{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:02:01Z","timestamp":1790071321415,"version":"4.0.1"},"reference-count":128,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Programmed cell death (PCD) plays a crucial role in maintaining the normal structure and function of the digestive tract in the body. Infection with <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) is an important factor leading to gastric damage, promoting the Correa cascade and accelerating the transition from gastritis to gastric cancer. Recent research has shown that several PCD signaling pathways are abnormally activated during <jats:italic>H. pylori<\/jats:italic> infection, and the dysfunction of PCD is thought to contribute to the development of gastric cancer and interfere with treatment. With the deepening of studies on <jats:italic>H. pylori<\/jats:italic> infection in terms of PCD, exploring the interaction mechanisms between <jats:italic>H. pylori<\/jats:italic> and the body in different PCD pathways may become an important research direction for the future treatment of <jats:italic>H. pylori<\/jats:italic> infection and <jats:italic>H. pylori<\/jats:italic>-related gastric cancer. In addition, biologically active compounds that can inhibit or induce PCD may serve as key elements for the treatment of this disease. In this review, we briefly describe the process of PCD, discuss the interaction between different PCD signaling pathways and the mechanisms of <jats:italic>H. pylori<\/jats:italic> infection or <jats:italic>H. pylori<\/jats:italic>-related gastric cancer, and summarize the active molecules that may play a therapeutic role in each PCD pathway during this process, with the expectation of providing a more comprehensive understanding of the role of PCD in <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1416819","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T05:19:36Z","timestamp":1722403176000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Programmed cell death in Helicobacter pylori infection and related gastric cancer"],"prefix":"10.3389","volume":"14","author":[{"given":"Yukun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fafeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.v19.12","article-title":"Helicobacter pylori outer inflammatory protein A (OipA) suppresses apoptosis of AGS gastric cells in vitro","volume":"19","author":"Al-Maleki","year":"2017","journal-title":"Cell. Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"12767","DOI":"10.3748\/wjg.v20.i36.12767","article-title":"Effect of Helicobacter pylori on gastric epithelial cells","volume":"20","author":"Alzahrani","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1080\/14787210.2020.1782739","article-title":"Role of vacuolating cytotoxin A in Helicobacter pylori infection and its impact on gastric pathogenesis","volume":"18","author":"Ansari","year":"2020","journal-title":"Expert Rev. Anti-Infective Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.cell.2007.11.027","article-title":"Autophagy and cell death: no longer at odds","volume":"131","author":"Bergmann","year":"2007","journal-title":"Cell"},{"key":"B5","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nri.2016.100","article-title":"Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis","volume":"16","author":"Cadwell","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/15548627.2019.1677322","article-title":"MCOLN1\/TRPML1 inhibition - a novel strategy used by Helicobacter pylori to escape autophagic killing and antibiotic eradication therapy in vivo","volume":"16","author":"Capurro","year":"2020","journal-title":"Autophagy"},{"key":"B7","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s00018-022-04135-2","article-title":"Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death","volume":"79","author":"Chaithongyot","year":"2022","journal-title":"Cell. Mol. Life sciences: CMLS"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1142\/S0192415X1650066X","article-title":"Inflammatory and apoptotic regulatory activity of tanshinone IIA in helicobacter pylori -infected cells","volume":"44","author":"Chen","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.biopha.2017.10.030","article-title":"L-ascorbic Acid-2-Glucoside inhibits Helicobacter pylori-induced apoptosis through mitochondrial pathway in Gastric Epithelial cells","volume":"97","author":"Chen","year":"2018","journal-title":"Biomedicine Pharmacotherapy = Biomedecine Pharmacotherapie"},{"key":"B10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12929-024-01017-6","article-title":"A matter of new life and cell death: programmed cell death in the mammalian ovary","volume":"31","author":"Chesnokov","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12929-018-0480-y","article-title":"Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related diseases","volume":"25","author":"Chmiela","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1196\/annals.1299.106","article-title":"NF-kappaB and Bcl-2 in Helicobacter pylori-induced apoptosis in gastric epithelial cells","volume":"1010","author":"Chu","year":"2003","journal-title":"Ann. New York Acad. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0966-842X(00)01936-3","article-title":"Pro-inflammatory programmed cell death","volume":"9","author":"Cookson","year":"2001","journal-title":"Trends Microbiol."