{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:43:06Z","timestamp":1789152186883,"version":"build-2803163510"},"reference-count":186,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Diabetes mellitus (DM) is a globally prevalent metabolic disorder characterized by impaired immune function due to poor glycaemia control, significantly increasing the risk of osteomyelitis. The occurrence of bone infection not only compromises patients\u2019 quality of life but also poses substantial challenges in clinical management. Recent studies have identified immunometabolic reprogramming as a pivotal player in the pathogenesis and progression of diabetic osteomyelitis. This reprogramming not only disrupts immune cell functionality but also modulates the local microenvironment, thereby impairing bone repair processes. Although preliminary research has explored the underlying mechanisms, a comprehensive understanding of the precise role of immunometabolic reprogramming and its potential therapeutic targeting in diabetic osteomyelitis remains elusive. This review synthesizes current advances in immunometabolic reprogramming within diabetic osteomyelitis, elucidates its biological mechanisms, and proposes novel intervention strategies to inform clinical practice and inspire future therapeutic development.<\/jats:p>","DOI":"10.3389\/fcimb.2025.1606317","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:28:22Z","timestamp":1761283702000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunometabolic reprogramming in diabetic osteomyelitis: from mechanisms to therapeutics"],"prefix":"10.3389","volume":"15","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Shan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Ying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Na","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Tong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4049\/jimmunol.2001321","article-title":"The IRE1\u03b1 Stress signaling axis is a key regulator of neutrophil antimicrobial effector function","volume":"207","author":"Abuaita","year":"2021","journal-title":"J. Immunol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00179-24","article-title":"Deciphering Staphylococcus aureus-host dynamics using dual activity-based protein profiling of ATP-interacting proteins","volume":"9","author":"Ahator","year":"2024","journal-title":"mSystems"},{"key":"B3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.surge.2020.01.007","article-title":"An evidence based narrative review on treatment of diabetic foot osteomyelitis","volume":"18","author":"Aicale","year":"2020","journal-title":"Surgeon"},{"key":"B4","doi-asserted-by":"publisher","first-page":"5151171","DOI":"10.1155\/jdr\/5151171","article-title":"Identifying promising immunomodulators for type 1 diabetes (T1D) and islet transplantation","volume":"2024","author":"Ajmal","year":"2024","journal-title":"J. Diabetes Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.tips.2024.12.003","article-title":"Exploring neutrophils as therapeutic targets in cardiometabolic diseases","volume":"46","author":"Albiero","year":"2025","journal-title":"Trends Pharmacol. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/MCO.0000000000001103","article-title":"Specialized pro-resolving lipid mediators in gut immunophysiology: from dietary precursors to inflammation resolution","volume":"28","author":"Albuquerque-Souza","year":"2025","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137105","article-title":"Pathology of diabetes-induced immune dysfunction","volume":"25","author":"Alexander","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"98","DOI":"10.18295\/squmj.10.2024.053","article-title":"Biofilm-Induced Bone Degradation in Osteomyelitis: Insights from a comprehensive ex vivo pathogen interaction study","volume":"25","author":"Al Ghaithi","year":"2025","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/nu15010123","article-title":"Essential minerals and metabolic adaptation of immune cells","volume":"15","author":"Alghamdi","year":"2023","journal-title":"Nutrients"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.2337\/dc13-0327","article-title":"Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes","volume":"37","author":"Aronson","year":"2014","journal-title":"Diabetes Care"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI188358","article-title":"Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury","volume":"135","author":"Baker","year":"2025","journal-title":"J. Clin. Invest."},{"key":"B12","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12964-023-01282-2","article-title":"The role of bone marrow microenvironment (BMM) cells in acute myeloid leukemia (AML) progression: immune checkpoints, metabolic checkpoints, and signaling pathways","volume":"21","author":"Bakhtiyari","year":"2023","journal-title":"Cell communication signaling: CCS"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3816","DOI":"10.1038\/s41467-020-17669-5","article-title":"STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1\u03b2 expression","volume":"11","author":"Balic","year":"2020","journal-title":"Nat. Commun."},{"key":"B14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/path.2684","article-title":"Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis","volume":"221","author":"Baud\u2019Huin","year":"2010","journal-title":"J. Pathol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.medcli.2023.09.015","article-title":"Risk factors associated with osteomyelitis due to Corynebacterium striatum in patients with diabetic foot","volume":"162","author":"Bermejo Olano","year":"2024","journal-title":"Med. Clin. (Barc)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12879-019-4751-3","article-title":"A multicenter randomized placebo controlled trial of rifampin to reduce pedal amputations for osteomyelitis in veterans with diabetes (VA INTREPID)","volume":"20","author":"Bessesen","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/antib11020032","article-title":"Immune cell metabolic fitness for life","volume":"11","author":"Bittman","year":"2022","journal-title":"Antibodies (Basel)"},{"key":"B18","doi-asserted-by":"publisher","first-page":"104835","DOI":"10.1016\/j.idnow.2023.104835","article-title":"Dalbavancin as salvage therapy in difficult-to-treat patients for diabetes-related foot osteomyelitis","volume":"54","author":"Boucher","year":"2024","journal-title":"Infect. Dis. Now"},{"key":"B19","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/s41581-021-00454-y","article-title":"Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function","volume":"17","author":"Brennan","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00170-22","article-title":"Modulation of gut microbiota metabolism in obesity-related type 2 diabetes reduces osteomyelitis severity","volume":"10","author":"Bui","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1172\/JCI133605","article-title":"Gut microbiome communication with bone marrow regulates susceptibility to amebiasis","volume":"130","author":"Burgess","year":"2020","journal-title":"J. Clin. Invest."