{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:54:43Z","timestamp":1773042883799,"version":"3.50.1"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Dengue is a vector-borne viral fever that is spread by the bites of Aedes mosquitoes. Matrix metalloproteinases (MMPs) play a significant role in the beginning and development of dengue pathogenesis, but their precise functions with respect to neutrophil-associated lung pathology are not understood. In the present study, we, for the first time, report that\n                    <jats:italic>in-vitro<\/jats:italic>\n                    cultured neutrophils secrete MMP-2 in response to dengue virus NS1 antigens in culture medium (the secretome). We have assessed the effect of neutrophil secretome on the apoptosis of A549 lung epithelial cells and found that it causes their death. This suggested that neutrophils cause apoptosis of lung epithelial cells via MMP-2-mediated mechanisms. The exposure of purified MMP-2 protein has also caused cell death of A549 epithelial cells by increasing the mRNA expression pattern of apoptotic genes. Atorvastatin (10 \u00b5M) treatment attenuated the change in the release of MMP-2 and further decreased the apoptosis of lung epithelial cells. Interestingly, it was seen that MMP-14 alone and NS1 antigen alone do not cause the apoptosis of lung epithelial cells, ruling out their direct involvement. The interactions of CD31-positive neutrophils in lungs and MMP-2 expression were also found in NS1-injected mice, supporting their role in\n                    <jats:italic>in-vivo<\/jats:italic>\n                    situations. In conclusion, this study suggests that the interaction of NS1-activated neutrophils with the alveolar epithelial cells participates in the lung pathogenesis involved in the acute respiratory distress syndrome (ARDS) in severe dengue disease. The present results are encouraging; however, further investigations are required to clarify the findings.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2025.1670259","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:32:29Z","timestamp":1765434749000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Elucidation of neutrophils-mediated effect of MMP-2 on lung epithelial cells; implications for acute respiratory distress syndrome and severe dengue pathogenesis"],"prefix":"10.3389","volume":"15","author":[{"given":"Rituraj","family":"Niranjan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khashpatika","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Sunil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vyshali","family":"Murugasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pitchavel","family":"Vidhyapriya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthukumaravel","family":"Subramaniam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305528","article-title":"Uncovering the knowledge gap: A web-based survey of healthcare providers\u2019 understanding and management of dengue fever in East Azerbaijan, Iran","volume":"19","author":"Abbasi","year":"2024","journal-title":"PloS One"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1063\/5.0204336","article-title":"The timeline of overseas imported cases acts as a strong indicator of dengue outbreak in mainland China","volume":"34","author":"Abdalgader","year":"2024","journal-title":"Chaos"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30549","article-title":"Role of statin in reducing cardiovascular diseases in human immunodeficiency virus (HIV) patients: A systematic review","volume":"14","author":"Abdelghafar","year":"2022","journal-title":"Cureus"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2024.e01993","article-title":"Dengue encephalopathy concurrent with secondary pulmonary tuberculosis in an elderly male with multiple comorbidities","volume":"36","author":"Abdullah","year":"2024","journal-title":"IDCases"},{"key":"B5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s12012-025-09962-w","article-title":"Taxifolin protects against 5-fluorouracil-induced cardiotoxicity in mice through mitigating oxidative stress, inflammation, and apoptosis: possible involvement of sirt1\/Nrf2\/HO-1 signaling","volume":"5","author":"Abukhalil","year":"2025","journal-title":"Cardiovasc. Toxicol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens13050349","article-title":"Co-infections and superinfections between HIV-1 and other human viruses at the cellular level","volume":"13","author":"Acchioni","year":"2024","journal-title":"Pathogens"},{"key":"B7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40794-022-00169-3","article-title":"Dynamics of dengue and SARS-COV-2 co-infection in an endemic area of Colombia","volume":"8","author":"Acosta-P\u00e9rez","year":"2022","journal-title":"Trop. Dis. Travel Med. Vaccines"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00057-23","article-title":"Viral infections and pathogenesis of glaucoma: a comprehensive review","volume":"36","author":"Ahmad","year":"2023","journal-title":"Clin. Microbiol. Rev."