},{"key":"B14","first-page":"S37","article-title":"Helicobacter pylori and gastric carcinogenesis","volume":"19","author":"Correa","year":"1995","journal-title":"Am. J. Surg. Pathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s10120-020-01118-9","article-title":"Autophagy induced by Helicobacter pylori infection is necessary for gastric cancer stem cell emergence","volume":"24","author":"Courtois","year":"2021","journal-title":"Gastric Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.dld.2022.04.013","article-title":"Occurrences and phenotypes of RIPK3-positive gastric cells in Helicobacter pylori infected gastritis and atrophic lesions","volume":"54","author":"Cui","year":"2022","journal-title":"Digestive Liver Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nature Reviews","volume":"15","author":"Czabotar","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"639","DOI":"10.4161\/auto.23782","article-title":"The impact of autophagic processes on the intracellular fate of Helicobacter pylori: more tricks from an enigmatic pathogen","volume":"9","author":"Deen","year":"2013","journal-title":"Autophagy"},{"key":"B19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1128\/IAI.00172-07","article-title":"Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells","volume":"75","author":"Ding","year":"2007","journal-title":"Infection Immun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1111\/j.1440-1746.2007.04912.x","article-title":"Helicobacter pylori and mitogen-activated protein kinases regulate the cell cycle, proliferation and apoptosis in gastric epithelial cells","volume":"23","author":"Ding","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12806","article-title":"Lactobacillus rhamnosus JB3 inhibits Helicobacter pylori infection through multiple molecular actions","volume":"26","author":"Do","year":"2021","journal-title":"Helicobacter"},{"key":"B24","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differentiation"},{"key":"B25","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1016\/S0016-5085(97)80012-1","article-title":"Helicobacter pylori, inflammation, mucosal damage, and apoptosis: pathogenesis and definition of gastric atrophy","volume":"113","author":"Genta","year":"1997","journal-title":"Gastroenterology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051801","article-title":"Proregenerative activity of IL-33 in gastric tissue cells undergoing helicobacter pylori-induced apoptosis","volume":"21","author":"Gonciarz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220636","article-title":"The effect of Helicobacter pylori infection and different H. pylori components on the proliferation and apoptosis of gastric epithelial cells and fibroblasts","volume":"14","author":"Gonciarz","year":"2019","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0092-8674(00)00003-9","article-title":"Apoptotic pathways: paper wraps stone blunts scissors","volume":"102","author":"Green","year":"2000","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.tim.2013.09.004","article-title":"Modulation of autophagy by Helicobacter pylori and its role in gastric carcinogenesis","volume":"21","author":"Greenfield","year":"2013","journal-title":"Trends Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/cmi.12396","article-title":"The secreted antigen, HP0175, of Helicobacter pylori links the unfolded protein response (UPR) to autophagy in gastric epithelial cells","volume":"17","author":"Halder","year":"2015","journal-title":"Cell. Microbiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4161\/gmic.25583","article-title":"Chronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer","volume":"4","author":"Hardbower","year":"2013","journal-title":"Gut Microbes"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.581364","article-title":"Sustained exposure to helicobacter pylori lysate inhibits apoptosis and autophagy of gastric epithelial cells","volume":"10","author":"He","year":"2020","journal-title":"Front. Oncol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/82732","article-title":"Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule","volume":"1","author":"Holler","year":"2000","journal-title":"Nat. Immunol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007468","article-title":"Increased programmed death-ligand 1 is an early epithelial cell response to helicobacter pylori infection","volume":"15","author":"Holokai","year":"2019","journal-title":"PloS Pathog."},{"key":"B35","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1126\/science.1236381","article-title":"Crystal structure of NLRC4 reveals its autoinhibition mechanism","volume":"341","author":"Hu","year":"2013","journal-title":"Science"},{"key":"B36","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.nano.2017.12.016","article-title":"Modulation of quantum dots and clearance of Helicobacter pylori with synergy of cell autophagy","volume":"14","author":"Huang","year":"2018","journal-title":"Nanomedicine: Nanotechnology Biology Med."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a036426","article-title":"Regulation of cell death and immunity by XIAP","volume":"12","author":"Jost","year":"2020","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1267\/ahc.07021","article-title":"Homeostatic mass control in gastric non-neoplastic epithelia under infection of Helicobacter pylori: an immunohistochemical analysis of cell growth, stem cells and programmed cell death","volume":"41","author":"Kato","year":"2008","journal-title":"Acta Histochemica Et Cytochemica."