{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:53:47Z","timestamp":1792547627969,"version":"4.5.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K20769, 19K07617, 22K15004, 21H02757"],"award-info":[{"award-number":["21K20769, 19K07617, 22K15004, 21H02757"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22ae0121035s012, 22fk0108145h0003, 22ae0121042h0002, 223fa727001h0001"],"award-info":[{"award-number":["22ae0121035s012, 22fk0108145h0003, 22ae0121042h0002, 223fa727001h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008664","name":"Ono Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Intestinal bacteria metabolize dietary substances to produce bioactive postbiotics, among which some are recognized for their role in promoting host health. We here explored the postbiotic potential of two omega-3 \u03b1-linolenic acid\u2013derived metabolites: <jats:italic>trans<\/jats:italic>-10-<jats:italic>cis<\/jats:italic>-15-octadecadienoic acid (t10,c15-18:2) and <jats:italic>cis<\/jats:italic>-9-<jats:italic>cis<\/jats:italic>-15-octadecadienoic acid (c9,c15-18:2). Dietary intake of lipids rich in omega-3 \u03b1-linolenic acid elevated levels of t10,c15-18:2 and c9,c15-18:2 in the serum and feces of mice, an effect dependent on the presence of intestinal bacteria. Notably, t10,c15-18:2 mitigated skin inflammation in mice that became hypersensitive after exposure to 2,4-dinitrofluorobenzene, an experimental model for allergic contact dermatitis. In particular, t10,c15-18:2\u2014but not c9,c15-18:2\u2014attenuated ear swelling and edema, characteristic symptoms of contact hypersensitivity. The anti-inflammatory effects of t10,c15-18:2 were due to its ability to suppress the release of vascular endothelial growth factor A from keratinocytes, thereby mitigating the enhanced vascular permeability induced by hapten stimulation. Our study identified retinoid X receptor as a functional receptor that mediates the downregulation of skin inflammation upon treatment with t10,c15-18:2. Our results suggest that t10,c15-18:2 holds promise as an omega-3 fatty acid\u2013derived postbiotic with potential therapeutic implications for alleviating the skin edema seen in allergic contact dermatitis\u2013induced inflammation.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1355679","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T10:18:29Z","timestamp":1716373109000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The omega-3 postbiotic trans-10-cis-15-octadecadienoic acid attenuates contact hypersensitivity in mice through downregulation of vascular endothelial growth factor A"],"prefix":"10.3389","volume":"14","author":[{"given":"Azusa","family":"Saika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Nagatake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenobu","family":"Kishino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabha","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Node","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kunisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.999001","article-title":"Human gut microbiota in health and disease: Unveiling the relationship","volume":"13","author":"Afzaal","year":"2022","journal-title":"Front. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tifs.2018.03.009","article-title":"Postbiotics: An evolving term within the functional foods field","volume":"75","author":"Aguilar-Toal\u00e1","year":"2018","journal-title":"Trends Food Sci. technology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","article-title":"Gut microbiota-derived metabolites as central regulators in metabolic disorders","volume":"70","author":"Agus","year":"2021","journal-title":"Gut."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell."},{"key":"B58","doi-asserted-by":"publisher","first-page":"7997","DOI":"10.1093\/nar\/gkt539","article-title":"VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level","volume":"41","author":"Arcondeguy","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s10456-014-9421-x","article-title":"Anti-VEGF therapy reduces intestinal inflammation in Endoglin heterozygous mice subjected to experimental colitis","volume":"17","author":"Ardelean","year":"2014","journal-title":"Angiogenesis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2332\/allergolint.10-OA-0207","article-title":"IL-6, VEGF, KC and RANTES are a major cause of a high irritant dermatitis to phthalic anhydride in C57BL\/6 inbred mice","volume":"59","author":"Bae","year":"2010","journal-title":"Allergol Int."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.3390\/nu12071913","article-title":"Conjugated linoleic acid and its beneficial effects in obesity, cardiovascular disease, and cancer","volume":"12","author":"Basak","year":"2020","journal-title":"Nutrients."