{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:11:28Z","timestamp":1770815488651,"version":"3.50.1"},"reference-count":117,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Bone marrow is vital for hematopoiesis, producing blood cells essential for oxygen transport, immune defense, and clotting. However, disorders like leukemia, lymphoma, aplastic anemia, and myelodysplastic syndromes can severely disrupt its function, leading to life-threatening complications. Traditional treatments, including chemotherapy and stem cell transplants, have significantly improved patient outcomes but are often associated with severe side effects and limitations, necessitating the exploration of safer, more targeted therapeutic strategies. Nanotechnology has emerged as a promising approach for addressing these challenges, particularly in the delivery of nutraceuticals\u2014bioactive compounds derived from food sources with potential therapeutic benefits. Despite their promise, nutraceuticals often face clinical limitations due to poor bioavailability, instability, and inefficient delivery to target sites. Nanoparticles offer a viable solution by enhancing the stability, absorption, and targeted transport of nutraceuticals to bone marrow while minimizing systemic side effects. This study explores a range of bone marrow disorders, conventional treatment modalities, and the potential of nanoparticles to enhance nutraceutical-based therapies. By improving targeted delivery and therapeutic efficacy, nanoparticles could revolutionize bone marrow disease management, providing patients with more effective and less invasive treatment options. These advancements represent a significant step toward safer and more efficient therapeutic approaches, ultimately improving patient prognosis and overall health.<\/jats:p>","DOI":"10.3389\/fcimb.2025.1575798","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:14:39Z","timestamp":1744348479000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Probiotics and nanoparticle-mediated nutrient delivery in the management of transfusion-supported diseases"],"prefix":"10.3389","volume":"15","author":[{"given":"Wendao","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nating","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.bioactmat.2023.08.018","article-title":"Biofabrication methods for reconstructing extracellular matrix mimetics","volume":"31","author":"Aazmi","year":"2024","journal-title":"Bioact. Mater."},{"key":"B2","doi-asserted-by":"publisher","first-page":"15232","DOI":"10.1038\/s41598-023-42292-x","article-title":"Effect of calcium carbonate nanoparticles, silver nanoparticles and advanced platelet-rich fibrin for enhancing bone healing in a rabbit model","volume":"13","author":"Abd-Elkawi","year":"2023","journal-title":"Sci. Rep."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12050868","article-title":"Future modulation of gut microbiota: from eubiotics to FMT, engineered bacteria, and phage therapy","volume":"12","author":"Airola","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1788","DOI":"10.1002\/mgg3.1788","article-title":"Current status of beta-thalassemia and its treatment strategies","volume":"9","author":"Ali","year":"2021","journal-title":"Mol. Genet. Genomic Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"35251","DOI":"10.1039\/d3ra07391b","article-title":"Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review","volume":"13","author":"Alshangiti","year":"2023","journal-title":"RSC Adv."},{"key":"B6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10875-010-9457-7","article-title":"Lactobacillus casei reduces the inflammatory joint damage associated with collagen-induced arthritis (CIA) by reducing the pro-inflammatory cytokines: Lactobacillus casei: COX-2 inhibitor","volume":"31","author":"Amdekar","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s40204-019-00125-z","article-title":"Bone tissue regeneration: biology, strategies and interface studies","volume":"8","author":"Ansari","year":"2019","journal-title":"Prog. Biomater."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8063647","article-title":"Immunomodulatory effects of probiotics on cytokine profiles","volume":"2018","author":"Azad","year":"2018","journal-title":"BioMed. Res. Int."},{"key":"B9","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1182\/asheducation-2013.1.394","article-title":"Novel therapy for Hodgkin lymphoma","volume":"2013","author":"Batlevi","year":"2013","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031128","article-title":"Strategies for bone regeneration: from graft to tissue engineering","volume":"22","author":"Battafarano","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/biology13040237","article-title":"Bone tissue engineering and nanotechnology: A promising combination for bone regeneration","volume":"13","author":"Bauso","year":"2024","journal-title":"Biol. (Basel)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1146\/annurev-chembioeng-061010-114257","article-title":"Tissue engineering and regenerative medicine: history, progress, and challenges","volume":"2","author":"Berthiaume","year":"2011","journal-title":"Annu. Rev. Chem. Biomol Eng."