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00529-22","article-title":"Hyperglycemia increases severity of staphylococcus aureus osteomyelitis and influences bacterial genes required for survival in bone","volume":"91","author":"Butrico","year":"2023","journal-title":"Infect. Immun."},{"key":"B23","doi-asserted-by":"publisher","first-page":"115951","DOI":"10.1016\/j.bcp.2023.115951","article-title":"Glycolithocholic acid increases the frequency of circulating Tregs through constitutive androstane receptor to alleviate postmenopausal osteoporosis","volume":"219","author":"Cai","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31502","article-title":"Pregnancy entails a metabolic rewiring of maternal circulating neutrophils","volume":"240","author":"Calo","year":"2025","journal-title":"J. Cell. Physiol."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102250","article-title":"Development of a competitive nutrient-based T-cell immunotherapy designed to block the adaptive warburg effect in acute myeloid leukemia","volume":"12","author":"Cao","year":"2024","journal-title":"Biomed."},{"key":"B26","doi-asserted-by":"publisher","first-page":"109584","DOI":"10.1016\/j.celrep.2021.109584","article-title":"The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans","volume":"36","author":"Case","year":"2021","journal-title":"Cell Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s11914-020-00627-x","article-title":"The gut microbiome and bone strength","volume":"18","author":"Castaneda","year":"2020","journal-title":"Curr. osteoporosis Rep."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2024-004181","article-title":"Metabolic features of neutrophilic differentiation of HL-60 cells in hyperglycemic environments","volume":"12","author":"C\u00e1zares-Preciado","year":"2024","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1039\/D1OB01932E","article-title":"The role of acetylated cyclooxygenase-2 in the biosynthesis of resolvin precursors derived from eicosapentaenoic acid","volume":"20","author":"Cebri\u00e1n-Prats","year":"2022","journal-title":"Org Biomol Chem."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1029475","article-title":"Regulation of bone health through physical exercise: Mechanisms and types","volume":"13","author":"Chang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s12967-025-06346-0","article-title":"Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors","volume":"23","author":"Chen","year":"2025","journal-title":"J. Trans. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s11684-025-1129-3","article-title":"Progress of research on the gut microbiome and its metabolite short-chain fatty acids in postmenopausal osteoporosis: a literature review","volume":"19","author":"Chen","year":"2025","journal-title":"Front. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.bioactmat.2022.07.030","article-title":"Multifunctional hydrogel enhances bone regeneration through sustained release of Stromal Cell-Derived Factor-1\u03b1 and exosomes","volume":"25","author":"Chen","year":"2023","journal-title":"Bioact Mater"},{"key":"B34","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.tim.2024.11.009","article-title":"The exometabolome as a hidden driver of bacterial virulence and pathogenesis","volume":"33","author":"Chugh","year":"2025","journal-title":"Trends Microbiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cmet.2020.11.003","article-title":"Dynamic cardiolipin synthesis is required for CD8(+) T cell immunity","volume":"32","author":"Corrado","year":"2020","journal-title":"Cell Metab."},{"key":"B36","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.cell.2015.03.021","article-title":"IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity","volume":"161","author":"Cui","year":"2015","journal-title":"Cell"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/nu16030431","article-title":"Moderate-intensity and high-intensity interval exercise training offer equal cardioprotection, with different mechanisms, during the development of type 2 diabetes in rats","volume":"16","author":"D\u2019Haese","year":"2024","journal-title":"Nutrients"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00509-23","article-title":"Triple threat: how diabetes results in worsened bacterial infections","volume":"92","author":"Darwitz","year":"2024","journal-title":"Infect. Immun."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00264-13","article-title":"Macrophage M1\/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection","volume":"4","author":"Davis","year":"2013","journal-title":"mBio"},{"key":"B40","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1053\/j.jfas.2020.06.029","article-title":"Efficacy and safety of bioactive glass S53P4 as a treatment for diabetic foot osteomyelitis","volume":"60","author":"De Giglio","year":"2021","journal-title":"J. Foot Ankle Surg."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411911","article-title":"Sequential targeting chondroitin sulfate-bilirubin nanomedicine attenuates osteoarthritis via reprogramming lipid metabolism in M1 macrophages","volume":"12","author":"Deng","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/ni.3269","article-title":"Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants","volume":"16","author":"De Rosa","year":"2015","journal-title":"Nat. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/jre.13212","article-title":"Oxytocin alleviates periodontitis in adult rats","volume":"59","author":"Dmytrenko","year":"2024","journal-title":"J. periodontal Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"254","DOI":"10.25270\/wnds\/21101","article-title":"The role of hemodynamic shear stress in healing chronic wounds","volume":"34","author":"Dormer","year":"2022","journal-title":"Wounds"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218636","article-title":"Characterizing the postmortem human bone microbiome from surface-decomposed remains","volume":"15","author":"Emmons","year":"2020","journal-title":"PloS One"},{"key":"B46","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1210\/endrev\/bnae025","article-title":"Postbiotic impact on host metabolism and immunity provides therapeutic potential in metabolic disease","volume":"46","author":"Fang","year":"2025","journal-title":"Endocr. Rev."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143006","article-title":"HLA allele prevalence in disease-modifying antirheumatic drugs-responsive enthesitis and\/or arthritis not fulfilling ASAS criteria: comparison with psoriatic and undifferentiated spondyloarthritis","volume":"10","author":"Favoino","year":"2021","journal-title":"J. Clin. Med."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/genes12111698","article-title":"Sirtuins as metabolic regulators of immune cells phenotype and function","volume":"12","author":"Fortuny","year":"2021","journal-title":"Genes (Basel)"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.2337\/dc17-1779","article-title":"Improved health-related quality of life in a phase 3 islet transplantation trial in type 1 diabetes complicated by severe hypoglycemia","volume":"41","author":"Foster","year":"2018","journal-title":"Diabetes Care"},{"key":"B50","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1093\/ejendo\/lvae084","article-title":"Central diabetes insipidus (vasopressin deficiency) after surgery for pituitary tumours: a systematic review and meta-analysis","volume":"191","author":"Fountas","year":"2024","journal-title":"Eur. J. Endocrinol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.emc.2024.01.003","article-title":"Diabetic foot infections in the emergency department","volume":"42","author":"Frazee","year":"2024","journal-title":"Emergency Med. Clinics North America"},{"key":"B52","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1021\/acssynbio.4c00589","article-title":"Advances in engineering myeloid cells for cell therapy applications","volume":"14","author":"Freitas","year":"2025","journal-title":"ACS Synth Biol."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1277102","article-title":"The role of intestinal microbes on intestinal barrier function and host immunity from a metabolite perspective","volume":"14","author":"Fu","year":"2023","journal-title":"Front. Immunol."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/science.adt4169","article-title":"T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption","volume":"390","author":"Gao","year":"2024","journal-title":"bioRxiv"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13121173","article-title":"Duration of antibiotic treatment for foot osteomyelitis in people with diabetes","volume":"13","author":"Gramberg","year":"2024","journal-title":"Antibiotics (Basel)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065161","article-title":"Pivotal role of intestinal microbiota and intraluminal metabolites for the maintenance of gut-bone physiology","volume":"24","author":"Gr\u00fcner","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310320","article-title":"Neutrophil function conversion driven by immune switchpoint regulator against diabetes-related biofilm infections","volume":"36","author":"Guo","year":"2024","journal-title":"Advanced materials (Deerfield Beach Fla.)"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3901","DOI":"10.2337\/db13-0236","article-title":"Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Prot\u00e9g\u00e9 trial","volume":"62","author":"Hagopian","year":"2013","journal-title":"Diabetes"},{"key":"B59","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1172\/JCI78492","article-title":"Anti-thymocyte globulin\/G-CSF treatment preserves \u03b2 cell function in patients with established type 1 diabetes","volume":"125","author":"Haller","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/jre.13168","article-title":"The impacts of oral and gut microbiota on alveolar bone loss in periodontitis","volume":"58","author":"Han","year":"2023","journal-title":"J. periodontal Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"bvae117","DOI":"10.1210\/jendso\/bvae117","article-title":"Emerging insights into the endocrine regulation of bone homeostasis by gut microbiome","volume":"8","author":"Hansdah","year":"2024","journal-title":"J. Endocrine Soc."},{"key":"B62","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00592-024-02386-y","article-title":"Predictors of successful antibiotic treatment of osteomyelitis in diabetic forefoot infection","volume":"62","author":"Hassanin","year":"2025","journal-title":"Acta Diabetol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-981-33-6785-2_10","article-title":"Lipid metabolism in tumor-infiltrating T cells","volume":"1316","author":"He","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"8742817","DOI":"10.1155\/mi\/8742817","article-title":"Gut microbiota-derived butyric acid alleviates glucocorticoid-associated osteonecrosis of the femoral head via modulating inflammatory cytokines in bone marrow mesenchymal stem cells","volume":"2025","author":"He","year":"2025","journal-title":"Mediators Inflammation"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1182\/blood.2023021453","article-title":"Inhibition of RHOA activity preserves the survival and hemostasis function of long-term cold-stored platelets","volume":"144","author":"Hegde","year":"2024","journal-title":"Blood"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204502","article-title":"Electroactive biomaterials for facilitating bone defect repair under pathological conditions","volume":"10","author":"Heng","year":"2023","journal-title":"Advanced Sci. (Weinheim Baden-Wurttemberg Germany)"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00498-24","article-title":"Live fast, die young: neutrophils streamline their metabolism to maximize inflammation","volume":"93","author":"Holder","year":"2025","journal-title":"Infect. Immun."