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical inflammasome activation by intracellular LPS independent of TLR4","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"B41","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s10020-023-00641-6","article-title":"Glycyrrhizin, an inhibitor of HMGB1 induces autolysosomal degradation function and inhibits Helicobacter pylori infection","volume":"29","author":"Khan","year":"2023","journal-title":"Mol. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/jgh.12663","article-title":"Helicobacter pylori vacuolating cytotoxin induces apoptosis via activation of endoplasmic reticulum stress in dendritic cells","volume":"30","author":"Kim","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1002\/eji.200939882","article-title":"Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation","volume":"40","author":"Kim","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.chom.2018.04.006","article-title":"Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1","volume":"23","author":"Kim","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B45","first-page":"1092","article-title":"Cancerogenesis in Helicobacter pylori infected stomach\u2013role of growth factors, apoptosis and cyclooxygenases","volume":"7","author":"Konturek","year":"2001","journal-title":"Med. Sci. Monitor: Int. Med. J. Exp. Clin. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.micpath.2018.10.012","article-title":"Inflammasome activation and regulation during Helicobacter pylori pathogenesis","volume":"125","author":"Kumar","year":"2018","journal-title":"Microbial Pathogenesis"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.v20.12","article-title":"Helicobacter pylori cholesterol glucosylation modulates autophagy for increasing intracellular survival in macrophages","volume":"20","author":"Lai","year":"2018","journal-title":"Cell. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061750","article-title":"Effect of astaxanthin on activation of autophagy and inhibition of apoptosis in helicobacter pylori-infected gastric epithelial cell line AGS","volume":"12","author":"Lee","year":"2020","journal-title":"Nutrients"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1046\/j.1365-2036.2001.01057.x","article-title":"Apoptosis and proliferation in Helicobacter pylori-associated gastric intestinal metaplasia","volume":"15","author":"Leung","year":"2001","journal-title":"Alimentary Pharmacol. Ther."},{"key":"B50","doi-asserted-by":"publisher","first-page":"7470","DOI":"10.1128\/JVI.74.16.7470-7477.2000","article-title":"Induction of necrotic-like cell death by tumor necrosis factor alpha and caspase inhibitors: novel mechanism for killing virus-infected cells","volume":"74","author":"Li","year":"2000","journal-title":"J. Virol."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2023.106388","article-title":"Chloroquine inhibited Helicobacter pylori-related gastric carcinogenesis by YAP-\u03b2-catenin-autophagy axis","volume":"184","author":"Li","year":"2023","journal-title":"Microbial Pathogenesis"},{"key":"B52","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s11274-023-03710-4","article-title":"Helicobacter pylori infection induces autophagy via ILK regulation of NOXs-ROS-Nrf2\/HO-1-ROS loop","volume":"39","author":"Li","year":"2023","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","article-title":"Cytochrome c and dATP-dependent formation of Apaf-1\/caspase-9 complex initiates an apoptotic protease cascade","volume":"91","author":"Li","year":"1997","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1042070","article-title":"Current and future perspectives for Helicobacter pylori treatment and management: From antibiotics to probiotics","volume":"12","author":"Liang","year":"2022","journal-title":"Front. Cell. Infection Microbiol."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00203","article-title":"Statin decreases helicobacter pylori burden in macrophages by promoting autophagy","volume":"6","author":"Liao","year":"2016","journal-title":"Front. Cell. Infection Microbiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.trecan.2023.04.012","article-title":"The conundrum of Helicobacter pylori-associated apoptosis in gastric cancer","volume":"9","author":"Lim","year":"2023","journal-title":"Trends Cancer"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104717","article-title":"Acute and chronic infection of H. pylori caused the difference in apoptosis of gastric epithelial cells","volume":"150","author":"Liu","year":"2021","journal-title":"Microb. Pathogen."