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110698","article-title":"Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration","volume":"110","author":"Bharadwaz","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35775-3.00013-8","article-title":"Bone marrow, blood cells, and the lymphoid\/lymphatic system","volume":"724","author":"Boes","year":"2017","journal-title":"Pathol. Basis Vet. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1004588","DOI":"10.3389\/fnut.2022.1004588","article-title":"Recent advances in carrageenan-based films for food packaging applications","volume":"9","author":"Cheng","year":"2022","journal-title":"Front. Nutr."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nano10050875","article-title":"Bone diseases: current approach and future perspectives in drug delivery systems for bone targeted therapeutics","volume":"10","author":"Chindamo","year":"2020","journal-title":"Nanomater. (Basel)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.BAD-0015-2016","article-title":"The potential of probiotics as a therapy for osteoporosis","volume":"5","author":"Collins","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1182\/blood.v96.8.2691","article-title":"Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia","volume":"96","author":"Coustan-Smith","year":"2000","journal-title":"Blood"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.578386","article-title":"Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: A door to the body","volume":"12","author":"Cristofori","year":"2021","journal-title":"Front. Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bonr.2018.02.001","article-title":"Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance","volume":"8","author":"Dar","year":"2018","journal-title":"Bone Rep."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010529","article-title":"Existing and novel biomaterials for bone tissue engineering","volume":"24","author":"Dec","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119375","article-title":"Trends in photothermal nanostructures for antimicrobial applications","volume":"24","author":"Dediu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1359\/JBMR.050401","article-title":"In silico modeling and simulation of bone biology: a proposal","volume":"20","author":"Defranoux","year":"2005","journal-title":"J. Bone Miner Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"22256","DOI":"10.1021\/acsomega.2c06216","article-title":"Decellularized extracellular matrix: the role of this complex biomaterial in regeneration","volume":"8","author":"de Paula","year":"2023","journal-title":"ACS Omega"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2023.100162","article-title":"Effect of probiotic supplementation on intestinal permeability in overweight and obesity: A systematic review of randomized controlled trials and animal studies","volume":"15","author":"DiMattia","year":"2024","journal-title":"Adv. Nutr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Intern. Emerg. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"7042","DOI":"10.1038\/s41598-024-57122-x","article-title":"Mechanistic study on the alleviation of postmenopausal osteoporosis by Lactobacillus acidophilus through butyrate-mediated inhibition of osteoclast activity","volume":"14","author":"Dong","year":"2024","journal-title":"Sci. Rep."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115276","article-title":"The impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: Mechanisms and therapeutic potentials","volume":"165","author":"Duan","year":"2023","journal-title":"BioMed. Pharmacother."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1002\/btpr.2147","article-title":"Role of gold nanoparticles as drug delivery vehicles for chondroitin sulfate in the treatment of osteoarthritis","volume":"31","author":"Dwivedi","year":"2015","journal-title":"Biotechnol. Prog."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29112584","article-title":"Nanomaterials in drug delivery: strengths and opportunities in medicine","volume":"29","author":"Egwu","year":"2024","journal-title":"Molecules"},{"key":"B31","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3109\/00016487309139720","article-title":"Histological Malignancy grading of squamous cell carcinoma of the palate","volume":"75","author":"Eneroth","year":"1973","journal-title":"Acta Otolaryngol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113921","article-title":"Modular design principle based on compartmental drug delivery systems","volume":"178","author":"Eleftheriadis","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling","volume":"11","author":"Eriksen","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.656950","article-title":"Pituitary apoplexy: A retrospective study of 33 cases from a single center","volume":"12","author":"Falhammar","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e2302132","DOI":"10.1002\/adhm.202302132","article-title":"Metallic materials for bone repair","volume":"13","author":"Fan","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00113","article-title":"Use of nanoparticles in tissue engineering and regenerative