{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:12:15Z","timestamp":1793293935817,"version":"4.5.0"},"reference-count":289,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["B2022262, A2022522, A2023450"],"award-info":[{"award-number":["B2022262, A2022522, A2023450"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012829","name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["20222144"],"award-info":[{"award-number":["20222144"]}],"id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["202106241649075233"],"award-info":[{"award-number":["202106241649075233"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["PY2021023, PY2021024, PY2021027, PY2021015"],"award-info":[{"award-number":["PY2021023, PY2021024, PY2021027, PY2021015"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut. This paper provides evidence for the role of periodontal bacteria in systemic diseases via the oral-gut axis and the far-reaching implications of maintaining periodontal health in reducing the risk of many intestinal and parenteral diseases. This may provide insight into the underlying pathogenesis of many systemic diseases and the search for new preventive and therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1478362","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T01:13:32Z","timestamp":1731633212000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["Periodontal bacteria influence systemic diseases through the gut microbiota"],"prefix":"10.3389","volume":"14","author":[{"given":"Mengying","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijun","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijuan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congman","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuerbiya","family":"Abuduxiku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.chom.2016.07.006","article-title":"Fap2 mediates Fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed Gal-GalNAc","volume":"20","author":"Abed","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/dj10020016","article-title":"Oral health and liver disease: bidirectional associations\u2014a narrative review","volume":"10","author":"\u00c5berg","year":"2022","journal-title":"Dentistry J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/prd.12362","article-title":"Microbial signatures of health, gingivitis, and periodontitis","volume":"86","author":"Abusleme","year":"2021","journal-title":"Periodontol. 2000"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/jcpe.2017.44.issue-11","article-title":"Periodontitis and Non-alcoholic Fatty Liver Disease, a population-based cohort investigation in the Study of Health in Pomerania","volume":"44","author":"Akinkugbe","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2334\/josnusd.16-0127","article-title":"Effect of nonsurgical periodontal treatment on clinical periodontal variables and salivary resistin levels in obese Asians","volume":"59","author":"Akram","year":"2017","journal-title":"J. Oral. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","article-title":"The gut-liver axis in liver disease: Pathophysiological basis for therapy","volume":"72","author":"Albillos","year":"2020","journal-title":"J. Hepatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e01421","DOI":"10.1128\/AEM.01421-20","article-title":"Long-term fluctuation of oral biofilm microbiota following different dietary phases","volume":"86","author":"Anderson","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/jcm10020208","article-title":"Association of periodontal status, number of teeth, and obesity: A cross-sectional study in Japan","volume":"10","author":"Aoyama","year":"2021","journal-title":"J. Clin. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1038\/srep04828","article-title":"Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota","volume":"4","author":"Arimatsu","year":"2014","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/alz.12192","article-title":"Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer\u2019s disease","volume":"17","author":"Arnsten","year":"2021","journal-title":"Alzheimer\u2019s Dementia."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11892-019-1180-z","article-title":"Fecal microbiota transplantation: a future therapeutic option for obesity\/diabetes","volume":"19","author":"Aron-Wisnewsky","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1136\/annrheumdis-2018-214856","article-title":"Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal","volume":"78","author":"Azzouz","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1177\/00220345231222800","article-title":"Effect of periodontitis and periodontal therapy on Oral and gut microbiota","volume":"103","author":"Baima","year":"2024","journal-title":"J. Dent. Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1002\/hep.27819","article-title":"Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy","volume":"62","author":"Bajaj","year":"2015","journal-title":"Hepatology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1152\/ajpgi.00230.2018","article-title":"Periodontal therapy favorably modulates the oral-gut-hepatic axis in cirrhosis","volume":"315","author":"Bajaj","year":"2018","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41368-022-00183-3","article-title":"Periodontitis may induce gut microbiota dysbiosis via salivary microbiota","volume":"14","author":"Bao","year":"2022","journal-title":"Int. J. Oral. sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3390\/biomedicines10010178","article-title":"Novel insight into the mechanisms of the bidirectional relationship between diabetes and periodontitis","volume":"10","author":"Barutta","year":"2022","journal-title":"Biomedicines"},{"key":"B18","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1177\/0022034521995423","article-title":"Oral microbiota transplant in dogs with naturally occurring periodontitis","volume":"100","author":"Beikler","year":"2021","journal-title":"J. Dent. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3390\/jpm11070625","article-title":"Exploring the oral microbiome in rheumatic diseases, state of art and future prospective in personalized medicine with an AI approach","volume":"11","author":"Bellando-Randone","year":"2021","journal-title":"J. Personalized Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"102248","DOI":"10.1016\/j.anaerobe.2020.102248","article-title":"Association between the gut and oral microbiome with obesity","volume":"70","author":"Benahmed","year":"2021","journal-title":"Anaerobe"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e129","DOI":"10.1016\/j.orcp.2011.11.005","article-title":"Periodontal treatment with topical antibiotics improves glycemic control in association with elevated serum adiponectin in patients with type 2 diabetes mellitus","volume":"7","author":"Bharti","year":"2013","journal-title":"Obes. Res. Clin. Pract."},{"key":"B22","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/mi.2015.32","article-title":"New developments in goblet cell mucus secretion and function","volume":"8","author":"Birchenough","year":"2015","journal-title":"Mucosal Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1136\/gutjnl-2015-309897","article-title":"Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response","volume":"66","author":"Blasco-Baque","year":"2017","journal-title":"Gut"},{"key":"B24","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s12016-018-8702-3","article-title":"The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis","volume":"55","author":"Blauvelt","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"B26","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41579-018-0129-6","article-title":"Fusobacterium nucleatum\u2014symbiont, opportunist and oncobacterium","volume":"17","author":"Brennan","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq8476","article-title":"Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis","volume":"15","author":"Brewer","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1161\/01.ATV.0000167525.69400.9c","article-title":"Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in normocholesterolemic and hypercholesterolemic pigs","volume":"25","author":"Brodala","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1177\/1352458520928301","article-title":"Gut commensals, dysbiosis, and immune response imbalance in the pathogenesis of multiple sclerosis","volume":"27","author":"Brown","year":"2021","journal-title":"Multiple Sclerosis J."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102563","article-title":"Safety and efficacy of faecal microbiota transplantation in patients with mild to moderate Parkinson\u2019s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial","volume":"71","author":"Bruggeman","year":"2024","journal-title":"EClinicalMedicine"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1126\/science.aal5240","article-title":"Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer","volume":"358","author":"Bullman","year":"2017","journal-title":"Science"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.3390\/ijms20143394","article-title":"Th17 cells and the IL-23\/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases","volume":"20","author":"Bunte","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e128","DOI":"10.1111\/odi.12205","article-title":"Microbial composition of atherosclerotic plaques","volume":"20","author":"Calandrini","year":"2014","journal-title":"Oral. Dis."