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-023-01916-3","article-title":"Comprehensive analysis of the function of helicobacter-associated ferroptosis gene YWHAE in gastric cancer through multi-omics integration, molecular docking, and machine learning","volume":"29","author":"Liu","year":"2024","journal-title":"Apoptosis: Int. J. Programmed Cell Death"},{"key":"B59","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrm3735","article-title":"Self-consumption: the interplay of autophagy and apoptosis","volume":"15","author":"Mari\u00f1o","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1073\/pnas.1417945112","article-title":"Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5","volume":"112","author":"Matusiak","year":"2015","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/hel.13031","article-title":"Transcriptomic remodeling of gastric cells by Helicobacter pylori outer membrane vesicles","volume":"29","author":"Melo","year":"2024","journal-title":"Helicobacter"},{"key":"B63","first-page":"285","article-title":"Role of Helicobacter pylori in gastric cancer: advances and controversies","volume":"20","author":"Meng","year":"2015","journal-title":"Discovery Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"B65","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nri3131","article-title":"Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways","volume":"12","author":"Mocarski","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.2015238","article-title":"Autophagy mediates ER stress and inflammation in Helicobacter pylori-related gastric cancer","volume":"14","author":"Mommersteeg","year":"2022","journal-title":"Gut Microbes"},{"key":"B67","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.bbcan.2017.11.003","article-title":"Genetic\u00a0host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms","volume":"1869","author":"Mommersteeg","year":"2018","journal-title":"Biochim. Et Biophys. Acta Rev. Cancer"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1038\/s41418-021-00814-y","article-title":"Molecular mechanisms of cell death in neurological diseases","volume":"28","author":"Moujalled","year":"2021","journal-title":"Cell Death Differentiation"},{"key":"B69","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.tim.2023.04.001","article-title":"The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis","volume":"31","author":"Nabavi-Rad","year":"2023","journal-title":"Trends Microbiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1086\/596660","article-title":"Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling","volume":"199","author":"Nagy","year":"2009","journal-title":"J. Infect. Dis."},{"key":"B72","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"B73","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/cr.2013.169","article-title":"Historical landmarks of autophagy research","volume":"24","author":"Ohsumi","year":"2014","journal-title":"Cell Res."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040803","article-title":"Helicobacter pylori avoids the critical activation of NLRP3 inflammasome-mediated production of oncogenic mature IL-1\u03b2 in human immune cells","volume":"12","author":"Pachathundikandi","year":"2020","journal-title":"Cancers"},{"key":"B75","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-3-319-41171-2_6","article-title":"Inflammasome activation by helicobacter pylori and its implications for persistence and immunity","volume":"397","author":"Pachathundikandi","year":"2016","journal-title":"Curr. Topics Microbiol. Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.bcp.2019.02.003","article-title":"Helicobacter pylori infection promotes autophagy through Nrf2-mediated heme oxygenase upregulation in human gastric cancer cells","volume":"162","author":"Paik","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010628","article-title":"Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis","volume":"18","author":"Palrasu","year":"2022","journal-title":"PloS Pathog."},{"key":"B78","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1093\/jnci\/89.12.863","article-title":"Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis","volume":"89","author":"Peek","year":"1997","journal-title":"J. Natl. Cancer Institute"},{"key":"B79","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3109\/00365529709000195","article-title":"Induction of acute gastritis and epithelial apoptosis by Helicobacter pylori lipopolysaccharide","volume":"32","author":"Piotrowski","year":"1997","journal-title":"Scandinavian J. Gastroenterol."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0323-9","article-title":"Helicobacter pylori-controlled c-Abl localization promotes cell migration and limits apoptosis","volume":"17","author":"Posselt","year":"2019","journal-title":"Cell communication signaling: CCS"},{"key":"B81","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/sj.cdd.4400998","article-title":"Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins","volume":"9","author":"Puthalakath","year":"2002","journal-title":"Cell Death Differentiation"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1053\/j.gastro.2012.01.043","article-title":"Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans","volume":"142","author":"Raju","year":"2012","journal-title":"Gastroenterology"},{"key":"B83","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4161\/auto.6.1.10222","article-title":"Methods to monitor autophagy in H. pylori vacuolating cytotoxin A (VacA)-treated cells","volume":"6","author":"Raju","year":"2010","journal-title":"Autophagy"},{"key":"B84","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ni.1864","article-title":"The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses","volume":"11","author":"Rathinam","year":"2010","journal-title":"Nat. Immunol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"630","DOI":"10.3748\/wjg.v20.i3.630","article-title":"Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role","volume":"20","author":"Ricci","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s12876-017-0640-7","article-title":"Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer","volume":"17","author":"Rosania","year":"2017","journal-title":"BMC