{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:12:24Z","timestamp":1773645144302,"version":"3.50.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the clinical effectiveness of dual-wavelength laser with periodontal flap surgery in managing periodontic-endodontic lesions (PEL) and its impact on periodontal parameters and inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 106 PEL patients were randomly assigned to a study group or a control group (53 each). All patients first received root canal treatment. The control group underwent conventional periodontal flap surgery, whereas the study group received adjunctive dual-wavelength laser treatment (Nd: YAG for root canal disinfection and Er: YAG for periodontal pocket debridement). Pain visual analogue scale (VAS) scores were recorded prior to treatment and at 1 and 7 days postoperatively. Periodontal parameters, gingival crevicular fluid (GCF) and serum inflammatory markers, and bacterial infection\/clearance rates were assessed at baseline and 3 months post-treatment. Clinical efficacy and incidences of tooth mobility, periodontitis recurrence, and percussion pain were evaluated at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety-nine patients completed follow-up (48 in the study group and 51 in the control group). On postoperative day 1, VAS scores increased in both groups but were significantly lower in the study group (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05); by day 7, VAS scores declined with no between-group difference (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;gt; 0.05). At 3 months, PD, CAL, GI, PLI, and levels of IL-1\u03b2, IL-6, and MMP-8 decreased in both groups, with greater improvements in the study group (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). The study group also exhibited lower bacterial infection rates and higher bacterial clearance (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05). At 6 months, the study group showed higher treatment success and lower rates of tooth mobility, recurrence, and percussion pain (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dual-wavelength laser adjunctive therapy enhances the clinical efficacy of periodontal flap surgery in PEL, significantly improving periodontal healing, reducing inflammation, and promoting bacterial clearance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1773155","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:40:23Z","timestamp":1773643223000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dual-wavelength laser combined with periodontal flap surgery on periodontal parameters and inflammatory factors in patients with periodontic-endodontic lesions"],"prefix":"10.3389","volume":"16","author":[{"given":"Lijie","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Stomatology, Tongxiang First People\u2019s Hospital","place":["Tongxiang, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongxiang First People\u2019s Hospital","place":["Tongxiang, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenxi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongxiang First People\u2019s Hospital","place":["Tongxiang, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijie","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tongxiang First People\u2019s Hospital","place":["Tongxiang, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.34172\/joddd.2021.023","article-title":"Clinical and microbiological evaluation of 940-nm diode laser as an adjunct to modified Widman flap for the management of chronic periodontitis: A 6-month randomized split-mouth clinical trial","volume":"15","author":"Agarwal","year":"2021","journal-title":"J. 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