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00106","article-title":"Fusobacterium nucleatum activates endoplasmic reticulum stress to promote Crohn\u2019s disease development via the upregulation of CARD3 expression","volume":"11","author":"Cao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.4049\/jimmunol.1201053","article-title":"Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential","volume":"189","author":"Carrion","year":"2012","journal-title":"J. Immunol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00840","article-title":"Quantitative molecular detection of 19 major pathogens in the interdental biofilm of periodontally healthy young adults","volume":"7","author":"Carrouel","year":"2016","journal-title":"Front. Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1902\/jop.2010.100321","article-title":"Association between chronic periodontal disease and obesity: a systematic review and meta-analysis","volume":"81","author":"Chaffee","year":"2010","journal-title":"J. Periodontol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1007\/s00125-020-05112-9","article-title":"Improved oral hygiene is associated with decreased risk of new-onset diabetes: a nationwide population-based cohort study","volume":"63","author":"Chang","year":"2020","journal-title":"Diabetologia"},{"key":"B39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/path.v250.2","article-title":"Fusobacterium nucleatum facilitates ulcerative colitis through activating IL-17F signaling to NF-\u03baB via the upregulation of CARD3 expression","volume":"250","author":"Chen","year":"2020","journal-title":"J. pathol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"323","DOI":"10.7150\/thno.38870","article-title":"Fusobacterium nucleatum promotes metastasis in colorectal cancer by activating autophagy signaling via the upregulation of CARD3 expression","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165601","article-title":"Risk of atrial fibrillation or flutter associated with periodontitis: a nationwide, population-based, cohort study","volume":"11","author":"Chen","year":"2016","journal-title":"PloS One"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039743","article-title":"Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer","volume":"7","author":"Chen","year":"2012","journal-title":"PloS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.smim.2017.09.006","article-title":"Microbiome, inflammation and colorectal cancer","volume":"32","author":"Chen","year":"2017","journal-title":"Semin. Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1080\/19490976.2019.1695494","article-title":"Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS\/KRT7","volume":"11","author":"Chen","year":"2020","journal-title":"Gut Microbes"},{"key":"B45","doi-asserted-by":"crossref","first-page":"112152","DOI":"10.1016\/j.jphotobiol.2021.112152","article-title":"Gut flora-targeted photobiomodulation therapy improves senile dementia in an A\u00df-induced Alzheimer\u2019s disease animal model","volume":"216","author":"Chen","year":"2021","journal-title":"J. Photochem. Photobiol. B: Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.3390\/cells11071239","article-title":"The influence of gut dysbiosis in the pathogenesis and management of ischemic stroke","volume":"11","author":"Chidambaram","year":"2022","journal-title":"Cells"},{"key":"B47","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.clim.2016.06.002","article-title":"Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet\u2019s disease","volume":"169","author":"Coit","year":"2016","journal-title":"Clin. Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.autrev.2014.11.009","article-title":"Beh\u00e7et\u2019s syndrome patients exhibit specific microbiome signature","volume":"14","author":"Consolandi","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"7247","DOI":"10.3748\/wjg.v27.i42.7247","article-title":"Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions","volume":"27","author":"Coquant","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature12480","article-title":"Dietary intervention impact on gut microbial gene richness","volume":"500","author":"Cotillard","year":"2013","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"14578","DOI":"10.1038\/s41598-022-18771-y","article-title":"Inflammatory cytokines directly disrupt the bovine intestinal epithelial barrier","volume":"12","author":"Crawford","year":"2022","journal-title":"Sci. Rep."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev"},{"key":"B55","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/jre.2019.54.issue-1","article-title":"Periodontal condition and levels of bacteria associated with periodontitis in individuals with bipolar affective disorders: A case-control study","volume":"54","author":"Cunha","year":"2019","journal-title":"J. Periodontal Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/S2213-8587(18)30038-X","article-title":"Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial","volume":"6","author":"D\u2019Aiuto","year":"2018","journal-title":"Lancet Diabetes endocrinol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/1744666X.2019.1700113","article-title":"Periodontitis: a newly identified comorbidity in psoriasis and psoriatic arthritis","volume":"16","author":"Dalm\u00e1dy","year":"2020","journal-title":"Expert Rev. Clin. Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.immuni.2009.09.012","article-title":"The gut immune barrier and the blood-brain barrier: are they so different","volume":"31","author":"Daneman","year":"2009","journal-title":"Immunity"},{"key":"B59","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/s41385-019-0160-6","article-title":"Microbes, metabolites, and the gut\u2013lung axis","volume":"12","author":"Dang","year":"2019","journal-title":"Mucosal Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1177\/0022034512453589","article-title":"Porphyromonas gingivalis as a potential community activist for disease","volume":"91","author":"Darveau","year":"2012","journal-title":"J. Dent. Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.4049\/jimmunol.1301970","article-title":"Periodontal pathogens directly promote autoimmune experimental arthritis by inducing a TLR2-and IL-1\u2013driven Th17 response","volume":"192","author":"de Aquino","year":"2014","journal-title":"J. Immunol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02598","article-title":"The E-cadherin cleavage associated to pathogenic bacteria infections can favor bacterial invasion and transmigration, dysregulation of the immune response and cancer induction in humans","volume":"10","author":"Devaux","year":"2019","journal-title":"Front. Microbiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1161\/hc3401.093153","article-title":"Immunopathogenesis of atherosclerosis","volume":"1524","author":"Diet","year":"2001","journal-title":"Circulation"},{"key":"B64","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.1902\/jop.2013.134008","article-title":"The epidemiological evidence behind the association between periodontitis and incident atherosclerotic cardiovascular disease","volume":"84","author":"Dietrich","year":"2013","journal-title":"J. Periodontol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3390\/ijms24021084","article-title":"A reciprocal link between oral, gut microbiota during periodontitis: the potential role of probiotics in reducing dysbiosis-induced inflammation","volume":"24","author":"Di Stefano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer\u2019s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.3390\/jcm8101753","article-title":"Oral\u2013gut microbiota and arthritis: is there an evidence-based axis","volume":"8","author":"Drago","year":"2019","journal-title":"J. Clin. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/femsre\/fuy035","article-title":"Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis","volume":"43","author":"du Teil Espina","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00380-016-0841-y","article-title":"Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease","volume":"32","author":"Emoto","year":"2017","journal-title":"Heart Vessels"},{"key":"B70","doi-asserted-by":"publisher","first-page":"908","DOI":"10.5551\/jat.32672","article-title":"Analysis of gut microbiota in coronary artery disease patients: a possible link between gut microbiota and coronary artery disease","volume":"23","author":"Emoto","year":"2016","journal-title":"J. Atheroscl. thrombosis"},{"key":"B71","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1136\/gutjnl-2016-312580","article-title":"Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study","volume":"67","author":"Fan","year":"2018","journal-title":"Gut"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-02027-5","article-title":"Oral P. gingivalis impairs gut permeability and mediates immune responses associated with neurodegeneration in LRRK2 R1441G mice","volume":"17","author":"Feng","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"B73","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.jhep.2016.11.008","article-title":"Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice","volume":"66","author":"Ferrere","year":"2017","journal-title":"J. Hepatol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13229-016-0110-z","article-title":"Blood\u2013brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders","volume":"7","author":"Fiorentino","year":"2016","journal-title":"Mol. autism"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1007\/s10096-014-2081-3","article-title":"Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome","volume":"33","author":"Flanagan","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00351","article-title":"Metabolic remodeling, inflammasome activation, and pyroptosis in macrophages stimulated by Porphyromonas gingivalis and its outer membrane vesicles","volume":"7","author":"Fleetwood","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1399-302X.2006.00276.x","article-title":"Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study","volume":"21","author":"Ford","year":"2006","journal-title":"Oral. Microbiol. Immunol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.tim.2020.11.004","article-title":"The oral host\u2013microbial interactome: an ecological chronometer of health","volume":"29","author":"Freire","year":"2021","journal-title":"Trends Microbiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"7297","DOI":"10.1007\/s12035-018-0937-8","article-title":"Bidirectional neural interaction between central dopaminergic and gut lesions in Parkinson\u2019s disease models","volume":"55","author":"Garrido-Gil","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/prd.12271","article-title":"Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol. 2000"},{"key":"B81","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/0022034518805739","article-title":"The oral microbiota is modified by systemic diseases","volume":"98","author":"Graves","year":"2019","journal-title":"J. Dent. Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/jcpe.2018.45.issue-2","article-title":"A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes An update of the EFP-AAP review","volume":"45","author":"Graziani","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1074\/jbc.M114.618249","article-title":"Transmission of atherosclerosis susceptibility with gut microbial transplantation","volume":"290","author":"Gregory","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cytogfr.2014.10.009","article-title":"An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17","volume":"26","author":"Grine","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"B85","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/(ISSN)1527-6473","article-title":"Dental health status of liver transplant candidates","volume":"13","author":"Guggenheimer","year":"2007","journal-title":"Liver Transpl."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1136\/gutjnl-2020-321187","article-title":"Exosomes derived from Fusobacterium nucleatum-infected colorectal cancer cells facilitate tumour metastasis by selectively carrying miR-1246\/92b-3p\/27a-3p and CXCL16","volume":"70","author":"Guo","year":"2021","journal-title":"Gut"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-020-01677-w","article-title":"FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2","volume":"39","author":"Guo","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"key":"B89","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1600-0625.2011.01412.x","article-title":"IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion","volume":"21","author":"Gutowska-Owsiak","year":"2012","journal-title":"Exp. Dermatol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/prd.12421","article-title":"Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities","volume":"89","author":"Hajishengallis","year":"2022","journal-title":"Periodontol. 2000"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-020-02348-z","article-title":"Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model","volume":"22","author":"Hamamoto","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.580577","article-title":"Endotoxemia by Porphyromonas gingivalis alters endocrine functions in brown adipose tissue","volume":"10","author":"Hatasa","year":"2021","journal-title":"Front. Cell. Infection Microbiol."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2024.1413842","article-title":"An inflammatory paradox: strategies inflammophilic oral pathobionts employ to exploit innate immunity via neutrophil manipulation","volume":"5","author":"Higashi","year":"2024","journal-title":"Front. Oral. Health"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s10620-019-05777-2","article-title":"The \u201cleaky gut\u201d: tight junctions but loose associations","volume":"65","author":"Hollander","year":"2020","journal-title":"Dig Dis. Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00401-014-1343-6","article-title":"Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats","volume":"128","author":"Holmqvist","year":"2014","journal-title":"Acta Neuropathol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.chom.2023.03.018","article-title":"Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles","volume":"31","author":"Hong","year":"2023","journal-title":"Cell Host Microbe"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in health and diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"B100","doi-asserted-by":"publisher","first-page":"567","DOI":"10.13459\/j.cnki.cjap.2014.06.013","article-title":"A dysfunction of CD4+ T lymphocytes in peripheral immune system of Parkinson\u2019s disease model mice","volume":"30","author":"Huang","year":"2014","journal-title":"Zhongguo ying yong sheng li xue za zhi= Zhongguo yingyong shenglixue zazhi= Chin. J. Appl. Physiol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jre.12936","article-title":"Periodontitis and Systemic Lupus Erythematosus: A systematic review and meta-analysis","volume":"57","author":"Hussain","year":"2022","journal-title":"J. Periodontal Res."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00045","article-title":"gingivalis in periodontal disease and atherosclerosis\u2013scenes of action for antimicrobial peptides and complement","volume":"6","author":"Hussain","year":"2015","journal-title":"Front. Immunol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41569-020-0367-y","article-title":"Novel gut microbiota-derived metabolite promotes platelet thrombosis via adrenergic receptor signalling","volume":"17","author":"Huynh","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/j.1600-0765.2006.00962.x","article-title":"Susceptibility of various oral bacteria to antimicrobial peptides and to phagocytosis by neutrophils","volume":"42","author":"Ji","year":"2007","journal-title":"J. Periodontal Res."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/s41467-024-45473-y","article-title":"Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17\/Treg cell balance axis","volume":"15","author":"Jia","year":"2024","journal-title":"Nat. Commun."},{"key":"B106","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/s41467-017-00900-1","article-title":"The gut microbiome in atherosclerotic cardiovascular disease","volume":"8","author":"Jie","year":"2017","journal-title":"Nat. Commun."},{"key":"B107","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1124\/mol.113.091165","article-title":"Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities","volume":"85","author":"Jin","year":"2014","journal-title":"Mol. Pharmacol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1111\/jcmm.2019.23.issue-4","article-title":"The role of intestinal microbiota in cardiovascular disease","volume":"23","author":"Jin","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.3390\/nu12071983","article-title":"A revolutionizing approach to autism spectrum disorder using the microbiome","volume":"12","author":"Johnson","year":"2020","journal-title":"Nutrients"},{"key":"B110","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1177\/00220345231160747","article-title":"High-resolution detection of translocation of oral bacteria to the gut","volume":"102","author":"Kageyama","year":"2023","journal-title":"J. Dent. Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"G929","DOI":"10.1152\/ajpgi.00315.2013","article-title":"Colonic inflammation and secondary bile acids in alcoholic cirrhosis","volume":"306","author":"Kakiyama","year":"2014","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"18398","DOI":"10.1038\/s41598-021-97868-2","article-title":"Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model","volume":"11","author":"Kashiwagi","year":"2021","journal-title":"Sci. Rep."