Gastroenterol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s12876-023-02944-8","article-title":"A novel role for Helicobacter pylori cytotoxin-associated gene A in negative regulation of autophagy in human gastric cells","volume":"23","author":"Sakatani","year":"2023","journal-title":"BMC Gastroenterol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41419-019-1859-8","article-title":"SIRT1-targeted miR-543 autophagy inhibition and epithelial-mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer","volume":"10","author":"Shi","year":"2019","journal-title":"Cell Death Dis."},{"key":"B89","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B90","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1136\/gut.43.5.592","article-title":"Helicobacter pylori induced apoptosis","volume":"43","author":"Shirin","year":"1998","journal-title":"Gut"},{"key":"B91","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s00284-005-0103-1","article-title":"Helicobacter pylori induces apoptosis of T- and B-cell lines and translocates mitochondrial apoptosis-inducing factor to nucleus","volume":"52","author":"Singh","year":"2006","journal-title":"Curr. Microbiol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"27084","DOI":"10.1074\/jbc.273.42.27084","article-title":"Pro-caspase-3 is a major physiologic target of caspase-8","volume":"273","author":"Stennicke","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1158\/0008-5472.CAN-14-2291","article-title":"Modification of helicobacter pylori peptidoglycan enhances NOD1 activation and promotes cancer of the stomach","volume":"75","author":"Suarez","year":"2015","journal-title":"Cancer Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"B96","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1399-0039.2006.00701.x","article-title":"PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies","volume":"69","author":"Sun","year":"2007","journal-title":"Tissue Antigens"},{"key":"B97","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.4161\/auto.20159","article-title":"Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori","volume":"8","author":"Tang","year":"2012","journal-title":"Autophagy"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00058","article-title":"Helicobacter pylori Secreted Protein HP1286 Triggers Apoptosis in Macrophages via TNF-Independent and ERK MAPK-Dependent Pathways","volume":"7","author":"Tavares","year":"2017","journal-title":"Front. Cell. Infection Microbiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"370","DOI":"10.4161\/auto.5.3.7663","article-title":"Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells","volume":"5","author":"Terebiznik","year":"2009","journal-title":"Autophagy"},{"key":"B101","doi-asserted-by":"publisher","first-page":"8036","DOI":"10.1038\/s41598-017-08176-7","article-title":"Binding of the Helicobacter pylori OipA causes apoptosis of host cells via modulation of Bax\/Bcl-2 levels","volume":"7","author":"Teymournejad","year":"2017","journal-title":"Sci. Rep."},{"key":"B102","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jmii.2016.01.002","article-title":"Modulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by Helicobacter pylori in immune pathogenesis of gastric mucosal damage","volume":"50","author":"Tsai","year":"2017","journal-title":"J. Microbiology Immunology Infection = Wei Mian Yu Gan Ran Za Zhi"},{"key":"B103","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1080\/15548627.2018.1515530","article-title":"CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy","volume":"15","author":"Tsugawa","year":"2019","journal-title":"Autophagy"},{"key":"B104","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/imr.12541","article-title":"Caspase-8: regulating life and death","volume":"277","author":"Tummers","year":"2017","journal-title":"Immunol. Rev."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1128\/IAI.01443-13","article-title":"Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T cells","volume":"82","author":"Winter","year":"2014","journal-title":"Infection Immun."},{"key":"B106","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4103\/1319-3767.173756","article-title":"MicroRNA-155-enhanced autophagy in human gastric epithelial cell in response to Helicobacter pylori","volume":"22","author":"Wu","year":"2016","journal-title":"Saudi J. Gastroenterol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1572-0241.2001.03447.x","article-title":"Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis","volume":"96","author":"Xia","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40360-021-00509-7","article-title":"Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells","volume":"22","author":"Xie","year":"2021","journal-title":"BMC Pharmacol. Toxicol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1080\/19490976.2020.1774311","article-title":"Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection","volume":"11","author":"Xie","year":"2020","journal-title":"Gut