{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:43:32Z","timestamp":1791333812842,"version":"4.3.1"},"reference-count":223,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016218","name":"Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016218","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>The clinical outcome of DENV and other Flaviviruses infections represents a spectrum of severity that ranges from mild manifestations to severe disease, which can ultimately lead to death. Nonetheless, most of these infections result in an asymptomatic outcome that may play an important role in the persistent circulation of these viruses. Also, although little is known about the mechanisms that lead to these asymptomatic infections, they are likely the result of a complex interplay between viral and host factors. Specific characteristics of the infecting viral strain, such as its replicating efficiency, coupled with host factors, like gene expression of key molecules involved in the immune response or in the protection against disease, are among crucial factors to study. This review revisits recent data on factors that may contribute to the asymptomatic outcome of the world\u2019s widespread DENV, highlighting the importance of silent infections in the transmission of this pathogen and the immune status of the host.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1284651","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T08:48:26Z","timestamp":1700815706000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Flying under the radar \u2013 impact and factors influencing asymptomatic DENV infections"],"prefix":"10.3389","volume":"13","author":[{"given":"Paulo","family":"Henriques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Caldeira-Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Margarida","family":"Vig\u00e1rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Abecasis","year":"2012","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1157613","article-title":"Anopheline mosquito saliva contains bacteria that are transferred to a mammalian host through blood feeding","volume":"14","author":"Accoti","year":"2023","journal-title":"Front. Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"12766","DOI":"10.1073\/pnas.96.22.12766","article-title":"Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor","volume":"96","author":"Agnello","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.4269\/ajtmh.14-0142","article-title":"Micronutrients and dengue","volume":"91","author":"Ahmed","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-86","article-title":"Elevated levels of vitamin D and deficiency of mannose binding lectin in dengue hemorrhagic fever","volume":"9","author":"Alagarasu","year":"2012","journal-title":"Virol. J."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit436","article-title":"The dengue virus NS1 protein; new roles in pathogenesis due to similarities with and affinity for the high-density lipoprotein (HDL)","volume":"19","author":"Alcal\u00e1","year":"2023","journal-title":"PloS Pathog."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01664-21","article-title":"Dengue virus NS1 uses scavenger receptor B1 as a cell receptor in cultured cells","volume":"96","author":"Alcal\u00e1","year":"2022","journal-title":"J. Virol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/infdis\/jit436","article-title":"A shorter time interval between first and second dengue infections is associated with protection from clinical illness in a school-based cohort in Thailand","volume":"209","author":"Anderson","year":"2014","journal-title":"J. Infec. Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11262-012-0756-3","article-title":"Complete genome sequencing and evolutionary analysis of dengue virus serotype 1 isolates from an outbreak in Kerala, South India","volume":"45","author":"Anoop","year":"2012","journal-title":"Virus Genes"},{"key":"B10","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ijid.2023.07.010","article-title":"Global prevalence of asymptomatic dengue infections - a systematic review and meta-analysis. International","volume":"134","author":"Asish","year":"2023","journal-title":"J. Infect. Dis."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00276-11","article-title":"Complement-mediated neutralization of dengue virus requires mannose-binding lectin","volume":"2","author":"Avirutnan","year":"2011","journal-title":"MBio"},{"key":"B12","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3201\/eid1705.101125","article-title":"Travel-related dengue virus infection, the Netherlands 2006\u20132007","volume":"17","author":"Baaten","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1111\/j.1365-3156.2006.01641.x","article-title":"High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua","volume":"11","author":"Balmaseda","year":"2006","journal-title":"Trop. Med. Int. Health"},{"key":"B14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1086\/648592","article-title":"Trends in patterns of dengue transmission over 4 years in a pediatric cohort study in Nicaragua","volume":"201","author":"Balmaseda","year":"2010","journal-title":"J. Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.ento.52.110405.091454","article-title":"Yellow fever: A disease that has yet to be conquered","volume":"52","author":"Barrett","year":"2007","journal-title":"Annu. Rev. Entomol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1097\/00002030-199207000-00013","article-title":"Specific nutrient abnormalities in asymptomatic HIV-1 infection","volume":"6","author":"Beach","year":"1992","journal-title":"Aids"},{"key":"B17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41390-021-01630-3","article-title":"Epigenetic regulation of pediatric and neonatal immune responses","volume":"91","author":"Bermick","year":"2022","journal-title":"Pediatr. Res."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008564","article-title":"Zika virus dynamics: Effects of inoculum dose, the innate immune response and viral interference","volume":"17","author":"Best","year":"2021","journal-title":"PloS Comput. Biol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-5-1","article-title":"Concurrent infections by all four dengue virus serotypes during an outbreak of dengue in 2006 in Delhi, India","volume":"5","author":"Bharaj","year":"2008","journal-title":"Virol. J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003904","article-title":"Lower low-density lipoprotein cholesterol levels are associated with severe dengue outcome","volume":"9","author":"Biswas","year":"2015","journal-title":"PloS Negl. Trop. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3201\/eid1804.111374","article-title":"Subclinical infections with crimean-congo hemorrhagic fever virus, Turkey","volume":"18","author":"Bodur","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050512","article-title":"Complex modulation of the aedes aEgypti transcriptome in response to dengue virus infection","volume":"7","author":"Bonizzoni","year":"2012","journal-title":"PloS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"9100","DOI":"10.1128\/JVI.00316-07","article-title":"Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon production","volume":"81","author":"Bourne","year":"2007","journal-title":"J. Virol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/QCO.0b013e32816b5cad","article-title":"Experimental infections with west nile virus\u2019","volume":"20","author":"Bowen","year":"2007","journal-title":"Curr. Opin. Infect. Dis."