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A 35-year-old patient with chronic aseptic meningitis, for which repeated microbiological testing of CSF was unrevealing, was finally diagnosed with <jats:italic>Candida albicans (C. albicans)<\/jats:italic> meningitis with cauda equina involvement using metagenomic next-generation sequencing (mNGS). This report highlights the diagnostic challenges and the difficulties of treating shunt-associated fungal meningitis.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1322847","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T04:52:00Z","timestamp":1713502320000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case report: Chronic Candida albicans meningitis: a rare entity diagnosed by metagenomic next-generation sequencing"],"prefix":"10.3389","volume":"14","author":[{"given":"Andrea B.","family":"Kuenzli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy D.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner J.","family":"Z`Graggen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura N.","family":"Walti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonas","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Lazarevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Schrenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Oberli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s12883-022-02873-1","article-title":"Evaluation of the epidemiologic, clinical, radiologic, and treatment methods of patients with subacute and chronic meningitis","volume":"22","author":"Bineshfar","year":"2022","journal-title":"BMC Neurol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.656066","article-title":"Case report: a candida meningitis in an immunocompetent patient detected through the next-generation sequencing","volume":"8","author":"Cao","year":"2021","journal-title":"Front. 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