{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:39:39Z","timestamp":1783719579356,"version":"3.55.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Carbapenem-resistant <jats:italic>Acinetobacter baumannii<\/jats:italic> (CRAB) has emerged as a predominant strain of healthcare-associated infections worldwide, particularly in intensive care units (ICUs). Therefore, it is imperative to study the molecular epidemiology of CRAB in the ICUs using multiple molecular typing methods to lay the foundation for the development of infection prevention and control strategies. This study aimed to determine the antimicrobial susceptibility profile, the molecular epidemiology and conduct homology analysis on CRAB strains isolated from ICUs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sensitivity to various antimicrobials was determined using the minimum inhibitory concentration (MIC) method, Kirby-Bauer disk diffusion (KBDD), and E-test assays. Resistance genes were identified by polymerase chain reaction (PCR). Molecular typing was performed using multilocus sequence typing (MLST) and multiple-locus variable-number tandem repeat analysis (MLVA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 79 isolates collected, they exhibited high resistance to\u00a0various antimicrobials but showed low resistance to levofloxacin, trimethoprim-sulfamethoxazole, and tetracyclines. Notably, all isolates of <jats:italic>A. baumannii<\/jats:italic> were identified as multidrug-resistant <jats:italic>A. baumannii<\/jats:italic> (MDR-AB). The <jats:italic>bla<\/jats:italic><jats:sub>OXA-51-like<\/jats:sub>, <jats:italic>adeJ<\/jats:italic>, and <jats:italic>adeG<\/jats:italic> genes were all detected, while the detection rates of <jats:italic>bla<\/jats:italic><jats:sub>OXA-23-like<\/jats:sub> (97.5%), <jats:italic>adeB<\/jats:italic> (93.67%), <jats:italic>bla<\/jats:italic><jats:sub>ADC<\/jats:sub> (93.67%), <jats:italic>qacE\u03941-sul1<\/jats:italic> (84.81%) were higher; most of the Ambler class A and class B genes were not detected. MLST analysis on the 79 isolates identified five sequence types (STs), which belonged to group 3 clonal complexes 369. ST1145<jats:sup>Ox<\/jats:sup> was the most frequently observed ST with a count of 56 out of 79 isolates (70.89%). MLST analysis for non-sensitive tigecycline isolates, which were revealed ST1145<jats:sup>Ox<\/jats:sup> and ST1417<jats:sup>Ox<\/jats:sup> as well. By using the MLVA assay, the 79 isolates could be grouped into a total of 64 distinct MTs with eleven clusters identified in them. Minimum spanning tree analysis defined seven different MLVA complexes (MCs) labeled MC1 to MC6 along with twenty singletons. The locus MLVA-AB_2396 demonstrated the highest Simpson\u2019s diversity index value at 0.829 among all loci tested in this study while also having one of the highest variety of tandem repeat species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The molecular diversity and clonal affinities within the genomes of the CRAB strains were clearly evident, with the identification of ST1144<jats:sup>Ox<\/jats:sup>, ST1658<jats:sup>Ox<\/jats:sup>, and ST1646<jats:sup>Ox<\/jats:sup>qaq representing novel findings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcimb.2023.1280372","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T13:21:25Z","timestamp":1701436885000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Molecular epidemiology and antimicrobial resistance patterns of carbapenem-resistant Acinetobacter baumannii isolates from patients admitted at ICUs of a teaching hospital in Zunyi, China"],"prefix":"10.3389","volume":"13","author":[{"given":"Lin","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rengui","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"key":"B1","first-page":"702","article-title":"Study on in vitro drug sensitivity of minocycline combined with 11 antibiotics against Multidrug resistant Acinetobacter baumannii","volume":"27","author":"AI","year":"2018","journal-title":"Chin. J. New Drugs"},{"key":"B2","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1128\/JCM.43.9.4382-4390.2005","article-title":"Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii","volume":"43","author":"Bartual","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01631-17","article-title":"Risk Factors and Outcomes Associated with Multidrug-Resistant Acinetobacter baumannii upon Intensive Care Unit Admission","volume":"62","author":"Blanco","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"B4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1177\/0885066616688165","article-title":"Mortality in patients with septic shock by multidrug resistant bacteria: risk factors and impact of sepsis treatments","volume":"34","author":"Busani","year":"2019","journal-title":"J. Intensive Care Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1186\/s12879-018-3511-0","article-title":"Molecular characterization of multidrug resistant strains of Acinetobacter