{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:16:42Z","timestamp":1770747402630,"version":"3.49.0"},"reference-count":113,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    The co-evolution of resistance and virulence in\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    poses a significant challenge in the management of pyogenic liver abscesses (PLA), particularly with the advent of carbapenem-resistant hypervirulent\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    (CR-hv\n                    <jats:italic>KP<\/jats:italic>\n                    ). This review specifically addresses PLA to consolidate current knowledge on how key virulence factors\u2014such as the K1\/K2 capsule, hypermucoviscosity, and aerobactin\u2014contribute to hepatic infection. It also examines the molecular mechanisms, including plasmid fusion and horizontal gene transfer, that are believed to facilitate the convergence of hypervirulence and carbapenem resistance. Additionally, the review discusses the unique clinical challenges presented by CR-hv\n                    <jats:italic>KP<\/jats:italic>\n                    in the context of PLA, including diagnostic delays, antimicrobial treatment failures, and complications in drainage. Emerging countermeasures, such as rapid molecular diagnostics and novel anti-virulence strategies, are also explored. By integrating contemporary molecular insights with the specific clinical challenges of PLA management, this review provides an updated translational perspective aimed at bridging the gap between pathogenesis and therapeutic strategies for CR-hv\n                    <jats:italic>KP<\/jats:italic>\n                    -associated infections.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1767477","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:51:15Z","timestamp":1770706275000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Co-evolution of resistance and virulence in Klebsiella pneumoniae liver abscess: PLA-specific mechanisms and therapeutic dilemmas"],"prefix":"10.3389","volume":"16","author":[{"given":"Han","family":"Lin","sequence":"first","affiliation":[{"name":"School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Department of Infectious Disease, Gongli Hospital of Shanghai Pudong New Area","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenghaoyu","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology","place":["Shanghai, China"]},{"name":"Department of Infectious Disease, Gongli Hospital of Shanghai Pudong New Area","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Gongli Hospital of Shanghai Pudong New Area","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00874-18","article-title":"Fighting antibiotic-resistant klebsiella pneumoniae with \u201cSweet\u201d Immune targets","volume":"9","author":"Adamo","year":"2018","journal-title":"mBio"},{"key":"B2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1093\/bfgp\/elab038%JBriefingsinFunctionalGenomics","article-title":"Potential therapeutic targets of Klebsiella pneumoniae: a multi-omics review perspective","volume":"21","author":"Ali","year":"2021","journal-title":"Briefings Funct. 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