},{"key":"B68","doi-asserted-by":"publisher","first-page":"257","DOI":"10.34172\/aim.33355","article-title":"Efficacy of N-acetyl-cysteine as adjuvant therapy for diabetic foot osteomyelitis: an open-label randomized controlled trial","volume":"28","author":"Hooshmand Gharabagh","year":"2025","journal-title":"Arch. Iran Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","first-page":"4121","DOI":"10.2147\/JIR.S514002","article-title":"Osteoimmunology in osteoarthritis: unraveling the interplay of immunity, inflammation, and joint degeneration","volume":"18","author":"Hu","year":"2025","journal-title":"J. Inflammation Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"9783","DOI":"10.1007\/s11033-022-07474-2","article-title":"Immune cell metabolism and metabolic reprogramming","volume":"49","author":"Hu","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3692","DOI":"10.7150\/ijms.57360","article-title":"Hyperbaric oxygen therapy: an effective auxiliary treatment method for large jaw cysts","volume":"18","author":"Huang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"217466","DOI":"10.1016\/j.canlet.2025.217466","article-title":"Metabolic reprogramming of neutrophils in the tumor microenvironment: Emerging therapeutic targets","volume":"612","author":"Huang","year":"2025","journal-title":"Cancer Lett."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irab093","article-title":"In patients with lower extremity burns and osteomyelitis, diabetes mellitus increases amputation rate","volume":"31","author":"Iles","year":"2021","journal-title":"J. Burn Care Res"},{"key":"B75","doi-asserted-by":"publisher","first-page":"102000","DOI":"10.1016\/j.foot.2023.102000","article-title":"Is the duration of diabetic foot ulcers an independent risk factor for developing diabetic foot osteomyelitis","volume":"56","author":"Jaroenarpornwatana","year":"2023","journal-title":"Foot (Edinb)"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.752708","article-title":"Gut-bone axis: A non-negligible contributor to periodontitis","volume":"11","author":"Jia","year":"2021","journal-title":"Front. Cell. infection Microbiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"104546","DOI":"10.1016\/j.cellimm.2022.104546","article-title":"Lipid metabolism and neutrophil function","volume":"377","author":"Jiang","year":"2022","journal-title":"Cell. Immunol."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13071639","article-title":"Novel treatments for diabetic foot osteomyelitis: A narrative review","volume":"13","author":"Jing","year":"2025","journal-title":"Microorganisms"},{"key":"B79","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s13287-024-03850-w","article-title":"Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress","volume":"15","author":"Jolibois","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"B80","doi-asserted-by":"publisher","first-page":"165940","DOI":"10.1016\/j.bbadis.2020.165940","article-title":"Glucose induces metabolic reprogramming in neutrophils during type 2 diabetes to form constitutive extracellular traps and decreased responsiveness to lipopolysaccharides","volume":"1866","author":"Joshi","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15447","article-title":"Exercise-induced increase in M2 macrophages accelerates wound healing in young mice","volume":"10","author":"Kawanishi","year":"2022","journal-title":"Physiol. Rep."},{"key":"B82","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1097\/MNH.0000000000000714","article-title":"Gut microbiome, parathyroid hormone, and bone","volume":"30","author":"Kermgard","year":"2021","journal-title":"Curr. Opin. Nephrol. hypertension"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1056\/NEJMoa043980","article-title":"Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes","volume":"352","author":"Keymeulen","year":"2005","journal-title":"N Engl. J. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s12663-020-01371-6","article-title":"Diabetic maxillary osteomyelitis: A worrisome vulnerability-our experience","volume":"21","author":"Khandelwal","year":"2022","journal-title":"J. Maxillofac. Oral. Surg."},{"key":"B85","doi-asserted-by":"publisher","first-page":"915","DOI":"10.4093\/dmj.2025.0508","article-title":"Diabetes mellitus and infectious diseases: current evidence and clinical implications","volume":"49","author":"Kim","year":"2025","journal-title":"Diabetes Metab. J"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00863-23","article-title":"Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections","volume":"14","author":"Lane","year":"2023","journal-title":"mBio"},{"key":"B87","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-2613.2006.00507.x","article-title":"Chronic inflammation: a failure of resolution","volume":"88","author":"Lawrence","year":"2007","journal-title":"Int. J. Exp. Pathol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1093\/jleuko\/qiae025","article-title":"Metabolic regulation of neutrophil functions in homeostasis and diseases","volume":"116","author":"Leblanc","year":"2024","journal-title":"J. Leukoc. Biol."},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179458","article-title":"Mitochondrial plasticity and glucose metabolic alterations in human cancer under oxidative stress-from viewpoints of chronic inflammation and neutrophil extracellular traps (NETs)","volume":"25","author":"Lee","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B90","doi-asserted-by":"publisher","first-page":"100759","DOI":"10.1016\/j.isci.2019.100759","article-title":"Human plasma-like medium improves T lymphocyte activation","volume":"23","author":"Leney-Greene","year":"2020","journal-title":"iScience"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301325R","article-title":"The endocannabinoid anandamide activates pro-resolving pathways in human primary macrophages by engaging both CB(2) and GPR18 receptors","volume":"38","author":"Leuti","year":"2024","journal-title":"FASEB J."},{"key":"B92","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.immuni.2021.02.018","article-title":"Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8(+) T cells during the primary immune response","volume":"54","author":"Levine","year":"2021","journal-title":"Immunity"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.14336\/AD.2022.0129","article-title":"The potential role of cytokines in diabetic intervertebral disc degeneration","volume":"13","author":"Li","year":"2022","journal-title":"Aging Dis."