{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:19:19Z","timestamp":1773674359785,"version":"3.50.1"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Gouty arthritis (GA), a metabolic and immunologic disease, primarily affects joints. Dysbiosis of intestinal flora is an important cause of GA. The metabolic disorders of intestinal flora leading to GA and immune disorders might play an important role in patients with hyperuricemia and established GA. However, the exact mechanisms, through which the dysbiosis of intestinal flora causes the development of GA, are not fully understood yet. Moreover, several therapies commonly used to treat GA might alter the intestinal flora, suggesting that modulation of the intestinal flora might help prevent or treat GA. Therefore, a better understanding of the changes in the intestinal flora of GA patients might facilitate the discovery of new diagnostic and therapeutic approaches. The current review article discusses the effects of intestinal flora dysbiosis on the pathogenesis of GA and the cross-regulatory effects between gut flora and drugs for treating GA. This article also highlights the modulatory effects of gut flora by traditional Chinese medicine (TCM) to lower uric acid levels and relieve joint pain as well as provides a summary and outlook, which might help guide future research efforts.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1341953","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:10:35Z","timestamp":1723093835000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Study on the effects of intestinal flora on gouty arthritis"],"prefix":"10.3389","volume":"14","author":[{"given":"Niqin","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiang","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongdong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3390\/nu10101499","article-title":"Impact of diet-modulated butyrate production on intestinal barrier function and inflammation","volume":"1010","author":"Bach Knudsen","year":"2018","journal-title":"Nutrients"},{"key":"B2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/1751-7915.13769","article-title":"Lipoteichoic acid from bifidobacterium animalis subsp. Lactis bpl1: A novel postbiotic that reduces fat deposition via igf-1 pathway","volume":"153","author":"Balaguer","year":"2022","journal-title":"Microbial Biotechnol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1073\/pnas.1322269111","article-title":"The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition","volume":"1116","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.4014\/jmb.2002.02032","article-title":"The inhibitory effect of gut microbiota and its metabolites on colorectal cancer","volume":"3011","author":"Chen","year":"2020","journal-title":"J. Microbiol. Biotechnol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.945533","article-title":"Therapeutic approaches to colorectal cancer via strategies based on modulation of gut microbiota","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110765","article-title":"Dendrobium officinalis six nostrum ameliorates urate under-excretion and protects renal dysfunction in lipid emulsion-induced hyperuricemic rats","volume":"132","author":"Chen","year":"2020","journal-title":"BioMed. Pharmacother."},{"key":"B7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.bmt.2022.11.007","article-title":"Living probiotic biomaterials for osteoporosis therapy","volume":"1","author":"Chen","year":"2023","journal-title":"Biomed. Technol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: At the interface of health and disease","volume":"134","author":"Cho","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41522-021-00235-2","article-title":"Metagenomic analysis revealed the potential role of gut microbiome in gout","volume":"71","author":"Chu","year":"2021","journal-title":"NPJ Biofilms Microbiomes"},{"key":"B10","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1097\/BOR.0000000000000366","article-title":"Factors modulating the inflammatory response in acute gouty arthritis","volume":"292","author":"Cleophas","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"4867402","year":"2012","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.10.010","article-title":"The gut microbiota facilitates drifts in the genetic diversity and infectivity of bacterial viruses","volume":"226","author":"De Sordi","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/03602532.2023.2186313","article-title":"Effects of intestinal flora on pharmacokinetics and pharmacodynamics of drugs","author":"D\u017eidi\u0107-Krivi\u0107","year":"2023","journal-title":"Drug Metab. Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1002\/art.41247","article-title":"2020 american college of rheumatology guideline for the management of gout","volume":"726","author":"FitzGerald","year":"2020","journal-title":"Arthritis Rheumatol. (Hoboken N.J.)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.coph.2013.08.006","article-title":"Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host","volume":"136","author":"Ganapathy","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.2174\/1381612826666200211121916","article-title":"Impact of prebiotics on enteric diseases and oxidative stress","volume":"2622","author":"Gao","year":"2020","journal-title":"Curr. Pharm. Design"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.929346","article-title":"How do intestinal probiotics restore the intestinal barrier","volume":"13","author":"Gou","year":"2022","journal-title":"Front. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s00394-020-02414-x","article-title":"Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in uox-knockout mice","volume":"604","author":"Guo","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/srep20602","article-title":"Intestinal microbiota distinguish gout patients from healthy humans","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep."},{"key":"B20","doi-asserted-by":"publisher","first-page":"288","DOI":"10.14202\/vetworld.2022.288\u2013298","article-title":"Immunosuppression by piperine as a regulator of the nlrp3 inflammasome through mapk\/nf-\u03bab in monosodium urate-induced rat gouty arthritis","volume":"152","author":"Jati","year":"2022","journal-title":"Vet. World"},{"key":"B21","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"4917422","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","first-page":"490","DOI":"10.25122\/jml-2020-0065","article-title":"Impact of the synbiotics and urate-lowering therapy on gut microbiota and cytokine profile in patients with chronic gouty arthritis","volume":"134","author":"Kondratiuk","year":"2020","journal-title":"J. Med. Life"},{"key":"B23","doi-asserted-by":"publisher","first-page":"14665","DOI":"10.1021\/acs.jafc.2c04602","article-title":"Bifidobacterium breve ccfm1078 alleviates collagen-induced arthritis in rats via modulating the gut microbiota and repairing the intestinal barrier damage","volume":"7046","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00955","article-title":"Simiao decoction alleviates gouty arthritis by modulating proinflammatory cytokines and the gut ecosystem","volume":"11","author":"Lin","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12906-023-04042-4","article-title":"Gut microbiota mediated the therapeutic efficiency of Simiao decoction in the treatment of gout arthritis mice","volume":"23","author":"Lin","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"key":"B26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bmt.2022.12.003","article-title":"Advance in oral delivery of living material","volume":"3","author":"Liu","year":"2023","journal-title":"Biomed. Technol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1039\/c2mb25227a","article-title":"Metabolite target analysis of human urine combined with pattern recognition techniques for the study of symptomatic gout","volume":"811","author":"Liu","year":"2012","journal-title":"Mol. Biosyst."},{"key":"B28","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1093\/jpp\/rgac024","article-title":"Phytochemicals in traditional chinese medicine can treat gout by regulating intestinal flora through inactivating nlrp3 and inhibiting xod activity","volume":"747","author":"Liu","year":"2022","journal-title":"J. Pharm. Pharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/art.41955","article-title":"Association of increased serum lipopolysaccharide, but not microbial dysbiosis, with obesity-related osteoarthritis","volume":"74","author":"Loeser","year":"2022","journal-title":"Arthritis Rheumatol. (Hoboken N.J.)"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The human intestinal microbiome in health and disease","volume":"37524","author":"Lynch","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011678","article-title":"Dietary fiber intake and risks of proximal and distal colon cancers: A meta-analysis","volume":"9736","author":"Ma","year":"2018","journal-title":"Medicine"},{"key":"B32","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nature25979","article-title":"Extensive impact of non-antibiotic drugs on human gut bacteria","volume":"5557698","author":"Maier","year":"2018","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1017\/S0007114509991553","article-title":"The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition","volume":"103","author":"M\u00e4kivuokko","year":"2010","journal-title":"Br. J. Nutr."},{"key":"B35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/01.NPR.0000696896.83494.fe","article-title":"An update on gout diagnosis and management for the primary care provider","volume":"4510","author":"Mbuyi","year":"2020","journal-title":"Nurse Practitioner"},{"key":"B36","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13075-015-0609-2","article-title":"An update on the genetic architecture of hyperuricemia and gout","volume":"171","author":"Merriman","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00036-17","article-title":"The first microbial colonizers of the human gut: Composition, activities, and health implications of the infant gut microbiota","volume":"814","author":"Milani","year":"2017","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"7054","DOI":"10.1039\/D1FO00198A","article-title":"Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism","volume":"1215","author":"Ni","year":"2021","journal-title":"Food Funct."