},{"key":"B9","first-page":"1","article-title":"Dengue: A global health concern","volume":"17","author":"Alghsham","year":"2023","journal-title":"Int. J. Health Sci. (Qassim)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/s12985-024-02608-3","article-title":"The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection","volume":"21","author":"Allela","year":"2024","journal-title":"Virol. J."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/cells13211750","article-title":"Dual inhibition of phosphodiesterase 3 and 4 enzymes by ensifentrine protects against MRSA-induced lung endothelial and epithelial dysfunction","volume":"13","author":"Al Matni","year":"2024","journal-title":"Cells"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1354510","article-title":"Dengue in Pune city, India (2017-2019): a comprehensive analysis","volume":"12","author":"Arankalle","year":"2024","journal-title":"Front. Public Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1016\/j.cub.2005.10.041","article-title":"Bax\/Bak-dependent release of DDP\/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death","volume":"15","author":"Arnoult","year":"2005","journal-title":"Curr. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1476-4598-12-65","article-title":"BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove","volume":"12","author":"Azad","year":"2013","journal-title":"Mol. Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.yjmcc.2024.11.013","article-title":"MMP-2 inhibition attenuates ER stress-mediated cell death during myocardial ischemia-reperfusion injury by preserving IRE1alpha","volume":"198","author":"Bassiouni","year":"2025","journal-title":"J. Mol. Cell Cardiol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00632-1","article-title":"Dengue fever: working towards global control considering biological, social, and planetary determinants","volume":"23","author":"Bellissimo-Rodrigues","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.3892\/mmr.2016.5519","article-title":"The anti\u2212dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression","volume":"14","author":"Bryan-Marrugo","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e633","DOI":"10.1016\/j.clbc.2024.06.008","article-title":"Antiapoptotic and prometastatic roles of cytokine FAM3B in triple-negative breast cancer","volume":"24","author":"Caldeira","year":"2024","journal-title":"Clin. Breast Cancer"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/j.devcel.2022.03.019","article-title":"Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage","volume":"57","author":"Cao","year":"2022","journal-title":"Dev. Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1136\/annrheumdis-2013-204837","article-title":"Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2","volume":"74","author":"Carmona-Rivera","year":"2015","journal-title":"Ann. Rheum Dis."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081923","article-title":"Chemical constituents, antioxidant, anti-MMPs, and anti-hyaluronidase activities of thunbergia laurifolia lindl. Leaf extracts for skin aging and skin damage prevention","volume":"25","author":"Chaiyana","year":"2020","journal-title":"Molecules"},{"key":"B22","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1016\/j.celrep.2018.10.087","article-title":"BAX\/BAK-induced apoptosis results in caspase-8-dependent IL-1beta maturation in macrophages","volume":"25","author":"Chauhan","year":"2018","journal-title":"Cell Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1093\/infdis\/jiac383","article-title":"Association of neutrophil mediators with dengue disease severity and cardiac impairment in adults","volume":"226","author":"Chia","year":"2022","journal-title":"J. Infect. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.tcb.2008.01.007","article-title":"How do BCL-2 proteins induce mitochondrial outer membrane permeabilization","volume":"18","author":"Chipuk","year":"2008","journal-title":"Trends Cell Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.tim.2024.04.011","article-title":"Neutrophils - an understudied bystander in dengue","volume":"32","author":"Chua","year":"2024","journal-title":"Trends Microbiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"183716","DOI":"10.1016\/j.bbamem.2021.183716","article-title":"Apoptosis regulation at the mitochondria membrane level","volume":"1863","author":"Dadsena","year":"2021","journal-title":"Biochim. Biophys. Acta Biomembr"},{"key":"B27","doi-asserted-by":"publisher","first-page":"116563","DOI":"10.1016\/j.ejmech.2024.116563","article-title":"Derivatives