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.680328","article-title":"Exosomes derived from M2 macrophages facilitate osteogenesis and reduce adipogenesis of BMSCs","volume":"12","author":"Li","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B95","doi-asserted-by":"publisher","first-page":"106363","DOI":"10.1016\/j.jsbmb.2023.106363","article-title":"Resveratrol reverses Palmitic Acid-induced cow neutrophils apoptosis through shifting glucose metabolism into lipid metabolism via Cav-1\/CPT 1-mediated FAO enhancement","volume":"233","author":"Li","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040860","article-title":"Gut microbiota ecosystem governance of host inflammation, mitochondrial respiration and skeletal homeostasis","volume":"10","author":"Lian","year":"2022","journal-title":"Biomedicines"},{"key":"B97","doi-asserted-by":"publisher","first-page":"e132","DOI":"10.1093\/cid\/cis346","article-title":"2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections","volume":"54","author":"Lipsky","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"B98","doi-asserted-by":"publisher","first-page":"102640","DOI":"10.1016\/j.nano.2022.102640","article-title":"Neutrophil membrane-coated nanoparticles exhibit increased antimicrobial activities in an anti-microbial resistant K. pneumonia infection model","volume":"48","author":"Liu","year":"2023","journal-title":"Nanomedicine: nanotechnology biology Med."},{"key":"B99","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.it.2021.12.004","article-title":"Tumor microenvironment metabolites directing T cell differentiation and function","volume":"43","author":"Liu","year":"2022","journal-title":"Trends Immunol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12944-024-02207-9","article-title":"Role and mechanism of specialized pro-resolving mediators in obesity-associated insulin resistance","volume":"23","author":"Liu","year":"2024","journal-title":"Lipids Health Dis."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1038\/s41467-023-38985-6","article-title":"Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"B102","doi-asserted-by":"publisher","first-page":"243","DOI":"10.5455\/medarh.2020.74.243-245","article-title":"Successful treatment of diabetic foot osteomyelitis with dalbavancin","volume":"74","author":"Loupa","year":"2020","journal-title":"Med. Arch."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1002\/jbmr.4341","article-title":"Components of the gut microbiome that influence bone tissue-level strength","volume":"36","author":"Luna","year":"2021","journal-title":"J. Bone mineral research: Off. J. Am. Soc. Bone Mineral Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"115958","DOI":"10.1016\/j.biopha.2023.115958","article-title":"Targeting IL-12 family cytokines: A potential strategy for type 1 and type 2 diabetes mellitus","volume":"170","author":"Luo","year":"2024","journal-title":"BioMed. Pharmacother."},{"key":"B105","doi-asserted-by":"publisher","first-page":"e490","DOI":"10.1016\/S2665-9913(22)00098-4","article-title":"Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune-modifying therapies: a nationwide cohort study in the OpenSAFELY platform","volume":"4","author":"MacKenna","year":"2022","journal-title":"Lancet Rheumatol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1097\/IN9.0000000000000036","article-title":"The emerging role for neutrophil mitochondrial metabolism in lung inflammation","volume":"6","author":"Maldarelli","year":"2024","journal-title":"Immunometabolism (Cobham)"},{"key":"B107","article-title":"Immunometabolism at the crossroads of infection: mechanistic and systems-level perspectives from host and pathogen","volume":"2","author":"Malla","year":"2025","journal-title":"ArXiv"},{"key":"B108","doi-asserted-by":"publisher","first-page":"ofae582","DOI":"10.1093\/ofid\/ofae582","article-title":"High prescription rate of medications with rifampin drug-drug interactions in patients with diabetic foot osteomyelitis: should rifabutin be included in clinical trials for adjunctive therapy","volume":"11","author":"Mallarino-Haeger","year":"2024","journal-title":"Open Forum Infect. Dis."},{"key":"B109","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13024-025-00827-y","article-title":"Immune cell metabolic dysfunction in Parkinson\u2019s disease","volume":"20","author":"Mark","year":"2025","journal-title":"Mol. Neurodegener."},{"key":"B110","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/dom.16460","article-title":"Type 1 diabetes: A guide to autoimmune mechanisms for clinicians","author":"Mauvais","year":"2025","journal-title":"Diabetes Obes. Metab."},{"key":"B111","doi-asserted-by":"publisher","first-page":"9911072","DOI":"10.1155\/2021\/9911072","article-title":"Application and clinical effectiveness of antibiotic-loaded bone cement to promote soft tissue granulation in the treatment of neuropathic diabetic foot ulcers complicated by osteomyelitis: A randomized controlled trial","volume":"2021","author":"Mendame Ehya","year":"2021","journal-title":"J. Diabetes Res."},{"key":"B112","doi-asserted-by":"publisher","first-page":"5645","DOI":"10.1007\/s00330-023-09479-2","article-title":"Preliminary evaluation of dual-energy CT to quantitatively assess bone marrow edema in patients with diabetic foot ulcers and suspected osteomyelitis","volume":"33","author":"Mens","year":"2023","journal-title":"Eur. Radiol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1055\/a-1853-4777","article-title":"Update bone infections","volume":"148","author":"Meyer-Schwickerath","year":"2023","journal-title":"Dtsch Med. Wochenschr"},{"key":"B114","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.cmet.2020.09.004","article-title":"The gut microbiota at the service of immunometabolism","volume":"32","author":"Michaudel","year":"2020","journal-title":"Cell Metab."},{"key":"B115","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1177\/10711007231178530","article-title":"Percutaneous partial bone excision in the management of diabetic toe osteomyelitis","volume":"44","author":"Moosa","year":"2023","journal-title":"Foot Ankle Int."