{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:31:45Z","timestamp":1793277105394,"version":"4.5.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To construct a differential diagnostic model for Non-Tuberculous Mycobacterial Lung Disease (NTM-LD) and Pulmonary Tuberculosis Lung Disease (PTB-LD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of 300 NTM-LD and 300 PTB-LD patients (pathogen-confirmed) was performed. Patients were randomly split into training (2\/3) and validation (1\/3) sets. CT imaging, clinical data, and symptoms were analyzed. Logistic regression identified significant discriminative features, followed by random forest modeling to develop a diagnostic tool with web-based calculator. Model performance was validated using the independent validation set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Univariate and multivariate analyses identified key discriminative factors (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt;0.05): cough with sputum, hemoptysis, thin-walled cavities, centrilobular nodules, bronchiectasis, diabetes, and autoimmune diseases. The diagnostic model achieved 82.5% sensitivity and 85.5% specificity (ROC analysis), with validation showing 78% sensitivity and 85% specificity, confirming strong discriminative power and calibration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The model constructed based on patients\u2019 CT imaging, basic clinical data, and symptomatic signs demonstrates commendable performance in the differential diagnosis of NTM-LD and PTB-LD, offering a convenient and practical auxiliary tool for clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2025.1667339","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:25:02Z","timestamp":1761891902000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The innovative diagnostic model facilitates the differentiation between non - tuberculous mycobacterial lung disease and pulmonary tuberculosis"],"prefix":"10.3389","volume":"15","author":[{"given":"Mingkun","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1186\/s12879-024-10067-y","article-title":"Comparative analysis of non-tuberculous mycobacterial lung disease and lung colonization: a case-control study","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Infect. 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