{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:22:07Z","timestamp":1774380127290,"version":"3.50.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) increases the incidence of active tuberculosis (TB). This study aimed to assess the prevalence and risk factors of latent tuberculosis infection (LTBI) among T2DM in Shenzhen, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 1,363 patients with T2DM and no prior history of TB were enrolled from three tertiary general hospitals. The interferon-gamma release assay (IGRA) was conducted to assess LTBI. Simple and multiple logistic regression analyses were conducted to identify the risk factors related with LTBI among type 2 diabetics. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) between T2DM and LTBI were estimated using multiple logistic regression, which also corrected for possible covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of LTBI among type 2 diabetics was 63.7%. No notable differences were observed in socio-demographic characteristics between LTBI and non-LTBI subjects. Identified risk factors for LTBI included higher education levels, living with a relative with TB, an HbA1c level above 7%, and a hemoglobin level exceeding 14 g\/dL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>More than half of patients with T2DM are affected by LTBI. Specific environmental exposures and poor glycemic control\u2014evidenced by glycosylated hemoglobin (HbA1c) levels exceeding 7% and hemoglobin levels above 14 g\/dL\u2014have been recognized as significant risk factors for LTBI in type 2 diabetics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1692527","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T16:04:23Z","timestamp":1774368263000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of risk factors for latent tuberculosis infection among type 2 diabetics: a hospital-based multicenter cross-sectional study"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhenyang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Tuberculosis Prevention and Control, Shenzhen Bao\u2019an Center for Chronic Disease Control","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Shenzhen Hospital, Southern Medical University","place":["Shenzhen, China"]},{"name":"School of Nursing, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikai","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nursing, Shenzhen Hospital, Southern Medical University","place":["Shenzhen, China"]},{"name":"School of Nursing, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nursing, Shenzhen Hospital, Southern Medical University","place":["Shenzhen, China"]},{"name":"School of Nursing, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yawei","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Lung Disease, Shenzhen Baoan District People\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis Prevention and Control, Shenzhen Bao\u2019an Center for Chronic Disease Control","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nursing, Shenzhen Hospital, Southern Medical University","place":["Shenzhen, China"]},{"name":"School of Nursing, Southern Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1186\/s12879-024-09931-8","article-title":"Latent tuberculosis infection and diagnostic performance of the tuberculin skin test among type 2 diabetics in Sana\u2019a city, Yemen","volume":"24","author":"Abdul-Ghani","year":"2024","journal-title":"BMC Infect. 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