{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:04:12Z","timestamp":1788991452817,"version":"build-2803163510"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To explore the genetic characteristics of the\n                      <jats:italic>Mycobacterium abscessus<\/jats:italic>\n                      complex (MABC) population in China, given its rising clinical importance among nontuberculous mycobacteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted population genetic analyses on 360 MABC genomes from China, focusing on core genome multilocus sequence typing (cgMLST), pan-genome characterization, population genetics, and antimicrobial resistance gene profiling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our analysis identified 273\n                      <jats:italic>M. abscessus<\/jats:italic>\n                      subsp.\n                      <jats:italic>abscessus<\/jats:italic>\n                      (Mab\n                      <jats:sub>A<\/jats:sub>\n                      ) and 87\n                      <jats:italic>M. abscessus<\/jats:italic>\n                      subsp.\n                      <jats:italic>massiliense<\/jats:italic>\n                      (Mab\n                      <jats:sub>M<\/jats:sub>\n                      ) isolates, uncovering 68 sequence types (STs), with ST5 being the most common. cgMLST classified 33.3% of isolates into six dominant circulating clones (DCCs) and 49.4% into 59 genomic clusters at a threshold of 25 different alleles, including 18 international clusters linking Chinese isolates with seven other countries. The MABC pan-genome is open, with Mab\n                      <jats:sub>A<\/jats:sub>\n                      exhibiting greater accessory gene diversity and higher gene turnover compared to Mab\n                      <jats:sub>M<\/jats:sub>\n                      . Mobile genetic elements (MGEs), such as prophages and genomic islands, were prevalent across all genomes. 139 to 151 virulence factors (VFs) were identified per genome, with distinct accessory VFs in Mab\n                      <jats:sub>A<\/jats:sub>\n                      and Mab\n                      <jats:sub>M<\/jats:sub>\n                      affecting immune modulation and metabolism. Resistance gene profiling revealed ubiquitous\n                      <jats:italic>mtrA<\/jats:italic>\n                      ,\n                      <jats:italic>RbpA<\/jats:italic>\n                      , and\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>MAB<\/jats:sub>\n                      , with Mab\n                      <jats:sub>A<\/jats:sub>\n                      -specific\n                      <jats:italic>erm(41)<\/jats:italic>\n                      conferring resistance to macrolides and \u03b2-lactams. Common\n                      <jats:italic>rrs<\/jats:italic>\n                      and\n                      <jats:italic>rrl<\/jats:italic>\n                      gene mutations indicated widespread resistance to aminoglycosides and macrolides, while\n                      <jats:italic>gyrA<\/jats:italic>\n                      mutations suggested emerging fluoroquinolone resistance. An acquired\n                      <jats:italic>erm(46)<\/jats:italic>\n                      gene, likely obtained via phage-mediated horizontal gene transfer, was detected in one Mab\n                      <jats:sub>A<\/jats:sub>\n                      strain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study provides key genetic insights into the dynamics of MABC in China. The widespread distribution of DCCs, high genomic clustering rates, open pan-genome, and distinct resistance patterns between Mab\n                      <jats:sub>A<\/jats:sub>\n                      and Mab\n                      <jats:sub>M<\/jats:sub>\n                      , along with MGEs, highlight the need for targeted surveillance and tailored therapies to address emerging challenges in MABC infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2024.1496896","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:24:02Z","timestamp":1737332642000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Population genetic analysis of clinical Mycobacterium abscessus complex strains in China"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiangchen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuxian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"D690","DOI":"10.1093\/nar\/gkac920","article-title":"CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database","volume":"51","author":"Alcock","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.001126","article-title":"Introduction and benchmarking of pyMLST: open-source software for assessing bacterial clonality using core genome MLST","volume":"9","author":"Biguenet","year":"2023","journal-title":"Microbial Genomics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e00428","DOI":"10.1128\/jcm.00428-23","article-title":"Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm (55)","volume":"61","author":"Brown-Elliott","year":"2023","journal-title":"J. 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