{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:58:55Z","timestamp":1779400735640,"version":"3.53.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the effects of a comprehensive nursing protocol combined with a probiotic intervention on improving gastrointestinal function, reducing non-infectious complications, and enhancing the quality of life in patients with advanced digestive malignancies undergoing chemotherapy, thereby providing evidence-based support for chemotherapy nursing care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 300 advanced digestive malignancy patients undergoing chemotherapy at Our Oncology Specialty Hospital from January 2021 to December 2024 were randomly divided into a control group (150 patients) and an observation group (150 patients) using a random number table. The control group received conventional chemotherapy nursing care, while the observation group received a combined probiotic intervention along with comprehensive nursing care. Baseline data, gastrointestinal function scores (bloating, diarrhea, constipation, nausea\/vomiting), nutritional status indicators (serum albumin, prealbumin, BMI), and quality of life scores (EORTC QOLQ-C30) were recorded before and after 2, 4, and 8 weeks of intervention. Non-infectious complications and nursing satisfaction were also evaluated. The dynamic effects of the intervention were analyzed using Generalized Estimation Equations (GEE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences were observed between the groups at baseline (P&amp;gt;0.05). However, after 2, 4, and 8 weeks of intervention, the observation group exhibited significantly improved gastrointestinal function, with lower scores across all dimensions compared to the control group (P&amp;lt;0.05). At week 8, the total gastrointestinal function score in the observation group (1.57\u00a0\u00b1\u00a00.58) was significantly lower than the control group (3.74\u00a0\u00b1\u00a01.05) (t=22.156, P\u00a0=\u00a00.000). The observation group also showed significantly higher nutritional indicators: serum albumin (41.53\u00a0\u00b1\u00a02.96 vs. 36.18\u00a0\u00b1\u00a03.42), prealbumin (276.41\u00a0\u00b1\u00a017.53 vs. 218.65\u00a0\u00b1\u00a020.37), and BMI (23.58\u00a0\u00b1\u00a02.86 vs. 22.37\u00a0\u00b1\u00a03.21) (P&amp;lt;0.01). Additionally, the observation group had higher quality of life scores and lower complication rates (P&amp;lt;0.05), with increased nursing satisfaction. GEE analysis confirmed that the observation group showed greater improvements in all measured indicators over time compared to the control group (P&amp;lt;0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The comprehensive nursing protocol with probiotic intervention significantly improves gastrointestinal function, enhances nutritional status, reduces non-infectious complications, and boosts the quality of life in chemotherapy patients with advanced digestive malignancy. This intervention demonstrates substantial clinical benefits and therapeutic value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2025.1718665","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T18:22:08Z","timestamp":1767723728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive nursing care for advanced digestive malignancy patients during chemotherapy based on probiotic intervention: a randomized controlled study on improvement of gastrointestinal function and prevention of complications"],"prefix":"10.3389","volume":"15","author":[{"given":"Feng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chennuo","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3332\/ecancer.2017.779","article-title":"Prognostic value of a patient-reported functional score versus physician-reported Karnofsky performance status score in brain metastases","volume":"11","author":"Agarwal","year":"2017","journal-title":"Ecancermedicalscience"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.cell.2023.03.011","article-title":"Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment","volume":"186","author":"Bender","year":"2023","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.3390\/nu15132971","article-title":"Efficacy and safety of a parenteral nutrition program for patients with RAS wild-type metastatic colorectal cancer administered first-line cetuximab plus chemotherapy: A propensity score matching study","volume":"15","author":"Chang","year":"2023","journal-title":"Nutrients"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1007\/s00520-014-2487-6","article-title":"Substantial decreases in the number and diversity of microbiota during chemotherapy-induced gastrointestinal mucositis in a rat model","volume":"23","author":"Fijlstra","year":"2015","journal-title":"Supportive Care Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/apha.14188","article-title":"Endoplasmic reticulum stress in the pathogenesis of chemotherapy-induced mucositis: Physiological mechanisms and therapeutic implications","volume":"240","author":"Heindryckx","year":"2024","journal-title":"Acta Physiologica"},{"key":"B6","doi-asserted-by":"publisher","first-page":"102195","DOI":"10.1016\/j.esmoop.2023.102195","article-title":"2023 MASCC and ESMO guideline update for the prevention of chemotherapy-and radiotherapy-induced nausea and vomiting","volume":"9","author":"Herrstedt","year":"2024","journal-title":"ESMO Open"},{"key":"B7","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/nu17020270","article-title":"Nutritional status and nutritional support in patients with gastrointestinal diseases","volume":"17","author":"Jab\u0142o\u0144ska","year":"2025","journal-title":"Nutrients"},{"key":"B8","doi-asserted-by":"publisher","first-page":"285","DOI":"10.7762\/cnr.2017.6.4.285","article-title":"Effect of personalized nutritional counseling on the nutritional status of hemodialysis patients","volume":"6","author":"Jo","year":"2017","journal-title":"Clin. 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