medicine","volume":"7","author":"Fathi-Achachelouei","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/00001574-200403000-00017","article-title":"Probiotics and prebiotics in gastrointestinal disorders","volume":"20","author":"Fedorak","year":"2004","journal-title":"Curr. Opin. Gastroenterol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/421746","article-title":"Biology of bone tissue: structure, function, and factors that influence bone cells","volume":"2015","author":"Florencio-Silva","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03341","article-title":"Modulation of bone turnover aberration: A target for management of primary osteoporosis in experimental rat model","volume":"6","author":"Fouad-Elhady","year":"2020","journal-title":"Heliyon"},{"key":"B40","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/ajh.24253","article-title":"Myelodysplastic syndromes: Contemporary review and how we treat","volume":"91","author":"Gangat","year":"2016","journal-title":"Am. J. Hematol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"17059","DOI":"10.1038\/boneres.2017.59","article-title":"Bone biomaterials and interactions with stem cells","volume":"5","author":"Gao","year":"2017","journal-title":"Bone Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12906-022-03713-y","article-title":"The ameliorative role of specific probiotic combinations on bone loss in the ovariectomized rat model","volume":"22","author":"Gholami","year":"2022","journal-title":"BMC Complement. Med. Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s40618-015-0424-2","article-title":"Pituitary apoplexy: considerations on a single center experience and review of the literature","volume":"39","author":"Giammattei","year":"2016","journal-title":"J. Endocrinol. Invest."},{"key":"B44","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.bioactmat.2023.09.017","article-title":"Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects","volume":"32","author":"Golebiowska","year":"2024","journal-title":"Bioact. Mater."},{"key":"B45","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1128\/CMR.00063-09","article-title":"Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1-associated diseases","volume":"23","author":"Gon\u00e7alves","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"711","DOI":"10.2217\/nnm-2019-0218","article-title":"Polyethylenimine-dextran-coated magnetic nanoparticles loaded with miR-302b suppress osteosarcoma in vitro and in vivo","volume":"15","author":"Gong","year":"2020","journal-title":"Nanomed. (Lond.)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00284-019-01679-8","article-title":"Probiotic bacteria: A promising tool in cancer prevention and therapy","volume":"76","author":"G\u00f3rska","year":"2019","journal-title":"Curr. Microbiol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051436","article-title":"Unraveling the puzzle: health benefits of probiotics-A comprehensive review","volume":"13","author":"Gul","year":"2024","journal-title":"J. Clin. Med."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1041647","article-title":"Effect of Lactobacillus casei fermented milk on fracture healing in osteoporotic mice","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1002\/ajh.25595","article-title":"Chronic lymphocytic leukemia: 2020 update on diagnosis, risk stratification and treatment","volume":"94","author":"Hallek","year":"2019","journal-title":"Am. J. Hematol."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1205792","article-title":"Engineered biomimetic micro\/nano-materials for tissue regeneration","volume":"11","author":"Han","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/foods10112685","article-title":"Probiotics and isoflavones as a promising therapeutic for calcium status and bone health: A narrative review","volume":"10","author":"Harahap","year":"2021","journal-title":"Foods"},{"key":"B53","doi-asserted-by":"publisher","first-page":"347","DOI":"10.22540\/jmni-25-001","article-title":"Biological basis of bone strength: anatomy, physiology and measurement","volume":"20","author":"Hart","year":"2020","journal-title":"J.\u00a0Musculoskelet. Neuronal. Interact."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114195","article-title":"The effect of probiotics on immune responses and their therapeutic application: A new treatment option for multiple sclerosis","volume":"159","author":"Hashemi","year":"2023","journal-title":"BioMed. Pharmacother."