},{"key":"B26","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/0035-9203(87)90041-1","article-title":"Why dengue haemorrhagic fever in Cuba? 1. Individual risk factors for dengue haemorrhagic fever\/dengue shock syndrome (DHF\/DSS)","volume":"81","author":"Bravo","year":"1987","journal-title":"Trans. R. Soc Trop. Med. Hyg."},{"key":"B27","doi-asserted-by":"publisher","first-page":"172","DOI":"10.4269\/ajtmh.1988.38.172","article-title":"A prospective study of dengue infections in Bangkok","volume":"38","author":"Burke","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B28","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12879-018-3186-6","article-title":"Identification of genetic variants associated with dengue or west nile virus disease: A systematic review and meta-analysis","volume":"18","author":"Cahill","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.3201\/eid2110.150847","article-title":"Zika virus outbreak, bahia, Brazil","volume":"21","author":"Campos","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1128\/JVI.06796-11","article-title":"Dengue virus capsid protein binding to hepatic Lipid Droplets (LD) is potassium ion dependent and is mediated by LD surface proteins","volume":"86","author":"Carvalho","year":"2012","journal-title":"J. Virol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1089\/jir.2014.0129","article-title":"Dengue virus control of type I IFN responses: A history of manipulation and control","volume":"35","author":"Castillo Ramirez","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.virol.2009.10.019","article-title":"JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol","volume":"396","author":"Ceballos-Olvera","year":"2010","journal-title":"Virol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0000000000001012","article-title":"Why is a child not a miniadult for infections","volume":"29","author":"Chappell","year":"2021","journal-title":"Infect. Dis. Clin. Pract."},{"key":"B34","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s13149-011-0165-1","article-title":"Infections inapparentes chez l\u2019Homme : un cheval de Troie pour l\u2019introduction et la diffusion des arbovirus transmis par des moustiques dans les r\u00e9gions non end\u00e9miques","volume":"104","author":"Chastel","year":"2011","journal-title":"Bull. Soc Pathol. Exot."},{"key":"B35","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1574-695X.2000.tb01474.x","article-title":"Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis","volume":"28","author":"Chaturvedi","year":"2000","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.coviro.2020.09.001","article-title":"Dengue mouse models for evaluating pathogenesis and countermeasures","volume":"43","author":"Chen","year":"2020","journal-title":"Curr. Opin. Virol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1128\/JVI.73.4.2650-2657.1999","article-title":"Bacterial lipopolysaccharide inhibits dengue virus infection of primary human monocytes\/macrophages by blockade of virus entry via a CD14-dependent mechanism","volume":"73","author":"Chen","year":"1999","journal-title":"J. Virol."},{"key":"B38","first-page":"170","article-title":"Review of dengue fever cases in Hong Kong during 1998 to 2005","volume":"14","author":"Chuang","year":"2008","journal-title":"Hong Kong Med. J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"20202715","DOI":"10.1098\/rspb.2020.2715","article-title":"Early events in hepatitis B infection: the role of inoculum dose","volume":"288","author":"Ciupe","year":"2021","journal-title":"Proc. Biol. Sci."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004262","article-title":"Epidemiology of infant dengue cases illuminates serotype-specificity in the interaction between immunity and disease, and changes in transmission dynamics","volume":"9","author":"Clapham","year":"2015","journal-title":"PloS Negl. Trop. Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1002\/eji.1830210820","article-title":"A single amino acid distinguishes the high-responder from the low-responder form of fc receptor II on human monocytes","volume":"21","author":"Clark","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.micinf.2008.12.006","article-title":"Human genetic determinants of dengue virus susceptibility","volume":"11","author":"Coffey","year":"2009","journal-title":"Microbes Infect."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8010039","article-title":"Humanized mice in dengue research: A comparison with other mouse models","volume":"8","author":"Coronel-Ruiz","year":"2020","journal-title":"Vaccines"},{"key":"B44","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/femsre\/fuu004","article-title":"Receptors and routes of dengue virus entry into the host cells","volume":"39","author":"Cruz-Oliveira","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002373","article-title":"Serum metabolome and lipidome changes in adult patients with primary dengue infection","volume":"7","author":"Cui","year":"2013","journal-title":"PloS Negl. Trop. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.chom.2009.05.016","article-title":"Autophagy, immunity, and microbial adaptations","volume":"5","author":"Deretic","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/v15030742","article-title":"Investigation of dengue infection in asymptomatic individuals during a recent outbreak in La R\u00e9union","volume":"15","author":"De Santis","year":"2023","journal-title":"Viruses"},{"key":"B48","doi-asserted-by":"publisher","first-page":"14688","DOI":"10.1073\/pnas.1508114112","article-title":"Asymptomatic humans transmit dengue virus to mosquitoes","volume":"112","author":"Duong","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1007\/s00705-015-2433-z","article-title":"Association of lipid profile alterations with severe forms of dengue in humans","volume":"160","author":"Dur\u00e1n","year":"2015","journal-title":"Arch. Virol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000975","article-title":"Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand","volume":"5","author":"Endy","year":"2011","journal-title":"PloS Negl. Trop. Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/aje\/kwf005","article-title":"Epidemiology of inapparent and symptomatic acute dengue virus infection: A prospective study of primary school children in Kamphaeng Phet, Thailand","volume":"156","author":"Endy","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"B52","volume-title":"Dengue outbreak in Madeira","year":"2014"},{"key":"B53","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/epidemiologia1010003","article-title":"Initial inoculum and the severity of COVID-19: A mathematical modeling study of the dose-response of SARS-coV-2 infections","volume":"1","author":"Fain","year":"2020","journal-title":"Epidemiologia"},{"key":"B54","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.nano.2013.06.004","article-title":"Dengue virus capsid protein interacts specifically with very low-density lipoproteins","volume":"10","author":"Faustino","year":"2014","journal-title":"Nanomedicine"},{"key":"B55","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.chom.2009.04.001","article-title":"Pathogenesis of flavivirus infections: using and abusing the host cell","volume":"5","author":"Fernandez-Garcia","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003444","article-title":"Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases","volume":"9","author":"Ferreira","year":"2013","journal-title":"PloS Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.humimm.2016.05.006","article-title":"Mannose-binding lectin gene (MBL2) polymorphisms related to the mannose-binding lectin low levels are associated to dengue disease severity","volume":"77","author":"Figueiredo","year":"2016","journal-title":"Hum. Immunol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029107","article-title":"Relationship between exposure to vector bites and antibody responses to mosquito salivary gland extracts","volume":"6","author":"Fontaine","year":"2011","journal-title":"PloS One"},{"key":"B59","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1097\/COH.0b013e32832f0a89","article-title":"Fc receptor-mediated antiviral antibodies","volume":"4","author":"Forthal","year":"2009","journal-title":"Curr. Opin. HIV AIDS"},{"key":"B60","doi-asserted-by":"publisher","first-page":"713.e5","DOI":"10.1016\/j.cmi.2015.03.016","article-title":"Molecular epidemiology suggests Venezuela as the origin of the dengue outbreak in Madeira, Portugal in 2012\u20132013","volume":"21","author":"Franco","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006975","article-title":"Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection","volume":"12","author":"Friberg","year":"2018","journal-title":"PloS Negl. Trop. Dis."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000617","article-title":"Serotype-specific differences in the risk of dengue hemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006","volume":"4","author":"Fried","year":"2010","journal-title":"PloS Negl. Trop. Dis."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.4269\/ajtmh.2010.09-0353","article-title":"Asymptomatic dengue infection in a Cuban population confirms the protective role of the RR variant of the fc\u03b3RIIa polymorphism","volume":"82","author":"Garc\u00eda","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B64","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1006\/viro.2001.1232","article-title":"Heparan sulfate-mediated binding of infectious dengue virus type 2 and yellow fever virus","volume":"292","author":"Germi","year":"2002","journal-title":"Virol."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00280","article-title":"Epidemiological risk factors associated with high global frequency of inapparent dengue virus infections","volume":"5","author":"Grange","year":"2014","journal-title":"Front. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<329::AID-JMV12>3.0.CO;2-G","article-title":"Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity","volume":"59","author":"Green","year":"1999","journal-title":"J. Med. Virol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"S24","DOI":"10.1016\/0899-9007(96)90013-1","article-title":"Regulation of lipid metabolism by cytokines during host defense","volume":"12","author":"Grunfeld","year":"1996","journal-title":"Nutrition"},{"key":"B68","doi-asserted-by":"publisher","first-page":"170","DOI":"10.4269\/ajtmh.1985.34.170","article-title":"A case of natural concurrent human infection with two dengue viruses","volume":"34","author":"Gubler","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B69","doi-asserted-by":"publisher","first-page":"581","DOI":"10.4269\/ajtmh.1978.27.581","article-title":"Epidemiologic, clinical, and virologic observations on dengue in the kingdom of Tonga","volume":"27","author":"Gubler","year":"1978","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6106582","article-title":"Toll-like receptors and RIG-I-like receptors play important roles in resisting flavivirus","volume":"2018","author":"Guo","year":"2018","journal-title":"J. Immunol. Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"16055","DOI":"10.1038\/nrdp.2016.55","article-title":"Dengue infection","volume":"18","author":"Guzman","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2021.100216","article-title":"Animals as potential reservoirs for dengue transmission: A systematic review","volume":"12","author":"Gwee","year":"2021","journal-title":"One Health"},{"key":"B73","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/s0065-3527(03)60011-4","article-title":"Neutralization and antibody-dependent enhancement of dengue viruses","volume":"60","author":"Halstead","year":"2003","journal-title":"Ad. Virus Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1093\/infdis\/jir012","article-title":"Intracellular cytokine production by dengue virus\u2013specific T cells correlates with subclinical secondary infection. J","volume":"203","author":"Hatch","year":"2011","journal-title":"Infect. Dis."},{"key":"B75","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.chom.2010.10.006","article-title":"Dengue virus-induced autophagy regulates lipid metabolism","volume":"8","author":"Heaton","year":"2010","journal-title":"Cell Host Microbe"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1099\/0022-1317-69-8-2101","article-title":"Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus","volume":"69","author":"Henchal","year":"1988","journal-title":"J. Gen. Virol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"55","DOI":"10.15585\/mmwr.mm6503e1","article-title":"Zika virus spreads to new areas - region of the Americas, May 2015-January 2016","volume":"65","author":"Hennessey","year":"2016","journal-title":"MMWR. Morb. Mortal."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1007\/s00705-007-1063-5","article-title":"Virucidal activities of medium- and long-chain fatty alcohols and lipids against respiratory syncytial virus and parainfluenza virus type 2: comparison at different pH levels","volume":"152","author":"Hilmarsson","year":"2007","journal-title":"Arch. Virol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1128\/JVI.02155-10","article-title":"Human igG subclasses: in vitro neutralization of and in vivo protection against West Nile virus","volume":"85","author":"Hofmeister","year":"2011","journal-title":"J. Virol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s11481-010-9234-7","article-title":"Arboviral encephalitides: transmission, emergence, and pathogenesis","volume":"5","author":"Hollidge","year":"2010","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/j.1365-2567.2012.03585.x","article-title":"Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice","volume":"136","author":"Jaiswal","year":"2012","journal-title":"Immunology"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007251","article-title":"Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice","volume":"4","author":"Jaiswal","year":"2009","journal-title":"PloS One"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/VRT.S34187","article-title":"Seroepidemiology of asymptomatic dengue virus infection in Jeddah, Saudi Arabia","volume":"7","author":"Jamjoom","year":"2016","journal-title":"Virol: Res. Treat."