baumannii isolated from pediatric intensive care unit in a Chinese tertiary hospital","volume":"18","author":"Chen","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.3390\/ijerph16071104","article-title":"Detection and colonization of multidrug resistant organisms in a regional teaching hospital of Taiwan","volume":"16","author":"Chen","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B7","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/s12879-018-3359-3","article-title":"High prevalence and clonal dissemination of OXA-72-producing Acinetobacter baumannii in a Chinese hospital: a cross sectional study","volume":"18","author":"Chen","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1128\/JCM.00606-13","article-title":"Optimized Multilocus variable-number tandem-repeat analysis assay and its complementarity with pulsed-field gel electrophoresis and multilocus sequence typing for Listeria monocytogenes clone identification and surveillance","volume":"51","author":"Chenal-Francisque","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"11669","DOI":"10.1038\/s41598-018-30144-y","article-title":"Multiple-Locus Variable Number Tandem Repeat Analysis (MLVA) and Tandem Repeat Sequence Typing (TRST), helpful tools for subtyping Staphylococcus lugdunensis","volume":"8","author":"Dahyot","year":"2018","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1128\/JCM.01714-16","article-title":"Next-generation epidemiology: using real-time core genome multilocus sequence typing to support infection control policy","volume":"54","author":"Dekker","year":"2016","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.2147\/IDR.S310478","article-title":"Molecular Epidemiology of Extensively-Drug Resistant Acinetobacter baumannii Sequence Type 2 Co-Harboring bla (NDM) and bla (OXA) From Clinical Origin","volume":"14","author":"Ejaz","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"B12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1471-2105-10-152","article-title":"Global optimal eBURST analysis of multilocus typing data using a graphic matroid approach","volume":"10","author":"Francisco","year":"2009","journal-title":"BMC Bioinf."},{"key":"B13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1471-2105-13-87","article-title":"PHYLOViZ: phylogenetic inference and data visualization for sequence based typing methods","volume":"13","author":"Francisco","year":"2012","journal-title":"BMC Bioinf."},{"key":"B14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/microorganisms5020018","article-title":"High Prevalence of bla(NDM-1), bla(VIM), qacE, and qacE\u03941 Genes and Their Association with Decreased Susceptibility to Antibiotics and Common Hospital Biocides in Clinical Isolates of Acinetobacter baumannii","volume":"5","author":"Gomaa","year":"2017","journal-title":"Microorganisms"},{"key":"B15","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1128\/JCM.39.11.4190-4192.2001","article-title":"Determining confidence intervals when measuring genetic diversity and the discriminatory abilities of typing methods for microorganisms","volume":"39","author":"Grundmann","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.jiph.2019.06.007","article-title":"Molecular epidemiology and decreased susceptibility to disinfectants in carbapenem-resistant Acinetobacter baumannii isolated from intensive care unit patients in central China","volume":"12","author":"Guo","year":"2019","journal-title":"J. Infect. Public Health"},{"key":"B17","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/1471-2180-11-171","article-title":"A multi locus variable number of tandem repeat analysis (MLVA) scheme for Streptococcus agalactiae genotyping","volume":"11","author":"Haguenoer","year":"2011","journal-title":"BMC Microbiol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000306","article-title":"Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii","volume":"5","author":"Hamidian","year":"2019","journal-title":"Microb. Genom"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1093\/jac\/dkv072","article-title":"Investigation of a possible outbreak of carbapenem-resistant Acinetobacter baumannii in Odense, Denmark using PFGE, MLST and whole-genome-based SNPs","volume":"70","author":"Hammerum","year":"2015","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e44597","DOI":"10.1371\/journal.pone.0044597","article-title":"Diversity of Acinetobacter baumannii in four French military hospitals, as assessed by multiple locus variable number of tandem repeats analysis","volume":"7","author":"Hauck","year":"2012","journal-title":"PloS One"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2019.190629","article-title":"Resistance trends among 1,294 nosocomial Acinetobacter baumannii strains from a tertiary general hospital in China 2014 - 2017","volume":"66","author":"He","year":"2020","journal-title":"Clin. Lab."