{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:35:58Z","timestamp":1790562958684,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Antimicrobial resistance in bacterial and fungal pathogens poses a major threat to global health, with\n                      <jats:italic>Candida auris<\/jats:italic>\n                      recently classified by the WHO as a critical priority pathogen. Antimicrobial peptides (AMPs) have emerged as promising candidates due to their broad-spectrum activity and membrane-disruptive mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, the antibacterial and antifungal efficacy of two CLEC3A-derived peptides, HT-47 and WRK-30, was evaluated in comparison to the reference AMP LL-37 and the drugs amphotericin B and penicillin\/streptomycin using viable count assays, biofilm assays, and scanning and transmission electron microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HT-47 and WRK-30 showed antibacterial activity against the ESKAPE pathogens\n                      <jats:italic>K. pneumoniae<\/jats:italic>\n                      and\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      , as well as antifungal effects against\n                      <jats:italic>C. albicans<\/jats:italic>\n                      ,\n                      <jats:italic>C. neoformans<\/jats:italic>\n                      , and particularly\n                      <jats:italic>C. auris<\/jats:italic>\n                      , with MIC50 values comparable to or lower than amphotericin B. Both peptides significantly inhibited more potent\n                      <jats:italic>C. auris<\/jats:italic>\n                      biofilm formation, compared to amphotericin B. SEM and TEM revealed extensive membrane and subcellular damage in peptide-treated fungal cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      CLEC3A-derived peptides HT-47 and WRK-30 exhibit potent and comparable antibacterial and antifungal activity, highlighting their potential as therapeutic candidates for combating multidrug-resistant pathogens, including\n                      <jats:italic>C. auris<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1756518","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:30:49Z","timestamp":1771828249000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["CLEC3A-derived peptides exhibit broad-spectrum activity against Candida auris and clinically relevant pathogens"],"prefix":"10.3389","volume":"16","author":[{"given":"Katinka","family":"Mies","sequence":"first","affiliation":[{"name":"Institute for Clinical Chemistry, Medical Faculty, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Hermes","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry, Medical Faculty, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Beckers","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry, Medical Faculty, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6rgelin","sequence":"additional","affiliation":[{"name":"Colzyx AB","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Simon","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Medicine and Microbiology, St. Marien Hospital","place":["Amberg, Germany"]},{"name":"Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne","place":["Cologne, Germany"]},{"name":"Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg","place":["Regensburg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"R\u00fcgamer","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jantsch","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne and Faculty of Medicine, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas R.","family":"Klatt","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry, Medical Faculty, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Streichert","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry, Medical Faculty, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzemal","family":"Elezagic","sequence":"additional","affiliation":[{"name":"Institute for Clinical Chemistry, Medical Faculty, University of Cologne","place":["Cologne, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1128\/CMR.00076-09","article-title":"Candida infections of the genitourinary tract","volume":"23","author":"Achkar","year":"2010","journal-title":"Clin. 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