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/s41385-022-00564-1","article-title":"Microbiome-based interventions to modulate gut ecology and the immune system","volume":"15","author":"Hitch","year":"2022","journal-title":"Mucosal Immunol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107100","article-title":"Novel nano-drug delivery system for natural products and their application","volume":"201","author":"Huang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/MED.0000000000000863","article-title":"The interaction between gut microbiome and bone health","volume":"31","author":"Inchingolo","year":"2024","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13121994","article-title":"Advances in use of nanomaterials for musculoskeletal regeneration","volume":"13","author":"Jampilek","year":"2021","journal-title":"Pharmaceutics"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1038\/sj.leu.2403958","article-title":"Pediatric acute myeloid leukemia: international progress and future directions","volume":"19","author":"Kaspers","year":"2005","journal-title":"Leukemia"},{"key":"B60","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/j.jfda.2018.01.002","article-title":"Benefaction of probiotics for human health: A review","volume":"26","author":"Kerry","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1007\/s12602-020-09735-7","article-title":"Probiotic composition and chondroitin sulfate regulate TLR-2\/4-mediated NF-\u03baB inflammatory pathway and cartilage metabolism in experimental osteoarthritis","volume":"13","author":"Korotkyi","year":"2021","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00513","article-title":"Biomaterials for the delivery of growth factors and other therapeutic agents in tissue engineering approaches to bone regeneration","volume":"9","author":"Kowalczewski","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3390\/gels9020100","article-title":"Development of scaffolds from bio-based natural materials for tissue regeneration applications: A review","volume":"9","author":"Krishani","year":"2023","journal-title":"Gels"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1216674","article-title":"Probiotics: mechanism of action, health benefits and their application in food industries","volume":"14","author":"Latif","year":"2023","journal-title":"Front. Microbiol."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/nu11050969","article-title":"Combination of Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Shows a Stronger Anti-Inflammatory Effect than Individual Strains in HT-29 Cells","volume":"11","author":"Li","year":"2019","journal-title":"Nutrients"},{"key":"B66","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/rb\/rbz019","article-title":"Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection","volume":"6","author":"Li","year":"2019","journal-title":"Regener. Biomater."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1342340","article-title":"Current developments and future perspectives of nanotechnology in orthopedic implants: an updated review","volume":"12","author":"Liang","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-020-01735-9","article-title":"Radiotherapy and the gut microbiome: facts and fiction","volume":"16","author":"Liu","year":"2021","journal-title":"Radiat. Oncol."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12020234","article-title":"The potential impact of probiotics on human health: an update on their health-promoting properties","volume":"12","author":"Maftei","year":"2024","journal-title":"Microorganisms"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3582989","article-title":"Probiotics as a new regulator for bone health: A systematic review and meta-analysis","volume":"2021","author":"Malmir","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.2147\/IJN.S303412","article-title":"Nanohydroxyapatite (nHAp) Doped with Iron Oxide Nanoparticles (IO), miR-21 and miR-124 Under Magnetic Field Conditions Modulates Osteoblast Viability, Reduces Inflammation and Inhibits the Growth of Osteoclast - A Novel Concept for Osteoporosis Treatment: Part 1","volume":"16","author":"Marycz","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"B72","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12951-020-00590-w","article-title":"Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action","volume":"18","author":"Marycz","year":"2020","journal-title":"J.\u00a0Nanobiotechnol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"10127","DOI":"10.2147\/IJN.S256542","article-title":"Fe3O4 magnetic nanoparticles under static magnetic field improve osteogenesis via RUNX-2 and inhibit osteoclastogenesis by the induction of apoptosis","volume":"15","author":"Marycz","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010184","article-title":"Probiotics mechanism of action on immune cells and beneficial effects on human health","volume":"12","author":"Mazziotta","year":"2023","journal-title":"Cells"},{"key":"B75","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.ctim.2013.08.018","article-title":"Probiotic bacteria in cancer patients undergoing chemotherapy and radiation therapy","volume":"21","author":"Mego","year":"2013","journal-title":"Complement. Ther. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s12185-015-1787-z","article-title":"The diagnosis and treatment of aplastic anemia: a review","volume":"101","author":"Miano","year":"2015","journal-title":"Int. J. Hematol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"4344","DOI":"10.1039\/C4NJ00741G","article-title":"Facile synthesis and morphogenesis of superparamagnetic iron oxide nanoparticles for high-performance supercapacitor applications","volume":"38","author":"Mitchell","year":"2014","journal-title":"New J. Chem."