{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:26:27Z","timestamp":1791822387221,"version":"4.3.4"},"reference-count":201,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Gastric cancer, a prevalent malignancy globally, is influenced by various factors. The imbalance in the gut microbiome and the existence of particular intratumoural microbiota could have a strong connection with the onset and progression of gastric cancer. High-throughput sequencing technology and bioinformatics analysis have revealed a close correlation between abnormal abundance of specific microbial communities and the risk of gastric cancer. These microbial communities contribute to gastric cancer progression through mechanisms including increasing cellular genomic damage, inhibiting DNA repair, activating abnormal signaling pathways, exacerbating tumor hypoxia, and shaping a tumor immune-suppressive microenvironment. This significantly impacts the efficacy of gastric cancer treatments, including chemotherapy and immunotherapy. Probiotic, prebiotic, antibiotic, carrier-based, dietary interventions, fecal microbiota transplantation, and traditional Chinese medicine show potential applications in gastric cancer treatment. However, the molecular mechanisms regarding dysbiosis of microbiota, including gut microbiota, and intra-tumoral microbiota during the progression of gastric cancer, as well as the therapeutic efficacy of microbiota-related applications, still require extensive exploration through experiments.<\/jats:p>","DOI":"10.3389\/fcimb.2025.1563061","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T05:22:49Z","timestamp":1748928169000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhou","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defeng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhou","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiu","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.chom.2016.07.006","article-title":"Fap2 mediates fusobacterium nucleatum colorectal adenocarcinoma enrichment by binding to tumor-expressed gal-galNAc","volume":"20","author":"Abed","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B2","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1282680","article-title":"Immune evasion by proteolytic shedding of natural killer group 2, member D ligands in Helicobacter pylori infection","volume":"15","author":"Anthofer","year":"2024","journal-title":"Front. In Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"110556","DOI":"10.1016\/j.nut.2019.110556","article-title":"High-fat-diet-induced modulations of leptin signaling and gastric microbiota drive precancerous lesions in the stomach","author":"Arita","year":"2019","journal-title":"Nutr. (Burbank Los Angeles County Calif.)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.3390\/nu11092127","article-title":"Dietary fat-accelerating leptin signaling promotes protumorigenic gastric environment in mice","volume":"11","author":"Arita","year":"2019","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/em.20546","article-title":"DNA damage and toxicogenomic analyses of hydrogen sulfide in human intestinal epithelial FHs 74 Int cells","volume":"51","author":"Attene-Ramos","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"key":"B7","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.ccr.2015.06.001","article-title":"Biological signaling by small inorganic molecules","volume":"306","author":"Basudhar","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1152\/physrev.1990.70.2.567","article-title":"Energy contributions of volatile fatty acids from the gastrointestinal tract in various species","volume":"70","author":"Bergman","year":"1990","journal-title":"Physiol. Rev."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1016\/j.ejca.2015.08.015","article-title":"Recurrent antibiotic exposure may promote cancer formation\u2013Another step in understanding the role of the human microbiota","volume":"51","author":"Boursi","year":"2015","journal-title":"Eur. J. Cancer (Oxford England: 1990)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"9300","DOI":"10.1073\/pnas.0409873102","article-title":"NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein","volume":"102","author":"Brandt","year":"2005","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B11","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S2468-1253(21)00431-3","article-title":"The role of mucins in gastrointestinal barrier function during health and disease","volume":"7","author":"Breugelmans","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1093\/jnci\/djad083","article-title":"The intratumor microbiome is associated with microsatellite instability","volume":"115","author":"Byrd","year":"2023","journal-title":"J. Natl. Cancer Instit."},{"key":"B13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.immuni.2013.11.020","article-title":"Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation","volume":"40","author":"Campbell","year":"2014","journal-title":"Immunity"},{"key":"B14","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1076245","article-title":"Clostridium butyricum potentially improves inflammation and immunity through alteration of the microbiota and metabolism of gastric cancer patients after gastrectomy","volume":"13","author":"Cao","year":"2022","journal-title":"Front. In Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e01243","DOI":"10.1128\/mBio.01243-14","article-title":"Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection","volume":"5","author":"Carbo","year":"2014","journal-title":"MBio"},{"key":"B17","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"H1066","DOI":"10.1152\/ajpheart.00515.2019","article-title":"GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling","volume":"320","author":"Castro","year":"2021","journal-title":"Am. J. Physiol. Heart Circulatory Physiol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.v4.6","article-title":"Microbiota in cancer: molecular mechanisms and therapeutic interventions","volume":"4","author":"Chen","year":"2023","journal-title":"MedComm"},{"key":"B20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41392-023-01332-8","article-title":"Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Trans. Target. Ther."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1103909","article-title":"dupA + H. pylori reduces diversity of gastric microbiome and increases risk of erosive gastritis","volume":"13","author":"Chen","year":"2023","journal-title":"Front. In Cell. Infect. Microbiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1007\/s12094-022-02875-y","article-title":"Characteristics of gut microbiota in patients with gastric cancer by surgery, chemotherapy and lymph node metastasis","volume":"24","author":"Chen","year":"2022","journal-title":"Clin. Trans. Oncol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1111\/jfds.2018.83.issue-12","article-title":"Baicalin, baicalein, and lactobacillus rhamnosus JB3 alleviated helicobacter pylori infections in vitro and in vivo","volume":"83","author":"Chen","year":"2018","journal-title":"J. Food Sci."