabe","year":"2008","journal-title":"Lab. Invest."},{"key":"B99","doi-asserted-by":"publisher","first-page":"7628","DOI":"10.1158\/0008-5472.CAN-05-0925","article-title":"JunB induced by constitutive CD30-extracellular signal-regulated kinase 1\/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma","volume":"65","author":"Watanabe","year":"2005","journal-title":"Cancer Res."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00444","article-title":"JunB controls intestinal effector programs in regulatory T cells","volume":"11","author":"Wheaton","year":"2020","journal-title":"Front. Immunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/1873-3468.13393","article-title":"Regulatory T cells sense effector T-cell activation through synchronized JunB expression","volume":"593","author":"Wu","year":"2019","journal-title":"FEBS Lett."},{"key":"B102","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10585-021-10108-9","article-title":"JUNB suppresses distant metastasis by influencing the initial metastatic stage","volume":"38","author":"Wutschka","year":"2021","journal-title":"Clin. Exp. Metastasis"},{"key":"B103","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"B104","doi-asserted-by":"publisher","first-page":"107753","DOI":"10.1016\/j.pharmthera.2020.107753","article-title":"Tumor microenvironment as a therapeutic target in cancer","volume":"221","author":"Xiao","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.2217\/epi-2021-0204","article-title":"Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer","volume":"13","author":"Xu","year":"2021","journal-title":"Epigenomics"},{"key":"B106","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1042\/Bj20150372","article-title":"c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21","volume":"471","author":"Yamaguchi","year":"2015","journal-title":"Biochem. J."},{"key":"B107","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1182\/blood-2002-05-1598","article-title":"JunB gene expression is inactivated by methylation in chronic myeloid leukemia","volume":"101","author":"Yang","year":"2003","journal-title":"Blood"},{"key":"B108","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.molcel.2012.06.027","article-title":"LincRNA-p21 suppresses target mRNA translation","volume":"47","author":"Yoon","year":"2012","journal-title":"Mol. Cell"},{"key":"B109","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1242\/jcs.196303","article-title":"JunB regulates angiogenesis and neurovascular parallel alignment in mouse embryonic skin","volume":"130","author":"Yoshitomi","year":"2017","journal-title":"J. Cell Sci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature03963","article-title":"Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins","volume":"437","author":"Zenz","year":"2005","journal-title":"Nature"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107624","article-title":"Biodegradable Hypocrellin B nanoparticles coated with neutrophil membranes for hepatocellular carcinoma photodynamics therapy effectively via JUNB\/ROS signaling","volume":"99","author":"Zhang","year":"2021","journal-title":"Int. Immunopharmacol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103240118","article-title":"Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response","volume":"118","author":"Zhang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B113","doi-asserted-by":"publisher","first-page":"16019","DOI":"10.1038\/s41598-018-34199-9","article-title":"The c-Jun and JunB transcription factors facilitate the transit of classical Hodgkin lymphoma tumour cells through G(1)","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1002\/jbmr.28","article-title":"Smurf1 Inhibits Mesenchymal Stem Cell Proliferation and Differentiation into Osteoblasts through JunB Degradation","volume":"25","author":"Zhao","year":"2010","journal-title":"J. Bone Mineral Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct Target Ther."},{"key":"B116","doi-asserted-by":"publisher","first-page":"6878","DOI":"10.1080\/21655979.2021.1973207","article-title":"Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)\/JUNB axis","volume":"12","author":"Zhu","year":"2021","journal-title":"Bioengineered"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1222265\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T02:35:15Z","timestamp":1693794915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1222265\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,4]]},"references-count":116,"alternative-id":["10.3389\/fcimb.2023.1222265"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2023.1222265","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,4]]},"article-number":"1222265"}}