},{"key":"B45","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.jnutbio.2006.01.007","article-title":"Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells","volume":"17","author":"Beppu","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1046\/j.1365-2133.1999.03205.x","article-title":"Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis","volume":"141","author":"Bhushan","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"Boukamp","year":"1988","journal-title":"J. Cell Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"127240","DOI":"10.1016\/j.jtemb.2023.127240","article-title":"Heavy metals in contact dermatitis: A review","volume":"79","author":"Chamani","year":"2023","journal-title":"J. Trace Elem Med. Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13068-022-02223-w","article-title":"Functional analysis of the dehydratase domains of the PUFA synthase from Emiliania huxleyi in Escherichia coli and Arabidopsis thaliana","volume":"15","author":"Chen","year":"2022","journal-title":"Biotechnol. Biofuels Bioprod."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1194\/jlr.M20008-JLR200","article-title":"Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse","volume":"43","author":"Clement","year":"2002","journal-title":"J. Lipid Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"de Vos","year":"2022","journal-title":"Gut."},{"key":"B68","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/nrd.2015.17","article-title":"Ten years of anti-vascular endothelial growth factor therapy","volume":"15","author":"Ferrara","year":"2016","journal-title":"Nat. Rev. Drug Discovery"},{"key":"B69","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1146\/annurev.med.58.061705.145635","article-title":"Targeting VEGF-A to treat cancer and age-related macular degeneration","volume":"58","author":"Ferrara","year":"2007","journal-title":"Annu. Rev. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9749","DOI":"10.1038\/s41598-021-88870-9","article-title":"Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid beta-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer's disease mouse model","volume":"11","author":"Fujita","year":"2021","journal-title":"Sci. Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1194\/jlr.M300120-JLR200","article-title":"Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator","volume":"44","author":"Granlund","year":"2003","journal-title":"J. Lipid Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3843","DOI":"10.1002\/embj.1994.13.issue-16","article-title":"Sp1-mediated transcriptional activation is repressed by Sp3","volume":"13","author":"Hagen","year":"1994","journal-title":"EMBO J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/jid.2012.284","article-title":"Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis","volume":"133","author":"Honda","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.jaci.2020.01.036","article-title":"Mast cells initiate the vascular response to contact allergens by sensing cell stress","volume":"145","author":"Hoppe","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/jidsymp.2011.5","article-title":"The cutaneous vascular system in chronic skin inflammation","volume":"15","author":"Huggenberger","year":"2011","journal-title":"J. Investig. Dermatol. Symp Proc."},{"key":"B43","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1471-4159.2010.06908.x","article-title":"Protection of cortical neurons from excitotoxicity by conjugated linoleic acid","volume":"115","author":"Hunt","year":"2010","journal-title":"J. Neurochem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1159\/000508953","article-title":"Anti-VEGF therapy reduces inflammation in diabetic macular edema","volume":"64","author":"Imazeki","year":"2021","journal-title":"Ophthalmic Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1089\/wound.2013.0517","article-title":"Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair","volume":"3","author":"Johnson","year":"2014","journal-title":"Adv. Wound Care (New Rochelle)."},{"key":"B12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1271\/bbb.67.179","article-title":"Structural analysis of conjugated linoleic acid produced by Lactobacillus plantarum, and factors affecting isomer production","volume":"67","author":"Kishino","year":"2003","journal-title":"Bioscience biotechnology Biochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"17808","DOI":"10.1073\/pnas.1312937110","article-title":"Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition","volume":"110","author":"Kishino","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1182\/blood-2003-08-2964","article-title":"Induction of cutaneous delayed-type hypersensitivity reactions in VEGF-A transgenic mice results in chronic skin inflammation associated with persistent lymphatic hyperplasia","volume":"104","author":"Kunstfeld","year":"2004","journal-title":"Blood."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/ncomms2023","article-title":"Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors","volume":"3","author":"Kurashima","year":"2012","journal-title":"Nat. Commun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"12035","DOI":"10.3390\/ijms222112035","article-title":"Angiogenesis in chronic inflammatory skin disorders","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"7269","DOI":"10.1021\/bi00483a016","article-title":"Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes","volume":"29","author":"Leger","year":"1990","journal-title":"Biochemistry."