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1002\/1878-0261.13691","article-title":"Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment","volume":"18","author":"Moraly","year":"2024","journal-title":"Mol. Oncol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/imr.13157","article-title":"The emerging role for metabolism in fueling neutrophilic inflammation","volume":"314","author":"Morrison","year":"2023","journal-title":"Immunol. Rev."},{"key":"B118","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B119","doi-asserted-by":"publisher","first-page":"S145","DOI":"10.1016\/j.mjafi.2020.06.008","article-title":"Non-radiation and non-drug-induced maxillary osteomyelitis: Study of underlying risk factors, presentation, management and treatment outcomes","volume":"78","author":"Nilesh","year":"2022","journal-title":"Med. J. Armed Forces India"},{"key":"B120","doi-asserted-by":"publisher","first-page":"12330","DOI":"10.3389\/ti.2024.12330","article-title":"Harnessing immune cell metabolism to modulate alloresponse in transplantation","volume":"37","author":"Noble","year":"2024","journal-title":"Transpl Int."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1002\/art.39837","article-title":"RANK-independent osteoclast formation and bone erosion in inflammatory arthritis","volume":"68","author":"O\u2019Brien","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179918","article-title":"Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db\/db Mice through Angiogenesis and Macrophage Polarization","volume":"23","author":"Ontoria-Oviedo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/s41467-023-36785-6","article-title":"Hollow-core fibers with reduced surface roughness and ultralow loss in the short-wavelength range","volume":"14","author":"Os\u00f3rio","year":"2023","journal-title":"Nat. Commun."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.41454","article-title":"Study of diabetic foot problems among patients attending the diabetic foot clinic at royal hampshire county hospital, United Kingdom: A single-centre experience","volume":"15","author":"Pakkiyaretnam","year":"2023","journal-title":"Cureus"},{"key":"B125","doi-asserted-by":"publisher","first-page":"111796","DOI":"10.1016\/j.intimp.2024.111796","article-title":"Integrated analyses revealed the potential role and immune link of mitochondrial dysfunction between periodontitis and type 2 diabetes mellitus","volume":"130","author":"Pan","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic pathways in immune cell activation and quiescence","volume":"38","author":"Pearce","year":"2013","journal-title":"Immunity"},{"key":"B127","doi-asserted-by":"publisher","first-page":"108753","DOI":"10.1016\/j.pharmthera.2024.108753","article-title":"Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation","volume":"265","author":"Peh","year":"2025","journal-title":"Pharmacol. Ther."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.21037\/qims-23-1138","article-title":"State of the art in the diagnostic evaluation of osteomyelitis: exploring the role of advanced MRI sequences-a narrative review","volume":"14","author":"Perera Molligoda Arachchige","year":"2024","journal-title":"Quantitative Imaging Med. Surg."},{"key":"B129","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s10555-022-10033-7","article-title":"Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation","volume":"41","author":"Pianko","year":"2022","journal-title":"Cancer metastasis Rev."},{"key":"B130","doi-asserted-by":"publisher","first-page":"iqad005","DOI":"10.1093\/oxfimm\/iqad005","article-title":"A cellular overview of immunometabolism in systemic lupus erythematosus","volume":"4","author":"Psarras","year":"2023","journal-title":"Oxf Open Immunol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s41043-025-00994-0","article-title":"A review of the relationship between gut microbiota and osteoporosis in high altitude environments","volume":"44","author":"Qiao","year":"2025","journal-title":"J. health population Nutr."},{"key":"B132","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ccell.2024.11.003","article-title":"Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity","volume":"43","author":"Qiu","year":"2025","journal-title":"Cancer Cell"},{"key":"B133","doi-asserted-by":"publisher","first-page":"105139","DOI":"10.1016\/j.micinf.2023.105139","article-title":"Pyruvate dehydrogenase kinase inhibitor dichloroacetate augments autophagy mediated constraining the replication of Mycobacteroides massiliense in macrophages","volume":"25","author":"Quan","year":"2023","journal-title":"Microbes Infect."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28135032","article-title":"Specialized pro-resolving lipid mediators: endogenous roles and pharmacological activities in infections","volume":"28","author":"Rasquel-Oliveira","year":"2023","journal-title":"Molecules"},{"key":"B135","article-title":"Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function","volume":"24","author":"Reed","year":"2025","journal-title":"bioRxiv"},{"key":"B136","doi-asserted-by":"publisher","first-page":"115206","DOI":"10.1016\/j.celrep.2024.115206","article-title":"Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets","volume":"44","author":"Ricci","year":"2025","journal-title":"Cell Rep."},{"key":"B137","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.12968\/jowc.2021.0074","article-title":"Piperacillin\/tazobactam-induced sudden severe thrombocytopenia in a patient with a pressure ulcer: a case report","volume":"33","author":"Roh","year":"2024","journal-title":"J. Wound Care"},{"key":"B138","doi-asserted-by":"publisher","first-page":"109863","DOI":"10.1016\/j.isci.2024.109863","article-title":"Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival","volume":"27","author":"Romero-Carrami\u00f1ana","year":"2024","journal-title":"iScience"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170848","article-title":"MMR vaccination induces trained immunity via functional and metabolic reprogramming of \u03b3\u03b4 T cells","volume":"134","author":"R\u00f6ring","year":"2024","journal-title":"J. Clin. Invest."},{"key":"B140","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.2337\/dc09-0773","article-title":"Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes","volume":"32","author":"Rother","year":"2009","journal-title":"Diabetes Care"},{"key":"B141","doi-asserted-by":"publisher","first-page":"108857","DOI":"10.1016\/j.celrep.2021.108857","article-title":"Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy","volume":"34","author":"Roverato","year":"2021","journal-title":"Cell Rep."