{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:47:14Z","timestamp":1789238834813,"version":"build-2803163510"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Previous studies have shown that\n                      <jats:italic>Taraxacum<\/jats:italic>\n                      (TM) possesses strong antioxidant, anti-inflammatory, and antibacterial activities, but the mechanism regarding how TM attenuates IBD requires further exploration. This study evaluated the therapeutic effects of TM (0.15, 0.75, and 1.5 g\/kg) on ulcerative colitis induced by Dextran Sulfate Sodium (DSS) in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 14 days of treatment following colitis induction, the herbal extract alleviated body weight loss and pathological abnormalities in the mice. In comparison to the DSS group, the 1.5 g\/kg The TM therapy group had markedly elevated levels of colonic T-SOD, T-AOC, and GSH-Px (P &amp;lt; 0.05), alongside a substantial decrease in MDA content (P &amp;lt; 0.05) and inflammatory cytokines (IL-2, IL-6, IFN-g, TNF-a) (P &amp;lt; 0.05). Furthermore, TM markedly elevated the concentrations of volatile fatty acids (acetate, propionate, isobutyrate, and butyrate) in the cecal contents (P &amp;lt; 0.05). The 0.75 and 1.5 g\/kg TM groups also elevated the expression of Claudin-1, Occludin, and ZO-1 (P &amp;lt; 0.05), whereas the DSS group showed reduced expression of these mucosal barrier proteins. Concerning gut microbiota, at the Phylum level, the relative abundance of\n                      <jats:italic>Firmicutes<\/jats:italic>\n                      was markedly elevated in the 1.5 g\/kg TM groups (P &amp;lt; 0.05),\n                      <jats:italic>Bacteroidetes<\/jats:italic>\n                      exhibited a considerable reduction (P &amp;lt; 0.05); TM alleviated colitis concurrent with the restoration of beneficial\n                      <jats:italic>Muribaculaceae<\/jats:italic>\n                      and reduction of harmful\n                      <jats:italic>Desulfovibrio<\/jats:italic>\n                      . Notably,\n                      <jats:italic>Desulfovibrio<\/jats:italic>\n                      was inhibited more effectively than in 5-ASA, a change associated with intestinal homeostasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TM alleviated colitis is correlated with enhancing antioxidant capacity, reducing inflammation, restoringbarrier integrity, and modulating the gut microbiota.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcimb.2026.1778487","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:40:05Z","timestamp":1774593605000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Taraxacum alleviates ulcerative colitis, accompanied by the modulation of gut microbiota and restoration of intestinal barrier integrity"],"prefix":"10.3389","volume":"16","author":[{"given":"Chunsheng","family":"Fu","sequence":"first","affiliation":[{"name":"Taizhou People\u2019s Hospital, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Taizhou People\u2019s Hospital, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chensen","family":"Xu","sequence":"additional","affiliation":[{"name":"Medical Department, Yangzhou University School of Medicine","place":["Yangzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilian","family":"Hua","sequence":"additional","affiliation":[{"name":"Taizhou People\u2019s Hospital, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ye","sequence":"additional","affiliation":[{"name":"Taizhou People\u2019s Hospital, Nanjing Medical University","place":["Taizhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.2741\/3413","article-title":"Mechanism of cytokine modulation of epithelial tight junction barrier","volume":"14","author":"Al-Sadi","year":"2009","journal-title":"Front. 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