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12865-016-0187-3","article-title":"Role of intestinal microbiota and metabolites on gut homeostasis and human diseases","volume":"18","author":"Lin","year":"2017","journal-title":"BMC Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/exd.14151","article-title":"Vascular endothelial growth factor-A as a promising therapeutic target for the management of psoriasis","volume":"29","author":"Luengas-Martinez","year":"2020","journal-title":"Exp. Dermatol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"4163","DOI":"10.1167\/iovs.02-0655","article-title":"Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia","volume":"44","author":"Lukiw","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/eji.201646536","article-title":"1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells","volume":"47","author":"Manabe","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158104","article-title":"Isolation of mature (Peritoneum-derived) mast cells and immature (Bone marrow-derived) mast cell precursors from mice","volume":"11","author":"Meurer","year":"2016","journal-title":"PloS One"},{"key":"B46","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1194\/jlr.M700275-JLR200","article-title":"The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARgamma-dependent and PPARgamma-independent mechanisms","volume":"49","author":"Miller","year":"2008","journal-title":"J. Lipid Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/S0022-2275(20)33384-8","article-title":"Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha","volume":"40","author":"Moya-Camarena","year":"1999","journal-title":"J. Lipid Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jmb.2012.11.017","article-title":"Structural insights into the mechanism and inhibition of the beta-hydroxydecanoyl-acyl carrier protein dehydratase from Pseudomonas aeruginosa","volume":"425","author":"Moynie","year":"2013","journal-title":"J. Mol. Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/sj.bjp.0703054","article-title":"Different role of IL-4 in the onset of hapten-induced contact hypersensitivity in BALB\/c and C57BL\/6 mice","volume":"129","author":"Nagai","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/s41385-021-00477-5","article-title":"Intestinal microbe-dependent omega3 lipid metabolite alphaKetoA prevents inflammatory diseases in mice and cynomolgus macaques","volume":"15","author":"Nagatake","year":"2022","journal-title":"Mucosal Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jaci.2017.09.053","article-title":"The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques","volume":"142","author":"Nagatake","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"10626","DOI":"10.1073\/pnas.0913545107","article-title":"Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression","volume":"107","author":"Nunez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"313","DOI":"10.4161\/bioe.24159","article-title":"Identification and characterization of an oleate hydratase-encoding gene from Bifidobacterium breve","volume":"4","author":"O'Connell","year":"2013","journal-title":"Bioengineered."},{"key":"B37","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/B978-0-12-813167-1.00006-2","article-title":"Hydratase, dehydrogenase, isomerase, and enone reductase involved in fatty acid saturation metabolism","author":"Ogawa","year":"2018","journal-title":"Lipid Modification by Enzymes Engineered Microbes: Elsevier;"},{"key":"B22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s41232-017-0042-9","article-title":"Regulation of blood vascular permeability in the skin","volume":"37","author":"Ono","year":"2017","journal-title":"Inflammation Regen."},{"key":"B59","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cardiores.2004.09.032","article-title":"Transcriptional regulation of the Vascular Endothelial Growth Factor gene\u2013a concert of activating factors","volume":"65","author":"Pages","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1007\/s10620-013-2990-5","article-title":"Is RXRalpha crucially involved in intestinal inflammation","volume":"59","author":"Pekow","year":"2014","journal-title":"Dig Dis. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.tifs.2020.12.004","article-title":"Postbiotics: Metabolites and mechanisms involved in microbiota-host interactions","volume":"108","author":"Peluzio","year":"2021","journal-title":"Trends Food Sci. Technology."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1016\/j.bbamem.2012.06.001","article-title":"The position of the double bond in monounsaturated free fatty acids is essential for the inhibition of the nicotinic acetylcholine receptor","volume":"1818","author":"Perillo","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B36","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2091-12-9","article-title":"Myosin-cross-reactive antigen (MCRA) protein from Bifidobacterium breve is a FAD-dependent fatty acid hydratase which has a function in stress protection","volume":"12","author":"Rosberg-Cody","year":"2011","journal-title":"BMC Biochem."