{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:43:34Z","timestamp":1782989014689,"version":"3.54.5"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Salmonella enterica<\/jats:italic> ser. Typhimurium is a common pathogen that poses a considerable public health threat, contributing to severe gastrointestinal diseases and widespread foodborne illnesses. The virulence of <jats:italic>S.<\/jats:italic> Typhimurium is regulated by quorum sensing (QS) and the type III secretion system (T3SS). This study investigated the inhibitory effects and anti-QS activity of epigallocatechin gallate (EGCG), which is a bioactive ingredient found in green tea, on the virulence of <jats:italic>S.<\/jats:italic> Typhimurium. <jats:italic>In vitro<\/jats:italic> bacterial experiments demonstrated that EGCG inhibited the production of autoinducers, biofilm formation, and flagellar activity by downregulating the expression of AI-1, AI-2, <jats:italic>Salmonella<\/jats:italic> pathogenicity islands (SPI)-1, SPI-2, and genes related to flagella, fimbriae, and curli fibers. In a mouse model of <jats:italic>S.<\/jats:italic> Typhimurium-induced enteritis, EGCG considerably reduced intestinal colonization by <jats:italic>S<\/jats:italic>. Typhimurium and alleviated intestinal damage. In conclusion, EGCG protects the intestines of mice infected with <jats:italic>S.<\/jats:italic> Typhimurium by inhibiting QS-induced virulence gene expression, demonstrating its potential as a therapeutic agent for controlling <jats:italic>S.<\/jats:italic> Typhimurium infections.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1432111","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T05:12:24Z","timestamp":1729055544000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Epigallocatechin gallate protects mice from Salmonella enterica ser. 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