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01261","article-title":"Mucosa-associated microbiota in gastric cancer tissues compared with non-cancer tissues","volume":"10","author":"Chen","year":"2019","journal-title":"Front. In Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"188826","DOI":"10.1016\/j.bbcan.2022.188826","article-title":"The microbiota and aging microenvironment in pancreatic cancer: Cell origin and fate","volume":"1877","author":"Chen","year":"2022","journal-title":"Biochim. Et Biophys. Acta Rev. On Cancer"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.844401","article-title":"Association of the microbiota and pancreatic cancer: opportunities and limitations","volume":"13","author":"Chen","year":"2022","journal-title":"Front. In Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.3390\/pharmaceutics14122745","article-title":"How Charge, Size and Protein Corona Modulate the Specific Activity of Nanostructured Lipid Carriers (NLC) against Helicobacter pylori","volume":"14","author":"Chitas","year":"2022","journal-title":"Pharmaceutics"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02014-23","article-title":"Control of Helicobacter pylori with engineered probiotics secreting selective guided antimicrobial peptides","volume":"11","author":"Choudhury","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1136\/gutjnl-2017-314281","article-title":"Mucosal microbiome dysbiosis in gastric carcinogenesis","volume":"67","author":"Coker","year":"2018","journal-title":"Gut"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1007\/s13238-018-0596-6","article-title":"Tongue coating microbiome as a potential biomarker for gastritis including precancerous cascade","volume":"10","author":"Cui","year":"2019","journal-title":"Protein Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.ccell.2021.08.006","article-title":"Microbiome and cancer","volume":"39","author":"Cullin","year":"2021","journal-title":"Cancer Cell"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/s41419-021-04396-y","article-title":"Interactions between gastric microbiota and metabolites in gastric cancer","volume":"12","author":"Dai","year":"2021","journal-title":"Cell Death Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0140-6736(70)90926-8","article-title":"Virus-like particles in serum of patients with Australia-antigen-associated hepatitis","volume":"1","author":"Dane","year":"1970","journal-title":"Lancet (London England)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1158\/1078-0432.CCR-20-4918","article-title":"Fecal microbiota transplantation from overweight or obese donors in cachectic patients with advanced gastroesophageal cancer: A randomized, double-blind, placebo-controlled, phase II study","volume":"27","author":"De Clercq","year":"2021","journal-title":"Clin. Cancer Res.: an Off. J. Am. Assoc. For Cancer Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1186\/s12964-023-01265-3","article-title":"Capsaicin orchestrates metastasis in gastric cancer via modulating expression of TRPV1 channels and driving gut microbiota disorder","volume":"21","author":"Deng","year":"2023","journal-title":"Cell Commun. Signal.: CCS"},{"key":"B37","doi-asserted-by":"publisher","first-page":"11250","DOI":"10.1039\/D0NR07981B","article-title":"Se@Albumin nanoparticles ameliorate intestinal mucositis caused by cisplatin via gut microbiota-targeted regulation","volume":"13","author":"Deng","year":"2021","journal-title":"Nanoscale"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.631140","article-title":"Low bifidobacterium abundance in the lower gut microbiota is associated with helicobacter pylori-related gastric ulcer and gastric cancer","volume":"12","author":"Devi","year":"2021","journal-title":"Front. In Microbiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"116134","DOI":"10.1016\/j.bcp.2024.116134","article-title":"Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis","volume":"223","author":"Di Giorgio","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.09.015","article-title":"A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors","volume":"185","author":"Dohlman","year":"2022","journal-title":"Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2105102","DOI":"10.1080\/19490976.2022.2105102","article-title":"Helicobacter pylori actively suppresses innate immune nucleic acid receptors","volume":"14","author":"Dooyema","year":"2022","journal-title":"Gut Microbes"},{"key":"B42","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1128\/IAI.66.12.6054-6057.1998","article-title":"Invasion of human oral epithelial cells by Prevotella intermedia","volume":"66","author":"Dorn","year":"1998","journal-title":"Infect. Immun."},{"key":"B43","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ejpb.2020.12.004","article-title":"Understanding the role of colon-specific microparticles based on retrograded starch\/pectin in the delivery of chitosan nanoparticles along the gastrointestinal tract","volume":"158","author":"Dos Santos","year":"2021","journal-title":"Eur. J. Pharma. Biopharma."},{"key":"B44","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1126\/science.1162986","article-title":"Real-time DNA sequencing from single polymerase molecules","volume":"323","author":"Eid","year":"2009","journal-title":"Sci. (New York N.Y.)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1372982","article-title":"The postbiotic sodium butyrate synergizes the antiproliferative effects of dexamethasone against the AGS gastric adenocarcinoma cells","volume":"11","author":"Eladwy","year":"2024","journal-title":"Front. In Nutr."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.3390\/nu14173458","article-title":"Co-Microencapsulation of Anthocyanins from Cornelian Cherry (Cornus mas L.) Fruits and Lactic Acid Bacteria into Antioxidant and Anti-Proliferative Derivative Powders","volume":"14","author":"Enache","year":"2022","journal-title":"Nutrients"},{"key":"B47","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/S0140-6736(64)91524-7","article-title":"Virus particles in cultured lymphoblasts from Burkitt\u2019s lymphoma","volume":"1","author":"Epstein","year":"1964","journal-title":"Lancet (London England)"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1136\/gutjnl-2019-319188","article-title":"Influence of gastrectomy for gastric cancer treatment on faecal microbiome and metabolome profiles","volume":"69","author":"Erawijantari","year":"2020","journal-title":"Gut"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.07.003","article-title":"Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation","volume":"185","author":"Federici","year":"2022","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1327893","article-title":"Association between oral microbiome and seven types of cancers in East Asian population: a two-sample Mendelian randomization analysis","volume":"10","author":"Feng","year":"2023","journal-title":"Front. In Mol. Biosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/gutjnl-2017-314205","article-title":"Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota","volume":"67","author":"Ferreira","year":"2018","journal-title":"Gut"},{"key":"B52","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.1073\/pnas.0504927102","article-title":"Activation of beta-catenin by carcinogenic Helicobacter pylori","volume":"102","author":"Franco","year":"2005","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B53","doi-asserted-by":"publisher","first-page":"29762","DOI":"10.1038\/srep29762","article-title":"Persisting and increasing neutrophil infiltration associates with gastric carcinogenesis and E-cadherin downregulation","volume":"6","author":"Fu","year":"2016","journal-title":"Sci. Rep."