{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:54:46Z","timestamp":1792616086875,"version":"4.5.0"},"reference-count":136,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) is widely recognized as a potent risk factor for gastric adenocarcinoma, although only a small percentage of infected individuals develop malignancy. Recent advances have provided insights into how <jats:italic>H. pylori<\/jats:italic> contributes to gastric tumorigenesis through the modulation of inflammation, DNA damage, and cellular junctions via shared host cell targets and signaling pathways. A thorough examination of the signaling pathways altered by <jats:italic>H. pylori<\/jats:italic> infection could facilitate the discovery of previously unidentified infectious causes of cancer. This, in turn, would support the development of preventive strategies for <jats:italic>H. pylori<\/jats:italic>-related gastric malignancies by understanding the molecular mechanisms underlying pathogenesis. This review highlights recent advancements in understanding how <jats:italic>H. pylori<\/jats:italic> influences host cell signaling pathways to impact inflammation, genomic stability, abnormal cell proliferation, and other biological processes that promote the onset and progression of gastric cancer.<\/jats:p>","DOI":"10.3389\/fcimb.2025.1601501","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T05:32:44Z","timestamp":1751002364000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["The intersection of Helicobacter pylori and gastric cancer: signaling pathways and molecular mechanisms"],"prefix":"10.3389","volume":"15","author":[{"given":"Zekun","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s12029-020-00518-5","article-title":"Molecular mechanism of Helicobacter pylori-induced gastric cancer","volume":"52","author":"Alipour","year":"2021","journal-title":"J. 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