},{"key":"B84","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1093\/trstmh\/tru092","article-title":"The whole iceberg: estimating the incidence of yellow fever virus infection from the number of severe cases","volume":"108","author":"Johansson","year":"2014","journal-title":"Trans.R. Soc Trop. Med. Hyg."},{"key":"B85","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/nature06536","article-title":"Global trends in emerging infectious diseases","volume":"451","author":"Jones","year":"2008","journal-title":"Nature"},{"key":"B86","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1128\/JVI.00118-14","article-title":"Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells","volume":"88","author":"Junjhon","year":"2014","journal-title":"J. Virol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"B88","doi-asserted-by":"publisher","first-page":"4332","DOI":"10.1128\/JCM.39.12.4332-4338.2001","article-title":"Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection","volume":"39","author":"Koraka","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"B89","first-page":"375","article-title":"Dengue haemorrhagic fever\/dengue shock syndrome: lessons from the Cuban epidemic 1981","volume":"67","author":"Kouri","year":"1989","journal-title":"Bull. World Health Organ."},{"key":"B90","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/aje\/kwp092","article-title":"The Nicaraguan pediatric dengue cohort study: study design, methods, use of information technology, and extension to other infectious diseases","volume":"170","author":"Kuan","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1365-2796.2004.01413.x","article-title":"Sindbis viruses and other alphaviruses as cause of human arthritic disease","volume":"256","author":"Laine","year":"2004","journal-title":"J. Intern. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1128\/JVI.06458-11","article-title":"Dengue-1 virus clade replacement in Thailand associated with enhanced mosquito transmission","volume":"86","author":"Lambrechts","year":"2012","journal-title":"J. Virol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2149\/tmh.2011-S08","article-title":"Host genetic susceptibility to severe dengue infection","volume":"39","author":"Lan","year":"2011","journal-title":"Trop. Med. Health"},{"key":"B94","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1046\/j.1365-2583.1999.820267.x","article-title":"Variation in the salivary peptide, maxadilan, from species in the Lutzomyia longipalpis complex","volume":"8","author":"Lanzaro","year":"1999","journal-title":"Insect. Mol. Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature12531","article-title":"Transcriptome and genome sequencing uncovers functional variation in humans","volume":"501","author":"Lappalainen","year":"2013","journal-title":"Nature"},{"key":"B96","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.apjtm.2016.01.013","article-title":"Concurrent infections of dengue viruses serotype 2 and 3 in patient with severe dengue from Jakarta, Indonesia","volume":"9","author":"Lardo","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.virol.2008.02.016","article-title":"Autophagic machinery activated by dengue virus enhances virus replication","volume":"374","author":"Lee","year":"2008","journal-title":"Virol."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006952","article-title":"Lipids and pathogenic flaviviruses: An intimate union","volume":"14","author":"Leier","year":"2018","journal-title":"PloS Pathog."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070390","article-title":"Human apolipoprotein A-I is associated with dengue virus and enhances virus infection through SR-BI","volume":"8","author":"Li","year":"2013","journal-title":"PloS One"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15061227","article-title":"Dengue infection spectrum in Guangzhou: A cross-sectional seroepidemiology study among community residents between 2013 and 2015","volume":"15","author":"Liu","year":"2018","journal-title":"Int. J. Environ. Res. Public. Health"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081211","article-title":"Use of anti-aedes aEgypti salivary extract antibody concentration to correlate risk of vector exposure and dengue transmission risk in Colombia","volume":"8","author":"Londono-Renteria","year":"2013","journal-title":"PloS One"},{"key":"B102","doi-asserted-by":"publisher","first-page":"725","DOI":"10.4269\/ajtmh.1999.61.725","article-title":"Common occurrence of concurrent infections by multiple dengue virus serotypes","volume":"61","author":"Loro\u00f1o-Pino","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B103","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41587-021-01037-9","article-title":"Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children","volume":"40","author":"Loske","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12879-018-3000-5","article-title":"Seroprevalence of dengue IgG antibodies in symptomatic and asymptomatic individuals three years after an outbreak in Zhejiang Province, China","volume":"18","author":"Luo","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.3201\/eid2507.181794","article-title":"Asymptomatic dengue virus infections, Cambodia 2012-2013","volume":"25","author":"Ly","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1084\/jem.166.6.1654","article-title":"Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies","volume":"166","author":"Macatonia","year":"1987","journal-title":"J. Exp. Med."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050205","article-title":"Spatial and temporal clustering of dengue virus transmission in Thai Villages","volume":"5","author":"Mammen","year":"2008","journal-title":"PloS Med."},{"key":"B108","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/vaccines7010010","article-title":"Time to micromanage the pathogen-host-vector interface: considerations for vaccine development","volume":"7","author":"Manning","year":"2019","journal-title":"Vaccines"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1093\/infdis\/jiab541","article-title":"Development of inapparent dengue associated with increased antibody levels to Aedes aEgypti salivary proteins: A longitudinal dengue cohort in Cambodia","volume":"226","author":"Manning","year":"2022","journal-title":"J. Infect. Dis."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214245","article-title":"Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations","volume":"14","author":"Marin-Palma","year":"2019","journal-title":"PloS One"},{"key":"B111","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1046\/j.0022-202x.2001.00037.x","article-title":"Human dendritic cells as targets of dengue virus infection","volume":"6","author":"Marovitch","year":"2001","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"B112","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1042\/BJ20112219","article-title":"The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif","volume":"444","author":"Martins","year":"2012","journal-title":"Biochem. J."