{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:07:52Z","timestamp":1790107672469,"version":"4.0.1"},"reference-count":152,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Chlamydia trachomatis<\/jats:italic> is a strict intracellular human pathogen. It is the main bacterial cause of sexually transmitted infections and the etiologic agent of trachoma, which is the leading cause of preventable blindness. Despite over 100 years since <jats:italic>C. trachomatis<\/jats:italic> was first identified, there is still no vaccine. However in recent years, the advancement of genetic manipulation approaches for <jats:italic>C. trachomatis<\/jats:italic> has increased our understanding of the molecular pathogenesis of <jats:italic>C. trachomatis<\/jats:italic> and progress towards a vaccine. In this mini-review, we aimed to outline the factors related to the developmental cycle phase and specific pathogenesis activity of <jats:italic>C. trachomatis<\/jats:italic> in order to focus priorities for future genetic approaches. We highlight the factors known to be critical for developmental cycle stages, gene expression regulatory factors, type III secretion system and their effectors, and individual virulence factors with known impacts.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1281823","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:18:55Z","timestamp":1697620735000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Molecular pathogenesis of Chlamydia trachomatis"],"prefix":"10.3389","volume":"13","author":[{"given":"Brittany","family":"Jury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmina M.","family":"Huston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence Don Wai","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.2217\/fmb.13.80","article-title":"Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism","volume":"8","author":"Abdelsamed","year":"2013","journal-title":"Future Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"6123","DOI":"10.1128\/JB.05976-11","article-title":"Identification and functional analysis of CT069 as a novel transcriptional regulator in chlamydia","volume":"193","author":"Akers","year":"2011","journal-title":"J. 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