{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:33:46Z","timestamp":1792481626469,"version":"4.5.0"},"reference-count":98,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Streptococcus oralis<\/jats:italic>, belonging to the viridans group streptococci (VGS), has been considered a member of normal flora mainly inhabiting the oral cavity. However, more recently, there has been growing recognition of its role as a causative agent in various life-threatening infectious diseases such as infective endocarditis (IE) and meningitis. Additionally, the differences in the prevalence, clinical features, and prognosis of opportunistic infections between <jats:italic>S. oralis<\/jats:italic> and other VGS species have been addressed. Particularly the predominance of <jats:italic>S. oralis<\/jats:italic> in IE has drawn critical attention. In potentially fatal infections, clinical neglect of <jats:italic>S. oralis<\/jats:italic> as an instigating agent might significantly impede early diagnosis and treatment. Nevertheless, to date, the infectious diseases associated with <jats:italic>S. oralis<\/jats:italic> have not yet been comprehensively described. Therefore, this review will give an overview of infectious diseases caused by <jats:italic>S. oralis<\/jats:italic> to uncover its hidden role as an opportunistic pathogen.<\/jats:p>","DOI":"10.3389\/fcimb.2024.1480961","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T06:10:27Z","timestamp":1730700627000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Insights into the role of Streptococcus oralis as an opportunistic pathogen in infectious diseases"],"prefix":"10.3389","volume":"14","author":[{"given":"Jingyi","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.46101","article-title":"Streptococcus oralis-induced meningoencephalitis and ventriculitis in a geriatric female patient","volume":"15","author":"Adly","year":"2023","journal-title":"Cureus"},{"key":"B2","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1080\/08880010390220144","article-title":"Viridans streptococcus bacteremia in children on chemotherapy for cancer: an underestimated problem","volume":"20","author":"Ahmed","year":"2003","journal-title":"Pediatr. 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