{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:50:48Z","timestamp":1776952248573,"version":"3.51.4"},"reference-count":117,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Blood-group antigens are increasingly recognized as key modulators of malaria susceptibility. This review synthesizes current evidence on how erythrocyte surface molecules shape parasite invasion, cytoadherence, immune evasion, and disease severity. We focus on a curated set of systems, ABO, Duffy, MNS, Gerbich, Knops, Diego, and others, and outline their molecular mechanisms affecting malaria. Population heterogeneity, parasite-host adaptations\/counter-adaptations, and clinical implications for risk stratification, transfusion safety, and vaccine design are also discussed.<\/jats:p>","DOI":"10.3389\/fcimb.2025.1727335","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:35:40Z","timestamp":1765348540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Blood group antigens and malaria susceptibility"],"prefix":"10.3389","volume":"15","author":[{"given":"Fang-Fang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/j.bbrc.2016.08.096","article-title":"Multiple Plasmodium vivax proteins of Pv-fam-a family interact with human erythrocyte receptor Band 3 and have a role in red cell invasion","volume":"478","author":"Alam","year":"2016","journal-title":"Biochem. 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