{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:55:06Z","timestamp":1781279706706,"version":"3.54.1"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Background<\/jats:title>\n \n Severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease, has a high case fatality rate (CFR) in severe patients. Thrombocytopenia is one of the features of SFTS, and a platelet count lower than 50\u00d710\n 9<\/jats:sup>\n \/L is a risk factor for mortality in patients with SFTS. However, there have been no studies on the value of platelet recovery in the prognosis of SFTS patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n From January 2009 to December 2020, laboratory-confirmed severe SFTS patients with platelet counts lower than 50\u00d710\n 9<\/jats:sup>\n \/L were enrolled and divided into a survival group and a death group based on 90-day prognosis. Descriptive analysis of baseline data compared characteristics between the survival and death groups. Multivariate Cox proportional hazards regression models identified independent mortality risk factors for SFTS patients. A nomogram-presented prediction model was constructed via multivariate Cox regression. The performance of nomogram was measured by the receiver operating characteristic (ROC) curve, calibration diagram, and decision curve analysis (DCA).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 144 SFTS patients with platelet counts&lt; 50\u00d710\n 9<\/jats:sup>\n \/L during the disease were included. After three months of follow-up, 109 patients survived and 35 patients died. The cut-off values for predicting fatal outcomes were 40\u00d710\n 9<\/jats:sup>\n \/L for platelet levels on day three (PLT Day3) and 50\u00d710\n 9<\/jats:sup>\n \/L for platelet levels on day five (PLT Day5), respectively. Statistical analysis showed a significant difference (p&lt;0.001) in platelet recovery to these levels within 3 or 5 days. Kaplan-Meier analysis showed that patients with unrecovered PLT on day 5 had a higher cumulative incidence of mortality than those with recovered PLT on day 5. Multivariate Cox regression found age \u226565, failure of platelet count to reach 50\u00d710\n 9<\/jats:sup>\n \/L in 5 days, prolonged APTT, and elevated LDH as independent mortality risk factors (p&lt;0.05). Subgroup analysis showed a significant association between whether the platelet count recovers to 50\u00d710\n 9<\/jats:sup>\n \/L within 5 days (PLT-Day5) and mortality in all subgroups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Whether the platelet count recovers to 50\u00d710\n 9<\/jats:sup>\n \/L within 5 days (PLT-Day5), aspartate aminotransferase (APTT), lactate dehydrogenase (LDH) and age are independent predictors of mortality in severe SFTS patients with platelet counts below 50\u00d710\n 9<\/jats:sup>\n \/L during the course of the disease. Patients whose platelet count recovers from the lowest value to 50\u00d710\n 9<\/jats:sup>\n \/L within five days have a better prognosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2025.1644207","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:16:05Z","timestamp":1762236965000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The predictive effect of platelet recovery on the prognosis of severe fever with thrombocytopenia syndrome"],"prefix":"10.3389","volume":"15","author":[{"given":"Bing","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyue","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxia","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baocheng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s12276-021-00610-1","article-title":"Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy","volume":"53","author":"Casel","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"755","DOI":"10.3760\/cma.j.issn.0578-1426.2012.10.005","article-title":"The clinical characteristics of 169 cases of severe fever with thrombocytopenia syndrome","volume":"51","author":"Cui","year":"2012","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"B3","doi-asserted-by":"publisher","first-page":"204\u2013206","DOI":"10.31524\/bkkmedj.2020.22.001","article-title":"Severe fever with thrombocytopenia syndrome virus: the first case report in Thailand","volume":"16","author":"Daengnoi","year":"2020","journal-title":"Bangkok Med. J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e41365","DOI":"10.1371\/journal.pone.0041365","article-title":"Cytokine and chemokine levels in patients with severe fever with thrombocytopenia syndrome virus","volume":"7","author":"Deng","year":"2012","journal-title":"PloS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e80802","DOI":"10.1371\/journal.pone.0080802","article-title":"Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome Bunyavirus infection in Northeast China","volume":"8","author":"Deng","year":"2013","journal-title":"PloS One"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/s1473-3099(15)00177-2","article-title":"Emerging tick-borne infections in mainland China: an increasing public health threat","volume":"15","author":"Fang","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.jtha.2023.02.006","article-title":"Severe fever with thrombocytopenia syndrome virus replicates in platelets and enhances platelet activation","volume":"21","author":"Fang","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"B8","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1186\/s12879-020-05303-0","article-title":"Severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis of epidemiology, clinical signs, routine laboratory diagnosis, risk factors, and outcomes","volume":"20","author":"He","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3349\/ymj.2019.60.6.592","article-title":"Higher fatality for severe fever with thrombocytopenia syndrome complicated by hemophagocytic lymphohistiocytosis","volume":"60","author":"Jung","year":"2019","journal-title":"Yonsei Med. J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e1007375","DOI":"10.1371\/journal.ppat.1007375","article-title":"An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus","volume":"15","author":"Kim","year":"2019","journal-title":"PloS Pathog."