},{"key":"B54","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0378-1097(02)00916-3","article-title":"Cloning and characterization of the L-cysteine desulfhydrase gene of Fusobacterium nucleatum","volume":"215","author":"Fukamachi","year":"2002","journal-title":"FEMS Microbiol. Lett."},{"key":"B55","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/apt.15675","article-title":"Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions","volume":"51","author":"Gantuya","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B56","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3390\/nu15224738","article-title":"Predicting personalized diets based on microbial characteristics between patients with superficial gastritis and atrophic gastritis","volume":"15","author":"Gao","year":"2023","journal-title":"Nutrients"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00202","article-title":"Association between gut microbiota and helicobacter pylori-related gastric lesions in a high-risk population of gastric cancer","volume":"8","author":"Gao","year":"2018","journal-title":"Front. In Cell. Infect. Microbiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"5716","DOI":"10.1039\/D1NR08513A","article-title":"Magneto-optical hyperthermia agents based on probiotic bacteria loaded with magnetic and gold nanoparticles","volume":"14","author":"Garc\u00e9s","year":"2022","journal-title":"Nanoscale"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02326","article-title":"Lactobacillus gasseri Suppresses the Production of Proinflammatory Cytokines in Helicobacter pylori-Infected Macrophages by Inhibiting the Expression of ADAM17","volume":"10","author":"Gebremariam","year":"2019","journal-title":"Front. In Immunol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade0997","article-title":"Biointerface mineralization generates ultraresistant gut microbes as oral biotherapeutics","volume":"9","author":"Geng","year":"2023","journal-title":"Sci. Adv."},{"key":"B61","doi-asserted-by":"publisher","first-page":"S73","DOI":"10.1079\/BJN2002632","article-title":"Diet and cancer: assessing the risk","author":"Gill","year":"2002","journal-title":"Br. J. Nutr."},{"key":"B62","doi-asserted-by":"publisher","first-page":"G981","DOI":"10.1152\/ajpgi.2000.278.6.G981","article-title":"Inhibition of human gastric H(+)-K(+)-ATPase alpha-subunit gene expression by Helicobacter pylori","volume":"278","author":"G\u00f6\u00f5z","year":"2000","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/nu13082692","article-title":"Effect of the interaction between dietary patterns and the gastric microbiome on the risk of gastric cancer","volume":"13","author":"Gunathilake","year":"2021","journal-title":"Nutrients"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1136\/gutjnl-2019-319696","article-title":"Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer","volume":"69","author":"Guo","year":"2020","journal-title":"Gut"},{"key":"B65","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1136\/gut.49.4.481","article-title":"Expression of human beta-defensin 2 (hBD-2) in Helicobacter pylori induced gastritis: antibacterial effect of hBD-2 against Helicobacter pylori","volume":"49","author":"Hamanaka","year":"2001","journal-title":"Gut"},{"key":"B66","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1365-2036.2007.03562.x","article-title":"Review article: the role of butyrate on colonic function","volume":"27","author":"Hamer","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"B67","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3390\/microorganisms8040465","article-title":"Cysteine residues in helicobacter pylori adhesin hopQ are required for CEACAM-hopQ interaction and subsequent cagA translocation","volume":"8","author":"Hamway","year":"2020","journal-title":"Microorganisms"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.v13.7","article-title":"The gut microbiome affects response of treatments in HER2-negative advanced gastric cancer","volume":"13","author":"Han","year":"2023","journal-title":"Clin. Trans. Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1128\/IAI.68.6.3140-3146.2000","article-title":"Interactions between periodontal bacteria and human oral epithelial cells: Fusobacterium nucleatum adheres to and invades epithelial cells","volume":"68","author":"Han","year":"2000","journal-title":"Infect. Immun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1002\/ijc.v151.10","article-title":"Progressive dysbiosis of human orodigestive microbiota along the sequence of gastroesophageal reflux, Barrett\u2019s esophagus and esophageal adenocarcinoma","volume":"151","author":"Hao","year":"2022","journal-title":"Int. J. Cancer"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12898","article-title":"Probiotics mitigate Helicobacter pylori-induced gastric inflammation and premalignant lesions in INS-GAS mice with the modulation of gastrointestinal microbiota","volume":"27","author":"He","year":"2022","journal-title":"Helicobacter"},{"key":"B72","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1186\/s12967-023-04599-1","article-title":"Oral microbiota disorder in GC patients revealed by 2b-RAD-M","volume":"21","author":"He","year":"2023","journal-title":"J. Trans. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1136\/gutjnl-2020-322780","article-title":"F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer","volume":"70","author":"Hong","year":"2021","journal-title":"Gut"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101810","article-title":"Decorating bacteria with a therapeutic nanocoating for synergistically enhanced biotherapy","volume":"17","author":"Hou","year":"2021","journal-title":"Small (Weinheim an Der Bergstrasse Germany)"},{"key":"B75","doi-asserted-by":"publisher","first-page":"7311","DOI":"10.3748\/wjg.v27.i42.7311","article-title":"Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients","volume":"27","author":"Hsieh","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41598-017-18596-0","article-title":"Increased abundance of clostridium and fusobacterium in gastric microbiota of patients with gastric cancer in Taiwan","volume":"8","author":"Hsieh","year":"2018","journal-title":"Sci. Rep."