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PD primarily affects the tissues surrounding the teeth, leading to inflammation of the gums and periodontal tissues, destruction of the alveolar bone, and even loosening of the teeth. Numerous studies have shown that PD is not limited to the oral cavity but is also associated with the occurrence of diseases in multiple systems throughout the body. In recent years, increasing attention has been directed toward the interaction between PD and prostate diseases. This article reviews the potential associations between PD and prostate conditions such as chronic prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). It explores the pathological mechanisms underlying this interaction and its clinical implications. Additionally, this article aims to identify potential pathogenic mechanisms and propose possible approaches for preventing and treating prostate diseases through the management of PD.<\/jats:p>","DOI":"10.3389\/fcimb.2025.1669490","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T05:39:45Z","timestamp":1759901985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between periodontal disease and prostate disease: a mini review"],"prefix":"10.3389","volume":"15","author":[{"given":"Shuxin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chensen","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.48252","article-title":"An in-depth look into the epidemiological and etiological aspects of prostate cancer: A literature review","volume":"15","author":"Al-Ghazawi","year":"2023","journal-title":"Cureus."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e17742","DOI":"10.7759\/cureus.17742","article-title":"Presence of specific periodontal pathogens in prostate gland diagnosed with chronic inflammation and adenocarcinoma","volume":"13","author":"Alluri","year":"2021","journal-title":"Cureus."},{"key":"B3","doi-asserted-by":"publisher","first-page":"104164","DOI":"10.1016\/j.jdent.2022.104164","article-title":"Does smoking explain the association between use of e-cigarettes and self-reported periodontal disease","volume":"122","author":"AlQobaly","year":"2022","journal-title":"J. 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