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00460-18","article-title":"Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome","volume":"3","author":"Kato","year":"2018","journal-title":"Msphere"},{"key":"B114","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/microorganisms9030496","article-title":"Interconnections between the oral and gut microbiomes: reversal of microbial dysbiosis and the balance between systemic health and disease","volume":"9","author":"Khor","year":"2021","journal-title":"Microorganisms"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.673708","article-title":"Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity","volume":"12","author":"Kinashi","year":"2021","journal-title":"Front. Immunol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/prd.12424","article-title":"Periodontal connection with intestinal inflammation: Microbiological and immunological mechanisms","volume":"89","author":"Kitamoto","year":"2022","journal-title":"Periodontol. 2000"},{"key":"B117","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/intimm\/dxac027","article-title":"Untangling the oral\u2013gut axis in the pathogenesis of intestinal inflammation","volume":"34","author":"Kitamoto","year":"2022","journal-title":"Int. Immunol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2020.05.048","article-title":"The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis","volume":"182","author":"Kitamoto","year":"2020","journal-title":"Cell"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-14260-9","article-title":"Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism","volume":"7","author":"Komazaki","year":"2017","journal-title":"Sci. Rep."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.3390\/nu11092128","article-title":"New and preliminary evidence on altered oral and gut microbiota in individuals with autism spectrum disorder (ASD): implications for ASD diagnosis and subtyping based on microbial biomarkers","volume":"11","author":"Kong","year":"2019","journal-title":"Nutrients"},{"key":"B121","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.1158\/0008-5472.CAN-21-0453","article-title":"Fusobacterium nucleatum promotes the development of colorectal cancer by activating a cytochrome P450\/epoxyoctadecenoic acid axis via TLR4\/Keap1\/NRF2 signaling","volume":"81","author":"Kong","year":"2021","journal-title":"Cancer Res."},{"key":"B122","doi-asserted-by":"publisher","first-page":"369ra176","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans\u2013induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"Konig","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B123","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.cmet.2017.09.008","article-title":"Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition","volume":"26","author":"Kootte","year":"2017","journal-title":"Cell Metab."},{"key":"B124","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1073\/pnas.1011383107","article-title":"Human oral, gut, and plaque microbiota in patients with atherosclerosis","volume":"108","author":"Koren","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.chom.2013.07.007","article-title":"Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment","volume":"14","author":"Kostic","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1093\/brain\/awy077","article-title":"Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo","volume":"141","author":"Kozina","year":"2018","journal-title":"Brain"},{"key":"B127","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.anaerobe.2017.04.011","article-title":"Distinct roles for dietary lipids and Porphyromonas gingivalis infection on atherosclerosis progression and the gut microbiota","volume":"45","author":"Kramer","year":"2017","journal-title":"Anaerobe"},{"key":"B128","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3748\/wjg.v29.i6.967","article-title":"Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis","volume":"29","author":"Kuraji","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1177\/00220345221125402","article-title":"Host genotype links to salivary and gut microbiota by periodontal status","volume":"102","author":"Kurushima","year":"2023","journal-title":"J. Dent. Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/2050640617715846","article-title":"Severe periodontitis and higher cirrhosis mortality","volume":"6","author":"Ladegaard Gr\u00f8nkj\u00e6r","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"B131","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1111\/jcpe.2013.40.issue-10","article-title":"Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti-citrullinated peptide antibody titres","volume":"40","author":"Lappin","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009085","article-title":"Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults","volume":"5","author":"Larsen","year":"2010","journal-title":"PloS One"},{"key":"B133","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature"},{"key":"B134","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/pathogens11010084","article-title":"The periodontopathic pathogen, porphyromonas gingivalis, involves a gut inflammatory response and exacerbates inflammatory bowel disease","volume":"11","author":"Lee","year":"2022","journal-title":"Pathogens"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1177\/00220345211009449","article-title":"Gut microbiota may mediate the influence of periodontitis on prediabetes","volume":"100","author":"Li","year":"2021","journal-title":"J. Dent. Res."},{"key":"B136","doi-asserted-by":"publisher","first-page":"25956","DOI":"10.18632\/aging.202174","article-title":"Periodontitis in elderly patients with type 2 diabetes mellitus: impact on gut microbiota and systemic inflammation","volume":"12","author":"Li","year":"2020","journal-title":"Aging (Albany NY)."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2180-8-26","article-title":"Intracellular survival and vascular cell-to-cell transmission of Porphyromonas gingivalis","volume":"8","author":"Li","year":"2008","journal-title":"BMC Microbiol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/jcpe.2017.44.issue-8","article-title":"Lipopolysaccharide, a possible molecular mediator between periodontitis and coronary artery disease","volume":"44","author":"Liljestrand","year":"2017","journal-title":"J. Clin. Periodontol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"364391","DOI":"10.1155\/2015\/364391","article-title":"Effects of intravenous injection of Porphyromonas gingivalis on rabbit inflammatory immune response and atherosclerosis","volume":"2015","author":"Lin","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B140","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.3390\/ijerph15112602","article-title":"Increased risk of ulcerative colitis in patients with periodontal disease: a nationwide population-based cohort study","volume":"15","author":"Lin","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/s41385-021-00413-7","article-title":"Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis","volume":"14","author":"Lin","year":"2021","journal-title":"Mucosal Immunol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1111\/j.1600-051X.2012.01923.x","article-title":"All-cause mortality and periodontitis in 60\u201370-year-old men: a prospective cohort study","volume":"39","author":"Linden","year":"2012","journal-title":"J. Clin. Periodontol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1038\/s41598-021-81263-y","article-title":"Fecal transplantation alleviates acute liver injury in mice through regulating Treg\/Th17 cytokines balance","volume":"11","author":"Liu","year":"2021","journal-title":"Sci. Rep."},{"key":"B144","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1080\/10641963.2018.1481420","article-title":"Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats","volume":"41","author":"Liu","year":"2019","journal-title":"Clin. Exp. Hypertens."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.693479","article-title":"Multifaceted impacts of periodontal pathogens in disorders of the intestinal barrier","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.bbi.2019.07.026","article-title":"IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson\u2019s disease","volume":"81","author":"Liu","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"B147","doi-asserted-by":"publisher","first-page":"30594","DOI":"10.1038\/srep30594","article-title":"Role of the gut microbiome in modulating arthritis progression in mice","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"B148","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/apm.2017.125.issue-1","article-title":"The human gastrointestinal tract and oral microbiota in inflammatory bowel disease: a state of the science review","volume":"125","author":"Lucas L\u00f3pez","year":"2017","journal-title":"APMIS"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00216","article-title":"Identification of salivary microbiota and its association with host inflammatory mediators in periodontitis","volume":"9","author":"Lundmark","year":"2019","journal-title":"Front. Cell. infection Microbiol."