},{"key":"B77","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1002\/cncr.v128.17","article-title":"Fusobacterium nucleatum impairs DNA mismatch repair and stability in patients with squamous cell carcinoma of the head and neck","volume":"128","author":"Hsueh","year":"2022","journal-title":"Cancer"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.640309","article-title":"Salivary microbiota for gastric cancer prediction: an exploratory study","volume":"11","author":"Huang","year":"2021","journal-title":"Front. In Cell. Infect. Microbiol."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.940687","article-title":"Bile reflux alters the profile of the gastric mucosa microbiota","volume":"12","author":"Huang","year":"2022","journal-title":"Front. In Cell. Infect. Microbiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1177\/153537020422900702","article-title":"Commensal bacteria, redox stress, and colorectal cancer: mechanisms and models","volume":"229","author":"Huycke","year":"2004","journal-title":"Exp. Biol. Med. (Maywood N.J.)"},{"key":"B81","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Sci. (New York N.Y.)"},{"key":"B82","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.ccell.2014.10.006","article-title":"Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia","volume":"26","author":"Jain","year":"2014","journal-title":"Cancer Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2044721","DOI":"10.1080\/19490976.2022.2044721","article-title":"Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori","volume":"14","author":"Jang","year":"2022","journal-title":"Gut Microbes"},{"key":"B84","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3390\/ph14040329","article-title":"Metformin modifies the gut microbiota of mice infected with helicobacter pylori","volume":"14","author":"Jauvain","year":"2021","journal-title":"Pharma. (Basel Switzerland)"},{"key":"B85","doi-asserted-by":"publisher","first-page":"16189","DOI":"10.1038\/nmicrobiol.2016.189","article-title":"Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs","volume":"2","author":"Javaheri","year":"2016","journal-title":"Nat. Microbiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2120744","DOI":"10.1080\/19490976.2022.2120744","article-title":"Deoxycholic acid induces gastric intestinal metaplasia by activating STAT3 signaling and disturbing gastric bile acids metabolism and microbiota","volume":"14","author":"Jin","year":"2022","journal-title":"Gut Microbes"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006631","article-title":"The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut","volume":"13","author":"Jones","year":"2017","journal-title":"PloS Pathog."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01780","article-title":"Characteristics of the salivary microbiota in patients with various digestive tract cancers","volume":"10","author":"Kageyama","year":"2019","journal-title":"Front. In Microbiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.chom.2015.03.005","article-title":"Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function","volume":"17","author":"Kelly","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B90","doi-asserted-by":"publisher","first-page":"4981. K","DOI":"10.3390\/nu14234981","article-title":"Altered gastric microbiota and inflammatory cytokine responses in patients with helicobacter pylori-negative gastric cancer","volume":"14","author":"Kim","year":"2022","journal-title":"Nutrients"},{"key":"B91","doi-asserted-by":"publisher","first-page":"101251","DOI":"10.1016\/j.xcrm.2023.101251","article-title":"Prior antibiotic administration disrupts anti-PD-1 responses in advanced gastric cancer by altering the gut microbiome and systemic immune response","volume":"4","author":"Kim","year":"2023","journal-title":"Cell Reports. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1053\/gast.2002.34751","article-title":"Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells","volume":"123","author":"Kim","year":"2002","journal-title":"Gastroenterology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1080\/19490976.2015.1105427","article-title":"Helicobacter pylori activates the TLR2\/NLRP3\/caspase-1\/IL-18 axis to induce regulatory T-cells, establish persistent infection and promote tolerance to allergens","volume":"6","author":"Koch","year":"2015","journal-title":"Gut Microbes"},{"key":"B94","doi-asserted-by":"publisher","first-page":"ftac005","DOI":"10.1093\/femspd\/ftac005","article-title":"Cordycepin exhibits anti-bacterial and anti-inflammatory effects against gastritis in Helicobacter pylori-infected mice","volume":"80","author":"Kong","year":"2022","journal-title":"Pathog. Dis."},{"key":"B95","first-page":"483","article-title":"Emerging role of fecal microbiota therapy in the treatment of gastrointestinal and extra-gastrointestinal diseases","volume":"66","author":"Konturek","year":"2015","journal-title":"J. Physiol. Pharmacol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2300846","DOI":"10.1080\/19490976.2023.2300846","article-title":"Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer","volume":"16","author":"Lee","year":"2024","journal-title":"Gut Microbes"},{"key":"B97","doi-asserted-by":"publisher","first-page":"4640","DOI":"10.1038\/s41598-023-31740-3","article-title":"Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer","volume":"13","author":"Lehr","year":"2023","journal-title":"Sci. Rep."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00089-24","article-title":"Distinct oral-associated gastric microbiota and Helicobacter pylori communities for spatial microbial heterogeneity in gastric cancer","volume":"9","author":"Lei","year":"2024","journal-title":"MSystems"},{"key":"B99","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1136\/gutjnl-2013-305178","article-title":"Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis","volume":"63","author":"Lertpiriyapong","year":"2014","journal-title":"Gut"},{"key":"B100","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1089\/ars.2008.2109","article-title":"Role of oxidative stress in pancreatic inflammation","volume":"11","author":"Leung","year":"2009","journal-title":"Antioxid. Redox Signaling"},{"key":"B101","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/cr.2007.115","article-title":"Mechanisms and functions of DNA mismatch repair","volume":"18","author":"Li","year":"2008","journal-title":"Cell Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1186\/s40168-021-01086-x","article-title":"Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype","volume":"9","author":"Li","year":"2021","journal-title":"Microbiome"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.781697","article-title":"The