{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:57:06Z","timestamp":1787936226362,"version":"build-2784847793"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007675","name":"International Center for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","award":["CRP\/MYS23-04_EC"],"award-info":[{"award-number":["CRP\/MYS23-04_EC"]}],"id":[{"id":"10.13039\/100007675","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The pathogenesis of severe malaria is primarily attributed to the cytoadherence properties of <jats:italic>Plasmodium<\/jats:italic>-infected erythrocytes (IRBC), which include rosetting and IRBC-endothelial cytoadherence. These cytoadherence events are influenced by various parasite- and host-derived factors. Previously, antibodies against human periostin (OSF-2), an inflammation-associated protein, were reported to inhibit rosetting. In this study, we aimed to characterize the OSF-2-mediated cytoadherence in infections caused by <jats:italic>Plasmodium falciparum<\/jats:italic> (the most fatal human malaria parasite) and <jats:italic>P. knowlesi<\/jats:italic> (an emerging, potentially fatal zoonotic malaria parasite).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Laboratory-adapted <jats:italic>P. falciparum<\/jats:italic> and <jats:italic>P. knowlesi<\/jats:italic> isolates were cultured, and the late-stage parasites were purified for experiments using recombinant human OSF-2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that OSF-2 at a concentration of 200 ng\/ml induced rosette-stimulation in both parasite species. Furthermore, we demonstrated the serum dependency of OSF-2-mediated rosetting. The rosette-stimulating effect of OSF-2 was completely abolished when IRBC were treated with a low concentration of trypsin. This suggests a role for <jats:italic>P. falciparum<\/jats:italic> erythrocyte membrane protein 1 (PfEMP1) in OSF-2-mediated rosetting by <jats:italic>P. falciparum<\/jats:italic>, and reveals the trypsin-sensitive nature of the P. knowlesi-derived ligands involved in OSF-2-mediated rosetting. We also found that OSF-2-mediated rosetting was independent of the ABO blood group. Additionally, we demonstrated the ability of OSF-2 to disrupt the IRBC-endothelial binding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This work contributes to our understanding of the host-parasite interactions in malaria pathobiology.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcimb.2025.1599872","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T05:30:57Z","timestamp":1747114257000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of periostin (OSF-2) in the cytoadherence phenomena mediated by malaria parasites"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhi-Ying","family":"Phong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Yie","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Ling","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul Izza","family":"Zakaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Nur","family":"Athirah-Azman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varakorn","family":"Kosaisavee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"R\u00e9nia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenn-Chyau","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1128\/iai.01233-13","article-title":"Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains","volume":"82","author":"Adams","year":"2014","journal-title":"Infection Immun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1179\/136485905X51508","article-title":"High-level cerebellar expression of cytokines and adhesion molecules in fatal, paediatric, cerebral malaria","volume":"99","author":"Armah","year":"2005","journal-title":"Ann. 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