},{"key":"B113","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ijid.2020.09.1446","article-title":"Dengue viremia kinetics in asymptomatic and symptomatic infection","volume":"101","author":"Matangkasombut","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"B114","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1600-065X.2008.00678.x","article-title":"Understanding the contribution of cellular immunity to dengue disease pathogenesis","volume":"225","author":"Mathew","year":"2008","journal-title":"Immunol. Rev."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040017","article-title":"The mannose receptor mediates dengue virus infection of macrophages","volume":"4","author":"Miller","year":"2008","journal-title":"PloS Pathog."},{"key":"B116","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1099\/jgv.0.000923","article-title":"A lethal model of disseminated dengue virus type 1 infection in AG129 mice","volume":"98","author":"Milligan","year":"2017","journal-title":"J. Gen. Virol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"691","DOI":"10.4269\/ajtmh.15-0199","article-title":"Association of fc\u03b3RIIa polymorphism with clinical outcome of dengue infection: first insight from Pakistan","volume":"93","author":"Mohsin","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B118","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jviromet.2009.09.018","article-title":"Development of an antibody-dependent enhancement assay for dengue virus using stable BHK-21 cell lines expressing fc gammaRIIA","volume":"163","author":"Moi","year":"2010","journal-title":"J. Virol. Methods"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002357","article-title":"Symptomatic versus inapparent outcome in repeat dengue virus infections is influenced by the time interval between infections and study year","volume":"7","author":"Montoya","year":"2013","journal-title":"PloS Negl. Trop. Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/jmv.1890220208","article-title":"Disease severity-related antigenic differences in dengue 2 strains detected by dengue 4 monoclonal antibodies","volume":"22","author":"Morens","year":"1987","journal-title":"J. Med. Virol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"8638","DOI":"10.1128\/JVI.00581-09","article-title":"Humanized mice show clinical signs of dengue fever according to infecting virus genotype","volume":"83","author":"Mota","year":"2009","journal-title":"J. Virol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/sj.embor.embor866","article-title":"Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses","volume":"4","author":"Navarro-Sanchez","year":"2003","journal-title":"EMBO Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.arcmed.2005.04.007","article-title":"Innate immune responses to dengue virus","volume":"36","author":"Navarro-S\u00e1nchez","year":"2005","journal-title":"Arch. Med. Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"9072","DOI":"10.1073\/pnas.1303395110","article-title":"Host and viral features of human dengue cases shape the population of infected and infectious aedes aEgypti mosquitoes","volume":"110","author":"Nguyet","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B126","first-page":"1962","article-title":"Dengue and Chikungunya Virus Infection in Man in Thailand, 1962-1964. I. Observations on Hospitalized Patients with Hemorrhagic Fever","volume-title":"Am. J. Trop. Med. Hyg.","author":"Nimmannitya","year":"1969"},{"key":"B127","doi-asserted-by":"publisher","first-page":"191","DOI":"10.4269\/ajtmh.2003.68.191","article-title":"Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999","volume":"68","author":"Nisalak","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B128","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.actatropica.2014.05.021","article-title":"Contrasting associations of polymorphisms in fc\u03b3RIIa and DC-SIGN with the clinical presentation of dengue infection in a Mexican population","volume":"138","author":"Noecker","year":"2014","journal-title":"Acta Trop."},{"key":"B129","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0140-6736(93)90237-B","article-title":"Outbreak of yellowfever in Kenya","volume":"341","author":"Okello","year":"1993","journal-title":"Lancet"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.micinf.2007.07.012","article-title":"Antibody response against saliva antigens of Anopheles Gambiae and Aedes aEgypti in travellers in tropical Africa","volume":"9","author":"Orlandi-Pradines","year":"2007","journal-title":"Microbes Infect."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760190004","article-title":"Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil","volume":"114","author":"Ornelas","year":"2019","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"B132","unstructured":"OsanaiC. H.\n            da RosaA. P. A. T.\n            TangA. T.\n            AmaralR. S.\n            PassosA. D. C.\n            TauilP. L.\n          Surto de dengue em Boa Vista, Roraima (nota pr\u00e9via)1983"},{"key":"B133","first-page":"445","article-title":"Epidemiological investigations of chikungunya epidemic at Barsi, Maharashtra State, India","volume":"23","author":"Padbidri","year":"1979","journal-title":"J. Hyg. Epidemiol. Microbiol. Immunol."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/srep39872","article-title":"Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study","volume":"7","author":"Pang","year":"2017","journal-title":"Sci. Rep."},{"key":"B135","doi-asserted-by":"publisher","first-page":"9322","DOI":"10.1073\/pnas.142287799","article-title":"Positional cloning of the murine flavivirus resistance gene","volume":"99","author":"Perelygin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001297","article-title":"STAT2 mediates innate immunity to dengue virus in the absence of STAT1 via the type I interferon receptor","volume":"7","author":"Perry","year":"2011","journal-title":"PloS Pathog."},{"key":"B137","doi-asserted-by":"publisher","first-page":"8276","DOI":"10.1128\/JVI.00365-09","article-title":"Cardif-mediated signaling controls the initial innate response to dengue virus in vivo","volume":"83","author":"Perry","year":"2009","journal-title":"J. Virol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1017\/S0950268812001070","article-title":"Estimated cumulative incidence of west nile virus infection in US adults 1999\u20132010\u2019","volume":"141","author":"Petersen","year":"2013","journal-title":"Epidemiol. Infect."},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/v9070163","article-title":"Susceptibility and lethality of western equine encephalitis virus in balb\/c mice when infected by the aerosol route","volume":"9","author":"Phelps","year":"2017","journal-title":"Viruses."