of D(-) glutamine-based MMP-2 inhibitors as an effective remedy for the management of chronic myeloid leukemia-Part-I: Synthesis, biological screening and in silico binding interaction analysis","volume":"274","author":"Das","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1186\/s12964-024-01779-4","article-title":"Immunomodulation in dengue: towards deciphering dengue severity markers","volume":"22","author":"Dash","year":"2024","journal-title":"Cell Commun. Signal"},{"key":"B29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s10863-024-10044-9","article-title":"Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress","volume":"56","author":"Deng","year":"2024","journal-title":"J. Bioenerg Biomembr"},{"key":"B30","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/S0898-6568(02)00124-9","article-title":"Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells","volume":"15","author":"Denoyelle","year":"2003","journal-title":"Cell Signal"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e70036","DOI":"10.1002\/hem3.70036","article-title":"Expression profile of Bcl-2 family proteins in newly diagnosed multiple myeloma patients","volume":"8","author":"De Ram\u00f3n","year":"2024","journal-title":"Hemasphere"},{"key":"B32","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/jcla.20393","article-title":"Plasma levels of matrix metalloproteinase-8 in patients with carotid atherosclerosis","volume":"24","author":"Djuric","year":"2010","journal-title":"J. Clin. Lab. Anal."},{"key":"B33","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/jleuko\/qiad099","article-title":"Dengue virus infection in mice induces bone marrow myeloid cell differentiation and generates Ly6Glow immature neutrophils with modulated functions","volume":"115","author":"Duggal","year":"2024","journal-title":"J. Leukoc. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"17958","DOI":"10.1038\/s41598-019-53238-7","article-title":"Statin treatment increases the clinical risk of tendinopathy through matrix metalloproteinase release - a cohort study design combined with an experimental study","volume":"9","author":"Eliasson","year":"2019","journal-title":"Sci. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1177\/0003319716688301","article-title":"Impact of statin therapy on plasma MMP-3, MMP-9, and TIMP-1 concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials","volume":"68","author":"Ferretti","year":"2017","journal-title":"Angiology"},{"key":"B36","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.medcle.2024.01.031","article-title":"Arbovirus - a threat to transfusion safety in Spain: a narrative review","volume":"163","author":"Gimenez-Richarte","year":"2024","journal-title":"Med. Clin. (Barc)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"22005","DOI":"10.1074\/jbc.M115.643064","article-title":"Bax\/bak-dependent, drp1-independent targeting of X-linked inhibitor of apoptosis protein (XIAP) into inner mitochondrial compartments counteracts smac\/DIABLO-dependent effector caspase activation","volume":"290","author":"Hamacher-Brady","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.61941","article-title":"The role of matrix metalloproteinase-2 (MMP2) in colorectal cancer progression: correlation with clinicopathological features and impact on cellular processes","volume":"16","author":"Ibraheem","year":"2024","journal-title":"Cureus"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.amjmed.2024.08.011","article-title":"Statin therapy, inflammation, and outcomes in patients hospitalized for COVID-19: A prospective multicenter cohort study","volume":"137","author":"Ismail","year":"2024","journal-title":"Am. J. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jacc.2023.04.050","article-title":"Dyslipidemia in human immunodeficiency virus disease: JACC review topic of the week","volume":"82","author":"Kalra","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.60655","article-title":"Lung manifestation of dengue fever: A retrospective study","volume":"16","author":"Keshav","year":"2024","journal-title":"Cureus"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252312547","article-title":"Neutrophils in the spotlight-an analysis of neutrophil function and phenotype in ARDS","volume":"25","author":"Kraus","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1134\/S0006297924110130","article-title":"Role of MMP-2 and MMP-9 in the relationship between inflammation, fibrosis, and apoptosis during progression of non-alcoholic fatty liver disease and diagnostic significance of plasma levels of their active forms","volume":"89","author":"Kurbatova","year":"2024","journal-title":"Biochem. (Mosc)"},{"key":"B44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.4149\/neo_2024_240116N24","article-title":"Calreticulin