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1007\/s11756-022-01147-y","article-title":"Recent advances in antiviral effects of probiotics: potential mechanism study in prevention and treatment of SARS-CoV-2","volume":"77","author":"Montazeri-Najafabady","year":"2022","journal-title":"Biol. (Bratisl)"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124616","article-title":"The role of extracellular matrix (ECM) adhesion motifs in functionalised hydrogels","volume":"28","author":"Morwood","year":"2023","journal-title":"Molecules"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2024.108831","article-title":"Au\/Ag2MoO4 nanocomposite: A dual-function catalyst for dye degradation and colorimetric detection","volume":"39","author":"Nguyen","year":"2024","journal-title":"Mater. Today Commun."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054312","article-title":"A review of biomimetic and biodegradable magnetic scaffolds for bone tissue engineering and oncology","volume":"24","author":"Paltanea","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.bioactmat.2024.06.022","article-title":"Fostering tissue engineering and regenerative medicine to treat musculoskeletal disorders in bone and muscle","volume":"40","author":"Park","year":"2024","journal-title":"Bioact. Mater."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/595962","article-title":"Effect of probiotics supplementation on bone mineral content and bone mass density","volume":"2014","author":"Parvaneh","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"B84","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1161\/01.str.2.4.327","article-title":"Cerebral apoplexy (stroke): pathogenesis, pathophysiology and therapy as illustrated by regional blood flow measurements in the brain","volume":"2","author":"Paulson","year":"1971","journal-title":"Stroke"},{"key":"B85","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1182\/blood.V57.4.712.712","article-title":"Acute nonlymphocytic leukemia, preleukemia, and acute myeloproliferative syndrome secondary to treatment of other Malignant diseases. Clinical and cytogenetic characteristics and results of in vitro culture of bone marrow and HLA typing","volume":"57","author":"Pedersen-Bjergaard","year":"1981","journal-title":"Blood"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1007\/s11739-019-02160-x","article-title":"Sickle cell disease: a review for the internist","volume":"14","author":"Pinto","year":"2019","journal-title":"Intern. Emerg. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1002\/cac2.12197","article-title":"Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020","volume":"41","author":"Qiu","year":"2021","journal-title":"Cancer Commun. (Lond.)"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.616713","article-title":"Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation","volume":"12","author":"Raheem","year":"2021","journal-title":"Front. Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41408-020-00359-2","article-title":"Multiple myeloma current treatment algorithms","volume":"10","author":"Rajkumar","year":"2020","journal-title":"Blood Cancer J."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/nu16081150","article-title":"The effectiveness of a lactobacilli-based probiotic food supplement on bone mineral density and bone metabolism in Australian early postmenopausal women: protocol for a double-blind randomized placebo-controlled trial","volume":"16","author":"Resciniti","year":"2024","journal-title":"Nutrients"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/s41467-018-03705-y","article-title":"Progress and challenges towards targeted delivery of cancer therapeutics","volume":"9","author":"Rosenblum","year":"2018","journal-title":"Nat. Commun."},{"key":"B92","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/gastroent12010006","article-title":"Role of probiotics and their metabolites in inflammatory bowel diseases (IBDs)","volume":"12","author":"Ryma","year":"2021","journal-title":"Gastroenterol. Insights"},{"key":"B93","first-page":"1224","article-title":"Delayed traumatic apoplexy","volume":"18","author":"Scheidegger","year":"1955","journal-title":"Schweiz Z Pathol. Bakteriol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"3405","DOI":"10.1039\/d3lc00154g","article-title":"A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading","volume":"23","author":"Scheinpflug","year":"2023","journal-title":"Lab. Chip."},{"key":"B95","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3322\/caac.21438","article-title":"Hodgkin lymphoma: A review and update on recent progress","volume":"68","author":"Shanbhag","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"B96","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.reth.2023.12.010","article-title":"Advancements in drug-loaded hydrogel systems for bone defect repair","volume":"25","author":"Shi","year":"2024","journal-title":"Regener. Ther."},{"key":"B97","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41413-023-00302-8","article-title":"Neuro-bone tissue engineering: emerging mechanisms, potential strategies, and current challenges","volume":"11","author":"Sun","year":"2023","journal-title":"Bone Res."