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.3201\/eid1911.130792","article-title":"Severe fever with thrombocytopenia syndrome, South Korea 2012","volume":"19","author":"Kim","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0008801","DOI":"10.1371\/journal.pntd.0008801","article-title":"Correlation between thrombocytopenia and host response in severe fever with thrombocytopenia syndrome","volume":"14","author":"Li","year":"2020","journal-title":"PloS Negl. Trop. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s41392-021-00541-3","article-title":"Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct Target Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/s1473-3099(18)30293-7","article-title":"Epidemiological and clinical features of laboratory-diagnosed severe fever with thrombocytopenia syndrome in China 2011-17: a prospective observational study","volume":"18","author":"Li","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1093\/cid\/cit530","article-title":"Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in China who had severe fever with thrombocytopenia syndrome","volume":"57","author":"Liu","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.2169\/internalmedicine.56.6904","article-title":"Hemophagocytic lymphohistiocytosis in a fatal case of severe fever with thrombocytopenia syndrome","volume":"56","author":"Nakano","year":"2017","journal-title":"Intern. Med."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2025.2520343","article-title":"Bandavirus dabieense: A review of epidemiology, clinical characteristics, pathophysiology, treatment and prevention","volume":"16","author":"Peng","year":"2025","journal-title":"Virulence"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.3201\/eid2812.221183","article-title":"Severe fever with thrombocytopenia syndrome virus infection, Thailand 2019-2020","volume":"28","author":"Rattanakomol","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.coviro.2018.03.005","article-title":"Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development","volume":"29","author":"Reece","year":"2018","journal-title":"Curr. Opin. Virol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107512","article-title":"Favipiravir, an anti-influenza drug against life-threatening RNA virus infections","volume":"209","author":"Shiraki","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"B21","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1093\/infdis\/jit603","article-title":"The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan","volume":"209","author":"Takahashi","year":"2014","journal-title":"J. Infect. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.3201\/eid2505.181463","article-title":"Endemic severe fever with thrombocytopenia syndrome, Vietnam","volume":"25","author":"Tran","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.907888","article-title":"NLR, A convenient early-warning biomarker of fatal outcome in patients with severe fever with thrombocytopenia syndrome","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Microbiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.3201\/eid2608.200135","article-title":"Genotypic heterogeneity of Orientia tsutsugamushi in scrub typhus patients and thrombocytopenia syndrome co-infection, Myanmar","volume":"26","author":"Win","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jcv.2016.03.017","article-title":"The prospective evaluation of viral loads in patients with severe fever with thrombocytopenia syndrome","volume":"78","author":"Yang","year":"2016","journal-title":"J. Clin. Virol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N Engl. J. Med."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103591","article-title":"Clinical efficacy and safety evaluation of favipiravir in treating patients with severe fever with thrombocytopenia syndrome","volume":"72","author":"Yuan","year":"2021","journal-title":"EBioMedicine"},{"key":"B28","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12250-016-3931-1","article-title":"Current status of severe fever with thrombocytopenia syndrome in China","volume":"32","author":"Zhan","year":"2017","journal-title":"Virol. Sin."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.3201\/eid2607.190611","article-title":"Serologic evidence of severe fever with thrombocytopenia syndrome virus and related viruses in Pakistan","volume":"26","author":"Zohaib","year":"2020","journal-title":"Emerg. Infect. Dis."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1644207\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:16:26Z","timestamp":1762236986000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1644207\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":29,"alternative-id":["10.3389\/fcimb.2025.1644207"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2025.1644207","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"article-number":"1644207"}}