{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:06:16Z","timestamp":1784786776134,"version":"3.55.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019448","name":"Zigong Science and Technology Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Background<\/jats:title>\n Aging underlies numerous diseases, including Parkinson\u2019s disease (PD) and constipation. A large proportion of patients with PD often suffer from constipation; however, it remains unclear whether older patients with constipation and those with Parkinson\u2019s disease share common gut microbiota characteristics.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n This study analyzed the characteristics of the gut microbiota in older adults with constipation or PD to identify differences and similarities and to evaluate the possible role of the microbiota in PD and constipation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Raw data from fecal samples of 860 selected older adults from the Gut Microbiota Database (GMrepo) were analyzed, including patients with PD (n=378), constipation (CP, n=189), and healthy participants (CON, n=293).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The CP group displayed a higher relative abundance of\n Bacteroides<\/jats:italic>\n and\n Akkermansia<\/jats:italic>\n , and a decreased relative abundance of\n Prevotella<\/jats:italic>\n ,\n Faecalibacterium<\/jats:italic>\n , and\n Agathobacterium<\/jats:italic>\n than the CON group. Similarly, the PD group exhibited an increased relative abundance of\n Bacteroides<\/jats:italic>\n ,\n Akkermansia<\/jats:italic>\n ,\n Parabacteroides<\/jats:italic>\n ,\n Phascolarctobacterium<\/jats:italic>\n , and\n Bifidobacterium<\/jats:italic>\n , and a decreased relative abundance of\n Escherichia-Shigella<\/jats:italic>\n ,\n Faecalibacterium<\/jats:italic>\n ,\n Agathobacterium<\/jats:italic>\n , and\n Prevotella<\/jats:italic>\n . Further analysis revealed that, compared with the CON group, most bacteria were enriched or deficient in the CP and PD groups, such as\n Bacteroides, Akkermansia<\/jats:italic>\n ,\n Faecalibacterium<\/jats:italic>\n ,\n Agathobacterium<\/jats:italic>\n , and\n Prevotella<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The microbiota composition and structure of older adults with constipation or PD were similar and significantly different from those of healthy controls. This may partially explain the coexistence of constipation and PD in terms of the gut microbiota.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1688918","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:39:25Z","timestamp":1784785165000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Older adults with constipation and Parkinson\u2019s disease share comparable gut microbiota"],"prefix":"10.3389","volume":"16","author":[{"given":"Leyong","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Cosmetic and Plastic Surgery, Zigong Fourth People\u2019s Hospital","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zigong Fourth People's Hospital","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Affiliated Hospital of Qingdao University","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Zigong Institute of Brain Science, Zigong Affiliated Hospital of Southwest Medical University","place":["Zigong, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zigong Fourth People's Hospital","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zigong Fourth People's Hospital","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zigong Fourth People's Hospital","place":["Zigong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/alz.12192","article-title":"Hypothesis: tau pathology is an initiating factor in sporadic Alzheimer's disease","volume":"17","author":"Arnsten","year":"2021","journal-title":"Alzheimers Dement"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.3390\/nu12123759","article-title":"The gut microbiome, aging, and longevity: a systematic review","volume":"12","author":"Badal","year":"2020","journal-title":"Nutrients"},{"key":"B3","doi-asserted-by":"publisher","first-page":"10719","DOI":"10.1073\/pnas.1711233114","article-title":"Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice","volume":"114","author":"Berer","year":"2017","journal-title":"Proc. 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