{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:23:13Z","timestamp":1792606993129,"version":"4.5.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Objective<\/jats:title>\n This study aimed to analyze the distribution characteristics and dynamic trends of antimicrobial resistance among pathogens isolated from blood cultures of adult patients at a large tertiary hospital in southern Jiangxi Province, China, from 2020 to 2024, in order to provide evidence-based guidance for the prevention and treatment of bloodstream infections.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This study conducted a retrospective analysis of non-repetitive isolates from blood cultures of adult patients at a large tertiary hospital in southern Jiangxi Province between 2020 and 2024. Statistical analysis was performed using WHONET 5.6 and SPSS Statistics 30 software.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n This study included a total of 3,695 pathogenic bacteria, with Gram-negative bacteria predominating (61.92%,2,288\/3,695). Among Gram-negative bacteria,\n Escherichia coli<\/jats:italic>\n (28.99%,1,071\/3,695) and\n Klebsiella pneumoniae<\/jats:italic>\n (14.72%,544\/3,695) were the most prevalent. Antimicrobial resistance analysis revealed that the detection rate of carbapenem-resistant\n Klebsiella pneumoniae (CRKP)<\/jats:italic>\n surged sharply from 1.2% (1\/82) in 2020 to 21.8% (26\/119) in 2024; the detection rate of carbapenem-resistant\n Acinetobacter baumannii (CRAB)<\/jats:italic>\n increased from 33.3%(5\/15) in 2020 to 76.5% (13\/17) in 2024. In contrast, the detection rate of methicillin-resistant\n Staphylococcus aureus (MRSA)<\/jats:italic>\n decreased significantly from 24.3% (17\/73) in 2020 to 13.5% (10\/74) in 2024. Among\n Enterococci<\/jats:italic>\n , the rate of high-level gentamicin resistance (HLGR, defined as resistance to 500 \u00b5g\/ml gentamicin) in\n Enterococcus faecium<\/jats:italic>\n increased significantly, from 10% (1\/10) in 2020 to 66.7% (14\/21) in 2024, and vancomycin-resistant\n Enterococcus faecium<\/jats:italic>\n (VREfm) was detected at a rate of 9.5% (2\/21) in 2024.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In a tertiary hospital in southern Jiangxi, China, Gram-negative bacteria predominate among Patients with positive blood cultures, with sharply rising detection rates of\n CRKP<\/jats:italic>\n ,\n CRAB<\/jats:italic>\n , and\n VREfm<\/jats:italic>\n posing a public health threat. Meanwhile, the declining prevalence of\n MRSA<\/jats:italic>\n indicates that infection control measures are effective against Gram-positive bacteria. Therefore, continuous surveillance of drug-resistant bacteria is essential, and antimicrobial stewardship measures must be implemented immediately to curb their spread. A limitation of this study is that it was conducted at a single center, which may restrict the generalizability of the findings to other regions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2025.1727877","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:31:35Z","timestamp":1768285895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Epidemiological characteristics and antimicrobial resistance of pathogens isolated from blood cultures in southern Jiangxi, China, 2020\u20132024"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhengting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3947\/ic.2022.0069","article-title":"Bloodstream infections in patients with hematologic diseases: causative organisms and factors associated with resistance","volume":"54","author":"Choi","year":"2022","journal-title":"Infect. 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