{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:47:50Z","timestamp":1774000070773,"version":"3.50.1"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Infect. Microbiol."],"abstract":"<jats:p>\n                    PANoptosis is a recently identified, inflammatory programmed cell death pathway that amalgamates features of pyroptosis, apoptosis, and necroptosis, executed via multiprotein complexes called PANoptosomes. Increasing evidence highlights PANoptosis has emerged as a potentially pivotal factor in the pathogenesis of several diseases, including viral and bacterial infections and malignancies. Given its extensive pathophysiological relevance, this review systematically explores the conceptual underpinnings, molecular mechanisms, and structural composition of PANoptosome. Special attention is devoted to elucidating the pathophysiological interactions between PANoptosis and tuberculosis (TB), with the aim of developing integrated diagnostic-therapeutic strategies and targeted pharmaceutical innovations for TB. Tuberculosis, a respiratory infectious disease caused by\n                    <jats:italic>Mycobacterium tuberculosis(M.tb)<\/jats:italic>\n                    , continues to pose a significant global health challenge.\n                  <\/jats:p>","DOI":"10.3389\/fcimb.2026.1786786","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:37:08Z","timestamp":1773988628000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress in PANoptosis mechanisms and their interplay with tuberculosis"],"prefix":"10.3389","volume":"16","author":[{"given":"Xue","family":"Ma","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute of Tuberculosis Research, Senior Department of Tuberculosis, The Eighth Medical Center of Chinese People's Liberation Army (PLA), General Hospital","place":["Beijing, China"]},{"name":"Graduate School, Hebei North University","place":["Zhangjiakou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute of Tuberculosis Research, Senior Department of Tuberculosis, The Eighth Medical Center of Chinese People's Liberation Army (PLA), General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute of Tuberculosis Research, Senior Department of Tuberculosis, The Eighth Medical Center of Chinese People's Liberation Army (PLA), General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiru","family":"An","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute of Tuberculosis Research, Senior Department of Tuberculosis, The Eighth Medical Center of Chinese People's Liberation Army (PLA), General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/mi.2011.3","article-title":"Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis","volume":"4","author":"Behar","year":"2011","journal-title":"Mucosal Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. 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