{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:47:07Z","timestamp":1792424827905,"version":"4.5.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Hypervirulent\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                      (hvKp) has emerged as a significant public health threat owing to its ability to cause invasive infections. This study aimed to investigate the clinical characteristics and epidemiological associations of hypervirulent Klebsiella pneumoniae (hvKp) and classical\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      (cKp) among patients treated at a tertiary hospital in Zhuhai City, Guangdong Province, China, during the period from January to December 2022, in the context of the ongoing COVID-19 pandemic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A total of 97 non-duplicated\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      isolates and corresponding clinical data were collected. Antimicrobial susceptibility testing, hypermucoviscosity phenotyping, sequence typing, capsular serotyping, and whole-genome sequencing were performed. Hypervirulent strains were identified by the presence of the\n                      <jats:italic>rmpA<\/jats:italic>\n                      ,\n                      <jats:italic>rmpA2<\/jats:italic>\n                      ,\n                      <jats:italic>iucA<\/jats:italic>\n                      ,\n                      <jats:italic>iroB<\/jats:italic>\n                      ,\n                      <jats:italic>peg-344<\/jats:italic>\n                      , and\n                      <jats:italic>peg-589<\/jats:italic>\n                      genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 97 isolates, 40 (41.2%) were classified as hvKp. Compared with cKp, hvKp was significantly more likely to cause bacteraemia (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05) and less likely to cause urinary tract infections (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). The K20 capsular serotype was significantly associated with hvKp isolates (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). The multidrug resistance rate among hvKp strains (22.5%) was markedly lower than that among cKp strains (56.63%), and extended-spectrum \u03b2-lactamase production was more common in cKp strains. Multilocus sequence typing identified 29 sequence types, including 24 novel types. Whole-genome sequencing of a multidrug-resistant hvKp isolate (Kp00198874) revealed an ST11-K64 strain resistant to all tested antibiotics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The prevalence of hvKp increased during the COVID-19 pandemic in Guangdong, China. The isolates identified in this study represent sporadic infections, and the emergence of ST11-K64 hypervirulent carbapenem-resistant K. pneumoniae (hv-CRKp) highlights the urgent need for continued surveillance and vigilance regarding hvKp-associated bacteraemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2025.1701929","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:34:24Z","timestamp":1768545264000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiological and characteristic differences of hypervirulent and classical Klebsiella pneumoniae: a clinical and genomic study in Southern China during the COVID-19 pandemic"],"prefix":"10.3389","volume":"15","author":[{"given":"Yushan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation 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