{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:45:32Z","timestamp":1779885932042,"version":"3.53.1"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Chlamydia<\/jats:italic> are Gram-negative, obligate intracellular bacterial pathogens that infect eukaryotic cells and reside within a host-derived vacuole known as the inclusion. To facilitate intracellular replication, these bacteria must engage in host-pathogen interactions to obtain nutrients and membranes required for the growth of the inclusion, thereby sustaining prolonged bacterial colonization. Autophagy is a highly conserved process that delivers cytoplasmic substrates to the lysosome for degradation. Pathogens have developed strategies to manipulate and\/or exploit autophagy to promote their replication and persistence. This review delineates recent advances in elucidating the interplay between <jats:italic>Chlamydia trachomatis<\/jats:italic> infection and autophagy in recent years, emphasizing the intricate strategies employed by both the <jats:italic>Chlamydia<\/jats:italic> pathogens and host cells. Gaining a deeper understanding of these interactions could unveil novel strategies for the prevention and treatment of <jats:italic>Chlamydia<\/jats:italic> infection.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1442995","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T05:10:19Z","timestamp":1725599419000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Autophagy: the misty lands of Chlamydia trachomatis infection"],"prefix":"10.3389","volume":"14","author":[{"given":"Shan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.2217\/fmb.13.80","article-title":"Genetic variation in Chlamydia trachomatis and their hosts: impact on disease severity and tissue tropism","volume":"8","author":"Abdelsamed","year":"2013","journal-title":"Future Microbiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4751","DOI":"10.1128\/IAI.72.8.4751-4762.2004","article-title":"Interaction of Chlamydia trachomatis serovar L2 with the host autophagic pathway","volume":"72","author":"Al-Younes","year":"2004","journal-title":"Infect. 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