{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:15:10Z","timestamp":1789172110755,"version":"build-2803163510"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"\n Background<\/jats:title>\n \n Streptococcus parasuis<\/jats:italic>\n is a bacterial species recently reclassified from\n Streptococcus suis<\/jats:italic>\n . It has been isolated from pigs and cattle, where it may cause various infections. Human infections caused by\n S. parasuis<\/jats:italic>\n are rare, with fewer than five publications reported human clinical case to date, and current knowledge regarding its pathogenic potential, antibiotic resistance, and evolutionary context in humans is limited.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In this study, the\n S. parasuis<\/jats:italic>\n strain S62 was isolated from the blood of a febrile patient. Whole-genome sequencing revealed a genome of 1.93 Mb with a G+C content of 39.5%. Phylogenetic and ANI analyses confirmed that S62 belongs to\n S. parasuis<\/jats:italic>\n and is closely related to strains 7500, 221006, NN1, and BS26. The genome harbors virulence-associated genes, including\n hasC<\/jats:italic>\n , and putative antibiotic resistance determinants such as a\n vanY<\/jats:italic>\n -like glycopeptide resistance gene and the\n patA\u2013patB<\/jats:italic>\n efflux system. Phenotypic antimicrobial susceptibility testing showed that S62 was sensitive to most tested antibiotics, with intermediate susceptibility observed only for tetracycline and clindamycin. Functional annotation highlighted the strain\u2019s metabolic versatility and potential for environmental adaptation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study provides a detailed genomic characterization of a human clinical\n S. parasuis<\/jats:italic>\n isolate, shedding light on its virulence potential, resistance determinants, and evolutionary relationships. These findings provide a baseline for further investigation and monitoring of\n S. parasuis<\/jats:italic>\n in human infections.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1759415","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:47:30Z","timestamp":1781848050000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Genomic characterization and phylogenetic analysis of a clinical Streptococcus parasuis isolate from a human patient"],"prefix":"10.3389","volume":"16","author":[{"given":"Jiachen","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Infectious Diseases and Endemic Diseases Control, Beijing Center for Disease Prevention and Control, Beijing Key Laboratory of Surveillance, Early Warning and Pathogen Research on Emerging Infectious Diseases, Beijing Research Center for Respiratory Infectious Diseases","place":["Beijing, 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