relationship between gut microbiome features and chemotherapy response in gastrointestinal cancer","volume":"11","author":"Li","year":"2021","journal-title":"Front. In Oncol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41586-022-04502-w","article-title":"Immune regulation by fungal strain diversity in inflammatory bowel disease","volume":"603","author":"Li","year":"2022","journal-title":"Nature"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1007\/s10120-021-01202-8","article-title":"Propionibacterium acnes overabundance in gastric cancer promote M2 polarization of macrophages via a TLR4\/PI3K\/Akt signaling","volume":"24","author":"Li","year":"2021","journal-title":"Gastric Cancer"},{"key":"B106","doi-asserted-by":"publisher","first-page":"2192501","DOI":"10.1080\/19490976.2023.2192501","article-title":"YAP and \u03b2-catenin cooperate to drive H. pylori-induced gastric tumorigenesis","volume":"15","author":"Li","year":"2023","journal-title":"Gut Microbes"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00533","article-title":"Regulatory T cells and plasmacytoid dendritic cells within the tumor microenvironment in gastric cancer are correlated with gastric microbiota dysbiosis: A preliminary study","volume":"10","author":"Ling","year":"2019","journal-title":"Front. In Immunol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1002\/1878-0261.13280","article-title":"Probiotic Lactobacillus rhamnosus GG (LGG) restrains the angiogenic potential of colorectal carcinoma cells by activating a proresolving program via formyl peptide receptor 1","volume":"16","author":"Liotti","year":"2022","journal-title":"Mol. Oncol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1038\/s42255-021-00502-8","article-title":"Microbial metabolite delta-valerobetaine is a diet-dependent obesogen","volume":"3","author":"Liu","year":"2021","journal-title":"Nat. Metab."},{"key":"B110","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.ebiom.2018.12.034","article-title":"Alterations of gastric mucosal microbiota across different stomach microhabitats in a cohort of 276 patients with gastric cancer","volume":"40","author":"Liu","year":"2019","journal-title":"EBioMedicine"},{"key":"B111","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1038\/s41564-019-0541-3","article-title":"Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity","volume":"4","author":"Long","year":"2019","journal-title":"Nat. Microbiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"156161","DOI":"10.1016\/j.phymed.2024.156161","article-title":"Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy","volume":"135","author":"Lu","year":"2024","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"e007699","DOI":"10.1136\/jitc-2023-007699","article-title":"Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors","volume":"11","author":"Magahis","year":"2023","journal-title":"J. For Immunother. Cancer"},{"key":"B114","doi-asserted-by":"publisher","first-page":"2186677","DOI":"10.1080\/19490976.2023.2186677","article-title":"Shotgun metagenomics of gastric biopsies reveals compositional and functional microbiome shifts in high- and low-gastric-cancer-risk populations from Colombia, South America","volume":"15","author":"Mannion","year":"2023","journal-title":"Gut Microbes"},{"key":"B115","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1172\/JCI126744","article-title":"Epithelial HIF-1\u03b1\/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis","volume":"129","author":"Masterson","year":"2019","journal-title":"J. Clin. Invest."},{"key":"B117","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrg2626","article-title":"Sequencing technologies - the next generation","volume":"11","author":"Metzker","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"B118","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1177\/1724600820914935","article-title":"The association of Helicobacter pylori CagA EPIYA motifs and vacA genotypes with homologous recombination repair markers during the gastric precancerous cascade","volume":"35","author":"Mi","year":"2020","journal-title":"Int. J. Biol. Markers"},{"key":"B119","doi-asserted-by":"publisher","first-page":"2015238","DOI":"10.1080\/19490976.2021.2015238","article-title":"Autophagy mediates ER stress and inflammation in Helicobacter pylori-related gastric cancer","volume":"14","author":"Mommersteeg","year":"2022","journal-title":"Gut Microbes"},{"key":"B120","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nrmicro2970","article-title":"Shallow breathing: bacterial life at low O(2)","volume":"11","author":"Morris","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2108655","DOI":"10.1080\/19490976.2022.2108655","article-title":"The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management","volume":"14","author":"Nabavi-Rad","year":"2022","journal-title":"Gut Microbes"},{"key":"B122","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type-specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Sci. (New York N.Y.)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2263936","DOI":"10.1080\/19490976.2023.2263936","article-title":"Targeting hypoxia-inducible factor-1 alpha suppresses Helicobacter pylori-induced gastric injury via attenuation of both cag-mediated microbial virulence and proinflammatory host responses","volume":"15","author":"Noto","year":"2023","journal-title":"Gut Microbes"},{"key":"B124","doi-asserted-by":"publisher","first-page":"e147822","DOI":"10.1172\/JCI147822","article-title":"Iron deficiency linked to altered bile acid metabolism promotes Helicobacter pylori-induced inflammation-driven gastric carcinogenesis","volume":"132","author":"Noto","year":"2022","journal-title":"J. Clin. Invest."},{"key":"B125","doi-asserted-by":"publisher","first-page":"e00955-19","DOI":"10.1128\/mBio.00955-19","article-title":"Modification of the gastric mucosal microbiota by a strain-specific helicobacter pylori oncoprotein and carcinogenic histologic phenotype","volume":"10","author":"Noto","year":"2019","journal-title":"MBio"},{"key":"B126","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00394-009-0030-1","article-title":"Ability of probiotic Lactobacillus casei DN 114001 to bind or\/and metabolise heterocyclic aromatic amines in vitro","volume":"48","author":"Nowak","year":"2009","journal-title":"Eur. J. Nutr."},{"key":"B127","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1007\/s00394-017-1436-9","article-title":"The preliminary study of prebiotic potential of Polish wild mushroom polysaccharides: the stimulation effect on Lactobacillus strains growth","volume":"57","author":"Nowak","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1126\/science.287.5457.1497","article-title":"Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion","volume":"287","author":"Odenbreit","year":"2000","journal-title":"Sci. (New York N.Y.)"