},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.919792","article-title":"Loss of gut barrier integrity in lupus","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Immunol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.3390\/jcm9123876","article-title":"Did the brain and oral microbiota talk to each other? A review of the literature","volume":"9","author":"Maitre","year":"2020","journal-title":"J. Clin. Med."},{"key":"B152","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/jcpe.13420","article-title":"Periodontal diseases and depression: A pre-clinical in vivo study","volume":"48","author":"Mart\u00ednez","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1111\/j.1600-051X.2009.01496.x","article-title":"Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients","volume":"36","author":"Martinez-Martinez","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.5897\/AJMR2016.8046","article-title":"Gut bacterial microbiota in psoriasis: A case control study","volume":"10","author":"Masallat","year":"2016","journal-title":"Afr. J. Microbiol. Res."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.3390\/nu9121348","article-title":"Short chain fatty acids in the colon and peripheral tissues: a focus on butyrate, colon cancer, obesity and insulin resistance","volume":"9","author":"McNabney","year":"2017","journal-title":"Nutrients"},{"key":"B156","doi-asserted-by":"publisher","first-page":"414","DOI":"10.7518\/hxkq.2016.04.019","article-title":"Periodontal inflammation affects the mechanical and immune barrier functions of mice gut","volume":"34","author":"Meilian","year":"2016","journal-title":"Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China J. Stomatol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.bbadis.2018.12.001","article-title":"Periodontitis and mechanisms of cardiometabolic risk: Novel insights and future perspectives","volume":"1865","author":"Mesa","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA)-Molecular Basis Disease"},{"key":"B158","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/dj10040068","article-title":"The stockholm study: over 30 years\u2019 Observation of the effect of oral infections on systemic health","volume":"10","author":"Meurman","year":"2022","journal-title":"Dentistry J."},{"key":"B159","doi-asserted-by":"publisher","first-page":"10679","DOI":"10.1073\/pnas.0403249101","article-title":"Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E","volume":"101","author":"Michelsen","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1038\/ctg.2016.53","article-title":"Fusobacterium nucleatumin colorectal carcinoma tissue according to tumor location","volume":"7","author":"Mima","year":"2016","journal-title":"Clin. Trans. gastroenterol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3920\/BM2012.0066","article-title":"Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota","volume":"5","author":"Miyazaki","year":"2014","journal-title":"Beneficial Microbes"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01108","article-title":"Infectious triggers in periodontitis and the gut in rheumatoid arthritis (RA): A complex story about association and causality","volume":"11","author":"M\u00f6ller","year":"2020","journal-title":"Front. Immunol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ijc.v140.3","article-title":"Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses\u2019 Health Study","volume":"140","author":"Momen-Heravi","year":"2017","journal-title":"Int. J. Cancer"},{"key":"B164","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/jcpe.2019.46.issue-3","article-title":"Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months","volume":"46","author":"Montenegro","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1172\/JCI25482","article-title":"Modulation of atherosclerosis in mice by Toll-like receptor 2","volume":"115","author":"Mullick","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B166","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00535-017-1368-4","article-title":"Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease","volume":"53","author":"Nakahara","year":"2018","journal-title":"J. Gastroenterol."},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134234","article-title":"Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver","volume":"10","author":"Nakajima","year":"2015","journal-title":"PloS One"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100778","article-title":"Novel gut-based pharmacology of metformin in patients with type 2 diabetes mellitus","volume":"9","author":"Napolitano","year":"2014","journal-title":"PloS One"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.633735","article-title":"The oral-gut-brain AXIS: the influence of microbes in Alzheimer\u2019s disease","volume":"15","author":"Narengaowa","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"B170","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1080\/19424396.2017.12222506","article-title":"Oral microbiota transplant: a potential new therapy for oral diseases","volume":"45","author":"Nascimento","year":"2017","journal-title":"J. California Dental Assoc."},{"key":"B171","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/jcpe.2015.42.issue-6","article-title":"Is weight gain associated with the incidence of periodontitis? A systematic review and meta-analysis","volume":"42","author":"Nascimento","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260433","article-title":"Development and characterization of an oral microbiome transplant among Australians for the treatment of dental caries and periodontal disease: A study protocol","volume":"16","author":"Nath","year":"2021","journal-title":"PloS One"},{"key":"B173","doi-asserted-by":"publisher","first-page":"532","DOI":"10.2174\/1573399815666190502113632","article-title":"The emerging role of branch chain amino acids in the prediction of diabetes: a brief review","volume":"16","author":"Nawaz","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.3390\/microorganisms11061586","article-title":"Exploring the potential of oral microbiome biomarkers for colorectal cancer diagnosis and prognosis: A systematic review","volume":"11","author":"Negrut","year":"2023","journal-title":"Microorganisms"},{"key":"B175","doi-asserted-by":"publisher","first-page":"108244","DOI":"10.1016\/j.diabres.2020.108244","article-title":"The association of periodontal disease with the complications of diabetes mellitus. A systematic review","volume":"165","author":"Nguyen","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"B176","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1111\/jam.v127.6","article-title":"Quercetin reduces atherosclerotic lesions by altering the gut microbiota and reducing atherogenic lipid metabolites","volume":"127","author":"Nie","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1177\/0022034518765735","article-title":"Severe periodontitis is associated with myocardial infarction in females","volume":"97","author":"Nordendahl","year":"2018","journal-title":"J. Dent. Res."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1002\/bies.201600008","article-title":"The gut-skin axis in health and disease: a paradigm with therapeutic implications","volume":"38","author":"O\u2019Neill","year":"2016","journal-title":"Bioessays"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1586422","DOI":"10.1080\/20002297.2019.1586422","article-title":"Can oral bacteria affect the microbiome of the gut","volume":"11","author":"Olsen","year":"2019","journal-title":"J. Oral. Microbiol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S1532-3382(12)70006-4","article-title":"State of the science: chronic periodontitis and systemic health","volume":"12","author":"Otomo-Corgel","year":"2012","journal-title":"J. Evidence Based Dental Practice"},{"key":"B181","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1038\/s41467-020-16967-2","article-title":"Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression","volume":"11","author":"Parhi","year":"2020","journal-title":"Nat. Commun."},{"key":"B182","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.3390\/cancers13092124","article-title":"Oral\u2013gut microbiome axis in gastrointestinal disease and cancer","volume":"13","author":"Park","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1093\/eurheartj\/ehy836","article-title":"Improved oral hygiene care attenuates the cardiovascular risk of oral health disease: a population-based study from Korea","volume":"40","author":"Park","year":"2019","journal-title":"Eur. Heart J."},{"key":"B184","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"B185","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s13167-020-00202-5","article-title":"Microbial and metabolomic analysis of gingival crevicular fluid in general chronic periodontitis patients: lessons for a predictive, preventive, and personalized medical approach","volume":"11","author":"Pei","year":"2020","journal-title":"EPMA J."