{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:35:45Z","timestamp":1792852545597,"version":"4.5.0"},"reference-count":185,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Periodontitis, a prevalent inflammatory oral disease, is intricately linked to disruptions in the oral microbiome, a state known as microbial dysbiosis. This review explores the pivotal roles of key pathogens, including\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    and\n                    <jats:italic>Tannerella forsythia<\/jats:italic>\n                    , in driving periodontitis and examines the underlying molecular mechanisms that disrupt microbial homeostasis. We discuss how interactions among bacterial species affect the oral ecosystem\u2019s balance and how microbial metabolites influence the host immune responses, contributing to disease progression. Leveraging these insights, we propose cutting-edge therapeutic approaches aimed at restoring microbial equilibrium. These include personalized pharmacological interventions tailored to individual microbiome profiles and innovative microbiome-targeted strategies such as probiotic formulations and bacteriophage therapy. By precisely modulating microbial communities, these strategies hold promise for enhancing treatment efficacy, preventing disease recurrence, and mitigating issues like antimicrobial resistance. Overall, this review paves the way for novel prevention and management techniques in periodontitis, offering significant improvements in oral health outcomes for patients.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2025.1556688","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T01:40:48Z","timestamp":1745977248000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Innovative strategies targeting oral microbial dysbiosis: unraveling mechanisms and advancing therapies for periodontitis"],"prefix":"10.3389","volume":"15","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guocheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02865-23","article-title":"Comparative analysis of Porphyromonas gingivalis A7436 and ATCC 33277 strains reveals differences in the expression of heme acquisition systems","volume":"12","author":"\u015amiga","year":"2024","journal-title":"Microbiol Spectr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/prd.12427","article-title":"Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis","volume":"89","author":"Albuquerque-Souza","year":"2022","journal-title":"Periodontol 2000"},{"key":"B3","doi-asserted-by":"publisher","first-page":"6630","DOI":"10.1038\/s41598-017-07014-0","article-title":"Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation","volume":"7","author":"Alippe","year":"2017","journal-title":"Sci. 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