},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.873232","article-title":"Comparison by age of the local interferon response to SARS-coV-2 suggests a role for IFN-\u03f5 and -\u03c9","volume":"13","author":"Pierangeli","year":"2022","journal-title":"Front. Immunol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.pt.2017.04.003","article-title":"Mosquito biting modulates skin response to virus infection","volume":"33","author":"Pingen","year":"2017","journal-title":"Trends Parasitol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"60","DOI":"10.4269\/ajtmh.2005.72.60","article-title":"Epidemiology of dengue and dengue hemorrhagic fever in A cohort of adults living in Bandung, West Java, Indonesia","volume":"72","author":"Porter","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B143","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3201\/eid0506.990615","article-title":"Dengue seroconversion among Israeli travelers to tropical countries","volume":"5","author":"Potasman","year":"1999","journal-title":"Emerg. Infect. Dis."},{"key":"B144","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/(sici)1096-9071(199811)56:3<280::aid-jmv18>3.0.co;2-i","article-title":"Elevated levels of IL-8 in dengue hemorrhagic fever","volume":"56","author":"Raghupathy","year":"1998","journal-title":"J. Med. Virol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s13071-015-0914-2","article-title":"Phlebotomus papatasi SP15: mRNA expression variability and amino acid sequence polymorphisms of field populations","volume":"8","author":"Ramalho-Ortig\u00e3o","year":"2015","journal-title":"Parasitol. Vectors."},{"key":"B146","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1128\/JVI.79.8.4557-4567.2005","article-title":"Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells","volume":"79","author":"Reyes-Del Valle","year":"2005","journal-title":"J. Virol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.1016\/S2214-109X(17)30496-5","article-title":"Does Immunity after Zika Virus Infection Cross-Protect against Dengue","volume":"6","author":"Ribeiro","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"B148","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s40249-017-0328-9","article-title":"Dengue-specific serotype related to clinical severity during the 2012\/2013 epidemic in centre of Brazil","volume":"6","author":"Rocha","year":"2017","journal-title":"Infect. Dis. Poverty"},{"key":"B149","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nri3014","article-title":"Immunity to dengue virus: A tale of original antigenic sin and tropical cytokine storms","volume":"11","author":"Rothman","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100278","article-title":"Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection","volume":"2","author":"Rouers","year":"2021","journal-title":"Cell Rep."},{"key":"B151","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4269\/ajtmh.1952.1.30","article-title":"Research on dengue during world war II","volume":"1","author":"Sabin","year":"1952","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00496","article-title":"Zika virus: the latest newcomer","volume":"7","author":"Saiz","year":"2016","journal-title":"Front. Microbiol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41586-018-0157-4","article-title":"Reconstruction of antibody dynamics and infection histories to evaluate dengue risk","volume":"557","author":"Salje","year":"2018","journal-title":"Nature"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000632","article-title":"Dengue virus capsid protein usurps lipid droplets for viral particle formation","volume":"5","author":"Samsa","year":"2009","journal-title":"PloS Pathog."},{"key":"B155","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1099\/jgv.0.000246","article-title":"Characterization of lethal dengue virus type 4 (DENV-4) TVP-376 infection in mice lacking both IFN-\u03b1\/\u03b2 and IFN-\u03b3 receptors (AG129) and comparison with the DENV-2 AG129 mouse model","volume":"96","author":"Sarathy","year":"2015","journal-title":"J. Gen. Virol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.trstmh.2008.01.024","article-title":"The enhancement of arbovirus transmission and disease by mosquito saliva is associated with modulation of the host immune response","volume":"102","author":"Schneider","year":"2008","journal-title":"Trans. R. Soc Trop. Med. Hyg."},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2021.100230","article-title":"Climate change and infectious disease in Europe: Impact, projection and adaptation","volume":"9","author":"Semanza","year":"2021","journal-title":"Lancet Regional Health \u2013 Europe."},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.595297","article-title":"Understanding early-life adaptive immunity to guide interventions for pediatric health","volume":"11","author":"Semmes","year":"2021","journal-title":"Front. Immunol."},{"key":"B159","volume-title":"Molecular virology and control of flaviviruses","author":"Shi","year":"2012"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00003-12","article-title":"Role of complement in dengue virus infection: protection or pathogenesis","volume":"3","author":"Shresta","year":"2012","journal-title":"MBio"},{"key":"B161","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.virol.2003.09.048","article-title":"Early activation of natural killer and B cells in response to primary dengue virus infection in A\/J mice","volume":"319","author":"Shresta","year":"2004","journal-title":"Virol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"3946","DOI":"10.4049\/jimmunol.175.6.3946","article-title":"Critical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in mice","volume":"175","author":"Shresta","year":"2005","journal-title":"J. Immunol."},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006220","article-title":"OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans","volume":"13","author":"Sierra","year":"2017","journal-title":"PloS Pathog."},{"key":"B164","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0008-8749(76)90105-2","article-title":"Antigen-bearing langerhans cells in skin, dermal lymphatics and in lymph nodes","volume":"25","author":"Silberberg-Sinakin","year":"1976","journal-title":"Cell. Immunol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/ejhg.2010.98","article-title":"Dengue hemorrhagic fever is associated with polymorphisms in JAK1","volume":"18","author":"Silva","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1086\/512162","article-title":"Patterns of host genome\u2014Wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever","volume":"195","author":"Simmons","year":"2007","journal-title":"J. Infect. Dis."},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal5088","article-title":"Increased adaptive immune responses and proper feedback regulation protect against clinical dengue","volume":"9","author":"Simon-Lori\u00e8re","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"B168","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bbrc.2014.12.028","article-title":"SR-BI mediates high density lipoprotein (HDL)-induced anti-inflammatory effect in macrophages","volume":"457","author":"Song","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154760","article-title":"Meta-analysis of dengue severity during infection by different dengue virus serotypes in primary and secondary infections","volume":"11","author":"Soo","year":"2016","journal-title":"PloS One"},{"key":"B170","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.antiviral.2014.07.002","article-title":"Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus","volume":"109","author":"Soto-Acosta","year":"2014","journal-title":"Antiviral Res."