{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:34:31Z","timestamp":1765780471334,"version":"3.48.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Understanding the immunoregulatory mechanism during cytomegalovirus (CMV) infection may help to combat CMV reactivation in immunocompromised or immunosuppressed individuals. Here we developed a CMV infection model in immunocompetent Sprague Dawley (SD) rats with Priscott strain and explored the cross-talk between autophagic dynamics and metabolism alterations in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells post infection. We previously found that primary CMV infection induced a remarkable increase of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells which reached the peak around week 3 and returned to pre-inoculation status since week 6 post viral infection. In this study, our results demonstrated that the autophagic activity of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells was augmented at week 3 while decreased at week 6, which was closely associated with the up- (week 3 and 4) or down-regulation (since week 6) of metabolic markers ENTPD1 and SLC27A2. Furthermore, the\n                    <jats:italic>in vitro<\/jats:italic>\n                    study showed that the levels of these metabolic markers in rat splenocytes were modulated by autophagy inhibitors and enhancers. Our study indicated that the dynamic alterations of autophagy exerted a critical role in regulating the metabolic adaptation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells during CMV infection process, and provides an ideal animal model for further research on the pathological mechanisms based on CMV latency.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2025.1673229","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:29:44Z","timestamp":1765780184000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Autophagic regulation of CD8+ T cell metabolic reprogramming defines acute and latent phases of cytomegalovirus infection in vivo"],"prefix":"10.3389","volume":"15","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai Ho Oscar","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin Tak Pan","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1006\/viro.1998.9196","article-title":"The Maastricht strain and England strain of rat cytomegalovirus represent different betaherpesvirus species rather than strains","volume":"246","author":"Beisser","year":"1998","journal-title":"Virology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/BF01311103","article-title":"Infection of laboratory rats with a new cytomegalo-like virus","volume":"76","author":"Bruggeman","year":"1983","journal-title":"Arch. 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