{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:38:09Z","timestamp":1787060289197,"version":"build-2736575974"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>Mast cells (MCs) are myeloid-derived immune cells that differentiate in peripheral tissues, where they are strategically located near epithelial surfaces. In the gastrointestinal tract, MCs regulate immune response through the release of mediators such as histamine, cytokines, and proteases; however, their excessive activation promotes inflammation, increases intestinal permeability, and contributes to disorders such as food allergies, inflammatory bowel disease, and chronic intestinal inflammation. Probiotics are live microorganisms that confer health benefits to the host when administered in adequate amounts and play a key role in gut immune regulation by modulating the microbiota, reinforcing epithelial barrier integrity, and promoting anti-inflammatory responses. Although MCs and probiotics have been extensively studied independently, their functional interplay in gut health and disease remains poorly defined. Here, we propose that probiotic-mast cell interactions represent an underexplored immunoregulatory axis in intestinal homeostasis. This mini-review synthesizes current evidence on the crosstalk between probiotics and MCs, highlighting the limited mechanistic understanding of these interactions and its potential therapeutic implications.<\/jats:p>","DOI":"10.3389\/fcimb.2026.1772010","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:44:10Z","timestamp":1775022250000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The interplay between probiotics and mast cells in gut inflammation: a mini-review"],"prefix":"10.3389","volume":"16","author":[{"given":"Maria Fernanda","family":"Herrera-Saldivar","sequence":"first","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Biol\u00f3gicas, Laboratorio de Inmunolog\u00eda y Virolog\u00eda","place":["San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Carolina","family":"Hernandez-Bautista","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Biol\u00f3gicas, Departamento de Biolog\u00eda Celular y Gen\u00e9tica","place":["San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Quiroga-Garza","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Biol\u00f3gicas, Laboratorio de Inmunolog\u00eda y Virolog\u00eda","place":["San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Manuel","family":"Vazquez-Guillen","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Biol\u00f3gicas, Laboratorio de Inmunolog\u00eda y Virolog\u00eda","place":["San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel","family":"Chacon-Salinas","sequence":"additional","affiliation":[{"name":"Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Departamento de Inmunolog\u00eda","place":["Ciudad de M\u00e9xico, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilia","family":"Rojas-Contreras","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Baja California Sur, Laboratorio de Ciencia y Tecnolog\u00eda de los Alimentos","place":["La Paz, Baja California Sur, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Vazquez-Juarez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas del Noroeste, S.C., Laboratorio de Gen\u00f3mica y Bioinform\u00e1tica","place":["La Paz, Baja California Sur, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Resendez-Perez","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Biol\u00f3gicas, Departamento de Biolog\u00eda Celular y Gen\u00e9tica","place":["San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes S.","family":"Tamez-Guerra","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Biol\u00f3gicas, Laboratorio de Inmunolog\u00eda y Virolog\u00eda","place":["San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodriguez-Padilla","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Ciencias Biol\u00f3gicas, Laboratorio de Inmunolog\u00eda y Virolog\u00eda","place":["San Nicol\u00e1s de los Garza, Nuevo Le\u00f3n, Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/2045572","article-title":"The role of combining probiotics in preventing and controlling inflammation: A focus on the anti-inflammatory and immunomodulatory effects of probiotics in an In Vitro model of IBD","volume":"2022","author":"Aghamohammad","year":"2022","journal-title":"Can. 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