{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:05:18Z","timestamp":1781265918656,"version":"3.54.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infection is the primary risk factor for the progress of gastric diseases. The persistent stomach colonization of <jats:italic>H. pylori<\/jats:italic> is closely associated with the development of gastritis and malignancies. Although the involvement of progranulin (PGRN) in various cancer types has been well-documented, its functional role and underlying mechanisms in gastric cancer (GC) associated with <jats:italic>H. pylori<\/jats:italic> infection remain largely unknown. This report demonstrated that PGRN was up-regulated in GC and associated with poor prognosis, as determined through local and public database analysis. Additionally, <jats:italic>H. pylori<\/jats:italic> induced the up-regulation of PGRN in gastric epithelial cells both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Functional studies have shown that PGRN promoted the intracellular colonization of <jats:italic>H. pylori<\/jats:italic>. Mechanistically, <jats:italic>H. pylori<\/jats:italic> infection induced autophagy, while PGRN inhibited autophagy to promote the intracellular colonization of <jats:italic>H. pylori<\/jats:italic>. Furthermore, PGRN suppressed <jats:italic>H. pylori<\/jats:italic>-induced autophagy by down-regulating decorin (DCN) through the mTOR pathway. In general, PGRN inhibited autophagy to facilitate intracellular colonization of <jats:italic>H. pylori<\/jats:italic> via the PGRN\/mTOR\/DCN axis. This study provides new insights into the molecular mechanisms underlying the progression of gastric diseases, suggesting PGRN as a potential therapeutic target and prognostic predictor for these disorders.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1425367","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T10:50:25Z","timestamp":1722423025000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN\/mTOR\/DCN axis in gastric epithelial cells"],"prefix":"10.3389","volume":"14","author":[{"given":"Linlin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongjiao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1046\/j.1462-5822.2002.00222.x","article-title":"Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells","volume":"4","author":"Amieva","year":"2002","journal-title":"Cell Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1095\/biolreprod42.2.317","article-title":"Acrosome biogenesis begins during meiosis: evidence from the synthesis and distribution of an acrosomal glycoprotein, acrogranin, during Guinea pig spermatogenesis","volume":"42","author":"Anakwe","year":"1990","journal-title":"Biol. 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