},{"key":"B186","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.2014.260.issue-1","article-title":"The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system","volume":"260","author":"Pelaseyed","year":"2014","journal-title":"Immunol. Rev."},{"key":"B187","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jaut.2014.03.005","article-title":"Long term effect of gut microbiota transfer on diabetes development","volume":"53","author":"Peng","year":"2014","journal-title":"J. Autoimmun."},{"key":"B188","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/nrrheum.2015.109","article-title":"Microbiome reflects status of RA and response to therapy","volume":"11","author":"Phillips","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"B189","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1002\/art.40003","article-title":"Evidence of the immune relevance of Prevotella copri, a gut microbe, in patients with rheumatoid arthritis","volume":"69","author":"Pianta","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.3390\/microorganisms11092358","article-title":"The role of Fusobacterium nucleatum in oral and colorectal carcinogenesis","volume":"11","author":"Pignatelli","year":"2023","journal-title":"Microorganisms"},{"key":"B191","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12903-015-0109-4","article-title":"Towards microbiome transplant as a therapy for periodontitis: an exploratory study of periodontitis microbial signature contrasted by oral health, caries and edentulism","volume":"15","author":"Pozhitkov","year":"2015","journal-title":"BMC Oral. Health"},{"key":"B192","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/ijo.2014.153","article-title":"The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents","volume":"39","author":"Psichas","year":"2015","journal-title":"Int. J. Obes."},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1059349","article-title":"Update on gut microbiota in cardiovascular diseases","volume":"12","author":"Qian","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B194","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1177\/00220345211070470","article-title":"Oral microbiota changes contribute to autism spectrum disorder in mice","volume":"101","author":"Qiao","year":"2022","journal-title":"J. Dent. Res."},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00212","article-title":"Psoriasis patients suffer from worse periodontal status\u2014a meta-analysis","volume":"6","author":"Qiao","year":"2019","journal-title":"Front. Med."},{"key":"B196","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nature13568","article-title":"Alterations of the human gut microbiome in liver cirrhosis","volume":"513","author":"Qin","year":"2014","journal-title":"Nature"},{"key":"B197","doi-asserted-by":"publisher","first-page":"4948","DOI":"10.1096\/fj.10-164921","article-title":"Germ-free C57BL\/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism","volume":"24","author":"Rabot","year":"2010","journal-title":"FASEB J."},{"key":"B198","doi-asserted-by":"publisher","first-page":"179","DOI":"10.5005\/jp-journals-10024-1296","article-title":"Evaluation of periodontal status in alcoholic liver cirrhosis patients: a comparative study","volume":"14","author":"Raghava","year":"2013","journal-title":"J. Contemp. Dental Practice"},{"key":"B199","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1001\/jamadermatol.2014.5585","article-title":"Identification of bacterial DNA in the peripheral blood of patients with active psoriasis","volume":"151","author":"Ram\u00edrez-Bosc\u00e1","year":"2015","journal-title":"JAMA Dermatol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.celrep.2016.03.091","article-title":"PYY-dependent restoration of impaired insulin and glucagon secretion in type 2 diabetes following Roux-En-Y gastric bypass surgery","volume":"15","author":"Ramracheya","year":"2016","journal-title":"Cell Rep."},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057178","article-title":"Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoEnull mice","volume":"8","author":"Rivera","year":"2013","journal-title":"PloS One"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.663328","article-title":"Humanized mouse models for the study of periodontitis: an opportunity to elucidate unresolved aspects of its immunopathogenesis and analyze new immunotherapeutic strategies","volume":"12","author":"Rojas","year":"2021","journal-title":"Front. Immunol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1177\/0022034517742139","article-title":"Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis","volume":"97","author":"Rosier","year":"2018","journal-title":"J. Dent. Res."},{"key":"B204","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.chom.2013.07.012","article-title":"Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin\/\u03b2-catenin signaling via its FadA adhesin","volume":"14","author":"Rubinstein","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01459","article-title":"The gut microbiome as a major regulator of the gut-skin axis","volume":"9","author":"Salem","year":"2018","journal-title":"Front. Microbiol."},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2021.781582","article-title":"Oral-gut-brain axis in experimental models of periodontitis: associating gut dysbiosis with neurodegenerative diseases","volume":"2","author":"Sansores-Espa\u00f1a","year":"2021","journal-title":"Front. aging"},{"key":"B207","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.3390\/nu14122426","article-title":"A cross-talk between diet and the oral microbiome: balance of nutrition on inflammation and immune system\u2019s response during periodontitis","volume":"14","author":"Santonocito","year":"2022","journal-title":"Nutrients"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02470","article-title":"Endotoxemia by Porphyromonas gingivalis injection aggravates non-alcoholic fatty liver disease, disrupts glucose\/lipid metabolism, and alters gut microbiota in mice","volume":"9","author":"Sasaki","year":"2018","journal-title":"Front. Microbiol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"6955","DOI":"10.1038\/s41598-017-07196-7","article-title":"Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system","volume":"7","author":"Sato","year":"2017","journal-title":"Sci. Rep."},{"key":"B210","doi-asserted-by":"publisher","first-page":"S51","DOI":"10.1111\/jcpe.12060","article-title":"Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases","volume":"84","author":"Schenkein","year":"2013","journal-title":"J. Periodontol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.chom.2018.09.009","article-title":"Compositional and temporal changes in the gut microbiome of pediatric ulcerative colitis patients are linked to disease course","volume":"24","author":"Schirmer","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B212","doi-asserted-by":"publisher","first-page":"e42693","DOI":"10.7554\/eLife.42693","article-title":"Extensive transmission of microbes along the gastrointestinal tract","volume":"8","author":"Schmidt","year":"2019","journal-title":"elife"},{"key":"B213","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/nm.4185","article-title":"Signals from the gut microbiota to distant organs in physiology and disease","volume":"22","author":"Schroeder","year":"2016","journal-title":"Nat. Med."},{"key":"B214","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/alz.12378","article-title":"Effect of periodontal treatment on preclinical Alzheimer\u2019s disease\u2014Results of a trial emulation approach","volume":"18","author":"Schwahn","year":"2022","journal-title":"Alzheimer\u2019s Dementia."},{"key":"B215","doi-asserted-by":"publisher","first-page":"82","DOI":"10.12932\/AP-100317-0044","article-title":"Elevated fecal calprotectin levels are associated with severity of atopic dermatitis in children","volume":"36","author":"Seo","year":"2018","journal-title":"Asian Pac J. Allergy Immunol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4251\/wjgo.v10.i3.71","article-title":"Fusobacterium nucleatum and colorectal cancer: A review","volume":"10","author":"Shang","year":"2018","journal-title":"World J. Gastrointest Oncol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/jcpe.2016.43.issue-2","article-title":"Association between periodontitis and mortality in stages 3\u20135 chronic kidney disease: NHANES III and linked mortality study","volume":"43","author":"Sharma","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"B218","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1177\/00220345231158269","article-title":"Ligature-induced periodontitis drives colorectal cancer: an experimental model in mice","volume":"102","author":"Shi","year":"2023","journal-title":"J. Dent. Res."},{"key":"B219","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1111\/jdv.v33.10","article-title":"Claudin-3\u2013a new intestinal integrity marker in patients with psoriasis: association with disease severity","volume":"33","author":"Sikora","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"B220","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3390\/jcm8071021","article-title":"Intestinal fatty acid binding protein, a biomarker of intestinal barrier, is associated with severity of psoriasis","volume":"8","author":"Sikora","year":"2019","journal-title":"J. Clin. Med."