{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:23:36Z","timestamp":1793366616306,"version":"4.5.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Cryptococcus neoformans<\/jats:italic> can invade the central nervous system by crossing the blood-brain barrier via a transcellular mechanism that relies on multiple host factors. In this narrative, we review the evidence that a direct interplay between <jats:italic>C. neoformans<\/jats:italic> and brain endothelial cells forms the basis for invasion and transmigration across the brain endothelium. Adherence and internalization of <jats:italic>C. neoformans<\/jats:italic> is dependent on transmembrane proteins, including a hyaluronic acid receptor and an ephrin receptor tyrosine kinase. We consider the role of EphA2 in facilitating the invasion of the central nervous system by <jats:italic>C. neoformans<\/jats:italic> and highlight experimental evidence supporting macropinocytosis as a potential mechanism of internalization and transcytosis. How macropinocytosis might be conclusively demonstrated in the context of <jats:italic>C. neoformans<\/jats:italic> is also discussed.<\/jats:p>","DOI":"10.3389\/fcimb.2023.1331429","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T09:50:48Z","timestamp":1702288248000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Macropinocytosis as a potential mechanism driving neurotropism of Cryptococcus neoformans"],"prefix":"10.3389","volume":"13","author":[{"given":"Dylan M.","family":"Lanser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia B.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiem","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Gelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/cmi.12811","article-title":"The blood-brain barrier internalises Cryptococcus neoformans via the EphA2-tyrosine kinase receptor","volume":"20","author":"Aaron","year":"2018","journal-title":"Cell Microbiol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205227","article-title":"Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro","volume":"20","author":"Ajikumar","year":"2019","journal-title":"Int. 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