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Cell. Infect. Microbiol."],"abstract":"<jats:p>Pneumonia is a common acute infectious disease affecting the lower respiratory tract. Innate immune cells within the lungs play a crucial role in the onset and progression of pneumonia. Various multidrug-resistant bacteria have evolved multiple strategies to evade innate immunity, posing significant challenges to the treatment of pneumonia. This review primarily explores the major innate immune cells in the lungs and their functions, the immune evasion mechanisms of common multidrug-resistant bacteria, and the latest research advances in targeted innate immunity-based anti-infective therapies. This review synthesizes recent advances in the interaction between the innate immune system of the lungs and multidrug-resistant bacteria. It systematically categorizes and compares the immune evasion mechanisms of multidrug-resistant bacteria across four core pathways. This aims to provide novel insights for treating pulmonary infections caused by these multidrug-resistant pathogens.<\/jats:p>","DOI":"10.3389\/fcimb.2026.1790950","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:36:46Z","timestamp":1773758206000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune evasion of multidrug-resistant bacteria: insights from lung innate immune cells and targeted therapies"],"prefix":"10.3389","volume":"16","author":[{"given":"Yingfei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tangdu Hospital, Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tangdu Hospital, Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tangdu Hospital, Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tangdu Hospital, Air Force Medical University","place":["Xi\u2019an, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s41590-019-0568-x","article-title":"Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection","volume":"21","author":"Aegerter","year":"2020","journal-title":"Nat. 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