},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2022.859209","article-title":"The microbiome in periodontitis and diabetes","volume":"3","author":"Silva","year":"2022","journal-title":"Front. Oral. Health"},{"key":"B222","doi-asserted-by":"publisher","first-page":"166836","DOI":"10.1016\/j.jmb.2021.166836","article-title":"Molecular strategies underlying Porphyromonas gingivalis virulence","volume":"433","author":"Silva","year":"2021","journal-title":"J. Mol. Biol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/joim.2016.280.issue-1","article-title":"Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis","volume":"280","author":"Slocum","year":"2016","journal-title":"J. Intern. Med."},{"key":"B224","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12895-020-00117-8","article-title":"Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study","volume":"20","author":"Smirnova","year":"2020","journal-title":"BMC Dermatol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/omi.12359","article-title":"Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells","volume":"37","author":"Sohn","year":"2022","journal-title":"Mol. Oral. Microbiol."},{"key":"B226","doi-asserted-by":"publisher","first-page":"101252","DOI":"10.1016\/j.diabet.2021.101252","article-title":"Cardiovascular risks of periodontitis and oral hygiene indicators in patients with diabetes mellitus","volume":"47","author":"Song","year":"2021","journal-title":"Diabetes Metab."},{"key":"B227","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1172\/JCI62308","article-title":"Brown adipose tissue regulates glucose homeostasis and insulin sensitivity","volume":"123","author":"Stanford","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.625780","article-title":"High fat diet dysbiotic mechanism of decreased gingival blood flow","volume":"12","author":"Stanisic","year":"2021","journal-title":"Front. Physiol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1159\/000477990","article-title":"A role for neuronal alpha-synuclein in gastrointestinal immunity","volume":"9","author":"Stolzenberg","year":"2017","journal-title":"J. Innate Immun."},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.594806","article-title":"Fusobacterium nucleatum promotes the development of ulcerative colitis by inducing the autophagic cell death of intestinal epithelial","volume":"10","author":"Su","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.705206","article-title":"Oral versus gastrointestinal mucosal immune niches in homeostasis and allostasis","volume":"12","author":"Su\u00e1rez","year":"2021","journal-title":"Front. Immunol."},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.715506","article-title":"Metabolic influences of gut microbiota dysbiosis on inflammatory bowel disease","volume":"12","author":"Sultan","year":"2021","journal-title":"Front. Physiol."},{"key":"B233","doi-asserted-by":"publisher","first-page":"104582","DOI":"10.1016\/j.phrs.2019.104582","article-title":"Oral microbiota and Alzheimer\u2019s disease: Do all roads lead to Rome","volume":"151","author":"Sureda","year":"2020","journal-title":"Pharmacol. Res."},{"key":"B234","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2014.02.004","article-title":"T cell epitope mimicry between Sj\u00f6gren\u2019s syndrome Antigen A (SSA)\/Ro60 and oral, gut, skin and vaginal bacteria","volume":"152","author":"Szymula","year":"2014","journal-title":"Clin. Immunol."},{"key":"B235","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1038\/s41467-020-15831-7","article-title":"Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis","volume":"11","author":"Tajik","year":"2020","journal-title":"Nat. Commun."},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2019.1651158","article-title":"Gingival epithelial barrier: regulation by beneficial and harmful microbes","volume":"7","author":"Takahashi","year":"2019","journal-title":"Tissue Barriers"},{"key":"B237","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1111\/j.1600-051X.2011.01777.x","article-title":"Stage of hepatocellular carcinoma is associated with periodontitis","volume":"38","author":"Tamaki","year":"2011","journal-title":"J. Clin. Periodontol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1056\/NEJMoa1109400","article-title":"Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk","volume":"368","author":"Tang","year":"2013","journal-title":"N Engl. J. Med."},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.1056","article-title":"An oral health optimized diet reduces the load of potential cariogenic and periodontal bacterial species in the supragingival oral plaque: A randomized controlled pilot study","volume":"9","author":"Tennert","year":"2020","journal-title":"Microbiologyopen"},{"key":"B240","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1016\/j.celrep.2015.02.049","article-title":"Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota","volume":"10","author":"Thompson","year":"2015","journal-title":"Cell Rep."},{"key":"B241","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1177\/0022034520911037","article-title":"Porphyromonas gingivalis induces insulin resistance by increasing BCAA levels in mice","volume":"99","author":"Tian","year":"2020","journal-title":"J. Dent. Res."},{"key":"B242","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.physbeh.2014.10.033","article-title":"Gastrointestinal microbiota in children with autism in Slovakia","volume":"138","author":"Tomova","year":"2015","journal-title":"Physiol. Behav."},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00665","article-title":"Immunopathogenesis of behcet\u2019s disease","volume":"10","author":"Tong","year":"2019","journal-title":"Front. Immunol."},{"key":"B244","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MRM.0000000000000155","article-title":"The diabetes pandemic and associated infections: suggestions for clinical microbiology","volume":"30","author":"Toniolo","year":"2019","journal-title":"Rev. Res. Med. Microbiol."},{"key":"B245","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/jre.12816","article-title":"Ingestion of Porphyromonas gingivalis exacerbates colitis via intestinal epithelial barrier disruption in mice","volume":"56","author":"Tsuzuno","year":"2021","journal-title":"J. Periodontal Res."},{"key":"B246","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/JLB.3MR0321-755R","article-title":"The microbiota-gut-bone axis and bone health","volume":"110","author":"Tu","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"B247","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"B248","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1111\/jdv.2017.31.issue-5","article-title":"Periodontitis and risk of psoriasis: A systematic review and meta-analysis","volume":"31","author":"Ungprasert","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"B249","doi-asserted-by":"publisher","first-page":"14636","DOI":"10.1074\/jbc.M113.459479","article-title":"Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB)","volume":"288","author":"van der Post","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B250","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1097\/01.MIB.0000438356.84263.3b","article-title":"Periodontitis and gingivitis in inflammatory bowel disease: a case\u2013control study","volume":"19","author":"Vavricka","year":"2013","journal-title":"Inflammation Bowel Dis."},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097811","article-title":"Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis","volume":"9","author":"Velsko","year":"2014","journal-title":"PloS One"},{"key":"B252","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/jcpe.2014.41.issue-5","article-title":"Activation of RANKL-induced osteoclasts and memory T lymphocytes by Porphyromonas gingivalis is serotype dependant","volume":"41","author":"Vernal","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"B253","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"},{"key":"B254","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.intimp.2015.01.007","article-title":"Subcutaneous vaccination with Porphyromonas gingivalis ameliorates periodontitis by modulating Th17\/Treg imbalance in a murine model","volume":"25","author":"Wang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.822190","article-title":"Oral and gut microbial dysbiosis and non-alcoholic fatty liver disease: the central role of Porphyromonas gingivalis","volume":"9","author":"Wang","year":"2022","journal-title":"Front. Med."