{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:02:53Z","timestamp":1771927373490,"version":"3.50.1"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The specific gut microbial signatures and their correlation with immune-inflammatory markers in infertile women with endometriosis remain underexplored.To investigate the differences in gut microbiota and their associations with biochemical immune markers in infertile women with endometriosis compared to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case-control study enrolled 32 infertile women with endometriosis and 13 control women with male-factor infertility. Fecal samples were collected for 16S rRNA sequencing to profile the gut microbiota, and serum samples were obtained to measure inflammation-related biomarkers. Bioinformatics analyses were applied to compare gut microbial community structures and to examine correlations between differentially abundant bacteria and immune markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The endometriosis group exhibited significant enrichment of Lachnospira, Bacilli, Lactobacillales, Parasutterella, Enterococcus, and Veillonella. Comparative analysis revealed significantly altered abundances of multiple taxa, including Lachnospira, Parasutterella, Alistipes, Enterococcus, Veillonella, Streptococcus, Desulfovibrionaceae, Ruminococcaceae, Bilophila, and Peptoniphilus (all P &amp;lt; 0.05). Several inter-species correlations were identified among these bacteria. Importantly, specific microbiota were correlated with immune markers: Streptococcus and Veillonella were positively correlated with macrophage migration inhibitory factor (MIF); Bilophila and Enterococcus were positively correlated with TNF-\u03b1 and IL-6; Veillonella was positively correlated with TNF-\u03b1; Desulfovibrionaceae was negatively correlated with TNF-\u03b1 and IL-6; and Parasutterella was negatively correlated with CA125.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory investigation, specific gut microbial signatures were observed in infertile patients with endometriosis, showing correlations with select systemic immune-inflammatory biomarkers. These initial observations point to a possible association between gut microbiota imbalance and the inflammatory aspects of endometriosis-associated infertility. Consequently, microbial modulation merits further investigation as a potential strategy to alleviate inflammation and potentially enhance reproductive outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1720894","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:10:01Z","timestamp":1769152201000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiota composition and systemic immune-inflammatory marker correlations in infertile women with endometriosis: a pilot case\u2013control study"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoli","family":"Dong","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Longyan First Affiliated Hospital of Fujian Medical University","place":["Longyan, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Center, Longyan First Affiliated Hospital of Fujian Medical University","place":["Longyan, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingpei","family":"Xu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Longyan First Affiliated Hospital of Fujian Medical University","place":["Longyan, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Longyan First Affiliated Hospital of Fujian Medical University","place":["Longyan, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Longyan First Affiliated Hospital of Fujian Medical University","place":["Longyan, Fujian, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110851","article-title":"Short-chain fatty acids (SCFAs) from gastrointestinal disorders, metabolism, epigenetics, central nervous system to cancer - A mini-review","volume":"388","author":"Abdelhalim","year":"2024","journal-title":"Chem. 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