},{"key":"B142","doi-asserted-by":"publisher","first-page":"9597582","DOI":"10.1155\/2023\/9597582","article-title":"Staphylococcus schleiferi: an uncommon pathogen in an immunocompetent adolescent with chronic osteomyelitis","volume":"2023","author":"Ruiz Holgado","year":"2023","journal-title":"Case Rep. Infect. Dis."},{"key":"B143","doi-asserted-by":"publisher","first-page":"103510","DOI":"10.1016\/j.retram.2025.103510","article-title":"Immune cell dysfunction: A critical player in development of diabetes complications","volume":"73","author":"Saadh","year":"2025","journal-title":"Curr. Res. Trans. Med."},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26185600","article-title":"Resveratrol, EGCG and vitamins modulate activated T lymphocytes","volume":"26","author":"Schwager","year":"2021","journal-title":"Molecules (Basel Switzerland)"},{"key":"B145","doi-asserted-by":"publisher","first-page":"20420188211054686","DOI":"10.1177\/20420188211054686","article-title":"The importance of physical activity in management of type 2 diabetes and COVID-19","volume":"12","author":"Seidu","year":"2021","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202301.0333.v1","article-title":"Do anti-biofilm antibiotics have a place in the treatment of diabetic foot osteomyelitis","volume":"12","author":"Senneville","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"B147","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s10020-024-00877-w","article-title":"Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation","volume":"30","author":"Serhan","year":"2024","journal-title":"Mol. Med."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212086","article-title":"The link between the gut microbiome and bone metastasis","volume":"25","author":"Sevcikova","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1177\/15353702221134093","article-title":"Endogenous drivers of altered immune cell metabolism","volume":"247","author":"Shanley","year":"2022","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1038\/s41598-024-51832-y","article-title":"The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis","volume":"14","author":"Silva","year":"2024","journal-title":"Sci. Rep."},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1101\/2025.05.27.656427","article-title":"Basal activation of ERK1\/2 blunts the antimicrobial activity of neutrophils from aged hosts against antibody opsonized Streptococcus pneumoniae","volume":"30","author":"Simmons","year":"2025","journal-title":"bioRxiv"},{"key":"B152","doi-asserted-by":"publisher","first-page":"18853","DOI":"10.1038\/s41598-025-03642-z","article-title":"GLUT1-mediated HMGB1 O-GlcNAcylation drives hyperglycemia-Induced neutrophil extracellular trap networks formation via TLR4 signaling and exacerbates fibroblast inflammation","volume":"15","author":"Sun","year":"2025","journal-title":"Sci. Rep."},{"key":"B153","doi-asserted-by":"publisher","first-page":"107517","DOI":"10.1016\/j.intimp.2021.107517","article-title":"Decreased expression of TIPE2 in the eye under high-glucose conditions tested in vivo and in vitro","volume":"95","author":"Suo","year":"2021","journal-title":"Int. Immunopharmacol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3390\/biom14060632","article-title":"TRPA1 covalent ligand JT010 modifies T lymphocyte activation","volume":"14","author":"Szab\u00f3","year":"2024","journal-title":"Biomolecules"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020479","article-title":"CXCR2 antagonist RIST4721 acts as a potent chemotaxis inhibitor of mature neutrophils derived from ex vivo-cultured mouse bone marrow","volume":"11","author":"Szymczak","year":"2023","journal-title":"Biomedicines"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040904","article-title":"Metabolism of innate immune cells in cancer","volume":"13","author":"Talty","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10061237","article-title":"Medical versus surgical treatment for the management of diabetic foot osteomyelitis: A systematic review","volume":"10","author":"Tard\u00e1guila-Garc\u00eda","year":"2021","journal-title":"J. Clin. Med."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s13577-023-00905-7","article-title":"Neutrophil (dys)function due to altered immuno-metabolic axis in type 2 diabetes: implications in combating infections","volume":"36","author":"Thimmappa","year":"2023","journal-title":"Hum. Cell"},{"key":"B159","doi-asserted-by":"publisher","first-page":"220248","DOI":"10.1098\/rsob.220248","article-title":"How neutrophil metabolism affects bacterial killing","volume":"12","author":"Toller-Kawahisa","year":"2022","journal-title":"Open Biol."},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9010053","article-title":"Orchestration of neutrophil extracellular traps (Nets), a unique innate immune function during chronic obstructive pulmonary disease (COPD) development","volume":"9","author":"Trivedi","year":"2021","journal-title":"Biomedicines"},{"key":"B161","doi-asserted-by":"publisher","first-page":"100605","DOI":"10.1016\/j.ctro.2023.100605","article-title":"Novel unconventional radiotherapy techniques: Current status and future perspectives - Report from the 2nd international radiation oncology online seminar","volume":"40","author":"Tubin","year":"2023","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13121125","article-title":"A comparison of causative pathogens in bone and prosthetic joint infections: implications for antimicrobial therapy","volume":"13","author":"Unsworth","year":"2024","journal-title":"Antibiotics (Basel Switzerland)"},{"key":"B163","doi-asserted-by":"publisher","first-page":"e00932","DOI":"10.1128\/IAI.00932-19","article-title":"Staphylococcus aureus osteomyelitis: bone, bugs, and surgery","volume":"88","author":"Urish","year":"2020","journal-title":"Infect. Immun."},{"key":"B164","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s12026-024-09508-2","article-title":"Exploring CCR5\u2009+\u2009T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation","volume":"72","author":"Urszula","year":"2024","journal-title":"Immunologic Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s00284-024-03748-z","article-title":"Diabetes and infectious diseases with a focus on melioidosis","volume":"81","author":"Uthaya Kumar","year":"2024","journal-title":"Curr. Microbiol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4068\/cmj.2023.59.2.109","article-title":"Diabetic pedal osteomyelitis and its treatment","volume":"59","author":"Venkatesan","year":"2023","journal-title":"Chonnam. Med. J."