},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.710165","article-title":"Fusobacterium nucleatum acts as a pro-carcinogenic bacterium in colorectal cancer: from association to causality","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00455","article-title":"Promising treatment for type 2 diabetes: fecal microbiota transplantation reverses insulin resistance and impaired islets","volume":"9","author":"Wang","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B258","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.4049\/jimmunol.179.4.2349","article-title":"Fimbrial proteins of Porphyromonas gingivalis mediate in vivo virulence and exploit TLR2 and complement receptor 3 to persist in macrophages","volume":"179","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"key":"B259","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41368-024-00282-3","article-title":"Promising dawn in tumor microenvironment therapy: engineering oral bacteria","volume":"16","author":"Wang","year":"2024","journal-title":"Int. J. Oral. Sci."},{"key":"B260","doi-asserted-by":"publisher","first-page":"6983","DOI":"10.3748\/wjg.v23.i38.6983","article-title":"Fecal microbiota transplantation prevents hepatic encephalopathy in rats with carbon tetrachloride-induced acute hepatic dysfunction","volume":"23","author":"Wang","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"B261","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1172\/JCI62308","article-title":"Commercializing equitable, accessible oral microbiome transplantation therapy","volume":"41","author":"Weyrich","year":"2024","journal-title":"Community Dent. Health"},{"key":"B262","doi-asserted-by":"publisher","first-page":"36023","DOI":"10.1038\/srep36023","article-title":"Zebrafish as a new model to study effects of periodontal pathogens on cardiovascular diseases","volume":"6","author":"Widziolek","year":"2016","journal-title":"Sci. Rep."},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4458","article-title":"Characterization of the salivary microbiome in people with obesity","volume":"6","author":"Wu","year":"2018","journal-title":"PeerJ"},{"key":"B264","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12903-020-01180-w","article-title":"Epidemiologic relationship between periodontitis and type 2 diabetes mellitus","volume":"20","author":"Wu","year":"2020","journal-title":"BMC Oral. Health"},{"key":"B265","doi-asserted-by":"publisher","first-page":"5898","DOI":"10.1016\/j.csbj.2021.10.028","article-title":"Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice","volume":"19","author":"Xiao","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"B266","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.chom.2017.06.014","article-title":"Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity","volume":"22","author":"Xiao","year":"2017","journal-title":"Cell Host Microbe"},{"key":"B267","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41419-018-0389-0","article-title":"Indoleamine 2, 3-dioxygenase expression regulates the survival and proliferation of Fusobacterium nucleatum in THP-1-derived macrophages","volume":"9","author":"Xue","year":"2018","journal-title":"Cell Death Dis."},{"key":"B268","doi-asserted-by":"publisher","first-page":"113176","DOI":"10.1016\/j.expneurol.2020.113176","article-title":"Chronic periodontitis induces microbiota-gut-brain axis disorders and cognitive impairment in mice","volume":"326","author":"Xue","year":"2020","journal-title":"Exp. Neurol."},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.766170","article-title":"Oral pathobiont-induced changes in gut microbiota aggravate the pathology of nonalcoholic fatty liver disease in mice","volume":"12","author":"Yamazaki","year":"2021","journal-title":"Front. Immunol."},{"key":"B270","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1053\/j.gastro.2016.11.018","article-title":"Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor\u2013 \u03baB, and up-regulating expression of microRNA-21","volume":"152","author":"Yang","year":"2017","journal-title":"Gastroenterology"},{"key":"B271","doi-asserted-by":"publisher","first-page":"8729","DOI":"10.3390\/ijms21228729","article-title":"Mutual interplay of host immune system and gut microbiota in the immunopathology of atherosclerosis","volume":"21","author":"Yeh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B272","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1128\/IAI.72.7.3743-3751.2004","article-title":"Activation of the phosphatidylinositol 3-kinase\/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis","volume":"72","author":"Yilmaz","year":"2004","journal-title":"Infect. Immun."},{"key":"B273","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-230X-12-16","article-title":"Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease","volume":"12","author":"Yoneda","year":"2012","journal-title":"BMC Gastroenterol."},{"key":"B274","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/nu8070405","article-title":"The emerging role of branched-chain amino acids in insulin resistance and metabolism","volume":"8","author":"Yoon","year":"2016","journal-title":"Nutrients"},{"key":"B275","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1161\/CIRCULATIONAHA.118.033714","article-title":"Bacteroides vulgatus and Bacteroides dorei reduce gut microbial lipopolysaccharide production and inhibit atherosclerosis","volume":"138","author":"Yoshida","year":"2018","journal-title":"Circulation"},{"key":"B276","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.cell.2017.07.008","article-title":"Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy","volume":"170","author":"Yu","year":"2017","journal-title":"Cell"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159539","article-title":"Intestinal microbiota promotes psoriasis-like skin inflammation by enhancing Th17 response","volume":"11","author":"Z\u00e1kostelsk\u00e1","year":"2016","journal-title":"PloS One"},{"key":"B278","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/jnc.v158.3","article-title":"Receptor for advanced glycation end products up-regulation in cerebral endothelial cells mediates cerebrovascular-related amyloid \u03b2 accumulation after Porphyromonas gingivalis infection","volume":"158","author":"Zeng","year":"2021","journal-title":"J. Neurochem."},{"key":"B279","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4103\/0972-124X.164750","article-title":"Association of serum immunoglobulin-G to Porphyromonas gingivalis with acute cerebral infarction in the Chinese population","volume":"19","author":"Zhang","year":"2015","journal-title":"J. Indian Soc. Periodontol."},{"key":"B280","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-018-0985-y","article-title":"Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B281","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat. Med."},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00318","article-title":"Secretory products of the human GI tract microbiome and their potential impact on Alzheimer\u2019s disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus","volume":"7","author":"Zhao","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B283","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41368-021-00136-2","article-title":"Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase","volume":"13","author":"Zhao","year":"2021","journal-title":"Int. J. Oral. Sci."},{"key":"B284","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40168-021-01107-9","article-title":"Fecal microbiota transplantation protects rotenone-induced Parkinson\u2019s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis","volume":"9","author":"Zhao","year":"2021","journal-title":"Microbiome"},{"key":"B285","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/genes13010013","article-title":"Causal association between periodontal diseases and cardiovascular diseases","volume":"13","author":"Zhou","year":"2021","journal-title":"Genes"},{"key":"B286","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1038\/s41598-017-01751-y","article-title":"Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota","volume":"7","author":"Zhou","year":"2017","journal-title":"Sci. Rep."},{"key":"B287","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"B288","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1902\/jop.2012.120254","article-title":"Local and circulating levels of adipocytokines in obese and normal weight individuals with chronic periodontitis","volume":"84","author":"Zimmermann","year":"2013","journal-title":"J. Periodontol."},{"key":"B289","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/jcpe.2018.45.issue-6","article-title":"Prevalence of diabetes mellitus in people clinically diagnosed with periodontitis: a systematic review and meta-analysis of epidemiologic studies","volume":"45","author":"Ziukaite","year":"2018","journal-title":"J. Clin. Periodontol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1478362\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T01:13:42Z","timestamp":1731633222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2024.1478362\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":289,"alternative-id":["10.3389\/fcimb.2024.1478362"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2024.1478362","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,15]]},"article-number":"1478362"}}