},{"key":"B129","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/hel.2016.21.issue-3","article-title":"The Effect of Probiotics on Gut Microbiota during the Helicobacter pylori Eradication: Randomized Controlled Trial","volume":"21","author":"Oh","year":"2016","journal-title":"Helicobacter"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1073\/pnas.0711183105","article-title":"Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse","volume":"105","author":"Ohnishi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B131","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3390\/molecules26020433","article-title":"Pectin-based formulations for controlled release of an ellagic acid salt with high solubility profile in physiological media","volume":"26","author":"Ortenzi","year":"2021","journal-title":"Mol. (Basel Switzerland)"},{"key":"B132","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1136\/gutjnl-2020-323392","article-title":"Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies","volume":"71","author":"Oster","year":"2022","journal-title":"Gut"},{"key":"B133","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3322\/canjclin.17.4.183","article-title":"St. Peregrine, O.S.M.\u2013the patron saint of cancer patients","volume":"17","author":"Pack","year":"1967","journal-title":"CA: A Cancer J. For Clinic."},{"key":"B134","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1038\/s41467-020-16967-2","article-title":"Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression","volume":"11","author":"Parhi","year":"2020","journal-title":"Nat. Commun."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006653","article-title":"Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use","volume":"13","author":"Parsons","year":"2017","journal-title":"PloS Pathog."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1158\/2326-6066.CIR-22-0107","article-title":"Gastric microbiome alterations are associated with decreased CD8+ Tissue-resident memory T cells in the tumor microenvironment of gastric cancer","volume":"10","author":"Peng","year":"2022","journal-title":"Cancer Immunol. Res."},{"key":"B137","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.cardiores.2004.07.012","article-title":"Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice","volume":"64","author":"Peng","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"2323235","DOI":"10.1080\/19490976.2024.2323235","article-title":"A metatranscriptomics strategy for efficient characterization of the microbiome in human tissues with low microbial biomass","volume":"16","author":"Pereira-Marques","year":"2024","journal-title":"Gut Microbes"},{"key":"B139","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nrc3773","article-title":"Inside and out: the activities of senescence in cancer","volume":"14","author":"P\u00e9rez-Mancera","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"B140","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13046-022-02366-6","article-title":"A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces Malignancy progression","volume":"41","author":"Piao","year":"2022","journal-title":"J. Exp. Clin. Cancer Res.: CR"},{"key":"B141","doi-asserted-by":"publisher","first-page":"48","DOI":"10.7150\/thno.65302","article-title":"Mucosal microbiome associates with progression to gastric cancer","volume":"12","author":"Png","year":"2022","journal-title":"Theranostics"},{"key":"B142","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1007\/s00210-024-03043-5","article-title":"Urolithin A exerts anti-tumor effects on gastric cancer via activating autophagy-Hippo axis and modulating the gut microbiota","volume":"397","author":"Qiao","year":"2024","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1080\/19490976.2019.1710092","article-title":"Helicobacter pylori antibiotic eradication coupled with a chemically defined diet in INS-GAS mice triggers dysbiosis and vitamin K deficiency resulting in gastric hemorrhage","volume":"11","author":"Quinn","year":"2020","journal-title":"Gut Microbes"},{"key":"B144","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1093\/nar\/26.23.5358","article-title":"Preselection of shotgun clones by oligonucleotide fingerprinting: an efficient and high throughput strategy to reduce redundancy in large-scale sequencing projects","volume":"26","author":"Radelof","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"B145","doi-asserted-by":"publisher","first-page":"9735","DOI":"10.3390\/ijms21249735","article-title":"Gastric adenocarcinomas and signet-ring cell carcinoma: unraveling gastric cancer complexity through microbiome analysis-deepening heterogeneity for a personalized therapy","volume":"21","author":"Ravegnini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/19490976.2016.1150414","article-title":"Taurocholic acid metabolism by gut microbes and colon cancer","volume":"7","author":"Ridlon","year":"2016","journal-title":"Gut Microbes"},{"key":"B147","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.3390\/nu12082345","article-title":"The Facts about Food after Cancer Diagnosis: A Systematic Review of Prospective Cohort Studies","volume":"12","author":"Rinninella","year":"2020","journal-title":"Nutrients"},{"key":"B148","doi-asserted-by":"crossref","first-page":"G795","DOI":"10.1152\/ajpgi.00431.2007","article-title":"Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding","volume":"294","author":"Saha","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","article-title":"DNA sequencing with chain-terminating inhibitors","volume":"74","author":"Sanger","year":"1977","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1002\/mc.22590","article-title":"Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway","volume":"56","author":"Santos","year":"2017","journal-title":"Mol. Carcinogen."},{"key":"B151","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ejpb.2018.02.030","article-title":"Lipid nanoparticles to counteract gastric infection without affecting gut microbiota","volume":"127","author":"Seabra","year":"2018","journal-title":"Eur. J. Pharma. Biopharma."},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1196084","article-title":"Lactobacillus acidophilus NCFM and Lactiplantibacillus plantarum Lp-115 inhibit Helicobacter pylori colonization and gastric inflammation in a murine model","volume":"13","author":"Shen","year":"2023","journal-title":"Front. In Cell. Infect. Microbiol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00535-012-0592-1","article-title":"How Helicobacter pylori infection controls gastric acid secretion","volume":"47","author":"Smolka","year":"2012","journal-title":"J. Gastroenterol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/357011a0","article-title":"Coley\u2019s toxins in perspective","volume":"357","author":"Starnes","year":"1992","journal-title":"Nature"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168050","article-title":"Rhamnogalacturonan-I based microcapsules for targeted drug release","volume":"11","author":"Svagan","year":"2016","journal-title":"PloS One"},{"key":"B156","doi-asserted-by":"publisher","first-page":"2130650","DOI":"10.1080\/19490976.2022.2130650","article-title":"Helicobacter pylori employs a general protein glycosylation system for the modification of outer membrane adhesins","volume":"14","author":"Teng","year":"2022","journal-title":"Gut Microbes"},{"key":"B157","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.jand.2023.07.008","article-title":"Prebiotics and the risk of upper digestive tract and stomach cancers: the prebiotiCa study","volume":"123","author":"Turati","year":"2023","journal-title":"J. Acad. Nutr. Diet."