regulates the expression of MMP14 and ADAR1 through EIF2AK2 signaling to promote the proliferation and progression of Malignant melanoma cells","volume":"71","author":"Liang","year":"2024","journal-title":"Neoplasma"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3760\/cma.j.cn121430-20231011-00862","article-title":"Aspirin reduces lung inflammatory response in acute lung injury\/acute respiratory distress syndrome: a Meta-analysis based on animal experiments","volume":"36","author":"Liu","year":"2024","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"B46","doi-asserted-by":"publisher","first-page":"ofac061","DOI":"10.1093\/ofid\/ofac061","article-title":"Olfactomedin 4 is a biomarker for the severity of infectious diseases","volume":"9","author":"Liu","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"046107","DOI":"10.1063\/5.0233961","article-title":"Apoptosis-associated genetic mechanisms in the transition from rheumatoid arthritis to osteoporosis: A bioinformatics and functional analysis approach","volume":"8","author":"Lo","year":"2024","journal-title":"APL Bioeng"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/s42003-021-02754-2","article-title":"Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection","volume":"4","author":"Malhi","year":"2021","journal-title":"Commun. Biol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0012071","article-title":"Endothelial and inflammatory pathophysiology in dengue shock: New insights from a prospective cohort study in Vietnam","volume":"18","author":"McBride","year":"2024","journal-title":"PloS Negl. Trop. Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1093\/infdis\/jiae252","article-title":"Neutrophil extracellular traps: an emerging therapeutic target to improve infectious disease outcomes","volume":"230","author":"Meier","year":"2024","journal-title":"J. Infect. Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13098-021-00727-3","article-title":"Galectin-3, metalloproteinase-2 and cardiovascular disease were independently associated with metalloproteinase-14 in patients with type 1 diabetes: a cross sectional study","volume":"13","author":"Melin","year":"2021","journal-title":"Diabetol. Metab. Syndr."},{"key":"B52","doi-asserted-by":"publisher","first-page":"110095","DOI":"10.1016\/j.virol.2024.110095","article-title":"Exploring the interplay between miRNAs, apoptosis and viral load, in Dengue virus infection","volume":"596","author":"Melo","year":"2024","journal-title":"Virology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.intimp.2019.05.022","article-title":"Nonstructural protein-1 (NS1) of dengue virus type-2 differentially stimulate expressions of matrix metalloproteinases in monocytes: protective effect of paracetamol","volume":"73","author":"Niranjan","year":"2019","journal-title":"Int. Immunopharmacol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.2174\/1386207325666220105150655","article-title":"Eosinophils restrict diesel exhaust particles-induced cell proliferation of lung epithelial A549 cells via interleukin-13 mediated mechanisms: implications for tissue remodeling and fibrosis","volume":"25","author":"Niranjan","year":"2022","journal-title":"Comb Chem. High Throughput Screen"},{"key":"B55","doi-asserted-by":"publisher","first-page":"109082","DOI":"10.1016\/j.intimp.2022.109082","article-title":"Atorvastatin attenuates NS1 (Non-structural protein-1) of dengue type-2 serotype-induced expressions of matrix metalloproteinases in HL-60 cells, differentiated to neutrophils: Implications for the immunopathogenesis of dengue viral disease","volume":"112","author":"Niranjan","year":"2022","journal-title":"Int. Immunopharmacol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000501209","article-title":"The involvement of neuroinflammation in dengue viral disease: importance of innate and adaptive immunity","volume":"26","author":"Niranjan","year":"2019","journal-title":"Neuroimmunomodulation"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00782-X","article-title":"Dengue control, if not by vaccination and vector strategies, then possibly by therapeutics","volume":"24","author":"Niranjan","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/s44319-024-00346-9","article-title":"Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs","volume":"26","author":"Nishimura","year":"2025","journal-title":"EMBO Rep."