{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:48:01Z","timestamp":1784796481223,"version":"3.55.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>We report a case of <jats:italic>Mycobacterium avium<\/jats:italic> keratitis, first detected in the laboratory, which is from an 81-year-old female patient with a 13-year history of recurrent keratitis after eye injuries. This patient underwent anterior chamber irrigation of the right eye, and autologous conjunctival flap covering plus medication, and the corneal ulcer healed. She recovered well after continuing with the medication for half a year. The patient was not immune-compromised. Complex eye diseases such as blurred vision and cataracts caused by advanced age, delayed symptoms caused by slow growth of <jats:italic>Mycobacterium avium<\/jats:italic> and low-grade inflammation, difficulty with laboratory culture, repeated medication use, and repeated illnesses were the main reasons for the prolonged failure to clarify the etiology of this case. Morphological examination provided important clues for the initial discovery of pathogenic bacteria. Remind to pay attention to the morphology of Mycobacterium under Gram staining and Rui\u2019s Giemsa staining. Acid fast staining and Deoxyribonucleic Acid(DNA) microarray chip method can be used as indicators for rapid diagnosis of Mycobacterium species.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1268668","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T18:38:11Z","timestamp":1695321491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cure of mycobacterium avium keratitis caused by trauma in elderly: case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoting","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaizhen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuilong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3109\/09273948.2014.920510","article-title":"Ophthalmic manifestation of disseminated cutaneous Mycobacterium avium-intracellulare complex in a child with a presumed primary IL-12 receptor defect","volume":"23","author":"Chong","year":"2015","journal-title":"Ocul Immunol. Inflammation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1016\/S0161-6420(98)99034-0","article-title":"Nontuberculous mycobacterial keratitis in south Florida","volume":"105","author":"Ford","year":"1998","journal-title":"Ophthalmology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.2169\/internalmedicine.55.6896","article-title":"Severe disseminated Mycobacterium avium infection in a patient with a positive serum autoantibody to interferon-gamma","volume":"55","author":"Ikeda","year":"2016","journal-title":"Intern. Med."},{"key":"B4","article-title":"Mycobacterium fortuitum Keratitis Clinicopathologic Correlates and Corticosteroid Effects in an Animal Model","volume":"11","author":"John","year":"1992","journal-title":"Animal Model. Cornea"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-198706030-00004","article-title":"Mycobacterium avium-intracellulare corneal ulcer","volume":"6","author":"Knapp","year":"1987","journal-title":"Cornea."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009356","article-title":"Delayed onset Mycobacterium intracellulare keratitis after laser in situ keratomileusis: A case report and literature review","volume":"96","author":"Ko","year":"2017","journal-title":"Med. (Baltimore)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.23.7331-7338.1999","article-title":"Sliding motility in mycobacteria","volume":"181","author":"Martinez","year":"1999","journal-title":"J Bacteriol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.80.11.962","article-title":"Nontuberculous mycobacterial keratitis: a study of 22 cases","volume":"80","author":"Samuel","year":"1996","journal-title":"Br J Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ajo.2016.03.035","article-title":"Endophthalmitis caused by nontuberculous mycobacterium: clinical features, antimicrobial susceptibilities, and treatment outcomes","volume":"168","author":"Shah","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199909000-00015","article-title":"An unreported side effect of topical clarithromycin when used successfully to treat Mycobacterium avium-intracellulare keratitis","volume":"18","author":"Tyagi","year":"1999","journal-title":"Cornea."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1268668\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T18:38:14Z","timestamp":1695321494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1268668\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":10,"alternative-id":["10.3389\/fcimb.2023.1268668"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2023.1268668","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"article-number":"1268668"}}