},{"key":"B158","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.foodchem.2015.04.029","article-title":"Increased oxidative and nitrosative reactions during digestion could contribute to the association between well-done red meat consumption and colorectal cancer","volume":"187","author":"Van Hecke","year":"2015","journal-title":"Food Chem."},{"key":"B159","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1146\/annurev-food-081315-032749","article-title":"A critical look at prebiotics within the dietary fiber concept","volume":"7","author":"Verspreet","year":"2016","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1046\/j.1462-5822.2001.00096.x","article-title":"Helicobacter pylori-mediated transcriptional regulation of the human beta-defensin 2 gene requires NF-kappaB","volume":"3","author":"Wada","year":"2001","journal-title":"Cell. Microbiol."},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200263","article-title":"Bile acid-microbiome interaction promotes gastric carcinogenesis","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci. (Weinheim Baden-Wurttemberg Germany)"},{"key":"B162","doi-asserted-by":"publisher","first-page":"2369336","DOI":"10.1080\/19490976.2024.2369336","article-title":"Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacy","volume":"16","author":"Wang","year":"2024","journal-title":"Gut Microbes"},{"key":"B163","doi-asserted-by":"publisher","first-page":"107148","DOI":"10.1016\/j.phrs.2024.107148","article-title":"The interactions between traditional Chinese medicine and gut microbiota in cancers: Current status and future perspectives","volume":"203","author":"Wei","year":"2024","journal-title":"Pharmacol. Res."},{"key":"B164","doi-asserted-by":"publisher","first-page":"10543","DOI":"10.1038\/s41467-024-54850-6","article-title":"Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression","volume":"15","author":"Wen","year":"2024","journal-title":"Nat. Commun."},{"key":"B165","doi-asserted-by":"publisher","first-page":"5032","DOI":"10.1039\/D3FO00099K","article-title":"Phenyl lactic acid alleviates Helicobacter pylori infection in C57BL\/6 mice","volume":"14","author":"Wu","year":"2023","journal-title":"Food Funct."},{"key":"B166","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1186\/s12964-024-01888-0","article-title":"Oncolytic avian reovirus-sensitized tumor infiltrating CD8+ T cells triggering immunogenic apoptosis in gastric cancer","volume":"22","author":"Wu","year":"2024","journal-title":"Cell Commun. Signal.: CCS"},{"key":"B167","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.7150\/jca.25280","article-title":"Tongue coating microbiota community and risk effect on gastric cancer","volume":"9","author":"Wu","year":"2018","journal-title":"J. Cancer"},{"key":"B168","doi-asserted-by":"publisher","first-page":"107476","DOI":"10.1016\/j.phrs.2024.107476","article-title":"Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer","volume":"209","author":"Wu","year":"2024","journal-title":"Pharmacol. Res."},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12786","article-title":"Helicobacter pylori infection is associated with the co-occurrence of bacteria in the oral cavity and the gastric mucosa","volume":"26","author":"Wu","year":"2021","journal-title":"Helicobacter"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12899","article-title":"Influences of Helicobacter pylori infection on diversity, heterogeneity, and composition of human gastric microbiomes across stages of gastric cancer development","volume":"27","author":"Xiao","year":"2022","journal-title":"Helicobacter"},{"key":"B171","doi-asserted-by":"publisher","first-page":"e28761","DOI":"10.1002\/jmv.28761","article-title":"Integration and viral oncogene expression of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma and gastric cancer","volume":"95","author":"Xu","year":"2023","journal-title":"J. Med. Virol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"107278","DOI":"10.1016\/j.phrs.2024.107278","article-title":"Akkermansia muciniphila-derived pentadecanoic acid enhances oxaliplatin sensitivity in gastric cancer by modulating glycolysis","volume":"206","author":"Xu","year":"2024","journal-title":"Pharmacol. Res."},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.11.051","article-title":"Microbial biomarkers of common tongue coatings in patients with gastric cancer","volume":"127","author":"Xu","year":"2019","journal-title":"Microb. Pathogen."},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1160821","article-title":"Alteration of gastric microbiota and transcriptome in a rat with gastric intestinal metaplasia induced by deoxycholic acid","volume":"14","author":"Xu","year":"2023","journal-title":"Front. In Microbiol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"25000","DOI":"10.1074\/jbc.M611567200","article-title":"FadA from Fusobacterium nucleatum utilizes both secreted and nonsecreted forms for functional oligomerization for attachment and invasion of host cells","volume":"282","author":"Xu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B176","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/ijc.v150.6","article-title":"Prospective study of oral microbiome and gastric cancer risk among Asian, African American and European American populations","volume":"150","author":"Yang","year":"2022","journal-title":"Int. J. Cancer"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.847610","article-title":"Mechanical bowel preparation is a risk factor for postoperative delirium as it alters the gut microbiota composition: A prospective randomized single-center study","volume":"14","author":"Yang","year":"2022","journal-title":"Front. In Aging Neurosci."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1111\/cas.v114.3","article-title":"Prognostic effects of the gastric mucosal microbiota in gastric cancer","volume":"114","author":"Yang","year":"2023","journal-title":"Cancer Sci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"e006280.","DOI":"10.1136\/jitc-2022-006280","article-title":"Development of the oncolytic virus, CF33, and its derivatives for peritoneal-directed treatment of gastric cancer peritoneal metastases","volume":"11","author":"Yang","year":"2023","journal-title":"J. For Immunother. Cancer"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947080","article-title":"Genetic mutation and tumor microbiota determine heterogenicity of tumor immune signature: Evidence from gastric and colorectal synchronous cancers","volume":"13","author":"Yang","year":"2022","journal-title":"Front. In Immunol."