},{"key":"B59","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.numecd.2022.10.005","article-title":"Statin therapy may protect against acute kidney injury in patients hospitalized for interstitial SARS-CoV2 pneumonia","volume":"33","author":"Piani","year":"2023","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s10753-017-0541-5","article-title":"Atorvastatin and simvastatin promoted mouse lung repair after cigarette smoke-induced emphysema","volume":"40","author":"Pinho-Ribeiro","year":"2017","journal-title":"Inflammation"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3390\/md22080369","article-title":"Antiviral Effect of Microalgae Phaeodactylum tricornutum Protein Hydrolysates against Dengue Virus Serotype 2","volume":"22","author":"Rivera-Serrano","year":"2024","journal-title":"Mar. Drugs"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.5455\/OVJ.2024.v14.i4.11","article-title":"Anti-inflammatory effect of Faloak (Sterculia quadrifida R. Br) stem bark on TNF-alpha, IL-1beta, and IL-6 in DENV-3-infected Wistar rats","volume":"14","author":"Riwu","year":"2024","journal-title":"Open Vet. J."},{"key":"B63","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1556\/1886.2024.00069","article-title":"Circulating dengue virus serotypes, demographics, and epidemiology in the 2023 dengue outbreak in Chittagong, Bangladesh","volume":"14","author":"Rob","year":"2024","journal-title":"Eur. J. Microbiol. Immunol. (Bp)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s40249-017-0328-9","article-title":"Dengue-specific serotype related to clinical severity during the 2012\/2013 epidemic in centre of Brazil","volume":"6","author":"Rocha","year":"2017","journal-title":"Infect. Dis. Poverty"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.65375","article-title":"Local transmission of dengue in South Florida: A case report","volume":"16","author":"Rodriguez","year":"2024","journal-title":"Cureus"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11071240","article-title":"A review: understanding molecular mechanisms of antibody-dependent enhancement in viral infections","volume":"11","author":"Sawant","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"B67","doi-asserted-by":"publisher","first-page":"101501","DOI":"10.1016\/j.bbrep.2023.101501","article-title":"In-Silico CLEC5A mRNA expression analysis to predict Dengue susceptibility in cancer patients","volume":"35","author":"Suchanti","year":"2023","journal-title":"Biochem. Biophys. Rep."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2024-0292OC","article-title":"Increased circulating extracellular superoxide dismutase attenuates platelet-neutrophil interactions","volume":"72","author":"Sul","year":"2024","journal-title":"Am. J. Respir. Cell Mol. Biol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.65175","article-title":"Clinical profile of dengue seropositive infection from a tertiary care hospital situated in Mysuru, South India","volume":"16","author":"Tejashree","year":"2024","journal-title":"Cureus"},{"key":"B70","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1165\/rcmb.2018-0254OC","article-title":"Attenuation of Allergen-, IL-13-, and TGF-alpha-induced Lung Fibrosis after the Treatment of rIL-15 in Mice","volume":"61","author":"Upparahalli Venkateshaiah","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402421","article-title":"Spontaneous inflammation resolution inspired nanoparticles promote neutrophil apoptosis and macrophage efferocytosis for acute respiratory distress syndrome treatment","volume":"14","author":"Wang","year":"2024","journal-title":"Adv. Healthc Mater"},{"key":"B72","doi-asserted-by":"publisher","first-page":"71","DOI":"10.24976\/Discov.Med.202436180.6","article-title":"Curcumin inhibits bladder cancer by inhibiting invasion via AKT\/MMP14 pathway","volume":"36","author":"Wang","year":"2024","journal-title":"Discov. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"9119","DOI":"10.2147\/JIR.S488463","article-title":"Role of cellular senescence genes and immune infiltration in sepsis and sepsis-induced ARDS based on bioinformatics analysis","volume":"17","author":"Wu","year":"2024","journal-title":"J. Inflammation Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"104739","DOI":"10.1016\/j.ebiom.2023.104739","article-title":"Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice","volume":"95","author":"Zhang","year":"2023","journal-title":"EBioMedicine"},{"key":"B75","doi-asserted-by":"publisher","first-page":"51957","DOI":"10.1021\/acsami.4c09022","article-title":"Artificial neutrophil-mediated CEBPA-saRNA delivery to ameliorate ALI\/ARDS","volume":"16","author":"Zhang","year":"2024","journal-title":"ACS Appl. Mater Interfaces"}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1670259\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:32:33Z","timestamp":1765434753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1670259\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":75,"alternative-id":["10.3389\/fcimb.2025.1670259"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2025.1670259","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"article-number":"1670259"}}