{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:59:20Z","timestamp":1792904360457,"version":"4.5.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["804199"],"award-info":[{"award-number":["804199"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["273838"],"award-info":[{"award-number":["273838"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The oral cavity harbors over 700 bacterial species, and disruption of this balance can lead to periodontitis, which has been linked to systemic conditions including respiratory disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this longitudinal clinical trial, 57 never-smoking adults with stage I\u2013II periodontitis underwent full-mouth periodontal disinfection. Airway resistance and subgingival plaque sampling (analyzed by shotgun metagenomics) was measured at baseline and six weeks after therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Periodontal treatment significantly improved clinical periodontal parameters, and was associated with reductions in airway resistance. Microbiome analysis showed a shift from periodontitis-associated taxa, including\n                      <jats:italic>Prevotella<\/jats:italic>\n                      ,\n                      <jats:italic>Porphyromonas<\/jats:italic>\n                      , and\n                      <jats:italic>Tannerella<\/jats:italic>\n                      , toward health-associated species such as\n                      <jats:italic>Actinomyces oris<\/jats:italic>\n                      , and\n                      <jats:italic>Rothia dentocariosa<\/jats:italic>\n                      . Higher airway resistance was associated with a greater relative abundance of periodontitis-associated bacteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Together, findings suggest that periodontal therapy promotes a healthier oral microbiome and is associated with improved lung function in non-smokers with no prior lung disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1725666","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:00:24Z","timestamp":1773817224000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of periodontal therapy on the oral microbiome and lung function: an intervention study"],"prefix":"10.3389","volume":"16","author":[{"given":"Anders","family":"R\u00f8sland","sequence":"first","affiliation":[{"name":"Department of Clinical Dentistry, Section of Periodontics, University Of Bergen","place":["Bergen, Norway"]},{"name":"Department of Clinical Dentistry, Centre for Translational Oral Research (TOR), University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University Of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein Atle","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Centre for Translational Oral Research (TOR), University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Malinovschi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Physiology, Uppsala University","place":["Uppsala, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar F.","family":"Bun\u00e6s","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Section of Periodontics, University Of Bergen","place":["Bergen, Norway"]},{"name":"Department of Clinical Dentistry, Centre for Translational Oral Research (TOR), University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi J.","family":"Bertelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University Of Bergen","place":["Bergen, Norway"]},{"name":"Oral Health Centre of Expertise in Western Norway","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12362","article-title":"Microbial signatures of health, gingivitis, and periodontitis","volume":"86","author":"Abusleme","year":"2021","journal-title":"Periodontol 2000"},{"key":"B2","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo","year":"1975","journal-title":"Int. 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