},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.641322","article-title":"Role of the gastric microbiome in gastric cancer: from carcinogenesis to treatment","volume":"12","author":"Yang","year":"2021","journal-title":"Front. In Microbiol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"104347","DOI":"10.1016\/j.ebiom.2022.104347","article-title":"Roux-en-Y reconstruction alleviates radical gastrectomy-induced colitis via down-regulation of the butyrate\/NLRP3 signaling pathway","volume":"86","author":"Yao","year":"2022","journal-title":"EBioMedicine"},{"key":"B183","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s42255-019-0045-8","article-title":"Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy","volume":"1","author":"Ye","year":"2019","journal-title":"Nat. Metab."},{"key":"B184","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1007\/s12602-023-10073-7","article-title":"Probiotics influence gut microbiota and tumor immune microenvironment to enhance anti-tumor efficacy of doxorubicin","volume":"16","author":"Ye","year":"2024","journal-title":"Probiot. Antimicrob. Proteins"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206957","article-title":"Gastric Acid-Responsive ROS Nanogenerators for Effective Treatment of Helicobacter pylori Infection without Disrupting Homeostasis of Intestinal Flora","volume":"10","author":"Yu","year":"2023","journal-title":"Adv. Sci. (Weinheim Baden-Wurttemberg Germany)"},{"key":"B186","doi-asserted-by":"publisher","first-page":"2307542","DOI":"10.1080\/19490976.2024.2307542","article-title":"Gut microbiota modulate CD8+ T cell immunity in gastric cancer through Butyrate\/GPR109A\/HOPX","volume":"16","author":"Yu","year":"2024","journal-title":"Gut Microbes"},{"key":"B187","doi-asserted-by":"publisher","first-page":"110036","DOI":"10.1016\/j.biopha.2020.110036","article-title":"Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats","volume":"126","author":"Yu","year":"2020","journal-title":"Biomed. Pharmacother. = Biomed. Pharmacother."},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02994-21","article-title":"Fecal streptococcus alteration is associated with gastric cancer occurrence and liver metastasis","volume":"12","author":"Yu","year":"2021","journal-title":"MBio"},{"key":"B189","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s12602-021-09795-3","article-title":"Probiotic therapy (BIO-THREE) mitigates intestinal microbial imbalance and intestinal damage caused by oxaliplatin","volume":"14","author":"Yuan","year":"2022","journal-title":"Probiot. Antimicrob. Proteins"},{"key":"B190","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1111\/febs.v287.18","article-title":"Fusobacterium nucleatum promotes epithelial-mesenchymal transiton through regulation of the lncRNA MIR4435-2HG\/miR-296-5p\/Akt2\/SNAI1 signaling pathway","volume":"287","author":"Zhang","year":"2020","journal-title":"FEBS J."},{"key":"B191","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.3748\/wjg.v16.i23.2881","article-title":"Expression and significance of TLR4 and HIF-1alpha in pancreatic ductal adenocarcinoma","volume":"16","author":"Zhang","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202105738","article-title":"Metal-organic-framework-based hydrogen-release platform for multieffective helicobacter pylori targeting therapy and intestinal flora protective capabilities","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater. (Deerfield Beach Fla.)"},{"key":"B193","doi-asserted-by":"publisher","first-page":"11061","DOI":"10.1039\/D2FO02034C","article-title":"Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori infection in C57BL\/6 mice","volume":"13","author":"Zhao","year":"2022","journal-title":"Food Funct."},{"key":"B194","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12935-024-03215-6","article-title":"Modified Gexia-Zhuyu Tang inhibits gastric cancer progression by restoring gut microbiota and regulating pyroptosis","volume":"24","author":"Zhao","year":"2024","journal-title":"Cancer Cell Int."},{"key":"B195","doi-asserted-by":"publisher","first-page":"6294","DOI":"10.1039\/D1FO01375K","article-title":"Adjuvant treatment and molecular mechanism of probiotic compounds in patients with gastric cancer after gastrectomy","volume":"12","author":"Zheng","year":"2021","journal-title":"Food Funct."},{"key":"B196","doi-asserted-by":"publisher","first-page":"568","DOI":"10.7150\/jca.29072","article-title":"A randomised trial of probiotics to reduce severity of physiological and microbial disorders induced by partial gastrectomy for patients with gastric cancer","volume":"10","author":"Zheng","year":"2019","journal-title":"J. Cancer"},{"key":"B197","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.4049\/jimmunol.1700105","article-title":"Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2","volume":"199","author":"Zheng","year":"2017","journal-title":"J. Immunol. (Baltimore Md.: 1950)"},{"key":"B198","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1021\/acs.jafc.0c07597","article-title":"Vitamin B12 enriched in spinach and its effects on gut microbiota","volume":"69","author":"Zheng","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"B199","doi-asserted-by":"publisher","first-page":"4945","DOI":"10.7150\/thno.55209","article-title":"Candida albicans disorder is associated with gastric carcinogenesis","volume":"11","author":"Zhong","year":"2021","journal-title":"Theranostics"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.02.015","article-title":"Fecal Signatures of Streptococcus anginosus and Streptococcus constellatus for Noninvasive Screening and Early Warning of Gastric Cancer","volume":"162","author":"Zhou","year":"2022","journal-title":"Gastroenterology"},{"key":"B201","doi-asserted-by":"publisher","first-page":"155413","DOI":"10.1016\/j.phymed.2024.155413","article-title":"Gut microbiota-dependent modulation of pre-metastatic niches by Jianpi Yangzheng decoction in the prevention of lung metastasis of gastric cancer","volume":"128","author":"Zhu","year":"2024","journal-title":"Phytomed.: Int. J. Phytother. Phytopharmacol."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1563061\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T05:22:51Z","timestamp":1748928171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1563061\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":201,"alternative-id":["10.3389\/fcimb.2025.1563061"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2025.1563061","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"article-number":"1563061"}}