{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T08:48:40Z","timestamp":1771922920818,"version":"3.50.1"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    Cystic echinococcosis is an important parasitic zoonosis infecting numerous humans with high morbidity and mortality. As one of the etiologic agents,\n                    <jats:italic>Echinococcus ortleppi<\/jats:italic>\n                    infection in humans has been very rare. In this study, a 27-year-old man was diagnosed with cystic echinococcosis in Wuhan City of China, a non-endemic area. Next-generation sequencing identified that the etiologic agent was\n                    <jats:italic>E. ortleppi.<\/jats:italic>\n                    Its complete mitochondrion sequence (13,600 bp) has 99.92% identity to\n                    <jats:italic>E. ortleppi<\/jats:italic>\n                    from cattle in Japan. This is the third reported\n                    <jats:italic>E. ortleppi<\/jats:italic>\n                    infection case in China. Although extensive epidemiological investigations were performed, the infection source of this patient is still unclear. It is possible that there exists some hidden or unrecognized route of\n                    <jats:italic>E. ortleppi<\/jats:italic>\n                    transmission in China. Further investigation is needed to figure out and eliminate the risk factors.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2025.1719268","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:30:26Z","timestamp":1769081426000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A new case of Echinococcus ortleppi infection diagnosed by next-generation sequencing in China"],"prefix":"10.3389","volume":"15","author":[{"given":"Xishuai","family":"Jia","sequence":"first","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhua","family":"Tian","sequence":"additional","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Clinical Laboratory General Hospital of The Yangtze River Shipping Wuhan Brain Hospital","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention","place":["Wuhan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5527\/wjn.v14.i2.103027","article-title":"Echinococcus granulosus in atypical localizations: Five case reports","volume":"14","author":"Celik","year":"2025","journal-title":"World J. Nephrol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2021.102316","article-title":"First description of the emergence of Echinococcus ortleppi (G5 genotype) in sheep and goats in Iran","volume":"83","author":"Gholami","year":"2021","journal-title":"Parasitol. Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.3201\/eid2012.140641","article-title":"Echinococcus ortleppi infections in humans and cattle, France","volume":"20","author":"Grenouillet","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1186\/s13071-019-3653-y","article-title":"First description of Echinococcus ortleppi infection in China","volume":"12","author":"Shi","year":"2019","journal-title":"Parasit Vectors."},{"key":"B5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s40249-021-00907-3","article-title":"The pathology, phylogeny, and epidemiology of Echinococcus ortleppi (G5 genotype): a new case report of echinococcosis in China","volume":"10","author":"Wang","year":"2021","journal-title":"Infect. Dis. Poverty."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2024.102949","article-title":"Echinococcus ortleppi infection in humans: An emerging zoonosis in Asia","volume":"103","author":"Yoshida","year":"2024","journal-title":"Parasitol. Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s40249-020-00747-7","article-title":"Progress on the national echinococcosis control programme in China: analysis of humans and dogs population intervention during 2004-2014","volume":"9","author":"Yu","year":"2020","journal-title":"Infect. Dis. Poverty."}],"container-title":["Frontiers in Cellular and Infection Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1719268\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:43:14Z","timestamp":1771918994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcimb.2025.1719268\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":7,"alternative-id":["10.3389\/fcimb.2025.1719268"],"URL":"https:\/\/doi.org\/10.3389\/fcimb.2025.1719268","relation":{},"ISSN":["2235-2988"],"issn-type":[{"value":"2235-2988","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"article-number":"1719268"}}