},{"key":"B167","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1051\/medsci\/2024050","article-title":"Strong as death or how efferocytotic macrophages promote the resolution of inflammation","volume":"40","author":"Vetter","year":"2024","journal-title":"Med. Sci. (Paris)"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115528","article-title":"Omega-3 lipid mediators: modulation of the M1\/M2 macrophage phenotype and its protective role in chronic liver diseases","volume":"24","author":"Videla","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"12031","DOI":"10.1038\/s41598-022-15349-6","article-title":"Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice","volume":"12","author":"Vurusaner","year":"2022","journal-title":"Sci. Rep."},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050793","article-title":"Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis","volume":"12","author":"Wang","year":"2023","journal-title":"Cells"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1175570","article-title":"Activation effects on the physical characteristics of T lymphocytes","volume":"11","author":"Waugh","year":"2023","journal-title":"Front. bioengineering Biotechnol."},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.740493","article-title":"Spermine regulates immune and signal transduction dysfunction in diabetic cardiomyopathy","volume":"12","author":"Wei","year":"2021","journal-title":"Front. Endocrinol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"6892961","DOI":"10.1155\/2020\/6892961","article-title":"The antitumor efficacy of \u03b2-elemene by changing tumor inflammatory environment and tumor microenvironment","volume":"2020","author":"Xie","year":"2020","journal-title":"BioMed. Res. Int."},{"key":"B174","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1038\/s41467-025-57348-x","article-title":"Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model","volume":"16","author":"Xu","year":"2025","journal-title":"Nat. Commun."},{"key":"B175","doi-asserted-by":"publisher","first-page":"111229","DOI":"10.1016\/j.cellsig.2024.111229","article-title":"Recent advances in the effect of adipose tissue inflammation on insulin resistance","volume":"120","author":"Yan","year":"2024","journal-title":"Cell Signal"},{"key":"B176","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3892\/etm.2023.11866","article-title":"Exosomes from Ub\u2212HBcAg\u2212overexpressing dendritic cells induce T\u2212lymphocyte differentiation and enhance cytotoxic T\u2212lymphocyte activity","volume":"25","author":"Yang","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"B177","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1165\/rcmb.2020-0521OC","article-title":"TREM2 dictates antibacterial defense and viability of bone marrow-derived macrophages during bacterial infection","volume":"65","author":"Yang","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1759720X20966135","DOI":"10.1177\/1759720X20966135","article-title":"Re-appraising the potential of naringin for natural, novel orthopedic biotherapies","volume":"12","author":"Yu","year":"2020","journal-title":"Ther. Adv. musculoskeletal Dis."},{"key":"B179","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.2147\/IDR.S525682","article-title":"A rare case of osteomyelitis caused by scedosporium apiospermum in the right foot of an immunocompetent patient","volume":"18","author":"Yu","year":"2025","journal-title":"Infection Drug resistance"},{"key":"B180","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.3760\/cma.j.cn112137-20230602-00919","article-title":"Promoting critical care system and capacity building in pulmonary and critical care medicine subspecialties","volume":"103","author":"Zhan","year":"2023","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B181","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12866-023-03046-x","article-title":"Composition of pathogenic microorganism in chronic osteomyelitis based on metagenomic sequencing and its application value in etiological diagnosis","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Microbiol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.bioactmat.2023.08.008","article-title":"Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment","volume":"31","author":"Zhang","year":"2024","journal-title":"Bioactive materials"},{"key":"B183","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s00284-024-03801-x","article-title":"Roles of critical amino acids metabolism in the interactions between intracellular bacterial infection and macrophage function","volume":"81","author":"Zhang","year":"2024","journal-title":"Curr. Microbiol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"19","DOI":"10.25270\/wmp.2021.5.1925","article-title":"Sex differences in osteomyelitis of the foot in persons with diabetes mellitus: A meta-analysis","volume":"67","author":"Zhang","year":"2021","journal-title":"Wound Manag Prev."},{"key":"B185","doi-asserted-by":"publisher","first-page":"129704","DOI":"10.1016\/j.ijbiomac.2024.129704","article-title":"Bilirubin\/morin self-assembled nanoparticle-engulfed collagen\/polyvinyl alcohol hydrogel accelerates chronic diabetic wound healing by modulating inflammation and ameliorating oxidative stress","volume":"261","author":"Zhao","year":"2024","journal-title":"Int. J. Biol. Macromol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"106832","DOI":"10.1016\/j.phrs.2023.106832","article-title":"Resolvin D2 and its receptor GPR18 in cardiovascular and metabolic diseases: A promising biomarker and therapeutic target","volume":"195","author":"Zhao","year":"2023","journal-title":"Pharmacol. Res."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1606317\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T05:28:25Z","timestamp":1761283705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1606317\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":186,"alternative-id":["10.3389\/fcimb.2025.1606317"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2025.1606317","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"article-number":"1606317"}}