{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:51:49Z","timestamp":1793314309661,"version":"4.5.0"},"reference-count":170,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Vaginal microecology serves as a crucial defense mechanism in women\u2019s reproductive health. It encompasses vaginal anatomy, microbial flora, endocrine regulation, and immune responses.\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    species dominate this ecosystem, maintaining a dynamic balance essential for vaginal health. Studies have highlighted a strong association between vaginal microecology, human papillomavirus (HPV) infection, and cervical lesions. A well-balanced vaginal microenvironment enhances mucosal barriers and immune function, aiding in HPV prevention and clearance. Conversely, disruptions in vaginal microecology compromise these defenses, increasing susceptibility to HPV infection. Persistent high-risk HPV (HR-HPV) infections are key contributors to cervical lesions and may further destabilize the vaginal microbiota(VMB). Additionally, cervical lesion progression is influenced by local immune responses, with HPV infection potentially accelerating disease development by suppressing cervical immunity. This review explores the intricate association between vaginal microecology, HPV infection, and cervical lesions, offering insights into early diagnosis, prevention, and treatment strategies.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2025.1608195","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:31:06Z","timestamp":1750296666000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Advances in the interrelated nature of vaginal microecology, HPV infection, and cervical lesions"],"prefix":"10.3389","volume":"15","author":[{"given":"Mingyu","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-023-02693-6","article-title":"Status of common sexually transmitted infection in population referred for colposcopy and correlation with human papillomavirus infection","volume":"23","author":"A","year":"2023","journal-title":"BMC Womens Health"},{"key":"B2","first-page":"1313","article-title":"Impact of combined mycoplasmataceae and HPV co-infection on females with cervical intraepithelial neoplasia and carcinoma","volume":"26","author":"Adamopoulou","year":"2021","journal-title":"J. buon"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00140","article-title":"Mycoplasma hominis and Mycoplasma genitalium in the Vaginal Microbiota and Persistent High-Risk Human Papillomavirus Infection","volume":"5","author":"Adebamowo","year":"2017","journal-title":"Front. 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