{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:39:49Z","timestamp":1785937189010,"version":"3.56.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Rhino-orbital-cerebral mucormycosis (ROCM) is a rare, invasive, and fatal fungal disease that is often easily misdiagnosed in the early stages due to the lack of specific clinical manifestations and adequate auxiliary examinations. Early diagnosis and timely therapy are essential for successful treatment. In this report, we presented a 46-year-old man with diabetes who experienced gradual vision loss, right ptosis, swelling, and headaches that progressively worsened to death within 4 days after admission. It was finally confirmed as a fungal <jats:italic>Rhizopus arrhizus<\/jats:italic> infection by metagenomics next-generation sequencing (mNGS). Our report has proved that mNGS testing should be strongly recommended in highly suspected patients.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1375058","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T04:32:02Z","timestamp":1721104322000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Rhino-orbital-cerebral mucormycosis caused by Rhizopus arrhizus diagnosis via metagenomics next-generation sequencing: a case report"],"prefix":"10.3389","volume":"14","author":[{"given":"Jianhong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1007\/s11046-023-00785-3","article-title":"COVID-19 associated rhino-orbital-cerebral mucormycosis: clinical features, antifungal susceptibility, management and outcome in a tertiary hospital in Iran","volume":"188","author":"Abdorahimi","year":"2023","journal-title":"Mycopathologia"},{"key":"B2","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jiph.2022.02.007","article-title":"Mucormycosis and COVID-19 pandemic: Clinical and diagnostic approach","volume":"15","author":"Azhar","year":"2022","journal-title":"J. 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