},{"key":"B39","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.apsb.2019.10.007","article-title":"Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia","volume":"102","author":"Pan","year":"2020","journal-title":"Acta Pharm. Sinica. B"},{"key":"B40","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1136\/postgradmedj-2015-133285","article-title":"Gut microbiota, obesity and diabetes","volume":"921087","author":"Patterson","year":"2016","journal-title":"Postgraduate Med. J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jare.2017.04.008","article-title":"Gout: An old disease in new perspective - a review","volume":"85","author":"Ragab","year":"2017","journal-title":"J. Adv. Res."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2018_2648","article-title":"Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (scfas)","volume":"661","author":"Ratajczak","year":"2019","journal-title":"Acta Biochim. Polonica"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00268","article-title":"Combined signature of the fecal microbiome and metabolome in patients with gout","volume":"8","author":"Shao","year":"2017","journal-title":"Front. Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.toxlet.2020.09.018","article-title":"Colchicine increases intestinal permeability, suppresses inflammatory responses, and alters gut microbiota in mice","volume":"334","author":"Shi","year":"2020","journal-title":"Toxicol. Lett."},{"key":"B45","doi-asserted-by":"publisher","first-page":"E10539","DOI":"10.1073\/pnas.1810819115","article-title":"Intestinal barrier dysfunction orchestrates the onset of inflammatory host-microbiome cross-talk in a human gut inflammation-on-a-chip","volume":"11545","author":"Shin","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B46","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1038\/s41467-022-32277-1","article-title":"Regulatory mechanisms of lipopolysaccharide synthesis in escherichia coli","volume":"131","author":"Shu","year":"2022","journal-title":"Nat. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.1751-7915.2011.00290.x","article-title":"The human gut microbiome: Are we our enterotypes","volume":"45","author":"Siezen","year":"2011","journal-title":"Microbial Biotechnol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2478\/jtim-2022-0031","article-title":"Prevalence and risk factors of hyperuricemia and gout: A cross-sectional survey from 31 provinces in mainland China","volume":"102","author":"Song","year":"2022","journal-title":"J. Trans. Internal Med."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116736\\","article-title":"Integrated network pharmacology and gut microbiome analysis to reveal the mechanism of Qu-Zhuo-Tong-Bi decoction against hyperuricemia and gout","volume":"316","author":"Song","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.804306","article-title":"Alteration of gut microbiome and correlated amino acid metabolism contribute to hyperuricemia and th17-driven inflammation in uox-ko mice","volume":"13","author":"Song","year":"2022","journal-title":"Front. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00535-016-1242-9","article-title":"Microbiota metabolite short chain fatty acids, gpcr, and inflammatory bowel diseases","volume":"521","author":"Sun","year":"2017","journal-title":"J. Gastroenterol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nature25019","article-title":"Moving beyond microbiome-wide associations to causal microbe identification","volume":"5527684","author":"Surana","year":"2017","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","article-title":"Regulation of intestinal epithelial permeability by tight junctions","volume":"704","author":"Suzuki","year":"2013","journal-title":"Cell Mol. Life Sci."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.2382","article-title":"Probable potential role of urate transporter genes in the development of metabolic disorders","volume":"103","author":"Vadakedath","year":"2018","journal-title":"Cureus"},{"key":"B55","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1093\/nutrit\/nuw067","article-title":"Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing","volume":"754","author":"van der Beek","year":"2017","journal-title":"Nutr. Rev."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1023453","article-title":"Modified baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Physiol."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2196\/47012","article-title":"The impact of mHealth-based continuous care on disease knowledge, treatment compliance, and serum uric acid levels in Chinese patients with gout. Randomized controlled trial","volume":"12","author":"Wang","year":"2024","journal-title":"JMIR Mhealth Uhealth."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.935723","article-title":"Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.610556","article-title":"Qu-zhuo-tong-bi decoction alleviates gouty arthritis by regulating butyrate-producing bacteria in mice","volume":"11","author":"Wen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1126\/science.1208344","article-title":"Linking long-term dietary patterns with gut microbial enterotypes","volume":"3346052","author":"Wu","year":"2011","journal-title":"Sci. (New York N.Y.)"