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1111\/j.1537-2995.2012.03566.x","article-title":"Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico","volume":"52","author":"Stramer","year":"2012","journal-title":"Transfusion"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1016\/j.meegid.2011.06.009","article-title":"Dengue virus replication in infected human keratinocytes leads to activation of antiviral innate immune responses","volume":"11","author":"Surasombatpattana","year":"2011","journal-title":"Infect. Genet. Evol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1111\/j.1365-3156.2009.02261.x","article-title":"Serum lipid profile: A predictor of clinical outcome in dengue infection","volume":"14","author":"Suvarna","year":"2009","journal-title":"Trop. Med. Int. Health"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1056\/NEJMc0708673","article-title":"Dengue hemorrhagic fever transmitted by blood transfusion","volume":"359","author":"Tambyah","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B175","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1084\/jem.20021840","article-title":"DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells","volume":"197","author":"Tassaneetrithep","year":"2003","journal-title":"J. Exp. Med."},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010398","article-title":"Association between nutritional status and dengue severity in Thai children and adolescents","volume":"16","author":"Te","year":"2022","journal-title":"PloS Negl. Trop. Dis."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003812","article-title":"Arterial hypertension and skin allergy are risk factors for progression from dengue-to-dengue hemorrhagic fever: A case control study","volume":"9","author":"Teixeira","year":"2015","journal-title":"PloS Negl. Trop. Dis."},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006965","article-title":"Contributions from the silent majority dominate dengue virus transmission","volume":"14","author":"Ten Bosch","year":"2018","journal-title":"PloS Pathog."},{"key":"B179","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/imm.12638","article-title":"High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation","volume":"149","author":"Thacker","year":"2016","journal-title":"Immunol."},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001180","article-title":"Age-specificity of clinical dengue during primary and secondary infections","volume":"5","author":"Thai","year":"2011","journal-title":"PloS Negl. Trop. Dis."},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-2-34","article-title":"Differential expression of Aedes aEgypti salivary transcriptome upon blood feeding","volume":"2","author":"Thangamani","year":"2009","journal-title":"Parasitol. Vectors."},{"key":"B182","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.antiviral.2013.06.009","article-title":"Chikungunya fever: Epidemiology, clinical syndrome, pathogenesis and therapy","volume":"99","author":"Thiberville","year":"2013","journal-title":"Antiviral Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4269\/ajtmh.13-0595","article-title":"Clinical presentation of dengue by serotype and year of epidemic in Martinique","volume":"91","author":"Thomas","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B184","doi-asserted-by":"publisher","first-page":"990","DOI":"10.4269\/ajtmh.2008.78.990","article-title":"Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic","volume":"78","author":"Thomas","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B185","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1128\/MMBR.05015-11","article-title":"Into the eye of the cytokine storm","volume":"76","author":"Tisoncik","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B186","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12985-017-0685-9","article-title":"Involvement of fatty acid synthase in dengue virus infection","volume":"14","author":"Tongluan","year":"2017","journal-title":"Virol. J."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/s41467-019-09193-y","article-title":"Effects of infection history on dengue virus infection and pathogenicity","volume":"10","author":"Tsang","year":"2019","journal-title":"Nat. Commun."},{"key":"B188","doi-asserted-by":"publisher","first-page":"7395","DOI":"10.1038\/srep07395","article-title":"The dengue virus conceals double-stranded RNA in the intracellular membrane to escape from an interferon response","volume":"4","author":"Uchida","year":"2014","journal-title":"Sci. Rep."},{"key":"B189","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jiph.2018.08.009","article-title":"Association of IL4R-rs1805016 and IL6R-rs8192284 polymorphisms with clinical dengue in children from Colombian populations","volume":"12","author":"Useche","year":"2019","journal-title":"J. Infect. Public Health"},{"key":"B190","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1186\/s13071-019-3732-0","article-title":"Sylvatic cycles of arboviruses in non-human primates","volume":"12","author":"Valentine","year":"2019","journal-title":"Parasitol. Vectors."},{"key":"B191","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1086\/339539","article-title":"Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever","volume":"34","author":"van Gorp","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"B192","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1034\/j.1399-0039.2003.00037.x","article-title":"FcgammaR polymorphisms: implications for function, disease susceptibility and immunotherapy","volume":"61","author":"Van Sorge","year":"2003","journal-title":"Tissue Antigens"},{"key":"B193","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nrmicro2595","article-title":"Fever from the forest: prospects for the continued emergence of sylvatic dengue virus and its impact on public health","volume":"9","author":"Vasilakis","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1086\/315215","article-title":"Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity","volume":"181","author":"Vaughn","year":"2000","journal-title":"J. Infect. Dis."