{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:26:15Z","timestamp":1767853575671,"version":"3.49.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>There is evidence that in infected cells <jats:italic>in vitro<\/jats:italic> the meningococcal HrpA\/HrpB two-partner secretion system (TPS) mediates the exit of bacteria from the internalization vacuole and the docking of bacteria to the dynein motor resulting in the induction of pyroptosis. In this study we set out to study the role of the HrpA\/HrpB TPS in establishing meningitis and activating pyroptotic pathways in an animal model of meningitis using a reference serogroup C meningococcal strain, 93\/4286, and an isogenic <jats:italic>hrpB<\/jats:italic> knockout mutant, 93\/4286\u03a9<jats:italic>hrpB<\/jats:italic>. Survival experiments confirmed the role of HrpA\/HrpB TPS in the invasive meningococcal disease. In fact, the ability of the <jats:italic>hrpB<\/jats:italic> mutant to replicate in brain and spread systemically was impaired in mice infected with <jats:italic>hrpB<\/jats:italic> mutant. Furthermore, western blot analysis of brain samples during the infection demonstrated that: i. <jats:italic>N. meningitidis<\/jats:italic> activated canonical and non-canonical inflammasome pyroptosis pathways in the mouse brain; ii. the activation of caspase-11, caspase-1, and gasdermin-D was markedly reduced in the <jats:italic>hrpB<\/jats:italic> mutant; iii. the increase in the amount of IL-1\u03b2 and IL-18, which are an important end point of pyroptosis, occurs in the brains of mice infected with the wild-type strain 93\/4286 and is strongly reduced in those infected with 93\/4286\u03a9<jats:italic>hrpB<\/jats:italic>. In particular, the activation of caspase 11, which is triggered by cytosolic lipopolysaccharide, indicates that during meningococcal infection pyroptosis is induced by intracellular infection after the exit of the bacteria from the internalizing vacuole, a process that is hindered in the <jats:italic>hrpB<\/jats:italic> mutant. Overall, these results confirm, in an animal model, that the HrpA\/HrpB TPS plays a role in the induction of pyroptosis and suggest a pivotal involvement of pyroptosis in invasive meningococcal disease, paving the way for the use of pyroptosis inhibitors in the adjuvant therapy of the disease.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1384072","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T05:10:19Z","timestamp":1727068219000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Neisseria meningitidis activates pyroptotic pathways in a mouse model of meningitis: role of a two-partner secretion system"],"prefix":"10.3389","volume":"14","author":[{"given":"Chiara","family":"Pagliuca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Colicchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Caterina","family":"Resta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelfia","family":"Tal\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Scaglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mantova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Continisio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Pagliarulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Alifano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-622","article-title":"Domain exchange at the 3\u2019 end of the gene encoding the fratricide meningococcal two-partner secretion protein A","volume":"14","author":"Arenas","year":"2013","journal-title":"BMC Genomics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.tim.2019.07.001","article-title":"How BspC from Streptococcus agalactiae Interacts with Host Vimentin during Meningitis","volume":"27","author":"Beninati","year":"2019","journal-title":"Trends Microbiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.4049\/jimmunol.2200584","article-title":"Leptospira interrogans Prevents Macrophage Cell Death and Pyroptotic IL-1\u03b2 Release through Its Atypical Lipopolysaccharide","volume":"210","author":"Bonhomme","year":"2023","journal-title":"J. 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