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12941-018-0301-x","article-title":"Prevalence of Acinetobacter baumannii in Saudi Arabia: risk factors, antimicrobial resistance patterns and mechanisms of carbapenem resistance","volume":"18","author":"Ibrahim","year":"2019","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1045206","article-title":"Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.diagmicrobio.2016.08.024","article-title":"Comparison of molecular typing methods for the analyses of Acinetobacter baumannii from ICU patients","volume":"86","author":"Johnson","year":"2016","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.3390\/microorganisms9112365","article-title":"Virulence Characteristics of Biofilm-Forming Acinetobacter baumannii in Clinical Isolates Using a Galleria mellonella Model","volume":"9","author":"Khalil","year":"2021","journal-title":"Microorganisms"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00341-18","article-title":"Risk factors for gastrointestinal colonization and acquisition of carbapenem-resistant gram-negative bacteria among patients in intensive care units in Thailand","volume":"62","author":"Kiddee","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1128\/AAC.00633-13","article-title":"Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands","volume":"57","author":"Kim","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1093\/jac\/dkz055","article-title":"Using WGS to identify antibiotic resistance genes and predict antimicrobial resistance phenotypes in MDR Acinetobacter baumannii in Tanzania","volume":"74","author":"Kumburu","year":"2019","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"B29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12879-016-1399-0","article-title":"Infection with Acinetobacter baumannii in an intensive care unit in the Western part of Romania","author":"Lazureanu","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1017\/ice.2022.255","article-title":"Clean clothes or dirty clothes? Outbreak investigation of carbapenem-resistant Acinetobacter baumannii related to laundry contamination through multilocus sequence typing (MLST)","volume":"44","author":"Lee","year":"2022","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"300060518760435","DOI":"10.1177\/0300060518760435","article-title":"Preliminary experience of tigecycline treatment in critically ill children with ventilator-associated pneumonia","volume":"48","author":"Lin","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"743","DOI":"10.2147\/IDR.S299540","article-title":"Molecular epidemiology and mechanisms of carbapenem-resistant Acinetobacter baumannii isolates from ICU and respiratory department patients of a chinese university hospital","volume":"14","author":"Liu","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"B33","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.ijantimicag.2018.04.008","article-title":"NDM-1- and OXA-23-producing Acinetobacter baumannii isolated from intensive care unit patients in Tunisia","volume":"52","author":"Maamar","year":"2018","journal-title":"Int. J. Antimicrob. Agents"},{"key":"B34","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1146\/annurev.micro.59.030804.121325","article-title":"Multilocus sequence typing of bacteria","volume":"60","author":"Maiden","year":"2006","journal-title":"Annu. Rev. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.994303","article-title":"Molecular typing and antibiotic resistance patterns among clinical isolates of Acinetobacter baumannii recovered from burn patients in Tehran, Iran","volume":"13","author":"Maleki","year":"2022","journal-title":"Front. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1089\/mdr.2016.0101","article-title":"Investigation of Extensively Drug-Resistant blaOXA-23-Producing Acinetobacter baumannii Spread in a Greek Hospital","volume":"23","author":"Mavroidi","year":"2017","journal-title":"Microb. Drug Resist."},{"key":"B37","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1093\/bioinformatics\/btw582","article-title":"PHYLOViZ 2.0: providing scalable data integration and visualization for multiple phylogenetic inference methods","volume":"33","author":"Nascimento","year":"2017","journal-title":"Bioinformatics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1099\/jmm.0.076646-0","article-title":"Emergence of carbapenem-resistant Acinetobacter baumannii as the major cause of ventilator-associated pneumonia in intensive care unit patients at an infectious disease hospital in southern Vietnam","volume":"63","author":"Nhu","year":"2014","journal-title":"J. Med. Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.cmi.2018.09.017","article-title":"How to: molecular investigation of a hospital outbreak","volume":"25","author":"Nutman","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.846051","article-title":"Rectal colonization and nosocomial transmission of carbapenem-resistant Acinetobacter baumannii in an intensive care unit, southwest Nigeria","volume":"9","author":"Odih","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s10096-014-2124-9","article-title":"Combination antibiotic treatment versus monotherapy for multidrug-resistant, extensively drug-resistant, and pandrug-resistant Acinetobacter infections: a systematic review","volume":"33","author":"Poulikakos","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1128\/JCM.02003-10","article-title":"Identification of variable-number tandem-repeat (VNTR) sequences in Acinetobacter baumannii and interlaboratory validation of an optimized multiple-locus VNTR analysis typing scheme","volume":"49","author":"Pourcel","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e22935","DOI":"10.5812\/jjm.22935","article-title":"Distributions and types of multidrug-resistant Acinetobacter baumannii in different departments of a general hospital","volume":"8","author":"Qian","year":"2015","journal-title":"Jundishapur J. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"W246","DOI":"10.1093\/nar\/gkw359","article-title":"PHYLOViZ Online: web-based tool for visualization, phylogenetic inference, analysis and sharing of minimum spanning trees","volume":"44","author":"Ribeiro-Goncalves","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3855\/jidc.10556","article-title":"beta-lactamase genes in carbapenem resistance Acinetobacter baumannii isolates from a Turkish university hospital","volume":"13","author":"Say Coskun","year":"2019","journal-title":"J. Infect. Dev. Ctries"},{"key":"B46","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1128\/JCM.00624-11","article-title":"Adjusted Wallace coefficient as a measure of congruence between typing methods","volume":"49","author":"Severiano","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"637","DOI":"10.2147\/IDR.S398304","article-title":"Antimicrobial resistance patterns, sequence types, virulence and carbapenemase genes of carbapenem-resistant klebsiella pneumoniae clinical isolates from a tertiary care teaching hospital in Zunyi, China","volume":"16","author":"Shen","year":"2023","journal-title":"Infection Drug resistance"},{"key":"B48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.diagmicrobio.2018.01.008","article-title":"In vitro activities of carbapenems in combination with amikacin, colistin, or fosfomycin against carbapenem-resistant Acinetobacter baumannii clinical isolates","volume":"91","author":"Singkham-In","year":"2018","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1093\/cid\/ciy752","article-title":"Control of Carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa in Healthcare Facilities: A Systematic Review and Reanalysis of Quasi-experimental Studies","volume":"68","author":"Tomczyk","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1089\/mdr.2019.0232","article-title":"Outbreak of multidrug-resistant Acinetobacter baumannii ST208 producing OXA-23-like carbapenemase in a children\u2019s hospital in shanghai, China","volume":"27","author":"Wang","year":"2021","journal-title":"Microb. Drug Resist."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.3892\/etm.2020.8911","article-title":"Molecular typing, and integron and associated gene cassette analyses in Acinetobacter baumannii strains isolated from clinical samples","volume":"20","author":"Xu","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"B52","first-page":"651","article-title":"[Drug resistance of Acinetobacter baumannii in pediatric intensive care unit]","volume":"59","author":"Xu","year":"2021","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.633817","article-title":"Molecular epidemiology and clone transmission of carbapenem-resistant Acinetobacter baumannii in ICU rooms","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B54","first-page":"526","article-title":"Detection of resistance Genetic testing and homology of Acinetobacter baumannii with Carbapenem resistance","author":"Zhou","year":"2020","journal-title":"Chin. J. Infect. Control"},{"key":"B55","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1089\/mdr.2014.0183","article-title":"Genetic Characterization of ST195 and ST365 Carbapenem-Resistant Acinetobacter baumannii Harboring blaOXA-23 in Guangzhou, China","volume":"21","author":"Zhou","year":"2015","journal-title":"Microb. Drug Resist."},{"key":"B56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12941-022-00536-0","article-title":"Insight into carbapenem resistance and virulence of Acinetobacter baumannii from a children\u2019s medical centre in eastern China","volume":"21","author":"Zhu","year":"2022","journal-title":"Ann. Clin. Microbiol. Antimicrob."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1280372\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T13:21:28Z","timestamp":1701436888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1280372\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":56,"alternative-id":["10.3389\/fcimb.2023.1280372"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2023.1280372","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]},"article-number":"1280372"}}