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1897211","article-title":"Limosilactobacillus fermentum jl-3 isolated from \u201cjiangshui\u201d ameliorates hyperuricemia by degrading uric acid","volume":"131","author":"Wu","year":"2021","journal-title":"Gut Microbes"},{"key":"B62","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1159\/000521273","article-title":"Effects of washed microbiota transplantation on serum uric acid levels, symptoms, and intestinal barrier function in patients with acute and recurrent gout: A pilot study","volume":"405","author":"Xie","year":"2022","journal-title":"Digestive Dis. (Basel Switzerland)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1177\/20406223221117449","article-title":"Fecal microbiota transplantation treatment for type 1 diabetes mellitus with malnutrition: A case report","volume":"13","author":"Xie","year":"2022","journal-title":"Ther. Adv. Chronic Dis."},{"key":"B64","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s40168-020-00923-9","article-title":"The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases","volume":"81","author":"Xu","year":"2020","journal-title":"Microbiome"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1080\/13880209.2016.1195847","article-title":"Uric acid transporters hiding in the intestine","volume":"5412","author":"Xu","year":"2016","journal-title":"Pharm. Biol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/srep45176","article-title":"Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia","volume":"7","author":"Xue","year":"2017","journal-title":"Sci. Rep."},{"key":"B67","doi-asserted-by":"publisher","first-page":"7263","DOI":"10.1080\/21655979.2021.1976897","article-title":"Gut microbiota characterization in patients with asymptomatic hyperuricemia: Probiotics increased","volume":"121","author":"Yang","year":"2021","journal-title":"Bioengineered"},{"key":"B68","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.engreg.2024.02.002","article-title":"Emerging microfluidics for the modeling and treatment of arthritis","volume":"5","author":"Yang","year":"2024","journal-title":"Eng. Regen."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.845684","article-title":"The role of the intestine in the development of hyperuricemia","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Immunol."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02233","article-title":"Alterations of the gut microbiome associated with the treatment of hyperuricaemia in male rats","volume":"9","author":"Yu","year":"2018","journal-title":"Front. Microbiol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108327","article-title":"Interactions between NSAIDs, opioids and the gut microbiota - Future perspectives in the management of inflammation and pain","volume":"241","author":"Z\u00e1dori","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1196217","article-title":"Potential role of gut microbiota in prostate cancer: Immunity, metabolites, pathways of action","volume":"13","author":"Zha","year":"2023","journal-title":"Front. Oncol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1177\/15353702211006044","article-title":"Treatment and mechanism of fecal microbiota transplantation in mice with experimentally induced ulcerative colitis","volume":"24613","author":"Zhang","year":"2021","journal-title":"Exp. Biol. Med. (Maywood N.J.)"},{"key":"B74","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.molmed.2020.04.001","article-title":"The gut microbiota: Emerging evidence in autoimmune diseases","volume":"269","author":"Zhang","year":"2020","journal-title":"Trends Mol. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.3892\/mmr.2018.8520","article-title":"NLRP1 and NLRP3 inflammasomes mediate LPS\/ATP-induced pyroptosis in knee osteoarthritis","volume":"17","author":"Zhao","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.26355\/eurrev_202303_31804","article-title":"Investigation of the relationships among respiratory syncytial virus infection, t cell immune response and intestinal flora","volume":"276","author":"Zheng","year":"2023","journal-title":"Eur. Rev. For Med. Pharmacol. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1093\/ibd\/izy182","article-title":"Faecalibacterium prausnitzii produces butyrate to maintain th17\/treg balance and to ameliorate colorectal colitis by inhibiting histone deacetylase 1","volume":"249","author":"Zhou","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/nu16071086","article-title":"Resveratrol improves hyperuricemia and ameliorates renal injury by modulating the gut microbiota","volume":"16","author":"Zhou","year":"2024","journal-title":"Nutrients"}],"updated-by":[{"DOI":"10.3389\/fcimb.2024.1483349","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000}}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1341953\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T13:03:06Z","timestamp":1726837386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1341953\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":78,"alternative-id":["10.3389\/fcimb.2024.1341953"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2024.1341953","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fcimb.2024.1483349","asserted-by":"object"}]},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"article-number":"1341953"}}