{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:12:34Z","timestamp":1792393954059,"version":"4.4.0"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Parvimonas micra<\/jats:italic> (<jats:italic>P. micra<\/jats:italic>) has been identified as a pathogen capable of causing lung abscesses; however, its identification poses challenges due to the specialized culture conditions for anaerobic bacterial isolation. Only a few cases of lung abscesses caused by <jats:italic>P. micra<\/jats:italic> infection have been reported. Therefore, we describe the clinical characteristics of lung abscesses due to <jats:italic>P. micra<\/jats:italic> based on our case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on eight patients who were diagnosed with lung abscesses attributed to <jats:italic>P. micra<\/jats:italic>. Detection of <jats:italic>P. micra<\/jats:italic> was accomplished through target next-generation sequencing (tNGS). A systematic search of the PubMed database using keywords \u201clung abscess\u201d and \u201c<jats:italic>Parvimonas micra\/Peptostreptococcus micros<\/jats:italic>\u201d was performed to review published literature pertaining to similar cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the eight patients reviewed, all exhibited poor oral hygiene, with four presenting with comorbid diabetes. Chest computed tomography (CT) showed high-density mass shadows with necrosis and small cavities in the middle. Bronchoscopic examination revealed purulent sputum and bronchial mucosal inflammation. Thick secretions obstructed the airway, leading to the poor drainage of pus, and the formation of local abscesses leading to irresponsive to antibiotic therapy, which finally protracted recovery time. <jats:italic>P. micra<\/jats:italic> was successfully identified in bronchoalveolar lavage fluid (BALF) samples from all eight patients using tNGS; in contrast, sputum and BALF bacterial cultures yielded negative results, with <jats:italic>P. micra<\/jats:italic> cultured from only one empyema sample. Following appropriate antibiotic therapy, seven patients recovered. In previously documented cases, favorable outcomes were observed in 77.8% of individuals treated with antibiotics and 22.2% were cured after surgical interventions for <jats:italic>P. micra<\/jats:italic> lung abscesses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study enriches our understanding of the clinical characteristics associated with lung abscesses attributed to <jats:italic>P. micra<\/jats:italic>. Importantly, tNGS has emerged as a rapid and effective diagnostic test in scenarios where traditional sputum cultures are negative. Encouragingly, patients with lung abscesses caused by <jats:italic>P<\/jats:italic>. <jats:italic>micra<\/jats:italic> infection exhibit a favorable prognosis with effective airway clearance and judicious anti-infective management.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcimb.2024.1416884","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:10:18Z","timestamp":1720674618000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Target next-generation sequencing for the accurate diagnosis of Parvimonas micra lung abscess: a case series and literature review"],"prefix":"10.3389","volume":"14","author":[{"given":"Dongmei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"760.e1","DOI":"10.1016\/j.cmi.2018.09.001","article-title":"Clinical and microbiological features of bacteraemia with Gram-positive anaerobic cocci: a population-based retrospective study","volume":"25","author":"Badri","year":"2019","journal-title":"Clin.Microbiol. Infect."},{"key":"B2","first-page":"244","article-title":"Potential role of periodontal infection in respiratory diseases - a review","volume":"6","author":"Bansal","year":"2013","journal-title":"J. Med. Life"},{"key":"B3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.anaerobe.2018.09.003","article-title":"Parvimonasmicra bacteremia following endoscopic retrograde cholangiopancreatography: A new route of infection","volume":"54","author":"Boattini","year":"2018","journal-title":"Anaerobe"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e01161","DOI":"10.1002\/rcr2.1161","article-title":"Furious lung abscess due to Parvimonasmicra","volume":"11","author":"Fukushima","year":"2023","journal-title":"Respirol Case Rep."},{"key":"B5","doi-asserted-by":"publisher","first-page":"834","DOI":"10.3904\/kjim.2014.29.6.834","article-title":"Parvimonasmicra chest wall abscess following transthoracic lung needle biopsy","volume":"29","author":"Gorospe","year":"2014","journal-title":"Korean J. Intern. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/JPER.19-0043","article-title":"Poor oral hygiene is associated with the detection of obligate anaerobes in pneumonia","volume":"91","author":"Hata","year":"2020","journal-title":"J. Periodontol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1378\/chest.127.4.1378","article-title":"Endoscopic drainage of lung abscesses: technique and outcome","volume":"127","author":"Herth","year":"2005","journal-title":"Chest"},{"key":"B8","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3978\/j.issn.2305-5839.2015.07.08","article-title":"Lung abscess-etiology, diagnostic and treatment options","volume":"3","author":"Kuhajda","year":"2015","journal-title":"Ann. Transl. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1007\/s00330-021-08149-5","article-title":"Percutaneous transthoracic catheter drainage for lung abscess: a systematic review and meta-analysis","volume":"32","author":"Lee","year":"2022","journal-title":"EurRadiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e127","DOI":"10.1016\/j.jinf.2022.08.022","article-title":"Targeted next generation sequencing is comparable with metagenomic next generation sequencing in adults with pneumonia for pathogenic microorganism detection","volume":"85","author":"Li","year":"2022","journal-title":"J. Infect."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1700629","DOI":"10.1183\/13993003.00629-2017","article-title":"European Respiratory Society guidelines for the management of adult bronchiectasis","volume":"50","author":"Polverino","year":"2017","journal-title":"Eur. Respir. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1159\/000453003","article-title":"Bronchoscopic drainage of lung abscesses using a pigtail catheter","volume":"93","author":"Unterman","year":"2017","journal-title":"Respiration"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.17843\/rpmesp.2023.401.11956","article-title":"Pleural empyema by Parvimonasmicra in an immunocompetent patient: a case report","volume":"40","author":"Vilcarromero","year":"2023","journal-title":"Rev. Peruana medicina Exp. y saludpublica"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.amjmed.2021.02.017","article-title":"Cavitary lung mass presenting in an outpatient","volume":"134","author":"Yang","year":"2021","journal-title":"Am. J. Med."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3182383c9b","article-title":"Lung abscess: update on microbiology and management","volume":"21","author":"Yazbeck","year":"2014","journal-title":"Am. J. Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s12879-021-06058-y","article-title":"Severe pneumonia caused by Parvimonasmicra: a case report","volume":"21","author":"Yu","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016911","article-title":"Lung abscess by Actinomycesodontolyticus and Parvimonasmicra co-infection presenting as acute respiratory failure: A case report","volume":"98","author":"Yun","year":"2019","journal-title":"Med. (Abingdon)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.2147\/IDR.S304569","article-title":"Clinical characteristics of chronic lung abscess associated with parvimonasmicra diagnosed using metagenomic next-generation sequencing","volume":"14","author":"Zhang","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1226706","article-title":"Pediatric pulmonary infection caused by oral obligate anaerobes: Case Series","volume":"11","author":"Zhijun","year":"2023","journal-title":"Front. Pediatr."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1416884\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:10:21Z","timestamp":1720674621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1416884\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,11]]},"references-count":19,"alternative-id":["10.3389\/fcimb.2024.1416884"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2024.1416884","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,11]]},"article-number":"1416884"}}