{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:54:52Z","timestamp":1787496892686,"version":"build-2736575974"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    has already been stipulated as a \u201ccritical\u201d pathogen, emphasizing the urgent need for researching and developing novel antibacterial agents due to multidrug resistance. Bacterial biofilm formation facilitates cystic fibrosis development and restricts the antibacterial potential of many current antibiotics. The capacity of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    to form biofilms and resist antibiotics is closely correlated with quorum sensing (QS). Bacterial QS is being contemplated as a promising target for developing novel antibacterial agents. QS inhibitors are a promising strategy for treating chronic infections. This study reported that the active compound PT22 (1H-pyrrole-2,5-dicarboxylic acid) isolated from\n                    <jats:italic>Perenniporia tephropora<\/jats:italic>\n                    FF2, one endophytic fungus from\n                    <jats:italic>Areca catechu<\/jats:italic>\n                    L., presents QS inhibitory activity against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    . Combined with gentamycin or piperacillin, PT22 functions as a novel antibiotic accelerant against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    . PT22 (0.50 mg\/mL, 0.75 mg\/mL, and 1.00 mg\/mL) reduces the production of QS-related virulence factors, such as pyocyanin and rhamnolipid, and inhibits biofilm formation of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    PAO1 instead of affecting its growth. The architectural disruption of the biofilms was confirmed by visualization through scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Real-time quantitative PCR (RT-qPCR) indicated that PT22 significantly attenuated the expression of QS-related genes followed by docking analysis of molecules against QS activator proteins. PT22 dramatically increased the survival rate of\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    . PT22 combined with gentamycin or piperacillin presents significant inhibition of biofilm formation and eradication of mature biofilm compared to monotherapy, which was also confirmed by visualization through SEM and CLSM. After being treated with PT22 combined with gentamycin or piperacillin, the survival rates of\n                    <jats:italic>G. mellonella<\/jats:italic>\n                    were significantly increased compared to those of monotherapy. PT22 significantly enhanced the susceptibility of gentamycin and piperacillin against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    PAO1. Our results suggest that PT22 from\n                    <jats:italic>P. tephropora<\/jats:italic>\n                    FF2 as a potent QS inhibitor is a candidate antibiotic accelerant to combat the antibiotic resistance of\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2024.1413728","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:23:36Z","timestamp":1719879816000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["1H-Pyrrole-2,5-dicarboxylic acid, a quorum sensing inhibitor from one endophytic fungus in Areca catechu L., acts as antibiotic accelerant against Pseudomonas aeruginosa"],"prefix":"10.3389","volume":"14","author":[{"given":"Junsheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhennan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1007\/s00253-019-09618-0","article-title":"Natural quorum sensing inhibitors effectively downregulate gene expression of pseudomonas aeruginosa virulence factors","volume":"103","author":"Ahmed","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1093\/femsre\/fuw038","article-title":"Social interactions in bacterial cell\u2013cell signaling","volume":"41","author":"Asfahl","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/j.1365\u20132672.2006.03152.x","article-title":"Purification and characterization of the laccase secreted by the white rot fungus perenniporia tephropora and its role in the decolourization of synthetic dyes","volume":"102","author":"Ben","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-micro-092611-150055","article-title":"Pseudomonas aeruginosa twitching motility: type iv pili in action","volume":"66","author":"Burrows","year":"2012","journal-title":"Annu. Rev. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.899566","article-title":"Gentamicin augments the quorum quenching potential of cinnamaldehyde in vitro and protects caenorhabditis elegans from pseudomonas aeruginosa infection","volume":"12","author":"Chadha","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"121267","DOI":"10.1016\/j.lfs.2022.121267","article-title":"\u03b1-Terpineol synergizes with gentamicin to rescue Caenorhabditis elegans from Pseudomonas aeruginosa infection by attenuating quorum sensing-regulated virulence","volume":"313","author":"Chadha","year":"2023"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4328","DOI":"10.3892\/etm.2017.5110","article-title":"Combined effect of linolenic acid and tobramycin on pseudomonas aeruginosa biofilm formation and quorum sensing","volume":"14","author":"Chanda","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.890790","article-title":"A cyclic disulfide diastereomer from bioactive fraction of bruguiera gymnorhiza shows anti\u2013pseudomonas aeruginosa activity","volume":"13","author":"Dahibhate","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106753","article-title":"In-vitro antibacterial activity of omeprazole and esomeprazole in combination with ciprofloxacin as an alternative to repositioning against eskape pathogens and evaluation of the cleavage capacity of plasmid dna","volume":"61","author":"Da Rosa","year":"2023","journal-title":"Int. J. Antimicrob. Agents."},{"key":"B10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s11557-006-0053-4","article-title":"Endophytes and mycoparasites associated with an indigenous forest tree, theobroma gileri, in Ecuador and a preliminary assess- ment of their potential as biocontrol agents of cocoa diseases","volume":"2","author":"Evans","year":"2003","journal-title":"Mycol. Prog."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00443","article-title":"Itaconimides as novel quorum sensing inhibitors of pseudomonas aeruginosa","volume":"8","author":"Fong","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1042\/BCJ20220527","article-title":"Impact of fluoroquinolones and aminoglycosides on p. Aeruginosa virulence factor production and cytotoxicity","volume":"479","author":"Foulkes","year":"2022","journal-title":"Biochem. J."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/femsle\/fnx104","article-title":"Two-component systems required for virulence in pseudomonas aeruginosa","volume":"364","author":"Francis","year":"2017","journal-title":"FEMS Microbiol. Lett."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134684","article-title":"Quercetin influences quorum sensing in food borne bacteria: in-vitro and in-silico evidence","volume":"10","author":"Gopu","year":"2015","journal-title":"PloS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/nrmicro2199","article-title":"The type iii secretion system of pseudomonas aeruginosa: infection by injection","volume":"7","author":"Hauser","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1167\/iovs.19-27200","article-title":"Glycyrrhizin use for multi-drug resistant pseudomonas aeruginosa: in vitro and in vivo studies","volume":"60","author":"Hazlett","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"901","DOI":"10.2217\/fmb.13.57","article-title":"Targeting quorum sensing in pseudomonas aeruginosa biofilms: current and emerging inhibitors","volume":"8","author":"Jakobsen","year":"2013","journal-title":"Future Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s11274-013-1552-5","article-title":"Pyocyanin: production, applications, challenges and new insights","volume":"30","author":"Jayaseelan","year":"2014","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/md21050296","article-title":"Citrinin is a potential quorum sensing inhibitor against pseudomonas aeruginosa","volume":"21","author":"Ji","year":"2023","journal-title":"Mar. Drugs"},{"key":"B20","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s11101-020-09711-7","article-title":"Endophyte-produced antimicrobials: a review of potential lead compounds with a focus on quorum-sensing disruptors","volume":"20","author":"Joo","year":"2021","journal-title":"Phytochem. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00253-019-10201-w","article-title":"Regulation and controlling the motility properties of pseudomonas aeruginosa","volume":"104","author":"Khan","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1016\/0031-9422(92)83757-P","article-title":"Two pyrrole acids from berberis koreana","volume":"31","author":"Ko\u00e1lov\u00e1","year":"1992","journal-title":"Phytochemistry."},{"key":"B23","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jmii.2009.10.001","article-title":"Screening of traditional chinese medicinal plants for quorum-sensing inhibitors activity","volume":"44","author":"Koh","year":"2011","journal-title":"J. Microbiology Immunol. Infection."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091541","article-title":"Biodiversity, phylogeny, and antifungal functions of endophytic fungi associated with zanthoxylum bungeanum","volume":"17","author":"Li","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/14786419.2022.2103696","article-title":"A new alkaloid and two organic acids from portulaca oleracea l. And their bioactivities","volume":"38","author":"Liu","year":"2024","journal-title":"Nat. Prod. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s12088-019-00840-y","article-title":"Phomopsis tersa as inhibitor of quorum sensing system and biofilm forming ability of pseudomonas aeruginosa","volume":"60","author":"Meena","year":"2020","journal-title":"Indian J. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.631710","article-title":"Galleria mellonella larvae as an infection model to investigate srna-mediated pathogenesis in staphylococcus aureus","volume":"11","author":"M\u00e9nard","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01668","article-title":"2,4-di-tert-butylphenol isolated from an endophytic fungus, daldinia eschscholtzii, reduces virulence and quorum sensing in pseudomonas aeruginosa","volume":"11","author":"Mishra","year":"2020","journal-title":"Front. Microbiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00203-017-1437-3","article-title":"Quorum sensing inhibitors: can endophytes be prospective sources","volume":"200","author":"Mookherjee","year":"2018","journal-title":"Arch. Microbiol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106937","article-title":"Autoinducers modulation as a potential anti-virulence target of bacteria by phenolic compounds","volume":"62","author":"Moreno-Chamba","year":"2023","journal-title":"Int. J. Antimicrob. Agents."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00422","article-title":"Responses of pseudomonas aeruginosa to antimicrobials","volume":"4","author":"Morita","year":"2014","journal-title":"Front. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41579-019-0186-5","article-title":"Bacterial quorum sensing in complex and dynamically changing environments","volume":"17","author":"Mukherjee","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"17981","DOI":"10.1073\/pnas.1316981110","article-title":"A quorum-sensing inhibitor blocks pseudomonas aeruginosa virulence and biofilm formation","volume":"110","author":"O Loughlin","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nrmicro.2016.89","article-title":"Quorum sensing signal-response systems in gram-negative bacteria","volume":"14","author":"Papenfort","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.3390\/microorganisms9091807","article-title":"Characterization of pseudomonas aeruginosa quorum sensing inhibitors from the endophyte lasiodiplodia venezuelensis and evaluation of their antivirulence effects by metabolomics","volume":"9","author":"Pellissier","year":"2021","journal-title":"Microorganisms."},{"key":"B36","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/j.1365-2958.2011.07733.x","article-title":"The novel pseudomonas aeruginosa two-component regulator bfmr controls bacteriophage-mediated lysis and dna release during biofilm development through phda","volume":"81","author":"Petrova","year":"2011","journal-title":"Mol. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s13225-010-0029-1","article-title":"Occurrence and diversity of basidiomycetous endophytes from the oil palm, elaeis guineensis in Thailand","volume":"41","author":"Pinruan","year":"2010","journal-title":"Fungal Divers."},{"key":"B38","doi-asserted-by":"publisher","first-page":"5467","DOI":"10.1038\/srep05467","article-title":"Rna-seq-based transcriptome analysis of methicillin-resistant staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol","volume":"4","author":"Qin","year":"2014","journal-title":"Sci. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bcab.2013.01.002","article-title":"Hydrolytic enzymes and quorum sensing inhibitors from endophytic fungi of ventilago madraspatana gaertn","volume":"2","author":"Rajesh","year":"2013","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1365-2958.2005.04552.x","article-title":"Understanding the control of pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis","volume":"56","author":"Ramsey","year":"2005","journal-title":"Mol. Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.funbio.2018.07.003","article-title":"Anti-quorum sensing and antibiofilm potential of alternaria alternata, a foliar endophyte of carica papaya, evidenced by qs assays and in-silico analysis","volume":"122","author":"Rashmi","year":"2018","journal-title":"Fungal Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1086\/533452","article-title":"Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no eskape","volume":"197","author":"Rice","year":"2008","journal-title":"J. Infect. Diseases."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241511895","article-title":"Transcriptional regulators controlling virulence in pseudomonas aeruginosa","volume":"24","author":"S\u00e1nchez-Jim\u00e9nez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201242119","article-title":"Antiactivators prevent self-sensing in pseudomonas aeruginosa quorum sensing","volume":"119","author":"Smith","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: the who priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/cid\/ciac268","article-title":"Infectious diseases society of america 2022 guidance on the treatment of extended-spectrum \u03b2-lactamase producing enterobacterales (ESBL-e), carbapenem-resistant enterobacterales (CRE), and pseudomonas aeruginosa with difficult-to-treat resistance (DTR-P. aeruginosa)","volume":"75","author":"Tamma","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/srep11997","article-title":"Transcriptome analysis of the biofilm formed by methicillin-susceptible staphylococcus aureus","volume":"5","author":"Tan","year":"2015","journal-title":"Sci. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"Autodock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/21505594.2015.1135289","article-title":"Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing","volume":"7","author":"Tsai","year":"2016","journal-title":"Virulence."},{"key":"B50","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1146\/annurev.cellbio.21.012704.131001","article-title":"Quorum sensing: cell-to-cell communication in bacteria","volume":"21","author":"Waters","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"3387","DOI":"10.1128\/JB.00214-13","article-title":"Global control of gaca in secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium pseudomonas aeruginosa m18","volume":"195","author":"Wei","year":"2013","journal-title":"J. Bacteriol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3390\/cells12010195","article-title":"Pseudomonas aeruginosa cytotoxins: mechanisms of cytotoxicity and impact on inflammatory responses","volume":"12","author":"Wood","year":"2023","journal-title":"Cells."},{"key":"B53","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s00253-012-4189-7","article-title":"Cytotoxic metabolites from perenniporia tephropora, an endophytic fungus from taxus chinensis var. Mairei","volume":"97","author":"Wu","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.955952","article-title":"2-hydroxymethyl-1-methyl-5-nitroimidazole, one siderophore inhibitor, occludes quorum sensing in pseudomonas aeruginosa","volume":"12","author":"Yin","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s11274-022-03360-y","article-title":"Actinomycin d: a novel pseudomonas aeruginosa quorum sensing inhibitor from the endophyte streptomyces cyaneochromogenes rc1","volume":"38","author":"Zeng","year":"2022","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8030395","article-title":"Heat shock protein dnaj in pseudomonas aeruginosa affects biofilm formation via pyocyanin production","volume":"8","author":"Zeng","year":"2020","journal-title":"Microorganisms (Basel)."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00227","article-title":"Soil ph is a key determinant of soil fungal community composition in the ny-alesund region, svalbard (high arctic)","volume":"7","author":"Zhang","year":"2016","journal-title":"Front. Microbiol."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.790220","article-title":"Combined with mefloquine, resurrect colistin active in colistin-resistant pseudomonas aeruginosa in vitro and in vivo","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Microbiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijantimicag.2018.03.002","article-title":"Can the quorum sensing inhibitor resveratrol function as an aminoglycoside antibiotic accelerant against pseudomonas aeruginosa","volume":"52","author":"Zhou","year":"2018","journal-title":"Int. J. Antimicrob. Agents."},{"key":"B60","doi-asserted-by":"publisher","first-page":"9745","DOI":"10.1007\/s00253-018-9315-8","article-title":"Attenuation of pseudomonas aeruginosa biofilm by hordenine: a combinatorial study with aminoglycoside antibiotics","volume":"102","author":"Zhou","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2023.114573","article-title":"Anti-virulence activity of dihydrocuminyl aldehyde and nisin against spoilage bacterium pseudomonas aeruginosa xz01","volume":"177","author":"Zhou","year":"2023","journal-title":"Lwt-Food Sci. Technol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.114258","article-title":"Synergistic effect of propyl gallate and antibiotics against biofilms of serratia marcescens and erwinia carotovora in vitro","volume":"173","author":"Zhou","year":"2023","journal-title":"Lwt-Food Sci. Technol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00253-020-11013-z","article-title":"1-(4-amino-2-hydroxyphenyl)ethanone from phomopsis liquidambari showed quorum sensing inhibitory activity against pseudomonas aeruginosa","volume":"105","author":"Zhou","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1413728\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:23:39Z","timestamp":1719879819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1413728\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":63,"alternative-id":["10.3389\/fcimb.2024.1413728"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2024.1413728","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]},"article-number":"1413728"}}