},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1093\/pnasnexus\/pgad024","article-title":"Inapparent infections shape the transmission heterogeneity of dengue","volume":"2","author":"Vazquez-Prokopec","year":"2023","journal-title":"PNAS Nexus"},{"key":"B196","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijid.2019.10.045","article-title":"Prevalence of dengue antibodies in healthy children and adults in different Colombian endemic areas","volume":"91","author":"Velandia-Romero","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"B197","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12879-016-1668-y","article-title":"Serotype influences on dengue severity: A cross-sectional study on 485 confirmed dengue cases in vit\u00f3ria, Brazil","volume":"16","author":"Vicente","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"B198","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jiph.2013.01.004","article-title":"Episode of coexisting infections with multiple dengue virus serotypes in Central Karnataka, India","volume":"6","author":"Vinodkumar","year":"2013","journal-title":"J. Infect. Public Health"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004449","article-title":"Metabolomics-based discovery of small molecule biomarkers in serum associated with dengue virus infections and disease outcomes","volume":"10","author":"Voge","year":"2016","journal-title":"PloS Negl. Trop. Dis."},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006439","article-title":"Mosquito saliva alone has profound effects on the human immune system","volume":"12","author":"Vogt","year":"2018","journal-title":"PloS Negl. Trop. Dis."},{"key":"B201","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1017\/S0031182000007046","article-title":"Species-specific antigens in salivary glands of phlebotomine sandflies","volume":"122","author":"Volf","year":"2001","journal-title":"Parasitology"},{"key":"B202","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1046\/j.1365-2915.2000.00240.x","article-title":"Salivary proteins and glycoproteins in phlebotomine sandflies of various species, sex and age","volume":"14","author":"Volf","year":"2000","journal-title":"Med. Vet. Entomol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.3390\/v3122374","article-title":"The human antibody response to dengue virus infection","volume":"3","author":"Wahala","year":"2011","journal-title":"Viruses"},{"key":"B204","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.idm.2023.05.008","article-title":"Impact of climate change on dengue fever epidemics in South and Southeast Asian settings: A modelling study","volume":"8","author":"Wang","year":"2023","journal-title":"Infect. Dis. Model."},{"key":"B205","doi-asserted-by":"publisher","first-page":"123","DOI":"10.4269\/ajtmh.2003.69.123","article-title":"Transplacentally transferred maternal-infant antibodies to dengue virus","volume":"69","author":"Watanaveeradej","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B206","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nrmicro1006","article-title":"Transmission cycles, host range, evolution and emergence of arboviral disease","volume":"2","author":"Weaver","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"e4256-63","DOI":"10.1073\/pnas.1505956112","article-title":"Dengue virus infection elicits highly polarized CX3CR1+ Cytotoxic CD4+ T cells associated with protective immunity","volume":"112","author":"Weiskopf","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00093","article-title":"T-cell immunity to infection with dengue virus in humans","volume":"5","author":"Weiskopf","year":"2014","journal-title":"Front. Immunol."},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.es2014.19.8.20718","article-title":"The 2012 dengue outbreak in madeira: exploring the origins","volume":"19","author":"Wilder-Smith","year":"2014","journal-title":"Euro Surveill.: Bull. Eur. Mal. Trans."},{"key":"B210","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1056\/NEJMra041927","article-title":"Dengue in travelers","volume":"353","author":"Wilder-Smith","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B211","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1126\/science.1126766","article-title":"Aggresomes and autophagy generate sites for virus replication","volume":"312","author":"Wileman","year":"2006","journal-title":"Science"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.3390\/v15040814","article-title":"Transient blockade of type I interferon signalling promotes replication of dengue virus strain D2Y98P in adult wild-type mice","volume":"15","author":"Wilken","year":"2023","journal-title":"Viruses"},{"key":"B213","volume-title":"Dengue guidelines for diagnosis, treatment, prevention and control: new edition","year":"2009"},{"key":"B214","volume-title":"Zika situation report (Fact sheet)","year":"2016"},{"key":"B215","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1099\/jgv.0.001296","article-title":"Rift Valley fever: biology and epidemiology","volume":"100","author":"Wright","year":"2019","journal-title":"J. Gen. Virol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/77553","article-title":"Human skin langerhans cells are targets of dengue virus infection","volume":"6","author":"Wu","year":"2000","journal-title":"Nat. Med."},{"key":"B217","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.meegid.2017.11.009","article-title":"Host genetics and dengue fever","volume":"56","author":"Xavier-Carvalho","year":"2017","journal-title":"J. Mol. Epidemiol. Evol. Genet. Infect. Dis."},{"key":"B218","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.meegid.2013.08.017","article-title":"Single nucleotide polymorphisms in candidate genes and dengue severity in children: A case-control, functional and meta-analysis study","volume":"20","author":"Xavier-Carvalho","year":"2013","journal-title":"J. Mol. Epidemiol. Evol. Genet. Infect. Dis."},{"key":"B219","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.antiviral.2008.06.010","article-title":"Mouse models of dengue virus infection and disease","volume":"80","author":"Yauch","year":"2008","journal-title":"Antiviral Res."},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092240","article-title":"Lack of clinical manifestations in asymptomatic dengue infection is attributed to broad down-regulation and selective up-regulation of host defence response genes","volume":"9","author":"Yeo","year":"2014","journal-title":"PloS One"},{"key":"B221","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41586-021-04345-x","article-title":"Local and systemic responses to SARS-CoV-2 infection in children and adults","volume":"602","author":"Yoshida","year":"2022","journal-title":"Nature"},{"key":"B222","doi-asserted-by":"publisher","first-page":"999","DOI":"10.4269\/ajtmh.14-0628","article-title":"Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore","volume":"92","author":"Yung","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"B223","doi-asserted-by":"publisher","first-page":"7276","DOI":"10.1128\/JVI.03827-13","article-title":"Type I interferon signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccines","volume":"88","author":"Z\u00fcst","year":"2014","journal-title":"J. Virol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1284651\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T08:48:38Z","timestamp":1700815718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2023.1284651\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,24]]},"references-count":223,"alternative-id":["10.3389\/fcimb.2023.1284651"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2023.1284651","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,24]]},"article-number":"1284651"}}