Microbes"},{"key":"B110","doi-asserted-by":"publisher","first-page":"31104","DOI":"10.1074\/jbc.M112.387498","article-title":"Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA","volume":"287","author":"Yahiro","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110263","article-title":"A ferroptosis-related gene in Helicobacter pylori infection, SOCS1, serves as a potential prognostic biomarker and corresponds with tumor immune infiltration in stomach adenocarcinoma: In silico approach","volume":"119","author":"Yan","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/s41418-019-0480-9","article-title":"Autophagy and disease: unanswered questions","volume":"27","author":"Yang","year":"2020","journal-title":"Cell Death Differentiation"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.847716","article-title":"An overview of autophagy in helicobacter pylori infection and related gastric cancer","volume":"12","author":"Yang","year":"2022","journal-title":"Front. Cell. Infection Microbiol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B115","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.3892\/etm.2018.5701","article-title":"Eudesmin attenuates Helicobacter pylori-induced epithelial autophagy and apoptosis and leads to eradication of H. pylori infection","volume":"15","author":"Yang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B116","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s11033-020-06105-y","article-title":"FRA-1 suppresses apoptosis of Helicobacter pylori infected MGC-803 cells","volume":"48","author":"Yang","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"B117","doi-asserted-by":"publisher","first-page":"21770","DOI":"10.1002\/jcp.28925","article-title":"Epigenetic changes in gastric cancer induction by Helicobacter pylori","volume":"234","author":"Yousefi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105306","article-title":"Helicobacter pylori promotes epithelial-mesenchymal transition in gastric cancer by downregulating programmed cell death protein 4 (PDCD4)","volume":"9","author":"Yu","year":"2014","journal-title":"PloS One"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2022.105933","article-title":"IL-1\u03b2, an important cytokine affecting Helicobacter pylori-mediated gastric carcinogenesis","volume":"174","author":"Yuan","year":"2023","journal-title":"Microbial Pathogenesis."},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22050744","article-title":"Quercetin from Polygonum capitatum Protects against Gastric Inflammation and Apoptosis Associated with Helicobacter pylori Infection by Affecting the Levels of p38MAPK, BCL-2 and BAX","volume":"22","author":"Zhang","year":"2017","journal-title":"Molecules"},{"key":"B121","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00011-021-01522-6","article-title":"H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion","volume":"71","author":"Zhang","year":"2022","journal-title":"Inflammation Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.micpath.2017.06.012","article-title":"The leukocyte-associated immunoglobulin (Ig)-like receptor-1 modulating cell apoptosis and inflammatory cytokines secretion in THP-1 cells after Helicobacter pylori infection","volume":"109","author":"Zhang","year":"2017","journal-title":"Microbial Pathogenesis"},{"key":"B123","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.dci.2017.03.010","article-title":"Early apoptosis of monocytes induced by Helicobacter pylori infection through multiple pathways","volume":"73","author":"Zhang","year":"2017","journal-title":"Dev. Comp. Immunol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/path.4351","article-title":"Xenophagy in Helicobacter pylori- and Epstein-Barr virus-induced gastric cancer","volume":"233","author":"Zhang","year":"2014","journal-title":"J. Pathol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"942","DOI":"10.11817\/j.issn.1672-7347.2022.210779","article-title":"CagA and VacA inhibit gastric mucosal epithelial cell autophagy and promote the progression of gastric precancerous lesions","volume":"47","author":"Zhang","year":"2022","journal-title":"Zhong Nan Da Xue Xue Bao. Yi Xue Ban"},{"key":"B126","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00430-020-00688-w","article-title":"Outer inflammatory protein of Helicobacter pylori impacts IL-8 expression, adherence, cell apoptosis and cell cycle of gastric cells independent of its copy number","volume":"209","author":"Zhao","year":"2020","journal-title":"Med. Microbiol. Immunol."},{"key":"B127","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1007\/s00253-022-12011-z","article-title":"Helicobacter pylori promotes gastric cancer progression through the tumor microenvironment","volume":"106","author":"Zhu","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2023.109560","article-title":"PHKG2 regulates RSL3-induced ferroptosis in Helicobacter pylori related gastric cancer","volume":"740","author":"Zhu","year":"2023","journal-title":"Arch. Biochem. Biophysics"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1416819\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T05:19:43Z","timestamp":1722403183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1416819\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":128,"alternative-id":["10.3389\/fcimb.2024.1416819"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2024.1416819","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"article-number":"1416819"}}