},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3390\/nano13152185","article-title":"Biomaterials and encapsulation techniques for probiotics: current status and future prospects in biomedical applications","volume":"13","author":"Sun","year":"2023","journal-title":"Nanomater. (Basel)"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1079\/WPS19920013","article-title":"Landmarks in the history of poultry bone biology","volume":"285","author":"Sykes","year":"1992","journal-title":"World\u2019s Poult. Sci. J"},{"key":"B100","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bioactmat.2017.10.001","article-title":"3D bioactive composite scaffolds for bone tissue engineering","volume":"3","author":"Turnbull","year":"2018","journal-title":"Bioact. Mater."},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3390\/nu12040892","article-title":"Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research","volume":"12","author":"Uusitupa","year":"2020","journal-title":"Nutrients"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3390\/nu16030461","article-title":"Effects of multispecies probiotic supplementation on serum bone turnover markers in postmenopausal women with osteopenia: A randomized, double-blind, placebo-controlled trial","volume":"16","author":"Vanitchanont","year":"2024","journal-title":"Nutrients"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/nu16040546","article-title":"The anti-inflammatory and curative exponent of probiotics: A comprehensive and authentic ingredient for the sustained functioning of major human organs","volume":"16","author":"Virk","year":"2024","journal-title":"Nutrients"},{"key":"B104","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1016\/j.apsb.2022.08.013","article-title":"Smart drug delivery systems for precise cancer therapy","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"B105","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.bioactmat.2017.05.007","article-title":"Bone grafts and biomaterials substitutes for bone defect repair: A review","volume":"2","author":"Wang","year":"2017","journal-title":"Bioact. Mater."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100640","article-title":"Nano-crosslinked dynamic hydrogels for biomedical applications","volume":"20","author":"Wang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"B107","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1182\/blood.V94.7.2217.419k02_2217_2224","article-title":"Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8)","volume":"94","author":"Winkler","year":"1999","journal-title":"Blood"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.952523","article-title":"Recent advancement of bioinspired nanomaterials and their applications: A review","volume":"10","author":"Wu","year":"2022","journal-title":"Front.\u00a0Bioeng. Biotechnol."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.706105","article-title":"Mapping knowledge structure and research frontiers of ultrasound-induced blood-brain barrier opening: A scientometric study","volume":"15","author":"Wu","year":"2021","journal-title":"Front. Neurosci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s41392-023-01467-8","article-title":"Targeting strategies for bone diseases: signaling pathways and clinical studies","volume":"8","author":"Xu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101016","article-title":"A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications","volume":"26","author":"Yang","year":"2024","journal-title":"Mater. Today Bio"},{"key":"B112","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s13075-016-1025-y","article-title":"Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model","volume":"18","author":"Zhang","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2023.2295432","article-title":"Diets intervene osteoporosis via gut-bone axis","volume":"16","author":"Zhang","year":"2024","journal-title":"Gut Microbes"},{"key":"B114","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.bioactmat.2023.08.016","article-title":"Research advances of nanomaterials for the acceleration of fracture healing","volume":"31","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1423838","article-title":"Advancements in the impact of human microbiota and probiotics on leukemia","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Microbiol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1039\/d3na00851g","article-title":"Recent advances of nanoparticles on bone tissue engineering and bone cells","volume":"6","author":"Zhang","year":"2024","journal-title":"Nanoscale Adv."},{"key":"B117","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1016\/j.matt.2021.05.019","article-title":"Nanoscale materials-based platforms for the treatment of bone-related diseases","volume":"4","author":"Zhang","year":"2021","journal-title":"Matter"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1575798\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:14:40Z","timestamp":1744348480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1575798\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":117,"alternative-id":["10.3389\/fcimb.2025.1575798"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2025.1575798","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"article-number":"1575798"}}