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001687R","article-title":"omega3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor alpha","volume":"35","author":"Saika","year":"2021","journal-title":"FASEB J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1096\/fba.2019-00061","article-title":"17(S),18(R)-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression","volume":"2","author":"Saika","year":"2020","journal-title":"FASEB Bioadv."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e141","DOI":"10.1111\/ijd.13132","article-title":"Expression of vascular endothelial growth factor and other cytokines in atopic dermatitis, and correlation with clinical features","volume":"55","author":"Samochocki","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"11533","DOI":"10.1021\/bi034927y","article-title":"Trans unsaturated fatty acids are less oxidizable than cis unsaturated fatty acids and protect endogenous lipids from oxidation in lipoproteins and lipid bilayers","volume":"42","author":"Sargis","year":"2003","journal-title":"Biochemistry."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.3390\/nu11122868","article-title":"Dietary omega-3 fatty acid dampens allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice","volume":"11","author":"Sawane","year":"2019","journal-title":"Nutrients"},{"key":"B62","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/sj.emboj.7601539","article-title":"Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis","volume":"26","author":"Schmidt","year":"2007","journal-title":"EMBO J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.jid.2023.03.1668","article-title":"Mouse models of allergic contact dermatitis: practical aspects","volume":"143","author":"Schwarz","year":"2023","journal-title":"J. Invest. Dermatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1177\/1947601911423031","article-title":"Vascular Endothelial Growth Factor (VEGF) and its Receptor (VEGFR) signaling in angiogenesis: A crucial target for anti- and pro-angiogenic therapies","volume":"2","author":"Shibuya","year":"2011","journal-title":"Genes Cancer."},{"key":"B13","doi-asserted-by":"publisher","first-page":"112","DOI":"10.24508\/mms.2022.11.003","article-title":"Comprehensive analysis of fatty acid metabolites produced by gut microbiota using LC-MS\/MS-based lipidomics","volume":"6","author":"Tsuji","year":"2022","journal-title":"Med. Mass Spectrometry."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.3390\/ijms19082354","article-title":"Retinoid X receptor antagonists","volume":"19","author":"Watanabe","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"Weidinger","year":"2018","journal-title":"Nat. Rev. Dis. Primers."},{"key":"B57","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1182\/blood-2002-12-3793","article-title":"Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis","volume":"102","author":"Xia","year":"2003","journal-title":"Blood."},{"key":"B25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1346-8138.2007.00304.x","article-title":"Vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787\/ZK 222584 inhibits both the induction and elicitation phases of contact hypersensitivity","volume":"34","author":"Yamamoto","year":"2007","journal-title":"J. Dermatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ejphar.2009.12.007","article-title":"Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB\/c mice","volume":"629","author":"Yuan","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"5766","DOI":"10.3390\/ijms23105766","article-title":"MDM2-mediated ubiquitination of RXRbeta contributes to mitochondrial damage and related inflammation in atherosclerosis","volume":"23","author":"Zeng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1007\/s11746-997-0086-0","article-title":"Oxidative stability of conjugated linoleic acids relative to other polyunsaturated fatty acids","volume":"74","author":"Zhang","year":"1997","journal-title":"J. Am. Oil Chemists' Society."},{"key":"B19","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00403-006-0641-9","article-title":"Increased production of vascular endothelial growth factor in the lesions of atopic dermatitis","volume":"297","author":"Zhang","year":"2006","journal-title":"Arch. Dermatol. Res."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1355679\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T10:18:39Z","timestamp":1716373119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1355679\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":69,"alternative-id":["10.3389\/fcimb.2024.1355679"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2024.1355679","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"article-number":"1355679"}}